PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PIK3R1	6	PIK3CA	8	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Woscholski R (1994), Chamberlain MD (2004), Ren SY (2005), Kamal M (2010), Sun M (2010), Hein MY (2015), Fang D (2001), Xiong Y (2009), Ivanov AA (2017)	9
RASD2	1	GNB3	1	two hybrid	Hill C (2009)	1
AKT1	1	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Xiong Y (2009), Xiong Y (2009), Ivanov AA (2017)	3
RASD2	1	GNB1	4	two hybrid	Hill C (2009)	1
RASD2	1	PIK3R1	6	affinity chromatography technology, pull down	Bang S (2012), Bang S (2012)	2
RASD2	1	LRP6	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GNB2	3	RAF1	3	affinity chromatography technology	Pumiglia KM (1995)	1
RAF1	3	RASD2	1	pull down	Vargiu P (2004)	1
GNB1	4	PIK3CA	8	affinity chromatography technology	Xiong Y (2009)	1
RASD2	1	RABAC1	0	two hybrid	Venkatesan K (2009)	1
RASD2	1	GNB2	3	two hybrid	Hill C (2009)	1
AKT1	1	RAF1	3	enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Zimmermann S (1999), Zimmermann S (1999), Wang J (2009), Wang J (2009), Ivanov AA (2017)	5
RASD2	1	LRP5	8	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GNB1	4	PIK3R1	6	affinity chromatography technology, affinity chromatography technology	Xiong Y (2009), Xiong Y (2009)	2
AKT1	1	GNB1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Klein JB (2005), Xiong Y (2009), Xiong Y (2009)	3
RASD2	1	SLC4A7	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PIK3CA	8	RASD2	1	pull down	Vargiu P (2004)	1
RASD2	1	RAP1GDS1	0	affinity chromatography technology	Huttlin EL (2015)	1
PIK3CA	8	AKT1	1	affinity chromatography technology, protein complementation assay, affinity chromatography technology, enzymatic study	Mitra S (2011), Miao B (2010), Xiong Y (2009), Akil H (2015)	4
RASD2	1	AKT1	1	affinity chromatography technology	Bang S (2012)	1