PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ING5	3	MEAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Doyon Y (2006), Ullah M (2008), Huttlin EL (2017)	3
ING5	3	KAT6B	27	affinity chromatography technology, affinity chromatography technology	Doyon Y (2006), Doyon Y (2006)	2
SGO1	2	KAT6B	27	affinity chromatography technology	Hein MY (2015)	1
HNRNPL	3	KAT6B	27	affinity chromatography technology	Fei T (2017)	1
KAT6B	27	HIST3H3	0	affinity chromatography technology	Ali M (2012)	1
KAT6B	27	RUNX2	2	pull down, affinity chromatography technology, enzymatic study	Pelletier N (2002), Pelletier N (2002), Pelletier N (2002)	3
ATN1	2	KAT6B	27	two hybrid	Lim J (2006)	1
MEAF6	0	KAT6B	27	affinity chromatography technology	Huttlin EL (2017)	1
KAT6B	27	RUNX1	0	affinity chromatography technology	Pelletier N (2002)	1
HIST3H3	0	HNRNPL	3	unspecified method	Vermeulen M (2010)	1
UBE2I	0	KAT6B	27	enzymatic study	Gocke CB (2005)	1