PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ANKS1A	3	RANBP3	0	two hybrid	Grossmann A (2015)	1
RIN1	1	ANKS1A	3	affinity chromatography technology	Huttlin EL (2017)	1
TRIM25	5	SFN	1	affinity chromatography technology	Urano T (2002)	1
EGFR	5	YWHAB	1	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
PTPN12	2	PACSIN2	0	biochemical	Kristensen AR (2012)	1
TRIM25	5	DAB2IP	3	affinity chromatography technology	Choudhury NR (2017)	1
ERBB4	5	ANKS1A	3	unspecified method	Jones RB (2006)	1
PTPN12	2	ANKS1A	3	biochemical	Kristensen AR (2012)	1
UBC	7	HNRNPL	3	affinity chromatography technology	Matsumoto M (2005)	1
TRIM14	1	ANKS1A	3	bioid	Tan P (2017)	1
YWHAG	5	ANKS1A	3	affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Jin J (2004)	2
BAG3	4	YWHAG	5	affinity chromatography technology	Chen Y (2013)	1
YWHAB	1	YWHAG	5	affinity chromatography technology, biochemical	Couzens AL (2013), Wan C (2015)	2
ERBB4	5	PTPN12	2	two hybrid	Yao Z (2017)	1
YWHAB	1	ANKS1A	3	affinity chromatography technology	Couzens AL (2013)	1
SMARCD1	5	YWHAG	5	two hybrid	Wang J (2011)	1
HNRNPL	3	EGFR	5	affinity chromatography technology	Fei T (2017)	1
YWHAG	5	SFN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Benzinger A (2005), Benzinger A (2005), Huttlin EL (2015), Huttlin EL (2017)	4
EGFR	5	ANKS1A	3	unspecified method, two hybrid, protein complementation assay, affinity chromatography technology	Jones RB (2006), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	4
ANKS1A	3	ARHGAP10	1	two hybrid	Grossmann A (2015)	1
PTPN12	2	ARHGAP10	1	bioid	St-Denis N (2016)	1
PACSIN2	0	ANKS1A	3	biochemical	Kristensen AR (2012)	1
TRIM25	5	ANKS1A	3	affinity chromatography technology	Choudhury NR (2017)	1
YWHAB	1	UBC	7	affinity chromatography technology	Jin J (2004)	1
HNRNPL	3	ANKS1A	3	affinity chromatography technology	Fei T (2017)	1
EGFR	5	PIK3R3	0	unspecified method, two hybrid, imaging technique, protein complementation assay	Jones RB (2006), Kotlyar M (2015), Chen TC (2014), Petschnigg J (2014)	4
ERBB2	6	EGFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Scaltriti M (2009), Shtiegman K (2007), Haslekas C (2005), Riedemann J (2007), Burke P (2001), Meijer IM (2011), Chen TC (2014), Li J (2013), Li J (2013), Caiazza F (2010), Caiazza F (2010), Sharif A (2009)	12
HNRNPL	3	PIK3R3	0	affinity chromatography technology	Fei T (2017)	1
SFN	1	ANKS1A	3	affinity chromatography technology	Benzinger A (2005)	1
TRIM25	5	HNRNPL	3	affinity chromatography technology	Choudhury NR (2017)	1
RANBP3	0	SMARCD1	5	biochemical	Wan C (2015)	1
UBC	7	ANKS1A	3	pull down	Kim J (2010)	1
RB1	2	PIK3R3	0	affinity chromatography technology, pull down	Xia X (2003), Xia X (2003)	2
ANKS1A	3	TRIT1	0	two hybrid	Grossmann A (2015)	1
ANKS1A	3	NHLRC2	2	two hybrid	Grossmann A (2015)	1
BAG3	4	ANKS1A	3	affinity chromatography technology	Chen Y (2013)	1
EGFR	5	ERBB4	5	affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology	Meijer IM (2013), Kiuchi T (2014), Kiuchi T (2014)	3
TRIM25	5	PACSIN2	0	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	YWHAB	1	affinity chromatography technology	Choudhury NR (2017)	1
ERBB2	6	PIK3R3	0	unspecified method	Jones RB (2006)	1
TRIM14	1	BAG3	4	bioid	Tan P (2017)	1
ANKS1A	3	SMARCD1	5	two hybrid	Grossmann A (2015)	1
BAG3	4	YWHAB	1	affinity chromatography technology	Chen Y (2013)	1
DAB2IP	3	ANKS1A	3	affinity chromatography technology	Huttlin EL (2017)	1
YWHAG	5	UBC	7	affinity chromatography technology	Jin J (2004)	1
DEF6	0	ANKS1A	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DNPEP	2	ANKS1A	3	biochemical	Kristensen AR (2012)	1
EGFR	5	RIN1	1	affinity chromatography technology	Kong C (2007)	1
EGFR	5	SFN	1	affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Wu SL (2006), Wu SL (2006), Kotlyar M (2015), Petschnigg J (2014), Li J (2013)	5
ERBB4	5	ERBB2	6	affinity chromatography technology	Huang YZ (2000)	1
EGFR	5	UBC	7	affinity chromatography technology, affinity chromatography technology	Tong J (2009), Bishop N (2002)	2
TRIM25	5	PTPN12	2	affinity chromatography technology	Choudhury NR (2017)	1
HNRNPL	3	ERBB2	6	affinity chromatography technology	Fei T (2017)	1
ANKS1A	3	RB1	2	two hybrid	Grossmann A (2015)	1
TRIM47	2	ANKS1A	3	biochemical	Kristensen AR (2012)	1
TRIM47	2	PTPN12	2	biochemical	Kristensen AR (2012)	1
RIN1	1	YWHAG	5	affinity chromatography technology	Huttlin EL (2017)	1
ANKS1A	3	DOK3	5	two hybrid	Grossmann A (2015)	1
HIF1AN	0	ANKS1A	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Rodriguez J (2016)	2
ANKS1A	3	PIK3R3	0	two hybrid	Grossmann A (2015)	1
TRIM25	5	UBC	7	enzymatic study	Sanchez JG (2016)	1
ERBB2	6	RIN1	1	unspecified method	Jones RB (2006)	1
ERBB2	6	ANKS1A	3	unspecified method	Jones RB (2006)	1
ANKS1A	3	KLF15	1	two hybrid	Grossmann A (2015)	1
SFN	1	YWHAB	1	affinity chromatography technology	Huttlin EL (2017)	1
EGFR	5	PTPN12	2	protein complementation assay, two hybrid, protein complementation assay, affinity chromatography technology, two hybrid	Deribe YL (2009), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014), Yao Z (2017)	5
ANKS1A	3	EPHA8	4	affinity chromatography technology	Kim J (2010)	1
TRIM47	2	DNPEP	2	biochemical	Kristensen AR (2012)	1
HNRNPL	3	ARHGAP10	1	affinity chromatography technology	Fei T (2017)	1
PIK3R3	0	KLF15	1	two hybrid	Grossmann A (2015)	1
DNPEP	2	PTPN12	2	biochemical	Kristensen AR (2012)	1