PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CREBBP	29	CRTC1	4	affinity chromatography technology	Wu L (2005)	1
KCTD3	2	CRTC1	4	affinity chromatography technology	Boldt K (2016)	1
MEIS1	0	CREB1	1	affinity chromatography technology	Wang Z (2010)	1
CBY1	3	CRTC1	4	affinity chromatography technology	Boldt K (2016)	1
YWHAE	0	CBY1	3	affinity chromatography technology	Boldt K (2016)	1
KIF13B	13	CRTC1	4	affinity chromatography technology	Boldt K (2016)	1
SRPK2	1	CRTC1	4	enzymatic study	Lipp JJ (2015)	1
CREB1	1	EP300	36	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, far western blotting, pull down	Hussain MA (1999), Magenta A (2003), Subbaramaiah K (2011), Solomou EE (2001), Subbaramaiah K (2012), Tung WH (2011), Tung WH (2011), Lundblad JR (1995), Lundblad JR (1995)	9
MEIS1	0	CRTC1	4	affinity chromatography technology	Wang Z (2010)	1
YWHAE	0	MAP3K1	4	pull down	Fanger GR (1998)	1
XPO1	8	KCTD3	2	affinity chromatography technology	Kirli K (2015)	1
KCTD3	2	CBY1	3	affinity chromatography technology	Boldt K (2016)	1
YWHAE	0	CRTC1	4	affinity chromatography technology	Gloeckner CJ (2007)	1
CREBBP	29	EP300	36	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Crusselle-Davis VJ (2007), Dohda T (2004), Dohda T (2004)	3
CREBBP	29	CREB1	1	affinity chromatography technology, two hybrid, pull down, x-ray crystallography, pull down, pull down, affinity chromatography technology, fluorescent resonance energy transfe, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, two hybrid, affinity chromatography technology, far western blotting, pull down, far western blotting, pull down, far western blotting, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shi Y (2004), Kim J (2005), Shimomura A (1996), Radhakrishnan I (1997), Radhakrishnan I (1997), Sano Y (1998), Sano Y (1998), Zor T (2002), Giebler HA (2000), Zhang Q (2000), Ernst P (2001), Ledo F (2002), Poon SL (2008), Best JL (2004), Best JL (2004), Chan EC (2010), Yang F (2006), Solomou EE (2001), Du K (1998), Venza I (2001), Lundblad JR (1995), Lundblad JR (1995), Arias J (1994), Chrivia JC (1993), Chrivia JC (1993), Shi Y (2004), Ramirez JA (2007), Sun HS (2003), Sun HS (2003), Wang Y (2016)	30
XPO1	8	MAP3K1	4	affinity chromatography technology	Kirli K (2015)	1
MEIS1	0	CREBBP	29	affinity chromatography technology	Wang Z (2010)	1
EP300	36	CRTC1	4	affinity chromatography technology	Wu L (2005)	1
XPO1	8	CRTC1	4	affinity chromatography technology	Kirli K (2015)	1
KCTD3	2	KIF13B	13	affinity chromatography technology	Boldt K (2016)	1
YWHAE	0	XPO1	8	biochemical	Kristensen AR (2012)	1
CRTC1	4	MAP3K1	4	affinity chromatography technology, enzymatic study	Siu YT (2008), Siu YT (2008)	2
CREB1	1	CRTC1	4	two hybrid	Bandyopadhyay S (2010)	1
CBY1	3	KIF13B	13	affinity chromatography technology	Boldt K (2016)	1