PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
DERL2	0	DERL1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lilley BN (2005), Huang CH (2013), Christianson JC (2012)	3
UBXN4	0	UBE4A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Christianson JC (2012), Huttlin EL (2015), Raman M (2015), Raman M (2015), Huttlin EL (2017)	5
AMFR	2	DERL1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Morito D (2008), Ballar P (2007), Ye Y (2005), Zhong Y (2011)	4
UBXN4	0	AMFR	2	affinity chromatography technology	Liang J (2006)	1
7179	0	UBXN4	0	bioid	St-Denis N (2016)	1
ELAVL1	0	TCTN2	2	affinity chromatography technology	Abdelmohsen K (2009)	1
DERL2	0	UBXN4	0	affinity chromatography technology	Christianson JC (2012)	1
UBXN4	0	ODR4	0	affinity chromatography technology	Raman M (2015)	1
7179	0	AMFR	2	affinity chromatography technology	Yadav L (2017)	1
VCP	6	PSMA6	1	affinity chromatography technology	Lim PJ (2009)	1
TMEM17	0	UBXN4	0	bioid	Gupta GD (2015)	1
FGFR2	6	IP6K1	5	affinity chromatography technology	Huttlin EL (2017)	1
TMEM216	0	UBXN4	0	bioid	Gupta GD (2015)	1
DERL2	0	SEL1L	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lilley BN (2005), Lilley BN (2005), Huang CH (2013), Huang CH (2013), Huang CH (2013), Christianson JC (2012)	6
UBQLN1	1	PSMA6	1	affinity chromatography technology	Lim PJ (2009)	1
UBXN4	0	SLC27A4	2	affinity chromatography technology	Raman M (2015)	1
FGFR2	6	UBE4A	2	affinity chromatography technology	Huttlin EL (2017)	1
UBXN4	0	TOM1L1	1	two hybrid	Stelzl U (2005)	1
TMEM67	3	UBXN4	0	bioid	Gupta GD (2015)	1
AMFR	2	VCP	6	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, two hybrid, pull down, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhong X (2004), Zhong X (2004), Lee JN (2008), Cao J (2007), Ballar P (2007), Ballar P (2007), Ye Y (2005), Ye Y (2005), Zhong X (2004), Yang H (2010), Yang H (2010), Ballar P (2010), Jo Y (2011), St-Pierre P (2012), Grelle G (2006), Scheich C (2007), Ballar P (2006), Haenzelmann P (2011), Haenzelmann P (2011), Haenzelmann P (2011), Wang Q (2011), Yu CC (2013), Erzurumlu Y (2013), Liu S (2013), Wang Q (2011), Grelle G (2006), Grelle G (2006), Grelle G (2006), Grelle G (2006), Christianson JC (2012), Zhang T (2015), Khodayari N (2017)	32
AMFR	2	TOM1L1	1	two hybrid	Vinayagam A (2011)	1
UBQLN1	1	VCP	6	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lim PJ (2009), Yu CC (2013), Lim PJ (2009), Lim PJ (2009)	4
UBXN4	0	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Alexandru G (2008), Lim PJ (2009), Liang J (2006), Lim PJ (2009), Madsen L (2014), Raman M (2015)	6
ELAVL1	0	FBXO11	14	affinity chromatography technology	Abdelmohsen K (2009)	1
DERL1	2	CANX	4	affinity chromatography technology	You H (2017)	1
UBXN4	0	BCL11A	14	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBXN4	0	CANX	4	biochemical, affinity chromatography technology	Liang J (2006), Liang J (2006)	2
TCTN3	2	DERL2	0	bioid	Gupta GD (2015)	1
SEL1L	2	DERL1	2	affinity chromatography technology, affinity chromatography technology	Lilley BN (2005), Huang CH (2013)	2
UBXN4	0	UBXN6	1	affinity chromatography technology	Raman M (2015)	1
ELAVL1	0	UBXN6	1	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	VCP	6	affinity chromatography technology, pull down	Zhou HL (2013), Zhou HL (2013)	2
ELAVL1	0	UBE4A	2	affinity chromatography technology	Abdelmohsen K (2009)	1
TCTN3	2	UBXN4	0	bioid	Gupta GD (2015)	1
ELAVL1	0	DPP8	2	affinity chromatography technology	Abdelmohsen K (2009)	1
UBXN4	0	VPS13A	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Raman M (2015), Huttlin EL (2017)	3
UBXN4	0	ACTA2	1	affinity chromatography technology	Huttlin EL (2015)	1
SEL1L	2	UBXN4	0	affinity chromatography technology	Mueller B (2008)	1
NSFL1C	1	UBXN4	0	biochemical	Wan C (2015)	1
UBXN4	0	DPP8	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBXN4	0	PSMA6	1	affinity chromatography technology	Lim PJ (2009)	1
EVC2	5	UBXN4	0	bioid	Gupta GD (2015)	1
ELAVL1	0	UBXN4	0	affinity chromatography technology	Abdelmohsen K (2009)	1
VCP	6	CANX	4	affinity chromatography technology, biochemical	Yu CC (2013), Wan C (2015)	2
UBXN4	0	DERL1	2	affinity chromatography technology	Liang J (2006)	1
FGFR2	6	UBXN4	0	affinity chromatography technology	Huttlin EL (2017)	1
FGFR2	6	BCL11A	14	affinity chromatography technology	Huttlin EL (2017)	1
TCTN3	2	CANX	4	bioid	Gupta GD (2015)	1
ELAVL1	0	AMFR	2	affinity chromatography technology	Abdelmohsen K (2009)	1
UBXN6	1	NSFL1C	1	affinity chromatography technology	Raman M (2015)	1
VCP	6	TOM1L1	1	two hybrid	Vinayagam A (2011)	1
UBQLN1	1	UBXN4	0	two hybrid, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology	Lim PJ (2009), Lim PJ (2009), Lim PJ (2009), Rolland T (2014), Lim PJ (2009)	5
TCTN2	2	TCTN3	2	affinity chromatography technology	Boldt K (2016)	1
UBXN6	1	VCP	6	pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kern M (2009), Kern M (2009), Kern M (2009), Stapf C (2011), Stapf C (2011), Stapf C (2011), Alexandru G (2008), Haenzelmann P (2011), Haenzelmann P (2011), Allen MD (2006), Nagahama M (2009), Nagahama M (2009), Alexandru G (2012), Haines DS (2012), Yu CC (2013), Huttlin EL (2015), Madsen L (2014), Trusch F (2015), Raman M (2015), Raman M (2015), Guo X (2017), Guo X (2017), Huttlin EL (2017)	23
AMFR	2	DERL2	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Morito D (2008), Zhong Y (2011), Huang CH (2013), Christianson JC (2012), Zhang T (2015)	5
DERL2	0	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lilley BN (2005), Greenblatt EJ (2011), Huang CH (2013), Christianson JC (2012)	4
UBXN6	1	CANX	4	affinity chromatography technology	Haines DS (2012)	1
TCTN2	2	CANX	4	bioid	Gupta GD (2015)	1
TCTN2	2	TMEM67	3	affinity chromatography technology	Huttlin EL (2017)	1
UBXN4	0	IP6K1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Raman M (2015), Huttlin EL (2017)	3
UBXN4	0	FBXO11	14	affinity chromatography technology	Huttlin EL (2015)	1
VCP	6	DERL1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography	Wang Q (2008), Ballar P (2007), Schulze A (2005), Schulze A (2005), Ye Y (2005), Lilley BN (2005), Greenblatt EJ (2011), Younger JM (2006), Christianson JC (2012), You H (2017), Lim JJ (2016), Lim JJ (2016)	12
DERL1	2	PSMA6	1	affinity chromatography technology	You H (2017)	1
VCP	6	NSFL1C	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, unspecified method, two hybrid, affinity chromatography technology, two hybrid, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Uchiyama K (2003), Uchiyama K (2003), Alexandru G (2008), Alexandru G (2008), Vinayagam A (2011), Madsen L (2011), Fernandez-Saiz V (2010), Noguchi M (2005), Uchiyama K (2002), Uchiyama K (2002), Uchiyama K (2002), Alexandru G (2012), Fogeron ML (2013), Grelle G (2006), Grelle G (2006), Grelle G (2006), Rolland T (2014), Besten Wd (2012), Madsen L (2014), Zhang X (2015), Wan C (2015), Hein MY (2015), Raman M (2015), Raman M (2015), Wang T (2016), Guo X (2017), Park ES (2017), Huttlin EL (2017)	28
UBXN4	0	PPP1R7	4	affinity chromatography technology	Raman M (2015)	1
TCTN3	2	DERL1	2	bioid	Gupta GD (2015)	1
AMFR	2	SEL1L	2	affinity chromatography technology	Zhang T (2015)	1
TCTN2	2	UBXN4	0	bioid	Gupta GD (2015)	1
UBXN4	0	VPS13C	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Raman M (2015), Huttlin EL (2017)	3
AMFR	2	CANX	4	affinity chromatography technology	Jo Y (2011)	1
UBXN6	1	DERL1	2	pull down	Nagahama M (2009)	1
ELAVL1	0	TMEM216	0	affinity chromatography technology	Abdelmohsen K (2009)	1
AMFR	2	PSMA6	1	affinity chromatography technology	Christianson JC (2012)	1
ELAVL1	0	CANX	4	affinity chromatography technology	Abdelmohsen K (2009)	1