Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications
FPGS	2356	RALTITREXED	CHEMBL225071	antagonist	DrugBank	11916544
FPGS	2356	L-GLUTAMATE	CHEMBL575060		DrugBank	16686541, 16990006
FPGS	2356	FLUOROURACIL	CHEMBL185		NCI	9291820

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
FPGS	rs1544105	CT + TT	methotrexate	efficacy	yes		Genotypes CT + TT are associated with decreased response to methotrexate in people with Arthritis, Rheumatoid as compared to genotype CC.	19902562	655387805
FPGS	rs7856096	G	warfarin	dosage	yes	In the combined cohort each minor allele of rs7856096 contributed to -5.81 mg/week change in predicted dose (p= 3.93E-5) using the IWPC algorithm.	Allele G is associated with decreased dose of warfarin as compared to allele A.	25079360	1184512426
FPGS	rs7856096	AA	warfarin	dosage	no	in European-Americans, and Egyptians.	Genotype AA is not associated with dose of warfarin as compared to genotypes AG + GG.	26751406	1447677830
FPGS	rs7856096	G	warfarin	dosage	yes	In the discovery cohort the uncorrected p-value was 1.82E-8. P-values were adjusted using Bonferroni correction, with a significance cutoff of 3.22E-7 based on the 155,186 SNPs tested in the discovery cohort.	Allele G is associated with decreased dose of warfarin as compared to allele A.	25079360	1184512419