PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ARFIP2	0	PFKM	4	biochemical	Wan C (2015)	1
KRT15	2	HGS	5	two hybrid	Rolland T (2014)	1
ARFIP2	0	CEP63	2	two hybrid	Rolland T (2014)	1
KRT15	2	USHBP1	1	two hybrid	Rual JF (2005)	1
ITSN1	5	ARFIP2	0	two hybrid, protein complementation assay, affinity chromatography technology	Wong KA (2012), Wong KA (2012), Wong KA (2012)	3
ARF1	1	ARFIP2	0	pull down	Kanoh H (1997)	1
ITGB3BP	0	APP	1	pull down	Olah J (2011)	1
SARS	4	PFKM	4	biochemical	Wan C (2015)	1
RAC1	7	ARFIP2	0	two hybrid, pull down, two hybrid, x-ray crystallography, pull down, two hybrid	Shin OH (2001), Van Aelst L (1996), Van Aelst L (1996), Tarricone C (2001), Tarricone C (2001), Wang J (2011)	6
ITGB3BP	0	ARFIP2	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
ARFIP2	0	LY6D	0	two hybrid	Wang J (2011)	1
ARFIP2	0	TRIM54	1	two hybrid	Rolland T (2014)	1
EWSR1	2	ARFIP2	0	bioid	Elzi DJ (2014)	1
HGS	5	ING5	3	two hybrid	Rolland T (2014)	1
ARFIP2	0	STAT3	0	two hybrid	Wang J (2011)	1
HGS	5	APP	1	pull down, pull down, pull down	Pridgeon JW (2009), Olah J (2011), Virok DP (2011)	3
SNX1	2	APP	1	pull down	Olah J (2011)	1
HGS	5	SNX5	3	affinity chromatography technology, pull down	Sun Y (2013), Sun Y (2013)	2
HGS	5	SNX1	2	pull down, affinity chromatography technology	Chin LS (2001), Popoff V (2009)	2
ARF6	0	APP	1	pull down	Olah J (2011)	1
ARFIP2	0	ARF6	0	two hybrid, two hybrid, pull down, pull down	DSouza-Schorey C (1997), Shin OH (2001), Shin OH (2001), DSouza-Schorey C (1997)	4
CDKN2A	1	ARFIP2	0	two hybrid, affinity chromatography technology	Lu L (2001), Lu L (2001)	2
MOV10	6	STAT3	0	affinity chromatography technology	Castello A (2012)	1
CDH1	4	SNX1	2	bioid	Guo Z (2014)	1
MOV10	6	PFKM	4	affinity chromatography technology	Castello A (2012)	1
SNX1	2	SNX5	3	biochemical, affinity chromatography technology	Wan C (2015), Huttlin EL (2017)	2
ARFIP2	0	DTNBP1	1	two hybrid	Rual JF (2005)	1
ARFIP2	0	ARFIP1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
KRT15	2	HAUS1	0	two hybrid	Rolland T (2014)	1
CDH1	4	PDLIM5	0	bioid	Guo Z (2014)	1
ARFIP2	0	AGTRAP	1	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
SARS	4	ARFIP2	0	biochemical	Wan C (2015)	1
CDH1	4	ARFIP2	0	bioid	Guo Z (2014)	1
TRIM54	1	ATXN3	2	enzymatic study	Loch CM (2012)	1
ARF3	0	ARFIP1	2	two hybrid, pull down, pull down	Kanoh H (1997), Kanoh H (1997), Williger BT (1999)	3
CDKN2A	1	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
ARFIP2	0	MAL2	0	two hybrid	Rolland T (2014)	1
DUSP22	1	ARF5	0	affinity chromatography technology	Li X (2016)	1
NEURL1	0	ARFIP2	0	biochemical	Wan C (2015)	1
SARS	4	ARFIP1	2	biochemical	Wan C (2015)	1
ARL1	0	ARFIP2	0	two hybrid, two hybrid, affinity chromatography technology	Lu L (2003), Lu L (2001), Lu L (2001)	3
LYPD3	0	ARFIP2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MOV10	6	HGS	5	affinity chromatography technology	Castello A (2012)	1
ARFIP1	2	STAT3	0	biochemical	Kristensen AR (2012)	1
ITSN1	5	SNX5	3	two hybrid	Stelzl U (2005)	1
DUSP22	1	ARF1	1	affinity chromatography technology	Li X (2016)	1
CEP63	2	HAUS1	0	two hybrid, bioid	Rolland T (2014), Gupta GD (2015)	2
ARFIP2	0	USHBP1	1	two hybrid	Rolland T (2014)	1
SNX5	3	ARFIP2	0	biochemical	Kristensen AR (2012)	1
ARFIP2	0	HAUS1	0	two hybrid	Rolland T (2014)	1
RAC1	7	STAT3	0	two hybrid, affinity chromatography technology	Simon AR (2000), Simon AR (2000)	2
PFKM	4	ARFIP1	2	biochemical	Wan C (2015)	1
ATXN3	2	EWSR1	2	two hybrid	Lim J (2006)	1
USHBP1	1	HAUS1	0	two hybrid	Rolland T (2014)	1
SNX1	2	AGTRAP	1	two hybrid	Rolland T (2014)	1
ARFIP2	0	SNX1	2	two hybrid	Wang J (2011)	1
ITSN1	5	ARF6	0	protein complementation assay	Wong KA (2012)	1
ARF3	0	ARFIP2	0	two hybrid, pull down	Kanoh H (1997), Kanoh H (1997)	2
ARF1	1	ARF3	0	biochemical	Havugimana PC (2012)	1
TMEM17	0	ARFIP2	0	bioid	Gupta GD (2015)	1
TMEM17	0	HGS	5	bioid	Gupta GD (2015)	1
CEP63	2	USHBP1	1	two hybrid	Rual JF (2005)	1
ARFIP2	0	ING5	3	two hybrid	Rolland T (2014)	1
SARS	4	SNX5	3	biochemical	Kristensen AR (2012)	1
AKT1	1	APP	1	pull down	Olah J (2011)	1
MOV10	6	ING5	3	affinity chromatography technology	Castello A (2012)	1
DUSP22	1	ARFIP2	0	affinity chromatography technology	Huttlin EL (2017)	1
MOV10	6	ARFIP2	0	affinity chromatography technology	Castello A (2012)	1
DTNBP1	1	HAUS1	0	two hybrid	Rolland T (2014)	1
KRT15	2	ARFIP2	0	two hybrid	Rolland T (2014)	1
TMEM17	0	ARFIP1	2	bioid	Gupta GD (2015)	1
ARFIP2	0	PDLIM5	0	biochemical	Wan C (2015)	1
HGS	5	ARFIP2	0	two hybrid	Rolland T (2014)	1
TRIM54	1	USHBP1	1	two hybrid	Rolland T (2014)	1
ATXN3	2	APP	1	pull down	Olah J (2011)	1
ARF1	1	ARF5	0	biochemical	Wan C (2015)	1
TRIM54	1	HAUS1	0	two hybrid	Rolland T (2014)	1
ARFIP2	0	ARFIP2	0	x-ray crystallography, two hybrid	Tarricone C (2001), Rolland T (2014)	2
ATXN3	2	ARFIP2	0	affinity chromatography technology	Kristensen LV (2018)	1
DUSP22	1	ARL1	0	affinity chromatography technology	Li X (2016)	1
ARF5	0	ARFIP1	2	pull down	Kanoh H (1997)	1
CDH1	4	ARFIP1	2	bioid	Guo Z (2014)	1
AKT1	1	RAC1	7	enzymatic study	Kwon T (2000)	1
ARF1	1	ARFIP1	2	pull down	Kanoh H (1997)	1
CDH1	4	SNX5	3	bioid	Guo Z (2014)	1
MOV10	6	SNX1	2	affinity chromatography technology	Castello A (2012)	1
HGS	5	PFKM	4	pull down	Pridgeon JW (2009)	1
HGS	5	USHBP1	1	two hybrid	Rual JF (2005)	1
ARFIP2	0	APP	1	pull down	Olah J (2011)	1
ARF5	0	ARFIP2	0	pull down, two hybrid, pull down	Kanoh H (1997), Shin OH (2001), Shin OH (2001)	3
AKT1	1	ARFIP2	0	two hybrid	DSouza-Schorey C (1997)	1
MOV10	6	CDKN2A	1	affinity chromatography technology	Castello A (2012)	1
ARFIP2	0	SOCS2	1	two hybrid	Wang J (2011)	1