Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
PADI4 23569 CHEMBL1910970 CHEMBL1910970 inhibitor GuideToPharmacologyInteractions
PADI4 23569 L-CITRULLINE CHEMBL444814 DrugBank 16146736, 16412378, 16355400, 15345777, 16271291
PADI4 23569 AZITHROMYCIN CHEMBL529 DrugBank 17964793
PADI4 23569 STREPTOMYCIN CHEMBL372795 DrugBank 17964793

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
PADI4 rs2477134 G uric acid metabolism/PK yes Authors mention "some evidence of association in GENRES" for SNP previously associated with HCTZ-induced change in serum uric acid concentration in African Americans. Allele is not stated so assumed minor allele based on HapMap/dbSNP. Allele G is associated with increased concentrations of uric acid in people with Hypertension as compared to allele T. 29580174 1449270340
PADI4 rs2240340 T Tumor necrosis factor alpha efficacy no using either the absolute change in DAS28 or the proportion of good responders and non-responders as outcomes. Allele T is not associated with decreased response to Tumor necrosis factor alpha (TNF-alpha) inhibitors in people with Arthritis, Rheumatoid as compared to allele C. 25834819 1444702671