PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ELAVL1	0	TP53	0	affinity chromatography technology	Galban S (2003)	1
UIMC1	4	TP53	0	affinity chromatography technology, pull down	Yan J (2009), Yan J (2009)	2
ABRAXAS2	1	SPAG9	5	biochemical	Kristensen AR (2012)	1
BRCC3	0	SPAG9	5	biochemical	Kristensen AR (2012)	1
USP7	14	WWP2	7	two hybrid, affinity chromatography technology	Lim J (2006), Chaudhary N (2014)	2
HUWE1	22	PSMC5	4	affinity chromatography technology	Thompson JW (2014)	1
DEF6	0	ABRAXAS2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ABRAXAS2	1	BIRC6	15	affinity chromatography technology	Huttlin EL (2015)	1
UIMC1	4	ABRAXAS2	1	affinity chromatography technology	Sowa ME (2009)	1
UBC	7	HNRNPA2B1	2	affinity chromatography technology	Matsumoto M (2005)	1
BABAM2	2	BRCC3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Dong Y (2003), Dong Y (2003), Dong Y (2003), Sowa ME (2009), Sowa ME (2009), Wang B (2009), Wang B (2009), Shao G (2009), Cooper EM (2010), Hu X (2011), Hu X (2011), Patterson-Fortin J (2010), Patterson-Fortin J (2010), Feng L (2009), Feng L (2009), Feng L (2009)	17
WWP2	7	BRCC3	0	affinity chromatography technology	Chaudhary N (2014)	1
XKRX	1	ABRAXAS2	1	affinity chromatography technology	Huttlin EL (2017)	1
BRCC3	0	HUWE1	22	biochemical	Kristensen AR (2012)	1
SMURF2	3	UBC	7	enzymatic study, affinity chromatography technology, enzymatic study, pull down, pull down	Maspero E (2013), Zhang L (2013), Kristariyanto YA (2015), Mari S (2014), Zhang Y (2017)	5
TP53	0	UBC	7	affinity chromatography technology, affinity chromatography technology	Ayroldi E (2014), Ke JY (2014)	2
WWP2	7	UBC	7	enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Sheng Y (2012), Maspero E (2013), Soond SM (2013), Kristariyanto YA (2015)	4
ABRAXAS2	1	IFNAR1	4	imaging technique	Zheng H (2013)	1
BABAM2	2	ABRAXAS2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Sowa ME (2009), Hu X (2011), Hu X (2011), Kristensen AR (2012), Zhang J (2014), Yan K (2015), Zheng H (2013)	8
UBC	7	ABRAXAS2	1	pull down, pull down	Wang B (2009), Nathan JA (2013)	2
BRCC3	0	IFNAR1	4	enzymatic study	Zheng H (2013)	1
ABRAXAS2	1	HNRNPA2B1	2	biochemical	Kristensen AR (2012)	1
HUWE1	22	ABRAXAS2	1	biochemical	Kristensen AR (2012)	1
UIMC1	4	UBC	7	pull down, pull down, pull down, pull down, pull down, pull down, unspecified method, unspecified method, x-ray crystallography, pull down, x-ray crystallography, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down	Sobhian B (2007), Sobhian B (2007), Wang B (2009), Hu X (2012), Sekiyama N (2012), Cho HJ (2009), Markin CJ (2010), Sekiyama N (2012), Sekiyama N (2012), Sato Y (2009), Sato Y (2009), Nikkilae J (2009), Nikkilae J (2009), Wu J (2009), Guzzo CM (2012), Nathan JA (2013), Anamika A (2014), Kensche T (2012), Yan J (2007), Castaneda CA (2013), Nakasone MA (2013), Thach TT (2015), Zhang X (2017), Li Y (2017), Kristariyanto YA (2017)	25
WWP2	7	ABRAXAS2	1	affinity chromatography technology	Chaudhary N (2014)	1
THAP11	1	PSMC5	4	two hybrid, affinity chromatography technology	DeGrado-Warren J (2008), Huttlin EL (2017)	2
CYTIP	3	ABRAXAS2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DEF6	0	BABAM1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BABAM2	2	SHMT2	3	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Huttlin EL (2017)	2
BABAM2	2	TP53	0	affinity chromatography technology, affinity chromatography technology, biochemical	Dong Y (2003), Dong Y (2003), Dong Y (2003)	3
UBC	7	PSMC5	4	affinity chromatography technology, pull down, pull down	Matsumoto M (2005), Zhu Q (2004), Zhang X (2017)	3
ODF1	0	ABRAXAS2	1	affinity chromatography technology	Huttlin EL (2017)	1
SHMT1	1	SHMT2	3	biochemical, affinity chromatography technology	Kristensen AR (2012), Huttlin EL (2017)	2
ELAVL1	0	HNRNPA2B1	2	biochemical	Wan C (2015)	1
STK11	2	ABRAXAS2	1	affinity chromatography technology	Huttlin EL (2017)	1
GRB2	2	BABAM2	2	affinity chromatography technology	Brehme M (2009)	1
USP7	14	IFNAR1	4	affinity chromatography technology, affinity chromatography technology, pull down	Yu Y (2017), Yu Y (2017), Yu Y (2017)	3
ELAVL1	0	XPO1	8	affinity chromatography technology	Abdelmohsen K (2009)	1
FAM19A4	0	ABRAXAS2	1	affinity chromatography technology	Huttlin EL (2017)	1
USP7	14	HUWE1	22	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Thompson JW (2014), Thompson JW (2014), Hein MY (2015)	4
TNS2	3	HUWE1	22	two hybrid	Grossmann A (2015)	1
USP7	14	ABRAXAS2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Sowa ME (2009), Zhang J (2014), Zhang J (2014), Zhang J (2014)	4
ABRAXAS2	1	THAP11	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GRB2	2	HNRNPA2B1	2	affinity chromatography technology	Li J (2013)	1
XPO1	8	ABRAXAS2	1	affinity chromatography technology	Kirli K (2015)	1
WWP2	7	BABAM2	2	affinity chromatography technology	Chaudhary N (2014)	1
ABRAXAS2	1	TRAF7	11	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TP53	0	USP7	14	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, pull down, x-ray crystallography, unspecified method, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li M (2002), Li M (2002), Li M (2002), Li M (2002), Brooks CL (2007), Brooks CL (2007), Becker K (2007), Hu M (2006), Hu M (2006), Sarkari F (2010), Marchenko ND (2007), Epping MT (2011), Qing P (2011), Tang J (2006), Ma J (2010), Dai C (2011), Holowaty MN (2003), Sheng Y (2006), Sheng Y (2006), Sheng Y (2006), Yi P (2013), Yi P (2013), Zhang J (2014), Fang Z (2013), Ye M (2015), Lim KH (2015), Lim KH (2015), Reddy BA (2014), Reddy BA (2014)	29
TP53	0	HUWE1	22	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Chen D (2005), Chen D (2005), Chen D (2005), Chen D (2005), Rolfo A (2012), Rolfo A (2012)	6
ELAVL1	0	LAMC1	5	affinity chromatography technology	Abdelmohsen K (2009)	1
ABRAXAS2	1	3500	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BABAM1	1	SHMT2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Huttlin EL (2015), Huttlin EL (2017)	3
FAM189B	2	ABRAXAS2	1	affinity chromatography technology	Huttlin EL (2017)	1
GRB2	2	UBC	7	two hybrid	Bandyopadhyay S (2010)	1
IFNAR1	4	SHMT2	3	affinity chromatography technology, imaging technique, affinity chromatography technology	Zheng H (2013), Zheng H (2013), Zheng H (2013)	3
TNS1	6	BRCC3	0	affinity chromatography technology	St-Denis N (2016)	1
TNS2	3	BABAM2	2	affinity chromatography technology	Li X (2016)	1
TP53	0	ABRAXAS2	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang J (2014), Zhang J (2014), Zhang J (2014), Huttlin EL (2015), Huttlin EL (2017)	5
HUWE1	22	HNRNPA2B1	2	affinity chromatography technology	Thompson JW (2014)	1
TP53	0	STK11	2	affinity chromatography technology, fluorescent resonance energy transfe	Karuman P (2001), Ivanov AA (2017)	2
TNS1	6	BABAM1	1	affinity chromatography technology	St-Denis N (2016)	1
KLHL10	1	ABRAXAS2	1	affinity chromatography technology	Huttlin EL (2017)	1
TXNDC9	0	ABRAXAS2	1	biochemical	Kristensen AR (2012)	1
ARRDC1	4	WWP2	7	two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology	Rauch S (2011), Nabhan JF (2012), Shea FF (2012), Huttlin EL (2015), Yu H (2011), Huttlin EL (2017)	6
PSMC5	4	TP53	0	pull down, affinity chromatography technology, affinity chromatography technology, pull down	Zhu Q (2007), Zhu Q (2007), Kulikov R (2010), Kulikov R (2010)	4
SMURF2	3	ABRAXAS2	1	two hybrid	Colland F (2004)	1
TNS2	3	TNS1	6	affinity chromatography technology	Li X (2016)	1
TNS1	6	ABRAXAS2	1	affinity chromatography technology	St-Denis N (2016)	1
TNS2	3	SUV39H1	0	two hybrid	Grossmann A (2015)	1
PSMC5	4	BIRC6	15	affinity chromatography technology	Huttlin EL (2017)	1
TNS2	3	TRAF7	11	affinity chromatography technology	Li X (2016)	1
USP7	14	BRCC3	0	affinity chromatography technology	Sowa ME (2009)	1
TP53	0	BIRC6	15	affinity chromatography technology, affinity chromatography technology	Tang W (2015), Tang W (2015)	2
BRCC3	0	ABRAXAS2	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Cooper EM (2010), Hu X (2011), Hu X (2011), Feng L (2010), Kristensen AR (2012), Zhang J (2014), Huttlin EL (2015), Yan K (2015), Huttlin EL (2017), Zheng H (2013), Zheng H (2013)	12
UBC	7	BIRC6	15	affinity chromatography technology	Matsumoto M (2005)	1
ABRAXAS2	1	SHMT2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Huttlin EL (2017), Zheng H (2013), Zheng H (2013), Zheng H (2013), Zheng H (2013)	5
PSMC5	4	LAMC1	5	two hybrid	Albers M (2005)	1
SHMT2	3	UIMC1	4	affinity chromatography technology	Castello A (2012)	1
ABRAXAS2	1	3501	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBC	7	BABAM2	2	affinity chromatography technology, pull down, pull down	Matsumoto M (2005), Wang B (2009), Zhang X (2017)	3
GRB2	2	BABAM1	1	affinity chromatography technology	Brehme M (2009)	1
TNS2	3	BABAM1	1	affinity chromatography technology	Li X (2016)	1
USP7	14	SUV39H1	0	affinity chromatography technology, affinity chromatography technology	Mungamuri SK (2016), Mungamuri SK (2016)	2
ELAVL1	0	GRB2	2	affinity chromatography technology	Abdelmohsen K (2009)	1
ABRAXAS2	1	NUMA1	10	affinity chromatography technology, pull down	Yan K (2015), Yan K (2015)	2
SMURF2	3	XPO1	8	affinity chromatography technology, affinity chromatography technology, pull down	Kim DG (2016), Kim DG (2016), Kim DG (2016)	3
FAM189B	2	BABAM1	1	affinity chromatography technology	Huttlin EL (2017)	1
HUWE1	22	XPO1	8	affinity chromatography technology	Thompson JW (2014)	1
UBC	7	LAMC1	5	pull down	Zhang X (2017)	1
BRCC3	0	NUMA1	10	pull down, enzymatic study	Yan K (2015), Yan K (2015)	2
SPAG9	5	HUWE1	22	biochemical	Kristensen AR (2012)	1
BRCC3	0	TP53	0	affinity chromatography technology, affinity chromatography technology, biochemical	Dong Y (2003), Dong Y (2003), Dong Y (2003)	3
SUV39H1	0	ABRAXAS2	1	affinity chromatography technology	Huttlin EL (2017)	1
ABRAXAS2	1	SHMT1	1	affinity chromatography technology, affinity chromatography technology	Zheng H (2013), Zheng H (2013)	2
AUP1	0	ABRAXAS2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HUWE1	22	SHMT2	3	affinity chromatography technology	Thompson JW (2014)	1
UBC	7	HUWE1	22	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, enzymatic study	Nathan JA (2013), Bish RA (2007), Thompson JW (2014), Kristariyanto YA (2015), Zhang X (2017), Michel MA (2017)	6
ANKRD28	1	ABRAXAS2	1	bioid	Couzens AL (2013)	1
TP53	0	HNRNPA2B1	2	affinity chromatography technology	Fogeron ML (2013)	1
XPO1	8	ARRDC1	4	affinity chromatography technology	Kirli K (2015)	1
UIMC1	4	BRCC3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Sobhian B (2007), Sowa ME (2009), Sowa ME (2009), Wang B (2007), Wang B (2007), Wang B (2009), Shao G (2009), Hu X (2011), Patterson-Fortin J (2010), Feng L (2009), Feng L (2009), Feng L (2009), Feng L (2009), Nikkilae J (2009), Wu J (2009), Shao G (2009), Cho HJ (2013)	17
BABAM2	2	HNRNPA2B1	2	biochemical	Kristensen AR (2012)	1
BABAM1	1	ABRAXAS2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Hu X (2011), Hu X (2011), Zhang J (2014), Huttlin EL (2015), Yan K (2015), Huttlin EL (2017), Zheng H (2013), Zheng H (2013)	9
BRCC3	0	BABAM1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), Wang B (2009), Wang B (2009), Shao G (2009), Shao G (2009), Cooper EM (2010), Hu X (2011), Hu X (2011), Feng L (2009), Feng L (2009), Feng L (2009), Huttlin EL (2015), Huttlin EL (2017)	14
BABAM2	2	BABAM1	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Rual JF (2005), Ewing RM (2007), Sowa ME (2009), Sowa ME (2009), Wang B (2009), Wang B (2009), Shao G (2009), Shao G (2009), Hu X (2011), Hu X (2011), Hu X (2011), Patterson-Fortin J (2010), Feng L (2009), Feng L (2009), Feng L (2009), Feng L (2009), Feng L (2009), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	21
IFNAR1	4	SHMT1	1	affinity chromatography technology	Zheng H (2013)	1
GRB2	2	ABRAXAS2	1	affinity chromatography technology	Brehme M (2009)	1
ABRAXAS2	1	THAP5	1	two hybrid	Cilenti L (2011)	1
USP7	14	BABAM1	1	affinity chromatography technology	Sowa ME (2009)	1
USP7	14	UBC	7	enzymatic study, enzymatic study, unspecified method, enzymatic study, pull down	Bremm A (2010), Faesen AC (2011), Ernst A (2013), Holowaty MN (2003), Kwasna D (2018)	5
USP7	14	BABAM2	2	affinity chromatography technology	Sowa ME (2009)	1
UBC	7	BRCC3	0	pull down, enzymatic study, pull down	Wang B (2009), Shao G (2009), Zhang X (2017)	3
TNS2	3	ABRAXAS2	1	affinity chromatography technology, affinity chromatography technology	St-Denis N (2016), Li X (2016)	2
UIMC1	4	BABAM2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Sobhian B (2007), Sowa ME (2009), Sowa ME (2009), Wang B (2009), Wang B (2009), Shao G (2009), Hu X (2011), Patterson-Fortin J (2010), Feng L (2009), Feng L (2009), Feng L (2009), Feng L (2009), Feng L (2009), Wu J (2009)	14
TXNDC9	0	HUWE1	22	biochemical, affinity chromatography technology	Kristensen AR (2012), Thompson JW (2014)	2
FAM189B	2	BABAM2	2	affinity chromatography technology	Huttlin EL (2017)	1
ABRAXAS2	1	PSMC5	4	affinity chromatography technology	Huttlin EL (2017)	1
ABRAXAS2	1	LAMC1	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UIMC1	4	BABAM1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), Wang B (2009), Wang B (2009), Shao G (2009), Shao G (2009), Hu X (2011), Feng L (2009), Feng L (2009), Feng L (2009), Feng L (2009), Feng L (2009), Huttlin EL (2015), Huttlin EL (2017), Li Y (2017)	15
GRB2	2	BRCC3	0	affinity chromatography technology	Brehme M (2009)	1
ARRDC1	4	ABRAXAS2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ELAVL1	0	ABRAXAS2	1	affinity chromatography technology	Abdelmohsen K (2009)	1
SPAG9	5	TXNDC9	0	biochemical	Kristensen AR (2012)	1
BRCC3	0	SHMT2	3	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Huttlin EL (2017)	2
DEF6	0	BABAM2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBC	7	BABAM1	1	affinity chromatography technology, pull down	Matsumoto M (2005), Zhang X (2017)	2
DEF6	0	BRCC3	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
AUP1	0	UBC	7	affinity chromatography technology, affinity chromatography technology	Klemm EJ (2011), Klemm EJ (2011)	2