PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SHC1	0	HSP90AA1	7	affinity chromatography technology	Brehme M (2009)	1
HSP90AA1	7	FLT4	5	affinity chromatography technology	Taipale M (2012)	1
GRB2	2	HSP90AA1	7	affinity chromatography technology	Brehme M (2009)	1
HSP90AA1	7	IKBKG	0	affinity chromatography technology, affinity chromatography technology	Gano JJ (2010), Hein MY (2015)	2
EEF1A2	18	FLT4	5	affinity chromatography technology	Huttlin EL (2017)	1
CHRM3	1	FLT4	5	affinity chromatography technology	Huttlin EL (2017)	1
NEDD4	2	FLT4	5	pull down	Persaud A (2009)	1
PLVAP	2	FLT4	5	affinity chromatography technology	Huttlin EL (2015)	1
LGALS3	0	FLT4	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TNF	0	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Haas TL (2009), Ea CK (2006), Tokunaga F (2012), Verhelst K (2012), Draber P (2015), Pescatore A (2016)	6
IKBKG	0	FLT4	5	pull down	Fenner BJ (2010)	1
ITGB1	4	SHC1	0	affinity chromatography technology	Lee DY (2010)	1
PCDHGB1	3	FLT4	5	affinity chromatography technology	Huttlin EL (2017)	1
GRB2	2	SHC1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Blagoev B (2003), Skolnik EY (1993), Skolnik EY (1993), Puil L (1994), Satoh T (1996), Fixman ED (1996), Fixman ED (1996), Fixman ED (1996), Ishihara H (1997), Fournier E (1999), Ravichandran KS (1994), Lamprecht R (2002), Park RK (1999), Sakaguchi K (2001), Park RK (1999), Park RK (1999), Hallak H (2001), Yokote K (1994), Saci A (2002), Zhang S (1999), Lazar DF (1994), VanderKuur J (1995), Kanai M (1997), Spivak-Kroizman T (1994), Giordano V (1997), Drobot L (2005), Erdreich-Epstein A (1997), Takahashi Y (1999), Barber DL (1997), Ahn SC (2003), Odai H (1995), Panchamoorthy G (1996), Panchamoorthy G (1996), Brehme M (2009), Brehme M (2009), Brehme M (2009), Cerboni C (1998), Zhang L (1999), Brizzi MF (1996), Brizzi MF (1996), Liu BA (2012), Bisson N (2011), Fukazawa T (1996), Bisson N (2011), Umehara H (2002), Oksvold MP (2001), Oksvold MP (2001), Li J (2013), Li J (2013), Ueno H (1995), Prigent SA (1996), Wills MK (2014), Rausch O (1997), Ho JM (2002), Ho JM (2002), Yu WM (2006), Klint P (1995)	57
FLT4	5	GRB2	2	pull down	Pajusola K (1994)	1
FLT4	5	VEGFC	0	affinity chromatography technology	Lee J (1996)	1
MAS1	2	FLT4	5	affinity chromatography technology	Huttlin EL (2017)	1
VSIG4	1	FLT4	5	affinity chromatography technology	Huttlin EL (2015)	1
TNF	0	FLT4	5	affinity chromatography technology	Huttlin EL (2015)	1
LGALS3	0	ITGB1	4	affinity chromatography technology	Carvalho RS (2014)	1
TMEM52B	0	NEDD4	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EPN1	4	FLT4	5	affinity chromatography technology	Liu X (2014)	1
LGALS8	4	ITGB1	4	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Hadari YR (2000), Hadari YR (2000), Huttlin EL (2015), Huttlin EL (2017)	4
PTGER3	2	FLT4	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LIPH	1	FLT4	5	affinity chromatography technology	Huttlin EL (2015)	1
TMEM52B	0	FLT4	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FLT4	5	DUSP19	0	two hybrid	Yao Z (2017)	1
FLT4	5	ITGB1	4	affinity chromatography technology	Wang JF (2001)	1
FLT4	5	VEGFD	3	pull down	Baldwin ME (2001)	1
NPY2R	0	FLT4	5	affinity chromatography technology	Huttlin EL (2017)	1
FLT4	5	SHC1	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Pajusola K (1994), Pajusola K (1994), Fournier E (1999), Fournier E (1996), Fournier E (1996)	5
LGALS8	4	FLT4	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2