PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HIST1H3A	3	UBN1	3	bioid	Lambert JP (2015)	1
SMARCA4	19	5430	0	biochemical, biochemical, affinity chromatography technology, biochemical, imaging technique, affinity chromatography technology, affinity chromatography technology	Sif S (2001), Wang W (1996), Zhao K (1998), Reyes JC (1997), Ni Z (2005), Zhao LH (2005), Zhao LH (2005)	7
TFAP4	3	HDAC1	4	affinity chromatography technology, affinity chromatography technology	Ku WC (2009), Ku WC (2009)	2
XAGE1B	0	CABIN1	9	affinity chromatography technology	Huttlin EL (2017)	1
MEF2A	1	HIRA	5	affinity chromatography technology	Li X (2015)	1
TFAP4	3	SIN3A	13	affinity chromatography technology	Huttlin EL (2017)	1
SMARCA4	19	HDAC2	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference	Sif S (2001), Qiu Z (2008), Xu Z (2006), Pal S (2003), Battaglioli E (2002), Tando T (2010), Hang CT (2010), Shen JP (2017)	8
TLK2	16	ASF1A	0	two hybrid, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology	Sillje HH (2001), Sillje HH (2001), Pilyugin M (2009), Hein MY (2015), Huttlin EL (2017)	5
H3F3A	1	UBN1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ray-Gallet D (2011), Elsaesser SJ (2010), Lee JS (2016)	3
5430	0	HIRA	5	affinity chromatography technology, imaging technique	Ray-Gallet D (2011), Pchelintsev NA (2013)	2
HIRA	5	CABIN1	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yang JH (2011), Ray-Gallet D (2011), Lee JS (2016), Lee JS (2016)	4
HIST1H3A	3	HDAC2	1	affinity chromatography technology, enzymatic study, pull down	Nishioka K (2002), Gyoery I (2003), Li X (2014)	3
MEF2B	0	CABIN1	9	affinity chromatography technology, affinity chromatography technology	Ying CY (2013), Huttlin EL (2017)	2
MEF2A	1	HDAC1	4	affinity chromatography technology	Aude-Garcia C (2010)	1
ASF1A	0	ASF1B	0	affinity chromatography technology, affinity chromatography technology	Ask K (2012), Hein MY (2015)	2
UBN1	3	HIRA	5	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ray-Gallet D (2011), Tang Y (2012), Tang Y (2012), Tang Y (2012), Tang Y (2012), Tang Y (2012), Lee JS (2016), Lee JS (2016), Lee JS (2016), Pchelintsev NA (2013), Pchelintsev NA (2013)	11
MEF2B	0	MEF2D	5	affinity chromatography technology	Huttlin EL (2017)	1
HIRA	5	SMARCB1	1	imaging technique, affinity chromatography technology, affinity chromatography technology	Pchelintsev NA (2013), Pchelintsev NA (2013), Pchelintsev NA (2013)	3
HDAC1	4	SIN3A	13	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang Y (2003), Yao YL (2003), Yao YL (2003), Fleischer TC (2003), Fleischer TC (2003), Yang L (2003), Grozinger CM (1999), Zhang J (2002), Zhang J (2002), You A (2001), Zhang Y (1999), Zhang Y (2002), Tong JK (1998), Hassig CA (1998), Yasui D (2002), Huang EY (2000), Huang EY (2000), Kuzmichev A (2002), Kuzmichev A (2002), Martinowich K (2003), Martinowich K (2003), Suzuki M (2003), Suzuki M (2006), Nakamura T (2002), Wei Q (2005), Pflum MK (2001), Pflum MK (2001), Skowyra D (2001), Skowyra D (2001), Humphrey GW (2001), Sekhavat A (2007), Zhang Y (1998), Zhang Y (1998), Sun JM (2007), Karwowska-Desaulniers P (2007), Terhune SS (2010), Xue Y (1998), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Oh YM (2009), Wan C (2015), Hein MY (2015), Hsu DS (2014), Huttlin EL (2017)	45
SUV39H1	0	HIST1H3A	3	enzymatic study, enzymatic study, enzymatic study	Carbone R (2006), Kamoi K (2006), Mal AK (2006)	3
MEF2B	0	BORCS8-MEF2B	0	affinity chromatography technology	Huttlin EL (2017)	1
HDAC1	4	HDAC2	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, imaging technique, affinity chromatography technology	Hakimi MA (2002), Yao YL (2003), Yao YL (2003), Hakimi MA (2003), Fischle W (2002), Johnson CA (2002), Fischle W (2001), Fischer DD (2002), Fischer DD (2002), Ashburner BP (2001), Zhang Y (1999), Tong JK (1998), Tong JK (1998), Hassig CA (1998), Hassig CA (1998), Zhang Y (1997), van der Vlag J (1999), van der Vlag J (1999), Noh EJ (2009), Noh EJ (2009), Galasinski SC (2002), Galasinski SC (2002), Galasinski SC (2002), He S (2005), Humphrey GW (2001), Park JH (2004), Park JH (2004), Sekhavat A (2007), Zhang Y (1998), Zhang Y (1998), Adenuga D (2010), Xue Y (1998), Xue Y (1998), Martinez FP (2012), Martinez FP (2012), Cui S (2011), Havugimana PC (2012), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Joshi P (2013), Schnur N (2007), Schnur N (2007), Oh YM (2009), Wan C (2015), Hein MY (2015), Chen TC (2014), Huttlin EL (2017)	48
NFATC2	1	CABIN1	9	affinity chromatography technology	Gabriel CH (2016)	1
H3F3A	1	CABIN1	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ray-Gallet D (2011), Elsaesser SJ (2010), Lee JS (2016)	3
SMARCA4	19	HIST1H3A	3	pull down, pull down, pull down	Lavigne M (2009), Lavigne M (2009), Kouskouti A (2005)	3
MEF2D	5	YWHAQ	0	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Choi SJ (2001), Choi SJ (2001), Choi SJ (2001), Choi SJ (2001)	4
TFAP4	3	NFATC2	1	affinity chromatography technology, affinity chromatography technology	Ku WC (2009), Ku WC (2009)	2
AP1B1	6	AMPH	4	pull down, affinity chromatography technology	McMahon HT (1997), Huttlin EL (2017)	2
HIRA	5	ASF1B	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tang Y (2006), Tang Y (2006), Campos EI (2015), Huttlin EL (2017)	4
H3F3A	1	HIRA	5	imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Goldberg AD (2010), Tagami H (2004), Tagami H (2004), Ray-Gallet D (2011), Han J (2013), Elsaesser SJ (2010)	6
HIST1H3A	3	HIRA	5	bioid	Lambert JP (2015)	1
ASF1B	0	TLK2	16	affinity chromatography technology, two hybrid, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology	Ewing RM (2007), Sillje HH (2001), Sillje HH (2001), Li Z (2007), Pilyugin M (2009), Huttlin EL (2017)	6
HIST1H3A	3	ASF1B	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology	Tagami H (2004), Tagami H (2004), Groth A (2005), Groth A (2005), Lambert JP (2015), Huttlin EL (2017)	6
UBN1	3	SMARCA4	19	imaging technique, affinity chromatography technology, affinity chromatography technology	Pchelintsev NA (2013), Pchelintsev NA (2013), Pchelintsev NA (2013)	3
ASF1A	0	SMARCB1	1	imaging technique, affinity chromatography technology, affinity chromatography technology	Pchelintsev NA (2013), Pchelintsev NA (2013), Pchelintsev NA (2013)	3
TLK2	16	CABIN1	9	affinity chromatography technology	Huttlin EL (2017)	1
CDX1	3	CABIN1	9	affinity chromatography technology	Huttlin EL (2017)	1
NFATC2	1	YWHAQ	0	affinity chromatography technology	Gabriel CH (2016)	1
SMARCA4	19	CABIN1	9	affinity chromatography technology	Pchelintsev NA (2013)	1
UBN1	3	5430	0	affinity chromatography technology, affinity chromatography technology, imaging technique	Ray-Gallet D (2011), Ray-Gallet D (2011), Pchelintsev NA (2013)	3
SUV39H1	0	HDAC2	1	affinity chromatography technology, pull down	Vaute O (2002), Vaute O (2002)	2
HDAC1	4	H3F3A	1	affinity chromatography technology	Hein MY (2015)	1
MEF2D	5	HDAC1	4	affinity chromatography technology	Aude-Garcia C (2010)	1
DNM1	21	AMPH	4	pull down, pull down, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, pull down	Micheva KD (1997), Micheva KD (1997), Micheva KD (1997), Wigge P (1997), McMahon HT (1997), Chen-Hwang MC (2002), Grabs D (1997), Solomaha E (2005), Stamenova SD (2007)	9
HIRA	5	MEF2D	5	affinity chromatography technology	Yang JH (2011)	1
MEF2D	5	CABIN1	9	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology	Youn HD (2000), Youn HD (1999), Youn HD (1999), Pan F (2005), Pan F (2005)	5
NFATC2	1	TLK2	16	affinity chromatography technology	Gabriel CH (2016)	1
XAGE1B	0	HIRA	5	affinity chromatography technology	Huttlin EL (2017)	1
SMARCB1	1	CABIN1	9	affinity chromatography technology	Pchelintsev NA (2013)	1
SMARCB1	1	5430	0	biochemical, biochemical, biochemical	Sif S (2001), Wang W (1996), Cho H (1998)	3
NFATC2	1	SUV39H1	0	affinity chromatography technology	Baumgart S (2012)	1
CAMK4	4	CABIN1	9	enzymatic study	Pan F (2005)	1
UBN1	3	ASF1A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tang Y (2012), Hein MY (2015), Huttlin EL (2017), Pchelintsev NA (2013), Pchelintsev NA (2013)	5
CABIN1	9	YWHAQ	0	affinity chromatography technology	Pan F (2005)	1
NFATC2	1	SMARCA4	19	affinity chromatography technology	Gabriel CH (2016)	1
TFAP4	3	HDAC2	1	affinity chromatography technology, affinity chromatography technology	Ku WC (2009), Ku WC (2009)	2
SMARCB1	1	HDAC1	4	biochemical	Sif S (2001)	1
UBN1	3	SMARCB1	1	imaging technique, affinity chromatography technology, affinity chromatography technology	Pchelintsev NA (2013), Pchelintsev NA (2013), Pchelintsev NA (2013)	3
CDX1	3	HIRA	5	affinity chromatography technology	Huttlin EL (2017)	1
MEF2A	1	CABIN1	9	affinity chromatography technology	Li X (2015)	1
TFAP4	3	CABIN1	9	affinity chromatography technology, affinity chromatography technology	Ku WC (2009), Huttlin EL (2017)	2
NFATC2	1	HDAC1	4	affinity chromatography technology	Gabriel CH (2016)	1
PPP3CA	3	CABIN1	9	two hybrid	Sun L (1998)	1
MEF2D	5	NFATC2	1	affinity chromatography technology, pull down	Youn HD (2000), Youn HD (2000)	2
SMARCB1	1	SMARCA4	19	biochemical, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, genetic interference, affinity chromatography technology, affinity chromatography technology	Sif S (2001), Sullivan EK (2001), Wang W (1996), Wang W (1996), Otsuki T (2001), Zhao K (1998), Reyes JC (1997), Kaeser MD (2008), Kaeser MD (2008), Kaeser MD (2008), Kaeser MD (2008), Pal S (2003), Bultman SJ (2005), Gong F (2008), Medjkane S (2004), Ito T (2008), Sif S (1998), Dallas PB (1998), Tando T (2010), Bakshi R (2010), Bakshi R (2010), Mahmoudi T (2006), Mahmoudi T (2006), Bartlett C (2011), Nishimoto N (2012), Havugimana PC (2012), Wan C (2015), Shen JP (2017), Pchelintsev NA (2013), Pchelintsev NA (2013)	30
CABIN1	9	SIN3A	13	pull down, affinity chromatography technology, affinity chromatography technology	Youn HD (2000), Youn HD (2000), Youn HD (2000)	3
CABIN1	9	DNM1	21	affinity chromatography technology	Lai MM (2000)	1
EAF1	1	CABIN1	9	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ASF1A	0	SMARCA4	19	imaging technique, affinity chromatography technology, affinity chromatography technology	Pchelintsev NA (2013), Pchelintsev NA (2013), Pchelintsev NA (2013)	3
SUV39H1	0	HDAC1	4	affinity chromatography technology, pull down	Vaute O (2002), Vaute O (2002)	2
HDAC1	4	SMARCA4	19	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference	Qiu Z (2008), Battaglioli E (2002), Hang CT (2010), DiRenzo J (2000)	4
TFAP4	3	HIRA	5	affinity chromatography technology	Huttlin EL (2017)	1
HIST1H3A	3	ASF1A	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Tagami H (2004), Tagami H (2004), Akai Y (2010), Foltz DR (2009), Ask K (2012), Groth A (2005), Groth A (2005), Lambert JP (2015), Huttlin EL (2017), Zhang H (2013)	10
HIST1H3A	3	CABIN1	9	bioid	Lambert JP (2015)	1
SMARCB1	1	HDAC2	1	biochemical, biochemical	Sif S (2001), Havugimana PC (2012)	2
HIRA	5	SMARCA4	19	imaging technique, affinity chromatography technology, affinity chromatography technology	Pchelintsev NA (2013), Pchelintsev NA (2013), Pchelintsev NA (2013)	3
MEF2A	1	MEF2B	0	affinity chromatography technology, affinity chromatography technology	Li X (2015), Huttlin EL (2017)	2
ASF1B	0	CABIN1	9	affinity chromatography technology	Huttlin EL (2017)	1
H3F3A	1	ASF1A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tagami H (2004), Tagami H (2004), Drane P (2010), Drane P (2010), Elsaesser SJ (2012), Elsaesser SJ (2012), Elsaesser SJ (2012), Han J (2013), Ambagala AP (2009), Lee JS (2016), Zhang H (2013)	11
TFAP4	3	SMARCB1	1	affinity chromatography technology	Ku WC (2009)	1
SUV39H1	0	H3F3A	1	enzymatic study	Jang H (2007)	1
HECW2	13	CABIN1	9	affinity chromatography technology	Lu L (2013)	1
CABIN1	9	5430	0	affinity chromatography technology, affinity chromatography technology	Ray-Gallet D (2011), Ray-Gallet D (2011)	2
ASF1A	0	CABIN1	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017), Pchelintsev NA (2013)	3
SMARCA4	19	SIN3A	13	biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Sif S (2001), Sif S (2001), Kuzmichev A (2002), Kuzmichev A (2002), Qiu Z (2008), Xu Z (2006), Pal S (2003), Pal S (2003)	8
HDAC1	4	CABIN1	9	affinity chromatography technology	Youn HD (2000)	1
CABIN1	9	UBN1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ray-Gallet D (2011), Ray-Gallet D (2011), Tang Y (2012), Lee JS (2016), Pchelintsev NA (2013)	5
CABIN1	9	AP1B1	6	affinity chromatography technology	Lai MM (2000)	1
H3F3A	1	ASF1B	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tagami H (2004), Tagami H (2004), Lewis PW (2010), Drane P (2010), Elsaesser SJ (2012), Elsaesser SJ (2012), Elsaesser SJ (2012), Han J (2013)	8
CABIN1	9	AMPH	4	affinity chromatography technology, pull down	Lai MM (2000), Lai MM (2000)	2
ASF1A	0	5430	0	imaging technique	Pchelintsev NA (2013)	1
MEF2A	1	MEF2D	5	imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ornatsky OI (1996), Ornatsky OI (1996), Ornatsky OI (1996), Aude-Garcia C (2010), Li X (2015)	5
ASF1A	0	HIRA	5	x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tang Y (2006), Tang Y (2006), Tang Y (2006), Zhang R (2005), Zhang R (2005), Galvani A (2008), Yang JH (2011), Zhang R (2007), Hein MY (2015), Huttlin EL (2017), Lee JS (2016), Lee JS (2016), Pchelintsev NA (2013), Pchelintsev NA (2013)	14
BORCS8-MEF2B	0	CABIN1	9	x-ray crystallography, affinity chromatography technology, affinity chromatography technology, two hybrid	Han A (2003), Youn HD (1999), Youn HD (1999), Youn HD (1999)	4
HIST1H3A	3	HDAC1	4	affinity chromatography technology, pull down, affinity chromatography technology	Nishioka K (2002), Li X (2014), Hein MY (2015)	3
ASF1B	0	UBN1	3	affinity chromatography technology	Huttlin EL (2017)	1
SMARCB1	1	SIN3A	13	biochemical, pull down, affinity chromatography technology	Sif S (2001), Pal S (2003), Nakamura T (2002)	3
HDAC2	1	SIN3A	13	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Zhang Y (2003), Fleischer TC (2003), Fleischer TC (2003), Hakimi MA (2003), Yang L (2003), Laherty CD (1997), Zhang Y (2002), Tong JK (1998), Zhang Y (2005), Nakamura T (2002), Sekhavat A (2007), Zou J (2004), Sun JM (2007), Xue Y (1998), Tsai SC (2002), Brandl A (2012), Bantscheff M (2011), Joshi P (2013), Wan C (2015), Hsu DS (2014)	20
HDAC2	1	CABIN1	9	affinity chromatography technology	Youn HD (2000)	1
NFATC2	1	HIRA	5	affinity chromatography technology	Gabriel CH (2016)	1
SUV39H1	0	CABIN1	9	affinity chromatography technology, pull down, affinity chromatography technology	Jang H (2007), Jang H (2007), Jang H (2007)	3