PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SOX2	4	PRKAR1A	4	affinity chromatography technology	Cox JL (2013)	1
TP53	0	AIPL1	3	affinity chromatography technology	Boldt K (2016)	1
BACH2	6	BCL6	6	affinity chromatography technology, affinity chromatography technology	Ochiai K (2008), Ochiai K (2008)	2
TP53	0	RPL18A	0	affinity chromatography technology	Fogeron ML (2013)	1
APOBEC3D	0	PATZ1	1	affinity chromatography technology	Huttlin EL (2017)	1
PATZ1	1	PDE5A	3	affinity chromatography technology	Boldt K (2016)	1
POU5F1	0	PATZ1	1	affinity chromatography technology	Oliviero G (2015)	1
CLK1	1	PATZ1	1	enzymatic study	Lipp JJ (2015)	1
RNF4	1	PATZ1	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fedele M (2000), Fedele M (2000), Fedele M (2000), Pero R (2002), Pero R (2002)	5
PATZ1	1	AR	3	affinity chromatography technology, affinity chromatography technology	Pero R (2002), Pero R (2002)	2
CLEC11A	0	PATZ1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
AR	3	NR2C2	0	two hybrid, pull down	Lee YF (1999), Lee YF (1999)	2
POU5F1	0	PCGF1	1	affinity chromatography technology	Oliviero G (2015)	1
H2AFY2	0	PATZ1	1	affinity chromatography technology	Huttlin EL (2017)	1
MIOS	3	FGFR1OP	0	affinity chromatography technology	Boldt K (2016)	1
ESR1	0	PATZ1	1	affinity chromatography technology	Okada M (2015)	1
FGFR1OP	0	PDE5A	3	affinity chromatography technology	Boldt K (2016)	1
NR2C2	0	PATZ1	1	affinity chromatography technology	Hein MY (2015)	1
MITF	3	PATZ1	1	two hybrid, affinity chromatography technology, pull down	Morii E (2002), Morii E (2002), Morii E (2002)	3
ESR1	0	NR2C2	0	pull down, pull down	Shyr CR (2002), Shyr CR (2002)	2
FOXJ2	3	PATZ1	1	affinity chromatography technology	Li X (2015)	1
AR	3	RNF4	1	two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Moilanen AM (1998), Poukka H (2000), Moilanen AM (1998), Moilanen AM (1998), Pero R (2002), Pero R (2002), Poukka H (2000)	7
FGF3	1	PATZ1	1	affinity chromatography technology	Huttlin EL (2017)	1
FGFR1OP	0	AIPL1	3	affinity chromatography technology	Boldt K (2016)	1
PATZ1	1	PATZ1	1	affinity chromatography technology	Keskin N (2015)	1
ESR1	0	RPL18A	0	affinity chromatography technology	Tarallo R (2011)	1
RNF4	1	ESR1	0	two hybrid	Moilanen AM (1998)	1
RPL18A	0	PATZ1	1	affinity chromatography technology	Huttlin EL (2017)	1
BACH2	6	PATZ1	1	two hybrid	Kobayashi A (2000)	1
TP53	0	PATZ1	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Valentino T (2013), Valentino T (2013), Keskin N (2015), Keskin N (2015)	4
RBPJ	1	PATZ1	1	affinity chromatography technology	Li X (2015)	1
SIRT6	2	PATZ1	1	affinity chromatography technology	Huttlin EL (2017)	1
PATZ1	1	AIPL1	3	affinity chromatography technology	Boldt K (2016)	1
MIOS	3	PATZ1	1	affinity chromatography technology	Boldt K (2016)	1
PDE5A	3	AIPL1	3	affinity chromatography technology	Boldt K (2016)	1
PATZ1	1	BCL6	6	two hybrid, affinity chromatography technology, affinity chromatography technology	Pero R (2012), Pero R (2012), Pero R (2012)	3
OMD	0	PATZ1	1	affinity chromatography technology	Huttlin EL (2017)	1
SOX2	4	PATZ1	1	affinity chromatography technology	Cox JL (2013)	1
BACH1	3	PATZ1	1	two hybrid	Kobayashi A (2000)	1
TP53	0	ESR1	0	pull down, affinity chromatography technology, affinity chromatography technology	Liu G (2000), Duong V (2007), Saxena R (2016)	3
PRKAR1A	4	PATZ1	1	two hybrid, pull down	Yang WL (2010), Yang WL (2010)	2
PRG2	2	PATZ1	1	affinity chromatography technology	Huttlin EL (2015)	1
AR	3	TP53	0	genetic interference	Shenk JL (2001)	1
MIOS	3	PDE5A	3	affinity chromatography technology	Boldt K (2016)	1
RBPJ	1	TP53	0	affinity chromatography technology, affinity chromatography technology, pull down	Procopio MG (2015), Procopio MG (2015), Procopio MG (2015)	3
ZNF169	1	PATZ1	1	affinity chromatography technology	Huttlin EL (2017)	1
TP53	0	BCL6	6	pull down	Kotlyar M (2015)	1
P4HA3	3	PATZ1	1	affinity chromatography technology	Huttlin EL (2017)	1
BACH1	3	TP53	0	affinity chromatography technology, affinity chromatography technology, pull down	Dohi Y (2008), Dohi Y (2008), Dohi Y (2008)	3
MIOS	3	AIPL1	3	affinity chromatography technology	Boldt K (2016)	1
PCGF1	1	PATZ1	1	affinity chromatography technology	Oliviero G (2015)	1
FGFR1OP	0	PATZ1	1	affinity chromatography technology	Boldt K (2016)	1
POU5F1	0	SOX2	4	pull down, affinity chromatography technology, affinity chromatography technology	Remenyi A (2003), Xu C (2013), Oliviero G (2015)	3