PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
DISC1	6	TNIK	4	two hybrid	Camargo LM (2007)	1
AGTPBP1	4	CBY1	3	two hybrid	Lim J (2006)	1
DISC1	6	AGTPBP1	4	two hybrid	Camargo LM (2007)	1
AGTPBP1	4	TTLL4	0	affinity chromatography technology	Huttlin EL (2017)	1
XPO1	8	TNIK	4	affinity chromatography technology	Kirli K (2015)	1
CEP128	1	AGTPBP1	4	bioid	Gupta GD (2015)	1
AGTPBP1	4	ENO1	3	two hybrid	Lim J (2006)	1
FOXK1	5	AGTPBP1	4	affinity chromatography technology	Li X (2015)	1
PHLPP1	4	AGTPBP1	4	bioid	St-Denis N (2016)	1
XPO1	8	AGTPBP1	4	affinity chromatography technology	Kirli K (2015)	1
FBXL13	1	AGTPBP1	4	affinity chromatography technology	Fung E (2018)	1
TMOD1	1	AGTPBP1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ZUFSP	0	UBC	7	enzymatic study, x-ray crystallography, affinity chromatography technology, pull down, x-ray crystallography, enzymatic study, pull down, affinity chromatography technology, enzymatic study	Hermanns T (2018), Hermanns T (2018), Hermanns T (2018), Kwasna D (2018), Kwasna D (2018), Kwasna D (2018), Haahr P (2018), Haahr P (2018), Haahr P (2018)	9
PNKP	3	AGTPBP1	4	affinity chromatography technology	Koch CA (2004)	1
UBC	7	AGTPBP1	4	pull down	Zhang X (2017)	1
EGFR	5	XPO1	8	affinity chromatography technology	Foerster S (2013)	1
EGFR	5	AGTPBP1	4	affinity chromatography technology	Yao Z (2017)	1
AGTPBP1	4	PPFIA1	5	two hybrid	Lim J (2006)	1
AGTPBP1	4	CYCS	0	two hybrid	Lim J (2006)	1
XPO1	8	TTLL4	0	affinity chromatography technology	Kirli K (2015)	1
XPO1	8	FOXK1	5	affinity chromatography technology	Kirli K (2015)	1
EGFR	5	TNIK	4	affinity chromatography technology	Yao Z (2017)	1
EGFR	5	UBC	7	affinity chromatography technology, affinity chromatography technology	Tong J (2009), Bishop N (2002)	2
ZUFSP	0	AGTPBP1	4	affinity chromatography technology	Kwasna D (2018)	1
AGTPBP1	4	NYNRIN	7	two hybrid	Lim J (2006)	1
TNIK	4	AGTPBP1	4	two hybrid	Camargo LM (2007)	1
EGFR	5	CBY1	3	affinity chromatography technology	Yao Z (2017)	1
AGTPBP1	4	PPFIA4	1	two hybrid	Lim J (2006)	1