PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RBPMS	0	C1orf94	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
MTA3	3	RCOR3	0	affinity chromatography technology	Bantscheff M (2011)	1
MTA3	3	HMG20A	0	affinity chromatography technology	Bantscheff M (2011)	1
TRIP6	2	TEKT4	1	two hybrid	Rolland T (2014)	1
ELAVL1	0	HMG20A	0	affinity chromatography technology	Abdelmohsen K (2009)	1
SNAI1	1	KDM1A	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Lin T (2010), Lin T (2010), Lin Y (2010), Lin Y (2010), Lin Y (2010), Lin Y (2010), Wu ZQ (2012), Lin Y (2010), Huttlin EL (2015), Rivero S (2015)	10
FGF1	0	GSE1	14	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HDAC1	4	RALBP1	2	affinity chromatography technology	Hein MY (2015)	1
TCF4	26	KDM1A	2	affinity chromatography technology	Li X (2015)	1
DGCR6	0	C1orf94	1	two hybrid	Corominas R (2014)	1
AR	3	HDAC1	4	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gaughan L (2002), Gaughan L (2002), Gaughan L (2005), Gaughan L (2005), Gobinet J (2005), Peche LY (2015)	6
ELAVL1	0	GSE1	14	affinity chromatography technology	Abdelmohsen K (2009)	1
EYA2	2	RBPMS	0	two hybrid	Rual JF (2005)	1
NR2E1	0	GSE1	14	affinity chromatography technology	Yokoyama A (2008)	1
AR	3	GSE1	14	bioid	Lempiaeinen JK (2017)	1
TCF4	26	TCF3	7	two hybrid, affinity chromatography technology	Ravasi T (2010), Huttlin EL (2017)	2
HDAC1	4	RCOR3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bantscheff M (2011), Joshi P (2013), Hein MY (2015), Huttlin EL (2017)	4
CDC5L	2	GOLGA2	2	two hybrid	Rolland T (2014)	1
TRIM25	5	ELAVL1	0	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
HDAC2	1	RUNX1T1	1	affinity chromatography technology	Amann JM (2001)	1
ELAVL1	0	EXOSC6	0	affinity chromatography technology	Abdelmohsen K (2009)	1
TCF3	7	HDAC2	1	affinity chromatography technology	Kim MS (2007)	1
NINL	1	GSE1	14	bioid	Gupta GD (2015)	1
NTRK1	1	SRPK2	1	affinity chromatography technology	Emdal KB (2015)	1
NR3C1	2	KDM1A	2	bioid	Lempiaeinen JK (2017)	1
EYA2	2	GSE1	14	bioid	St-Denis N (2016)	1
HMG20B	2	GSE1	14	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NR3C1	2	HDAC2	1	affinity chromatography technology	Ito K (2000)	1
ELAVL1	0	RCOR3	0	affinity chromatography technology	Abdelmohsen K (2009)	1
FUS	0	GSE1	14	biochemical	Havugimana PC (2012)	1
HDAC1	4	HDAC2	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, imaging technique, affinity chromatography technology	Hakimi MA (2002), Yao YL (2003), Yao YL (2003), Hakimi MA (2003), Fischle W (2002), Johnson CA (2002), Fischle W (2001), Fischer DD (2002), Fischer DD (2002), Ashburner BP (2001), Zhang Y (1999), Tong JK (1998), Tong JK (1998), Hassig CA (1998), Hassig CA (1998), Zhang Y (1997), van der Vlag J (1999), van der Vlag J (1999), Noh EJ (2009), Noh EJ (2009), Galasinski SC (2002), Galasinski SC (2002), Galasinski SC (2002), He S (2005), Humphrey GW (2001), Park JH (2004), Park JH (2004), Sekhavat A (2007), Zhang Y (1998), Zhang Y (1998), Adenuga D (2010), Xue Y (1998), Xue Y (1998), Martinez FP (2012), Martinez FP (2012), Cui S (2011), Havugimana PC (2012), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Joshi P (2013), Schnur N (2007), Schnur N (2007), Oh YM (2009), Wan C (2015), Hein MY (2015), Chen TC (2014), Huttlin EL (2017)	48
HAO2	1	GSE1	14	affinity chromatography technology	Huttlin EL (2017)	1
GSE1	14	TEKT4	1	two hybrid	Rolland T (2014)	1
RBPMS	0	GSE1	14	two hybrid	Rual JF (2005)	1
SFMBT1	0	KDM1A	2	affinity chromatography technology	Hauri S (2016)	1
NTRK1	1	KDM1A	2	affinity chromatography technology	Emdal KB (2015)	1
NR2E1	0	HDAC1	4	affinity chromatography technology	Yokoyama A (2008)	1
MTA3	3	GSE1	14	affinity chromatography technology	Bantscheff M (2011)	1
SNAI1	1	RCOR3	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRIP6	2	GSE1	14	two hybrid	Rolland T (2014)	1
NTRK1	1	CDC5L	2	affinity chromatography technology	Emdal KB (2015)	1
DGCR6	0	GSE1	14	two hybrid	Corominas R (2014)	1
SNAI1	1	HDAC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Peinado H (2004), Peinado H (2004), Kim Y (2010), Tong ZT (2012), Tong ZT (2012), Hsu DS (2014)	6
AR	3	XRCC6	3	affinity chromatography technology	Mayeur GL (2005)	1
DOK4	3	RCOR3	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HDAC1	4	HMG20B	2	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hakimi MA (2002), Hakimi MA (2002), Hakimi MA (2002), Hakimi MA (2002), Bantscheff M (2011), Joshi P (2013), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	9
DOK4	3	KDM1A	2	affinity chromatography technology	Huttlin EL (2015)	1
HDAC1	4	KDM1A	2	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hakimi MA (2002), Hakimi MA (2003), You A (2001), You A (2001), Shi YJ (2005), Lee MG (2005), Humphrey GW (2001), Humphrey GW (2001), Humphrey GW (2001), Godmann M (2007), Godmann M (2007), Terhune SS (2010), Godmann M (2010), Godmann M (2010), Wang Y (2009), Nicholson TB (2011), Li Q (2011), Cui S (2011), Cui S (2011), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Wan C (2015), Hein MY (2015), Wang Q (2016), Huttlin EL (2017)	26
FAM136A	1	GSE1	14	affinity chromatography technology	Huttlin EL (2017)	1
SNAI1	1	HMG20B	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LLGL2	4	HMG20B	2	affinity chromatography technology	Huttlin EL (2017)	1
HDAC2	1	RCOR3	0	affinity chromatography technology, affinity chromatography technology	Bantscheff M (2011), Joshi P (2013)	2
HDAC2	1	HMG20A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bantscheff M (2011), Joshi P (2013), Hein MY (2015), Huttlin EL (2017), Rivero S (2015)	5
MTA3	3	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Fujita N (2003), Kwintkiewicz J (2011), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	8
ELAVL1	0	TCF3	7	affinity chromatography technology, affinity chromatography technology	Abdelmohsen K (2009), Teachenor R (2012)	2
DGCR6	0	GOLGA2	2	two hybrid	Corominas R (2014)	1
GSE1	14	CFAP206	1	two hybrid	Rolland T (2014)	1
LLGL2	4	HMG20A	0	affinity chromatography technology	Huttlin EL (2017)	1
LLGL2	4	RCOR3	0	affinity chromatography technology	Huttlin EL (2017)	1
NR2E1	0	KDM1A	2	affinity chromatography technology, affinity chromatography technology, pull down	Yokoyama A (2008), Yokoyama A (2008), Yokoyama A (2008)	3
RUNX1T1	1	GSE1	14	two hybrid	Rolland T (2014)	1
GOLGA2	2	KDM1A	2	two hybrid	Rolland T (2014)	1
KDM1A	2	RCOR3	0	affinity chromatography technology, two hybrid, biochemical	Bantscheff M (2011), Weimann M (2013), Wan C (2015)	3
ELAVL1	0	MTA3	3	affinity chromatography technology	Abdelmohsen K (2009)	1
FGF1	0	KDM1A	2	affinity chromatography technology	Huttlin EL (2015)	1
GSE1	14	RBM48	1	two hybrid	Stelzl U (2005)	1
HMG20A	0	GSE1	14	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
CEP63	2	GSE1	14	two hybrid	Camargo LM (2007)	1
SFMBT1	0	HDAC2	1	affinity chromatography technology	Hauri S (2016)	1
SNAI1	1	GSE1	14	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TCF4	26	HMG20A	0	affinity chromatography technology	Huttlin EL (2017)	1
TNIK	4	GSE1	14	two hybrid	Camargo LM (2007)	1
DOK4	3	GSE1	14	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NR3C1	2	C1orf94	1	protein complementation assay	Lievens S (2016)	1
ELAVL1	0	HDAC2	1	affinity chromatography technology	Abdelmohsen K (2009)	1
GOLGA2	2	RCOR3	0	two hybrid	Rolland T (2014)	1
SNAI1	1	HMG20A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017), Rivero S (2015)	3
GSE1	14	RCOR3	0	two hybrid, two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009), Rolland T (2014)	3
SRPK2	1	GSE1	14	enzymatic study	Lipp JJ (2015)	1
KDM1A	2	HMG20A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shi YJ (2005), Bantscheff M (2011), Hein MY (2015), Huttlin EL (2017), Boldt K (2016), Rivero S (2015)	6
HDAC1	4	SFMBT1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Hauri S (2016)	2
TRIM25	5	SRPK2	1	affinity chromatography technology	Choudhury NR (2017)	1
ELAVL1	0	NR3C1	2	affinity chromatography technology	Abdelmohsen K (2009)	1
HAO2	1	RBPMS	0	affinity chromatography technology	Huttlin EL (2017)	1
NTRK1	1	FUS	0	affinity chromatography technology	Emdal KB (2015)	1
TCF4	26	RUNX1T1	1	affinity chromatography technology, affinity chromatography technology	Li X (2015), Huttlin EL (2017)	2
HDAC2	1	KDM1A	2	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, genetic interference	Hakimi MA (2002), Hakimi MA (2003), Hakimi MA (2003), Hakimi MA (2003), Tong JK (1998), Lee MG (2005), Humphrey GW (2001), Humphrey GW (2001), Zibetti C (2010), Wang Y (2009), Li Q (2011), Cui S (2011), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Wan C (2015), Wong AS (2016)	17
RALBP1	2	GSE1	14	two hybrid	Rolland T (2014)	1
CDC5L	2	KDM1A	2	two hybrid	Camargo LM (2007)	1
MAPK3	4	GSE1	14	affinity chromatography technology	Hein MY (2015)	1
DOK4	3	HMG20A	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HMG20B	2	RCOR3	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SFMBT1	0	RCOR3	0	affinity chromatography technology	Hauri S (2016)	1
NR3C1	2	GSE1	14	bioid	Lempiaeinen JK (2017)	1
DGCR6	0	TCF4	26	two hybrid	Corominas R (2014)	1
FUS	0	CDC5L	2	affinity chromatography technology, affinity chromatography technology	Wang T (2014), Lleres D (2010)	2
KDM1A	2	MTA3	3	affinity chromatography technology, pull down, affinity chromatography technology	Wang Y (2009), Wang Y (2009), Li Q (2011)	3
TRIM25	5	XRCC6	3	affinity chromatography technology	Choudhury NR (2017)	1
GOLGA2	2	GSE1	14	two hybrid	Rolland T (2014)	1
NINL	1	RCOR3	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
NTRK1	1	GSE1	14	affinity chromatography technology	Emdal KB (2015)	1
TCF3	7	KDM1A	2	affinity chromatography technology	Teachenor R (2012)	1
HDAC1	4	RUNX1T1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Amann JM (2001), Zhang J (2004), Gelmetti V (1998), Liu S (2007), Liu S (2007), Chen TC (2014)	6
NR2E1	0	HDAC2	1	affinity chromatography technology	Yokoyama A (2008)	1
HDAC2	1	HMG20B	2	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hakimi MA (2002), Hakimi MA (2002), Hakimi MA (2002), Hakimi MA (2003), Hakimi MA (2002), Bantscheff M (2011), Joshi P (2013), Huttlin EL (2015), Huttlin EL (2017)	9
CDC5L	2	ELAVL1	0	affinity chromatography technology	Lleres D (2010)	1
TRIM25	5	HMG20A	0	affinity chromatography technology	Choudhury NR (2017)	1
HMG20A	0	RCOR3	0	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
HDAC1	4	GSE1	14	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bantscheff M (2011), Joshi P (2013), Hein MY (2015), Huttlin EL (2017)	4
NTRK1	1	TCF4	26	affinity chromatography technology	Emdal KB (2015)	1
HMG20B	2	KDM1A	2	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hakimi MA (2002), Hakimi MA (2002), Hakimi MA (2002), Hakimi MA (2003), Shi YJ (2005), Lee MG (2005), Hakimi MA (2002), Bantscheff M (2011), Huttlin EL (2015), Huttlin EL (2017)	10
NTRK1	1	GOLGA2	2	affinity chromatography technology	Emdal KB (2015)	1
GSE1	14	XRCC6	3	two hybrid	Stelzl U (2005)	1
SNAI1	1	HDAC1	4	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Peinado H (2004), Peinado H (2004), Lin T (2010), Tong ZT (2012), Tong ZT (2012), Wu ZQ (2012), Hsu DS (2014), Yuan K (2016), Yuan K (2016)	9
LLGL2	4	GSE1	14	affinity chromatography technology	Huttlin EL (2017)	1
AR	3	KDM1A	2	affinity chromatography technology, bioid	Choi H (2016), Lempiaeinen JK (2017)	2
TCF3	7	GSE1	14	affinity chromatography technology	Teachenor R (2012)	1
GSE1	14	GSE1	14	two hybrid	Rolland T (2014)	1
NTRK1	1	XRCC6	3	affinity chromatography technology	Emdal KB (2015)	1
C1orf94	1	CFAP206	1	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
HMG20B	2	HMG20A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017), Ceballos-Chavez M (2012), Ceballos-Chavez M (2012)	5
GSE1	14	NUDT18	0	two hybrid	Rual JF (2005)	1
EXOSC6	0	GSE1	14	two hybrid	Lehner B (2004)	1
TRIM25	5	FUS	0	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
TCF4	26	GSE1	14	affinity chromatography technology, affinity chromatography technology	Li X (2015), Huttlin EL (2017)	2
CEP63	2	TNIK	4	bioid	Firat-Karalar EN (2014)	1
SFMBT1	0	GSE1	14	affinity chromatography technology	Hauri S (2016)	1
HMG20A	0	SFMBT1	0	affinity chromatography technology	Huttlin EL (2017)	1
FGF1	0	HMG20A	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NR3C1	2	HDAC1	4	affinity chromatography technology, affinity chromatography technology, biochemical, fluorescent resonance energy transfe, pull down	Qiu Y (2006), Jee YK (2005), Kristensen AR (2012), Qiu Y (2011), Qiu Y (2011)	5
FGF1	0	RCOR3	0	affinity chromatography technology	Huttlin EL (2015)	1
CDC5L	2	GSE1	14	two hybrid	Camargo LM (2007)	1
MTA3	3	HDAC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Fujita N (2003), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Wan C (2015)	5
KDM1A	2	GSE1	14	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hakimi MA (2003), Lee MG (2005), Bantscheff M (2011)	3
NTRK1	1	ELAVL1	0	affinity chromatography technology	Emdal KB (2015)	1
MTA3	3	HMG20B	2	affinity chromatography technology	Bantscheff M (2011)	1
HDAC1	4	HMG20A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bantscheff M (2011), Joshi P (2013), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	5
ELAVL1	0	DOK4	3	affinity chromatography technology	Abdelmohsen K (2009)	1
TRIM25	5	GSE1	14	affinity chromatography technology	Choudhury NR (2017)	1
GSE1	14	C1orf94	1	two hybrid	Rolland T (2014)	1
NTRK1	1	HDAC2	1	affinity chromatography technology	Emdal KB (2015)	1
RUNX1T1	1	TCF3	7	affinity chromatography technology	Zhang J (2004)	1
HDAC2	1	GSE1	14	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hakimi MA (2003), Bantscheff M (2011), Joshi P (2013)	3