Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
FNTB 2342 LONAFARNIB CHEMBL298734 inhibitor ChemblInteractions
FNTB 2342 CHEMBL1229266 CHEMBL1229266 DrugBank 10592235
FNTB 2342 CHEMBL54044 CHEMBL54044 inhibitor GuideToPharmacologyInteractions
FNTB 2342 CHEMBL372164 CHEMBL372164 DrugBank 10592235
FNTB 2342 L-778123 CHEMBL279433 DrugBank 10592235
FNTB 2342 BMS-214662 CHEMBL351706 inhibitor GuideToPharmacologyInteractions
FNTB 2342 CHEMBL103134 CHEMBL103134 inhibitor GuideToPharmacologyInteractions
FNTB 2342 FARNESYL DIPHOSPHATE CHEMBL69330 DrugBank 10592235
FNTB 2342 TIPIFARNIB CHEMBL289228 inhibitor TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions, DrugBank 15805288

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
FNTB rs11623866 GG carboplatin efficacy yes The authors actually compared progression free survival (PFS) and overall survival (OS) for individuals with the GG, CG, or CC genotypes between treatment arms: lonafarnib, paclitaxel, and carboplatin (LTC) versus paclitaxel and carboplatin (TC) treatment. The PFS and OS were both much lower in women with the GG genotype who were on the LTC treatment arms. Genotype GG is associated with response to carboplatin, lonafarnib and paclitaxel in women with Ovarian Neoplasms. 26033044 1446899495