PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HSPG2	14	FN1	17	pull down, affinity chromatography technology	Hopf M (2001), Humphries JD (2009)	2
LPA	5	FN1	17	pull down, enzymatic study	Salonen EM (1989), Salonen EM (1989)	2
IGFBP3	1	FN1	17	pull down, two hybrid, pull down, affinity chromatography technology	Martin JA (2002), Gui Y (2001), Gui Y (2001), Gui Y (2001)	4
LGALS3	0	FN1	17	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CER1	0	FN1	17	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MYH9	19	GSN	3	affinity chromatography technology	Hein MY (2015)	1
VHL	0	CD44	1	pull down	Lai Y (2012)	1
FN1	17	KPNA2	0	affinity chromatography technology, two hybrid	Humphries JD (2009), Wang J (2011)	2
TEAD4	1	FN1	17	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LGALS9	0	ITGB1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FN1	17	FBLN1	1	pull down, two hybrid	Balbona K (1992), Wang J (2011)	2
FN1	17	MYH9	19	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Humphries JD (2009), Moussavi-Harami SF (2013), Moussavi-Harami SF (2013)	3
CD44	1	FN1	17	affinity chromatography technology, pull down	Jalkanen S (1992), Jalkanen S (1992)	2
FN1	17	GAPDH	0	affinity chromatography technology, affinity chromatography technology	Humphries JD (2009), Moussavi-Harami SF (2013)	2
FASLG	0	GRB2	2	affinity chromatography technology, pull down, pull down	Ghadimi MP (2002), Ghadimi MP (2002), Wenzel J (2001)	3
FN1	17	COL7A1	19	pull down, pull down	Lapiere JC (1994), Chen M (1997)	2
GRB2	2	HSPG2	14	affinity chromatography technology	Brehme M (2009)	1
FASLG	0	FN1	17	pull down, imaging technique	Aoki K (2001), Chen TC (2014)	2
GRB2	2	GAPDH	0	affinity chromatography technology	Brehme M (2009)	1
COL8A2	0	FN1	17	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ITGB1	4	ITGA5	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, pull down	Lobert VH (2010), Lobert VH (2010), Zhang H (2003), Rantala JK (2011), Havugimana PC (2012), Wan C (2015), Lee HS (2014)	7
GRB2	2	KPNA2	0	two hybrid	Wang J (2011)	1
GRB2	2	FN1	17	two hybrid, affinity chromatography technology	Wang J (2008), Humphries JD (2009)	2
LGALS9	0	FBLN1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FN1	17	C1QB	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Moussavi-Harami SF (2013), Huttlin EL (2015), Huttlin EL (2017)	3
LGALS8	4	ITGA5	7	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FN1	17	GDI2	1	affinity chromatography technology, affinity chromatography technology	Humphries JD (2009), Huttlin EL (2017)	2
IGFBP3	1	CD44	1	pull down	Martin JA (2002)	1
GSN	3	FN1	17	pull down, affinity chromatography technology, affinity chromatography technology	Lind SE (1984), Moussavi-Harami SF (2013), Moussavi-Harami SF (2013)	3
FN1	17	TNC	7	pull down, affinity chromatography technology	Chung CY (1995), Chung CY (1995)	2
ITGB1	4	TLN1	5	unspecified method, biochemical, pull down, pull down	Martel V (2001), Havugimana PC (2012), Anthis NJ (2009), Anthis NJ (2009)	4
FN1	17	TLN1	5	affinity chromatography technology, affinity chromatography technology	Humphries JD (2009), Humphries JD (2009)	2
TGM2	2	FN1	17	pull down, affinity chromatography technology	Heath DJ (2002), Humphries JD (2009)	2
LGALS9	0	FN1	17	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LGALS3	0	ITGB1	4	affinity chromatography technology	Carvalho RS (2014)	1
FN1	17	ITGB1	4	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Humphries JD (2009), Humphries JD (2009), Kharitidi D (2015), Lee HS (2014)	4
FN1	17	GSTP1	0	affinity chromatography technology, affinity chromatography technology	Humphries JD (2009), Moussavi-Harami SF (2013)	2
CER1	0	VHL	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FN1	17	ITGA5	7	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Busk M (1992), Lobert VH (2010), Humphries JD (2009), Humphries JD (2009), Kharitidi D (2015), Lee HS (2014)	6
LGALS8	4	ITGB1	4	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Hadari YR (2000), Hadari YR (2000), Huttlin EL (2015), Huttlin EL (2017)	4
LGALS9	0	LGALS3	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FN1	17	ITIH2	0	affinity chromatography technology, affinity chromatography technology	Moussavi-Harami SF (2013), Moussavi-Harami SF (2013)	2
GSTP1	0	TGM2	2	affinity chromatography technology	Piredda L (1999)	1
C1QB	1	VHL	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MYH9	19	CD44	1	affinity chromatography technology	Hein MY (2015)	1
TRIB3	0	FN1	17	two hybrid, affinity chromatography technology, affinity chromatography technology	Zhou Y (2008), Zhou Y (2008), Zhou Y (2008)	3
LGALS8	4	FN1	17	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CD44	1	ITGB1	4	imaging technique	Su YJ (2011)	1
GRB2	2	MYH9	19	two hybrid, affinity chromatography technology	Bandyopadhyay S (2010), Li J (2013)	2
VHL	0	TGM2	2	affinity chromatography technology, affinity chromatography technology	Kim DS (2011), Kim DS (2011)	2
VHL	0	FN1	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ohh M (1998), Stickle NH (2004), Lai Y (2011), Bonicalzi ME (2001), Iliopoulos O (1998), Russell RC (2008)	6
TLN1	5	ITGA5	7	imaging technique	Lilja J (2017)	1