PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MTA3	3	RBBP4	3	affinity chromatography technology, biochemical, affinity chromatography technology	Bantscheff M (2011), Wan C (2015), Hauri S (2016)	3
HDAC1	4	MTA1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Yao YL (2003), Yao YL (2003), Yao YL (2003), Mazumdar A (2001), Mazumdar A (2001), Yoo YG (2006), Liu XF (2004), Khaleque MA (2008), Terhune SS (2010), Xue Y (1998), Xue Y (1998), Cui S (2011), Cui S (2011), Havugimana PC (2012), Bantscheff M (2011), Joshi P (2013), Wan C (2015), Hein MY (2015), Huttlin EL (2017), Millard CJ (2016), Millard CJ (2016)	21
RBBP4	3	HDAC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Zhang Y (2003), Hakimi MA (2003), Zhang Y (2002), Tong JK (1998), Sun JM (2007), Sun JM (2007), Adenuga D (2010), Xue Y (1998), Xue Y (1998), Cui S (2011), Havugimana PC (2012), Bantscheff M (2011), Wan C (2015), Hauri S (2016)	14
EGLN3	0	ZFPM2	4	affinity chromatography technology	Rodriguez J (2016)	1
MTA1	3	HDAC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Yao YL (2003), Yao YL (2003), Hakimi MA (2003), Mazumdar A (2001), Mazumdar A (2001), Mazumdar A (2001), Li DQ (2010), Yan C (2003), Balasenthil S (2007), Ohshiro K (2010), Xue Y (1998), Xue Y (1998), Cui S (2011), Bantscheff M (2011), Joshi P (2013), Wan C (2015)	16
GATA1	1	HDAC1	4	affinity chromatography technology, affinity chromatography technology	Watamoto K (2003), Watamoto K (2003)	2
HDAC1	4	HDAC2	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, imaging technique, affinity chromatography technology	Hakimi MA (2002), Yao YL (2003), Yao YL (2003), Hakimi MA (2003), Fischle W (2002), Johnson CA (2002), Fischle W (2001), Fischer DD (2002), Fischer DD (2002), Ashburner BP (2001), Zhang Y (1999), Tong JK (1998), Tong JK (1998), Hassig CA (1998), Hassig CA (1998), Zhang Y (1997), van der Vlag J (1999), van der Vlag J (1999), Noh EJ (2009), Noh EJ (2009), Galasinski SC (2002), Galasinski SC (2002), Galasinski SC (2002), He S (2005), Humphrey GW (2001), Park JH (2004), Park JH (2004), Sekhavat A (2007), Zhang Y (1998), Zhang Y (1998), Adenuga D (2010), Xue Y (1998), Xue Y (1998), Martinez FP (2012), Martinez FP (2012), Cui S (2011), Havugimana PC (2012), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Joshi P (2013), Schnur N (2007), Schnur N (2007), Oh YM (2009), Wan C (2015), Hein MY (2015), Chen TC (2014), Huttlin EL (2017)	48
STAT3	0	ZFPM2	4	two hybrid	Wang J (2011)	1
UBQLN4	2	ZFPM2	4	two hybrid	Lim J (2006)	1
ZFPM2	4	HDAC2	1	affinity chromatography technology	Roche AE (2008)	1
ZFPM2	4	MTA2	1	affinity chromatography technology, affinity chromatography technology	Roche AE (2008), Roche AE (2008)	2
ZFPM2	4	HDAC1	4	affinity chromatography technology	Roche AE (2008)	1
MTA3	3	RBBP7	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bantscheff M (2011), Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016)	4
MTA3	3	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Fujita N (2003), Kwintkiewicz J (2011), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	8
ZFPM2	4	RBBP7	1	affinity chromatography technology, affinity chromatography technology	Roche AE (2008), Roche AE (2008)	2
STAT3	0	HDAC2	1	affinity chromatography technology, imaging technique	Yuan ZL (2005), Chen TC (2014)	2
RBBP4	3	RBBP7	1	biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	7
ZFPM2	4	MTA1	3	affinity chromatography technology, affinity chromatography technology	Roche AE (2008), Roche AE (2008)	2
DUSP23	1	ZFPM2	4	affinity chromatography technology	Li X (2016)	1
MTA1	3	RBBP7	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yao YL (2003), Roche AE (2008), Huttlin EL (2015), Huttlin EL (2017), Millard CJ (2016), Hauri S (2016)	6
GATA1	1	ZFPM2	4	two hybrid, pull down	Holmes M (1999), Holmes M (1999)	2
IL32	1	ZFPM2	4	two hybrid	Park YS (2014)	1
GATA4	4	ZFPM2	4	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, pull down	Svensson EC (1999), Svensson EC (1999), Svensson EC (1999), Takaya T (2008), Svensson EC (2000)	5
GATA4	4	HDAC2	1	affinity chromatography technology	Trivedi CM (2010)	1
EGLN3	0	CTBP2	7	affinity chromatography technology	Rodriguez J (2016)	1
MTA2	1	MTA1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Yao YL (2003), Yao YL (2003), Cui S (2011), Wan C (2015)	4
MTA3	3	MTA1	3	biochemical	Wan C (2015)	1
MTA1	3	RBBP4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, x-ray crystallography, unspecified method, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology	Yao YL (2003), Roche AE (2008), Cui S (2011), Cui S (2011), Rolland T (2014), Huttlin EL (2015), Alqarni SS (2014), Alqarni SS (2014), Alqarni SS (2014), Wan C (2015), Huttlin EL (2017), Millard CJ (2016), Millard CJ (2016), Millard CJ (2016), Hauri S (2016)	15
EGLN3	0	RBBP7	1	affinity chromatography technology	Rodriguez J (2016)	1
ITSN1	5	ZFPM2	4	two hybrid	Wong KA (2012)	1
CTBP2	7	HDAC2	1	affinity chromatography technology	Zhao LJ (2009)	1
MTA2	1	RBBP7	1	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Yao YL (2003), Zhang Y (1999), Feng Q (2001), Wang Y (2009), Fu J (2011), Havugimana PC (2012), Huttlin EL (2015), Huttlin EL (2017), Brasen C (2017), Brasen C (2017), Hauri S (2016)	11
ZFPM2	4	RBBP4	3	affinity chromatography technology, affinity chromatography technology	Roche AE (2008), Roche AE (2008)	2
MTA3	3	MTA2	1	affinity chromatography technology, biochemical	Bantscheff M (2011), Wan C (2015)	2
HDAC2	1	RBBP7	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Hakimi MA (2003), Adenuga D (2010), Xue Y (1998), Havugimana PC (2012), Bantscheff M (2011), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Hauri S (2016)	9
ZFPM2	4	MTA3	3	affinity chromatography technology	Roche AE (2008)	1
CTBP2	7	ZFPM2	4	pull down, two hybrid, pull down	Holmes M (1999), Holmes M (1999), Svensson EC (2000)	3
MTA2	1	HDAC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical	Yao YL (2003), Yao YL (2003), Hakimi MA (2003), Zhang Y (1999), Banach-Orlowska M (2009), Feng Q (2001), Humphrey GW (2001), Humphrey GW (2001), Wang Y (2009), Fu J (2011), Havugimana PC (2012), Bantscheff M (2011), Joshi P (2013), Wan C (2015)	14
MTA2	1	RBBP4	3	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, x-ray crystallography, affinity chromatography technology	Yao YL (2003), Zhang Y (1999), Banach-Orlowska M (2009), Pflum MK (2001), Feng Q (2001), Wang Y (2009), Cui S (2011), Havugimana PC (2012), Wan C (2015), Brasen C (2017), Brasen C (2017), Brasen C (2017), Hauri S (2016)	13
HDAC1	4	RBBP7	1	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yao YL (2003), Ng HH (1999), Zhang Y (1999), Zhang Y (1997), Banach-Orlowska M (2009), Humphrey GW (2001), Zhang Y (1998), Zhang Y (1998), Xue Y (1998), Havugimana PC (2012), Bantscheff M (2011), Joshi P (2013), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Yeh HH (2015), Yeh HH (2015), Huttlin EL (2017), Hauri S (2016)	19
RBBP4	3	HDAC1	4	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang Y (2003), Yao YL (2003), Nicolas E (2001), Nicolas E (2001), Grozinger CM (1999), You A (2001), Hassig CA (1997), Hassig CA (1997), Ng HH (1999), Zhang Y (1999), Zhang Y (2002), Hassig CA (1998), Zhang Y (1997), Banach-Orlowska M (2009), Pflum MK (2001), Pflum MK (2001), Skowyra D (2001), Humphrey GW (2001), Zhang Y (1998), Zhang Y (1998), Sun JM (2007), Sun JM (2007), Karwowska-Desaulniers P (2007), Terhune SS (2010), Xue Y (1998), Xue Y (1998), Cui S (2011), Cui S (2011), Havugimana PC (2012), Bantscheff M (2011), Joshi P (2013), Wan C (2015), Hein MY (2015), Huttlin EL (2017), Hauri S (2016)	35
HDAC1	4	MTA2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yao YL (2003), Yao YL (2003), You A (2001), Zhang Y (1999), Zhang Y (1999), Yasui D (2002), Banach-Orlowska M (2009), Banach-Orlowska M (2009), Cui Y (2006), Pflum MK (2001), Feng Q (2001), Humphrey GW (2001), Humphrey GW (2001), Humphrey GW (2001), Zhang Y (1998), Terhune SS (2010), Opsahl JA (2010), Wang Y (2009), Cui S (2011), Havugimana PC (2012), Bantscheff M (2011), Joshi P (2013), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Huttlin EL (2017), Boldt K (2016)	27
MTA3	3	HDAC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Fujita N (2003), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Wan C (2015)	5
STAT3	0	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Zhang Q (2005), Yuan ZL (2005), Gupta M (2011), Zhi Y (2012), Zhi Y (2012)	5