PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
DERL2	0	DERL1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lilley BN (2005), Huang CH (2013), Christianson JC (2012)	3
AMFR	2	DERL1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Morito D (2008), Ballar P (2007), Ye Y (2005), Zhong Y (2011)	4
FAF2	4	PEX19	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Christianson JC (2012), Huttlin EL (2015), Raman M (2015), Huttlin EL (2017)	4
UBL4A	0	FAF2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Xu Y (2012), Xu Y (2013)	3
DERL2	0	FAF2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Greenblatt EJ (2011), Christianson JC (2012), Christianson JC (2012), Christianson JC (2012), Huttlin EL (2015), Raman M (2015), Huttlin EL (2017)	7
INSIG1	0	AMFR	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Song BL (2005), Lee JN (2006), Ikeda Y (2009), Jo Y (2011), Jo Y (2011), Song BL (2005), Song BL (2005)	7
FAF2	4	VRK2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Raman M (2015), Huttlin EL (2017)	3
VCP	6	UFD1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Wang Q (2008), Ballar P (2007), Alexandru G (2008), Zhong X (2006), Fernandez-Saiz V (2010), Nagahama M (2009), Noguchi M (2005), Bruderer RM (2004), Bruderer RM (2004), Bruderer RM (2004), Erzurumlu Y (2013), Li JM (2013), Fogeron ML (2013), Haenzelmann P (2016), Haenzelmann P (2016), Haenzelmann P (2016), Raman M (2015), Raman M (2015), Mountassif D (2015), Wang T (2016), Guo X (2017)	21
FAF2	4	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Lee JN (2008), Alexandru G (2008), Alexandru G (2008), Mueller B (2008), Alexandru G (2012), Xu Y (2013), Christianson JC (2012), Besten Wd (2012), Madsen L (2014), Raman M (2015)	10
UBL4A	0	SLC25A4	0	affinity chromatography technology	Xu Y (2012)	1
AMFR	2	FAF2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lee JN (2008), Lee JN (2008), Alexandru G (2008), Wang Q (2011), Xu Y (2013), Wang Q (2011), Christianson JC (2012), Christianson JC (2012), Zhang T (2015)	9
UBL4A	0	UFD1	1	affinity chromatography technology	Sowa ME (2009)	1
INSIG1	0	VCP	6	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Lee JN (2008), Song BL (2005), Ikeda Y (2009), Song BL (2005)	4
ZFAND2B	1	VCP	6	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Glinka T (2014), Glinka T (2014), Glinka T (2014), Braunstein I (2015)	4
DERL2	0	BAG6	2	affinity chromatography technology, affinity chromatography technology	Claessen JH (2011), Claessen JH (2014)	2
BAG6	2	VCP	6	affinity chromatography technology, affinity chromatography technology, biochemical	Wang Q (2011), Yu CC (2013), Xu Y (2013)	3
UFD1	1	UBAC2	1	affinity chromatography technology	Raman M (2015)	1
AMFR	2	VCP	6	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, two hybrid, pull down, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhong X (2004), Zhong X (2004), Lee JN (2008), Cao J (2007), Ballar P (2007), Ballar P (2007), Ye Y (2005), Ye Y (2005), Zhong X (2004), Yang H (2010), Yang H (2010), Ballar P (2010), Jo Y (2011), St-Pierre P (2012), Grelle G (2006), Scheich C (2007), Ballar P (2006), Haenzelmann P (2011), Haenzelmann P (2011), Haenzelmann P (2011), Wang Q (2011), Yu CC (2013), Erzurumlu Y (2013), Liu S (2013), Wang Q (2011), Grelle G (2006), Grelle G (2006), Grelle G (2006), Grelle G (2006), Christianson JC (2012), Zhang T (2015), Khodayari N (2017)	32
AMFR	2	UBL4A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Wang Q (2011), Wang Q (2011), Liu Y (2014), Liu Y (2014)	4
NF1	16	VCP	6	affinity chromatography technology, pull down, pull down	Wang HF (2011), Wang HF (2011), Wang HF (2011)	3
UFD1	1	NPLOC4	4	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, x-ray crystallography, biochemical, affinity chromatography technology, affinity chromatography technology	Botta A (2001), Lass A (2008), Vong QP (2005), Bruderer RM (2004), Havugimana PC (2012), Li JM (2013), Pye VE (2007), Wan C (2015), Raman M (2015), Raman M (2015)	10
FAF2	4	RRM2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Raman M (2015), Huttlin EL (2017)	3
ELAVL1	0	PEX19	2	affinity chromatography technology	Abdelmohsen K (2009)	1
ZFAND2B	1	NPLOC4	4	affinity chromatography technology, affinity chromatography technology	Glinka T (2014), Glinka T (2014)	2
AUP1	0	VCP	6	affinity chromatography technology, affinity chromatography technology	Klemm EJ (2011), Klemm EJ (2011)	2
UBAC2	1	PEX19	2	affinity chromatography technology	Christianson JC (2012)	1
ELAVL1	0	FAF2	4	affinity chromatography technology, affinity chromatography technology, pull down	Abdelmohsen K (2009), Zhou HL (2013), Zhou HL (2013)	3
ELAVL1	0	RRM2	2	affinity chromatography technology	Abdelmohsen K (2009)	1
BAG6	2	SETDB1	3	two hybrid	Stelzl U (2005)	1
FAF2	4	UBQLN2	0	affinity chromatography technology, affinity chromatography technology, pull down	Xia Y (2013), Xia Y (2013), Xia Y (2013)	3
ELAVL1	0	UBQLN2	0	affinity chromatography technology	Abdelmohsen K (2009)	1
ZFAND2B	1	FAF2	4	affinity chromatography technology, affinity chromatography technology, biochemical	Glinka T (2014), Glinka T (2014), Glinka T (2014)	3
ELAVL1	0	VCP	6	affinity chromatography technology, pull down	Zhou HL (2013), Zhou HL (2013)	2
FAF2	4	NPLOC4	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), Raman M (2015), Raman M (2015)	4
FAF2	4	INSIG1	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Lee JN (2008), Lee JN (2008), Ikeda Y (2009), Kim H (2013)	4
NF1	16	FAF2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	Phan VT (2010), Phan VT (2010), Phan VT (2010), Phan VT (2010), Phan VT (2010), Huttlin EL (2015)	6
NPLOC4	4	UBAC2	1	affinity chromatography technology	Raman M (2015)	1
SETDB1	3	FAF2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Raman M (2015), Huttlin EL (2017)	3
AMFR	2	UBAC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Christianson JC (2012), Christianson JC (2012), Christianson JC (2012), Zhang T (2015), Zhang T (2015)	5
NPLOC4	4	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Lass A (2008), Ballar P (2007), Alexandru G (2008), Alexandru G (2008), Fernandez-Saiz V (2010), Noguchi M (2005), Bruderer RM (2004), Bruderer RM (2004), Lee JJ (2013), Erzurumlu Y (2013), Raman M (2015), Raman M (2015), Mountassif D (2015), Wang T (2016), Guo X (2017)	15
BAG6	2	FAF2	4	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Xu Y (2012), Xu Y (2013), Xu Y (2013), Raman M (2015)	4
FAF2	4	ACAD9	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Raman M (2015), Huttlin EL (2017)	3
AMFR	2	UFD1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Cao J (2007), Cao J (2007), Cao J (2007), Cao J (2007)	4
FAF2	4	UFD1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), Raman M (2015), Raman M (2015)	4
SLC25A4	0	FAF2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Raman M (2015), Raman M (2015), Raman M (2015)	3
UBL4A	0	VCP	6	affinity chromatography technology, affinity chromatography technology	Wang Q (2011), Xu Y (2012)	2
RRM2	2	NPLOC4	4	biochemical	Wan C (2015)	1
ELAVL1	0	AMFR	2	affinity chromatography technology	Abdelmohsen K (2009)	1
ZFAND2B	1	DERL1	2	affinity chromatography technology	Glinka T (2014)	1
DERL1	2	FAF2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Greenblatt EJ (2011), Suzuki M (2012), Suzuki M (2012), Xu Y (2013), Christianson JC (2012), Christianson JC (2012)	6
AMFR	2	DERL2	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Morito D (2008), Zhong Y (2011), Huang CH (2013), Christianson JC (2012), Zhang T (2015)	5
DERL2	0	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lilley BN (2005), Greenblatt EJ (2011), Huang CH (2013), Christianson JC (2012)	4
NPLOC4	4	UBQLN2	0	biochemical	Kristensen AR (2012)	1
AMFR	2	AUP1	0	affinity chromatography technology	Jo Y (2013)	1
UBL4A	0	BAG6	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, two hybrid, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Sowa ME (2009), Wang Q (2011), Wang Q (2011), Mariappan M (2010), Xu Y (2012), Xu Y (2012), Xu Y (2012), Xu Y (2012), Mock JY (2015), Mock JY (2015), Kuwabara N (2015), Kuwabara N (2015), Kuwabara N (2015), Wu W (2014), Wu W (2014), Wan C (2015), Hein MY (2015), Rodrigo-Brenni MC (2014), Huttlin EL (2017)	19
RPTOR	4	FAF2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Raman M (2015), Huttlin EL (2017)	3
VCP	6	DERL1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography	Wang Q (2008), Ballar P (2007), Schulze A (2005), Schulze A (2005), Ye Y (2005), Lilley BN (2005), Greenblatt EJ (2011), Younger JM (2006), Christianson JC (2012), You H (2017), Lim JJ (2016), Lim JJ (2016)	12
AMFR	2	BAG6	2	affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang Q (2011), Wang Q (2011), Wang Q (2011), Xu Y (2012), Xu Y (2012), Xu Y (2012), Wang Q (2011), Liu Y (2014), Zhang T (2015)	9
VCP	6	PEX19	2	affinity chromatography technology, affinity chromatography technology	Murakami K (2013), Murakami K (2013)	2
UBL4A	0	NPLOC4	4	affinity chromatography technology	Sowa ME (2009)	1
FAF2	4	UBAC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Christianson JC (2012), Christianson JC (2012), Christianson JC (2012), Christianson JC (2012), Zhang T (2015), Zhang T (2015), Raman M (2015), Olzmann JA (2013), Huttlin EL (2017)	9
AMFR	2	NPLOC4	4	affinity chromatography technology, affinity chromatography technology	Wang Q (2011), Wang Q (2011)	2
UBL4A	0	AUP1	0	affinity chromatography technology	Xu Y (2012)	1
AUP1	0	FAF2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Klemm EJ (2011), Klemm EJ (2011), Raman M (2015)	3
ELAVL1	0	INSIG1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	NPLOC4	4	affinity chromatography technology	Abdelmohsen K (2009)	1
ZFAND2B	1	BAG6	2	affinity chromatography technology, affinity chromatography technology	Glinka T (2014), Braunstein I (2015)	2