PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
LCA5	1	TRIM2	1	bioid	Gupta GD (2015)	1
ELAVL1	0	UBE2D3	1	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	TNFAIP3	3	affinity chromatography technology	Balkhi MY (2013)	1
MNAT1	0	TRIM2	1	two hybrid	Woodsmith J (2012)	1
UBE2E3	0	TRIM2	1	two hybrid	Markson G (2009)	1
NUFIP1	0	TRIM2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRIM3	2	PDHA1	7	biochemical	Wan C (2015)	1
TRIM3	2	UBE2D1	0	pull down	Raheja R (2014)	1
UBE2E2	1	TRIM2	1	two hybrid	Markson G (2009)	1
MTRNR2L1	0	TRIM2	1	affinity chromatography technology	Niikura T (2003)	1
UBE2D2	0	TRIM2	1	two hybrid	Markson G (2009)	1
TNIK	4	TRIM2	1	two hybrid	Camargo LM (2007)	1
UBAC1	2	TRIM2	1	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
ELAVL1	0	UBE2H	3	affinity chromatography technology	Abdelmohsen K (2009)	1
UBE2D1	0	TRIM8	6	two hybrid	Markson G (2009)	1
UBE2D4	0	TRIM2	1	two hybrid	Markson G (2009)	1
UBE2D4	0	TRIM8	6	two hybrid	Markson G (2009)	1
HSP90AA1	7	TRIM2	1	affinity chromatography technology	Taipale M (2012)	1
UBE2D2	0	TRIM8	6	two hybrid, pull down	Markson G (2009), Li Q (2011)	2
TRIM2	1	SIRPA	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
UBE2K	0	TRIM2	1	two hybrid	Markson G (2009)	1
TRIM3	2	UBE2D4	0	two hybrid	Napolitano LM (2011)	1
UBE2W	0	TRIM8	6	two hybrid	Markson G (2009)	1
HSP90AA1	7	TNFAIP3	3	affinity chromatography technology	Taipale M (2012)	1
DTNBP1	1	TRIM2	1	two hybrid	Camargo LM (2007)	1
UBE2D3	1	TRIM2	1	two hybrid	Markson G (2009)	1
UBE2W	0	TRIM2	1	two hybrid	Markson G (2009)	1
ELAVL1	0	TRIM2	1	affinity chromatography technology	Abdelmohsen K (2009)	1
TNFAIP3	3	UBE2D1	0	pull down, pull down	Wertz IE (2004), Lee JH (2017)	2
TRIM2	1	PDHA1	7	biochemical	Wan C (2015)	1
OTUB2	0	TRIM2	1	two hybrid	Hayes SD (2012)	1
ELAVL1	0	UBE2W	0	affinity chromatography technology	Abdelmohsen K (2009)	1
TRIM3	2	UBE2E1	1	pull down	Raheja R (2014)	1
OTUB2	0	TRIM8	6	two hybrid	Hayes SD (2012)	1
UBE2H	3	TRIM2	1	two hybrid	Markson G (2009)	1
TRIM2	1	LRRC8E	2	two hybrid	Yu H (2011)	1
UBE2E1	1	TRIM2	1	two hybrid	Markson G (2009)	1
MTRNR2L1	0	HSP90AA1	7	two hybrid	Maksimov VV (2006)	1
PDHA1	7	ELAVL1	0	affinity chromatography technology	Malty RH (2017)	1
UBE2D1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
UBE2D3	1	TRIM8	6	two hybrid	Markson G (2009)	1
UBE2U	0	TRIM2	1	two hybrid	van Wijk SJ (2009)	1
TNFAIP3	3	TRIM3	2	two hybrid	Hayes SD (2012)	1
ELAVL1	0	TRIM8	6	affinity chromatography technology	Abdelmohsen K (2009)	1
TRIM2	1	TRIM3	2	affinity chromatography technology	Huttlin EL (2017)	1
UBE2K	0	UBE2D2	0	biochemical	Wan C (2015)	1
TNFAIP3	3	TRIM2	1	two hybrid	Hayes SD (2012)	1
BCL2L11	4	TRIM2	1	pull down	Thompson S (2011)	1
ELAVL1	0	UBE2E2	1	affinity chromatography technology	Abdelmohsen K (2009)	1
TNFAIP3	3	TRIM8	6	two hybrid	Hayes SD (2012)	1
TRIM8	6	TRIM2	1	two hybrid	Woodsmith J (2012)	1
UBE2U	0	TRIM3	2	two hybrid	van Wijk SJ (2009)	1
TRIM3	2	UBE2D2	0	pull down	Raheja R (2014)	1
TRIM2	1	CIB3	0	two hybrid	Rolland T (2014)	1
UBE2D1	0	TRIM2	1	two hybrid, two hybrid	Markson G (2009), Napolitano LM (2011)	2
GJB5	0	TRIM2	1	two hybrid	Wang J (2011)	1