PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
GGA2	2	APP	1	pull down	Olah J (2011)	1
APP	1	BACE1	2	affinity chromatography technology	Lakshmana MK (2009)	1
GGA1	0	APP	1	affinity chromatography technology, pull down	Wahle T (2006), Wahle T (2006)	2
NXF1	0	BACE1	2	affinity chromatography technology	Castello A (2012)	1
SCGB1D4	1	BACE1	2	affinity chromatography technology	Huttlin EL (2017)	1
RANBP9	5	BACE1	2	affinity chromatography technology	Lakshmana MK (2009)	1
SORT1	1	BACE1	2	affinity chromatography technology, affinity chromatography technology	Finan GM (2011), Finan GM (2011)	2
CSNK1D	3	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
NCSTN	1	APP	1	affinity chromatography technology	Yu G (2000)	1
NXF1	0	GGA3	6	affinity chromatography technology	Castello A (2012)	1
BACE1	2	CSNK1D	3	imaging technique	Chen TC (2014)	1
SORT1	1	GGA1	0	two hybrid, pull down, two hybrid, unspecified method, pull down, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology	Jacobsen L (2002), Jacobsen L (2002), Shiba T (2002), Cramer JF (2010), Cramer JF (2010), Cramer JF (2010), Takatsu H (2001), Takatsu H (2001), Takatsu H (2001)	9
MMP2	2	BACE1	2	imaging technique	Chen TC (2014)	1
NCSTN	1	BACE1	2	pull down	Hattori C (2002)	1
RANBP9	5	COPS5	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Wang H (2013), Wang H (2013), Wang H (2013)	3
MOV10	6	GGA3	6	affinity chromatography technology	Castello A (2012)	1
BACE1	2	BRI3	0	affinity chromatography technology	Wickham L (2005)	1
MOV10	6	STUB1	4	affinity chromatography technology, affinity chromatography technology	Li S (2014), Castello A (2012)	2
APP	1	STUB1	4	affinity chromatography technology, affinity chromatography technology	Kumar P (2007), Kumar P (2007)	2
BACE1	2	KCNQ1	5	affinity chromatography technology, affinity chromatography technology	Agsten M (2015), Agsten M (2015)	2
GGA1	0	GGA3	6	imaging technique, pull down, pull down	Ghosh P (2003), Ghosh P (2003), Ghosh P (2003)	3
COPS5	0	NXF1	0	affinity chromatography technology	Bennett EJ (2010)	1
NXF1	0	STUB1	4	affinity chromatography technology	Castello A (2012)	1
STUB1	4	BACE1	2	enzymatic study, affinity chromatography technology	Singh AK (2015), Singh AK (2015)	2
BACE1	2	GGA3	6	affinity chromatography technology, pull down, affinity chromatography technology	He X (2003), He X (2003), von Einem B (2015)	3
PCSK9	3	BACE1	2	enzymatic study, pull down	Jonas MC (2008), Jonas MC (2008)	2
SORT1	1	GGA2	2	two hybrid, pull down, two hybrid, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology	Nielsen MS (2001), Nielsen MS (2001), Jacobsen L (2002), Jacobsen L (2002), Takatsu H (2001), Takatsu H (2001), Takatsu H (2001)	7
USP8	7	BACE1	2	enzymatic study	Yeates EF (2016)	1
PCSK9	3	STUB1	4	affinity chromatography technology	Xu W (2012)	1
GGA2	2	GGA3	6	pull down, pull down	Ghosh P (2003), Ghosh P (2003)	2
COPS5	0	MOV10	6	affinity chromatography technology	Bennett EJ (2010)	1
NXF1	0	PCSK9	3	affinity chromatography technology	Castello A (2012)	1
FBXO2	0	BACE1	2	affinity chromatography technology, enzymatic study	Gong B (2010), Gong B (2010)	2
SORT1	1	GGA3	6	affinity chromatography technology	Takatsu H (2001)	1
MOV10	6	BACE1	2	affinity chromatography technology	Castello A (2012)	1
GGA1	0	GGA2	2	imaging technique, pull down, pull down, affinity chromatography technology	Ghosh P (2003), Ghosh P (2003), Ghosh P (2003), Huttlin EL (2017)	4
BACE1	2	GGA2	2	affinity chromatography technology, pull down, affinity chromatography technology	He X (2003), He X (2003), von Einem B (2015)	3
FBXO2	0	STUB1	4	affinity chromatography technology, pull down, enzymatic study	Nelson RF (2006), Nelson RF (2006), Nelson RF (2006)	3
COPS5	0	BACE1	2	affinity chromatography technology	Wang H (2013)	1
BACE1	2	GGA1	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe, pull down, x-ray crystallography, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down	von Arnim CA (2004), von Arnim CA (2004), Shiba T (2004), Shiba T (2004), He X (2003), He X (2003), He X (2003), Wahle T (2005), Wahle T (2005), Wahle T (2005), von Einem B (2015), von Einem B (2015)	12
RANBP9	5	APP	1	affinity chromatography technology	Lakshmana MK (2009)	1
COPS5	0	APP	1	pull down, affinity chromatography technology	Olah J (2011), Wang H (2013)	2