PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ZWINT	1	APP	1	pull down	Olah J (2011)	1
TERT	7	SMG5	3	pull down	Snow BE (2003)	1
NXF1	0	SMG5	3	affinity chromatography technology	Castello A (2012)	1
BTRC	1	PCM1	5	bioid	Coyaud E (2015)	1
MOV10	6	UPF1	8	affinity chromatography technology, affinity chromatography technology	Li S (2014), Li S (2014)	2
RBM8A	2	SMG5	3	affinity chromatography technology	Izumi N (2010)	1
STUB1	4	TERT	7	pull down, affinity chromatography technology, affinity chromatography technology	Lee JH (2010), Lee JH (2010), Lee JH (2010)	3
SMG5	3	APP	1	pull down	Olah J (2011)	1
TP53	0	STUB1	4	affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Muller P (2008), Stankiewicz M (2010), Tripathi V (2007), Tripathi V (2007), Esser C (2005), Lim JH (2011), Wang J (2011), Burch L (2004), Landre V (2013), Horikawa I (2014), Horikawa I (2014), Horikawa I (2014), Fraser JA (2015), Narayan V (2015), Yue X (2016), Parrales A (2016), Parrales A (2016)	17
MOV10	6	BTRC	1	affinity chromatography technology	Castello A (2012)	1
CEP152	2	SMG5	3	bioid	Gupta GD (2015)	1
BTRC	1	SMG5	3	bioid	Coyaud E (2015)	1
MOV10	6	STUB1	4	affinity chromatography technology, affinity chromatography technology	Li S (2014), Castello A (2012)	2
APP	1	STUB1	4	affinity chromatography technology, affinity chromatography technology	Kumar P (2007), Kumar P (2007)	2
TP53	0	TERT	7	genetic interference, genetic interference	Xie L (2013), Xie L (2013)	2
RIPK4	0	SMG5	3	affinity chromatography technology	Rodriguez J (2016)	1
NXF1	0	STUB1	4	affinity chromatography technology	Castello A (2012)	1
UPF1	8	SMG6	9	affinity chromatography technology, affinity chromatography technology	Franks TM (2010), Kashima I (2010)	2
C6orf141	1	SMG5	3	affinity chromatography technology	Huttlin EL (2017)	1
SMG5	3	STUB1	4	affinity chromatography technology, enzymatic study	Lee H (2006), Lee H (2006)	2
RIPK4	0	TP53	0	affinity chromatography technology	Rodriguez J (2016)	1
EGLN3	0	SMG5	3	affinity chromatography technology	Rodriguez J (2016)	1
EGLN3	0	ZWINT	1	affinity chromatography technology	Rodriguez J (2016)	1
SMG6	9	HDAC8	9	affinity chromatography technology	Lee H (2006)	1
TP53	0	SMG5	3	affinity chromatography technology	Li X (2015)	1
NXF1	0	BTRC	1	affinity chromatography technology	Castello A (2012)	1
EGLN3	0	TP53	0	affinity chromatography technology	Rodriguez J (2016)	1
UPF1	8	RBM8A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yamashita A (2009), Yamashita A (2009), Kashima I (2006), Izumi N (2010), Izumi N (2010)	5
TP53	0	MOV10	6	affinity chromatography technology	Li X (2015)	1
EGLN3	0	STUB1	4	affinity chromatography technology	Rodriguez J (2016)	1
CEP152	2	TP53	0	bioid	Gupta GD (2015)	1
RBM8A	2	APP	1	pull down	Olah J (2011)	1
RIPK4	0	STUB1	4	affinity chromatography technology	Rodriguez J (2016)	1
BTRC	1	TP53	0	affinity chromatography technology, affinity chromatography technology	Xia Y (2009), Verma S (2011)	2
MOV10	6	SMG5	3	affinity chromatography technology	Castello A (2012)	1
CEP152	2	PCM1	5	bioid	Gupta GD (2015)	1
EGLN3	0	PCM1	5	affinity chromatography technology	Rodriguez J (2016)	1
UPF1	8	SMG5	3	affinity chromatography technology, affinity chromatography technology	Franks TM (2010), Izumi N (2010)	2
SMG6	9	RBM8A	2	affinity chromatography technology	Kashima I (2010)	1
PHB	0	TP53	0	imaging technique, affinity chromatography technology, pull down	Fusaro G (2003), Fusaro G (2003), Fusaro G (2003)	3
TP53	0	ZWINT	1	affinity chromatography technology	Fogeron ML (2013)	1
TERT	7	SMG6	9	pull down, affinity chromatography technology	Snow BE (2003), Sealey DC (2011)	2
BTRC	1	RIPK4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Loveless TB (2015), Loveless TB (2015), Rodriguez J (2016)	3
SMG6	9	SMG5	3	affinity chromatography technology	Kashima I (2010)	1
PHB	0	SMG5	3	affinity chromatography technology	Zhu B (2010)	1
PCM1	5	SMG5	3	bioid	Gupta GD (2015)	1
SMG5	3	HDAC8	9	affinity chromatography technology	Lee H (2006)	1
RBM8A	2	NXF1	0	pull down	Kataoka N (2001)	1
ZWINT	1	SMG5	3	affinity chromatography technology	Kops GJ (2005)	1