PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MAP1LC3B	1	ATG3	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Tanida I (2004), Gao W (2013)	3
79686	0	SQSTM1	0	two hybrid	Stelzl U (2005)	1
MOV10	6	TES	1	affinity chromatography technology	Castello A (2012)	1
BAG3	4	STK16	1	affinity chromatography technology	Chen Y (2013)	1
GABARAPL2	0	ATG3	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down	Ewing RM (2007), Behrends C (2010), Behrends C (2010), Sou YS (2006), Sou YS (2006)	5
ATG4B	1	KRT4	0	affinity chromatography technology	Behrends C (2010)	1
GABARAPL1	0	ULK1	8	affinity chromatography technology	Alemu EA (2012)	1
MOV10	6	GABARAPL1	0	affinity chromatography technology	Castello A (2012)	1
FANK1	1	ATG4B	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GABARAPL1	0	GABARAP	0	affinity chromatography technology	Behrends C (2010)	1
FBXW11	2	ATG4B	1	affinity chromatography technology	Sowa ME (2009)	1
FBXW11	2	STK3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim TY (2014), Kim TY (2014), Coyaud E (2015)	3
ATG3	4	ATG4B	1	affinity chromatography technology	Behrends C (2010)	1
MAP1LC3B	1	SQSTM1	0	two hybrid, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, x-ray crystallography, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, two hybrid, imaging technique, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Stelzl U (2005), Behrends C (2010), Vinayagam A (2011), Kirkin V (2009), Kirkin V (2009), Liang X (2013), Liang X (2013), Novak I (2010), Novak I (2010), Rogov VV (2012), Gao W (2013), Maruyama Y (2014), Maruyama Y (2014), Maruyama Y (2014), Yamashita SI (2014), Wurzer B (2015), Wurzer B (2015), Wurzer B (2015), Sun A (2017), Cohen-Kaplan V (2016), Dou Z (2015), Galindo-Moreno M (2017)	22
ATG4B	1	ANXA1	1	affinity chromatography technology	Behrends C (2010)	1
BAG3	4	SQSTM1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gamerdinger M (2009), Gamerdinger M (2009), Chen Y (2013)	3
YWHAB	1	STK3	1	affinity chromatography technology	Couzens AL (2013)	1
NXF1	0	GABARAPL1	0	affinity chromatography technology	Castello A (2012)	1
ULK1	8	GABARAPL2	0	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method	Okazaki N (2000), Okazaki N (2000), Behrends C (2010), Alemu EA (2012), Alemu EA (2012)	5
MAP1LC3B	1	GABARAPL2	0	pull down	Maruyama Y (2014)	1
FBXW11	2	AMBRA1	7	affinity chromatography technology	Low TY (2014)	1
SHMT2	3	ATG4B	1	affinity chromatography technology	Castello A (2012)	1
ATG10	0	ATG3	4	affinity chromatography technology	Behrends C (2010)	1
NXF1	0	ANXA1	1	affinity chromatography technology	Castello A (2012)	1
FBXW11	2	SHMT2	3	affinity chromatography technology	Low TY (2014)	1
NXF1	0	SQSTM1	0	affinity chromatography technology	Castello A (2012)	1
YWHAB	1	ATG4B	1	biochemical	Havugimana PC (2012)	1
MAP1LC3A	0	ATG3	4	affinity chromatography technology, pull down, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	Behrends C (2010), Gao Z (2010), Lee JS (2009), Sou YS (2006), Sou YS (2006), Zhang F (2014)	6
MAP1LC3B	1	ATG4B	1	two hybrid, affinity chromatography technology, two hybrid, two hybrid, enzymatic study, affinity chromatography technology	Stelzl U (2005), Behrends C (2010), Vinayagam A (2011), Novak I (2010), Tanida I (2004), Gao W (2013)	6
MOV10	6	ATG4B	1	affinity chromatography technology	Castello A (2012)	1
NXF1	0	TES	1	affinity chromatography technology	Castello A (2012)	1
GABARAPL1	0	ATG3	4	affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Tanida I (2006)	2
NXF1	0	ATG4B	1	affinity chromatography technology	Castello A (2012)	1
GABARAP	0	GABARAPL2	0	affinity chromatography technology	Behrends C (2010)	1
FBXW11	2	YWHAB	1	affinity chromatography technology	Coyaud E (2015)	1
SQSTM1	0	ULK1	8	affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology	Ro SH (2014), Ro SH (2014), Lim J (2015), Lim J (2015)	4
GABARAP	0	SQSTM1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Behrends C (2010), Kirkin V (2009), Maruyama Y (2014), Dunlop EA (2014), Wurzer B (2015), Wurzer B (2015)	6
SQSTM1	0	GABARAPL2	0	two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid	Rual JF (2005), Behrends C (2010), Vinayagam A (2011), Shvets E (2011), Kirkin V (2009), Kirkin V (2009), Maruyama Y (2014), Rolland T (2014), Yu H (2011)	9
CAMKK2	3	ATG4B	1	affinity chromatography technology	Behrends C (2010)	1
MAP1LC3A	0	SQSTM1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, biochemical, imaging technique, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, pull down, affinity chromatography technology	Shvets E (2008), Shvets E (2008), Behrends C (2010), Gao Z (2010), Pan JA (2011), Pankiv S (2007), Pankiv S (2007), Shvets E (2011), Tung YT (2010), Bjorkoy G (2005), Kirkin V (2009), Lim J (2011), Lim J (2011), Pan JA (2012), Lee DY (2013), Wang BS (2013), Wang BS (2013), Sansanwal P (2012), Shi J (2013), Fujita N (2013), Chen X (2014), Liu XD (2014), Noda NN (2008), Noda NN (2008), Matsuzawa Y (2015), Matsuzawa Y (2015), Rui YN (2015), Rui YN (2015), Ciuffa R (2015), Wang N (2013), Hua F (2015), Rui YN (2015), Cha-Molstad H (2015), Paul S (2012), Puvirajesinghe TM (2016), Wang L (2017), Cha-Molstad H (2017), Peng H (2017), Lee Y (2017)	39
ULK1	8	ATG4B	1	affinity chromatography technology	Behrends C (2010)	1
SQSTM1	0	ATG4B	1	affinity chromatography technology	Tanji K (2012)	1
MAP1LC3B	1	GABARAP	0	affinity chromatography technology	Behrends C (2010)	1
NXF1	0	BAG3	4	affinity chromatography technology	Castello A (2012)	1
FBXW11	2	BAG3	4	affinity chromatography technology	Low TY (2014)	1
AMBRA1	7	ATG3	4	affinity chromatography technology	Behrends C (2010)	1
MAP1LC3A	0	ATG4B	1	affinity chromatography technology, x-ray crystallography, enzymatic study, enzymatic study	Behrends C (2010), Satoo K (2009), Betin VM (2009), Betin VM (2009)	4
TES	1	SQSTM1	0	affinity chromatography technology	Sala S (2017)	1
BAG3	4	YWHAB	1	affinity chromatography technology	Chen Y (2013)	1
ATG3	4	GABARAP	0	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	Behrends C (2010), Behrends C (2010), Sou YS (2006), Sou YS (2006), Huttlin EL (2017)	5
MAP1LC3A	0	ULK1	8	affinity chromatography technology	Alemu EA (2012)	1
ULK1	8	GABARAP	0	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology	Ewing RM (2007), Okazaki N (2000), Okazaki N (2000), Alemu EA (2012), Alemu EA (2012), Dunlop EA (2014)	6
AMBRA1	7	GABARAP	0	affinity chromatography technology	Strappazzon F (2014)	1
MAP1LC3B	1	STK3	1	affinity chromatography technology	Behrends C (2010)	1
ATG10	0	ATG4B	1	affinity chromatography technology	Behrends C (2010)	1
MAP1LC3B	1	ULK1	8	affinity chromatography technology	Alemu EA (2012)	1
BAG3	4	ANXA1	1	affinity chromatography technology	Chen Y (2013)	1
MOV10	6	ANXA1	1	affinity chromatography technology	Castello A (2012)	1
BAG3	4	ATG4B	1	affinity chromatography technology, affinity chromatography technology	Chen Y (2013), Chen Y (2013)	2
ATG3	4	ATG12	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Tanida I (2002), Behrends C (2010), Behrends C (2010), Radoshevich L (2010), Qiu Y (2013), Huttlin EL (2017)	6
ATG4B	1	GABARAPL1	0	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study	Behrends C (2010), Behrends C (2010), Tanida I (2006), Betin VM (2009), Betin VM (2009)	5
FBXW11	2	MOV10	6	affinity chromatography technology, affinity chromatography technology	Low TY (2014), Huttlin EL (2017)	2
ULK1	8	AMBRA1	7	enzymatic study, affinity chromatography technology, affinity chromatography technology	Di Bartolomeo S (2010), Nazio F (2013), Nazio F (2013)	3
STK3	1	ATG4B	1	affinity chromatography technology	Behrends C (2010)	1
MAP1LC3A	0	GABARAPL1	0	imaging technique	Tanida I (2006)	1
ATG12	1	GABARAP	0	affinity chromatography technology	Behrends C (2010)	1
GABARAP	0	ATG4B	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Stelzl U (2005), Behrends C (2010), Behrends C (2010), Dunlop EA (2014)	4
STK16	1	ATG4B	1	affinity chromatography technology	Huttlin EL (2017)	1
ATG12	1	ATG10	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Huttlin EL (2015), Huttlin EL (2017)	3
BAG3	4	ATG3	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chen Y (2013), Chen Y (2013), Chen Y (2013)	3
ATG12	1	ATG4B	1	affinity chromatography technology	Behrends C (2010)	1
GABARAPL1	0	GABARAPL2	0	affinity chromatography technology	Behrends C (2010)	1
GABARAPL2	0	ATG4B	1	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, enzymatic study	Ewing RM (2007), Stelzl U (2005), Behrends C (2010), Behrends C (2010), Vinayagam A (2011), Betin VM (2009)	6
MOV10	6	SQSTM1	0	affinity chromatography technology	Castello A (2012)	1
79686	0	ATG4B	1	two hybrid	Stelzl U (2005)	1
AMBRA1	7	ATG4B	1	affinity chromatography technology	Behrends C (2010)	1
SQSTM1	0	GABARAPL1	0	two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, imaging technique, two hybrid	Rual JF (2005), Behrends C (2010), Wild P (2011), Kirkin V (2009), Zhang Y (2011), Zhang Y (2011), Rolland T (2014)	7
MAP1LC3A	0	STK3	1	affinity chromatography technology	Behrends C (2010)	1
TES	1	ATG4B	1	affinity chromatography technology	Sala S (2017)	1
MAP1LC3B	1	MAP1LC3A	0	affinity chromatography technology	Behrends C (2010)	1