PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
IQCE	3	HOOK2	0	two hybrid	Corominas R (2014)	1
TRIM23	3	CARD9	3	two hybrid	Rolland T (2014)	1
IQCE	3	MTUS2	4	two hybrid	Corominas R (2014)	1
CARD9	3	LZTS2	4	two hybrid	Rolland T (2014)	1
IQCE	3	TRIM27	2	two hybrid	Corominas R (2014)	1
IQCE	3	CARD9	3	two hybrid	Corominas R (2014)	1
CALM3	0	IQCE	3	two hybrid	Rolland T (2014)	1
IQCE	3	LZTS2	4	two hybrid	Corominas R (2014)	1
IQCE	3	TRIM23	3	two hybrid	Corominas R (2014)	1
IQCE	3	RPGRIP1	6	two hybrid	Corominas R (2014)	1
TRIM27	2	TRIM23	3	two hybrid, two hybrid	Reymond A (2001), Woodsmith J (2012)	2
CALM2	0	IQCE	3	two hybrid	Rolland T (2014)	1
IQCE	3	PSMA3	1	two hybrid, two hybrid	Corominas R (2014), Rolland T (2014)	2
IQCE	3	SPAG5	1	two hybrid	Corominas R (2014)	1
IQCE	3	TTC23L	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Corominas R (2014), Huttlin EL (2015), Huttlin EL (2017)	3
IQCE	3	GOLGA2	2	two hybrid	Corominas R (2014)	1
RFFL	0	IQCE	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CARD9	3	CEP70	1	two hybrid	Rolland T (2014)	1
IQCE	3	CEP70	1	two hybrid	Corominas R (2014)	1