PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ADRA2B	4	GGA3	6	affinity chromatography technology, pull down	Zhang M (2016), Zhang M (2016)	2
GGA3	6	RABEP1	4	two hybrid, unspecified method, affinity chromatography technology, x-ray crystallography, pull down, x-ray crystallography, two hybrid	Mattera R (2003), Miller GJ (2003), Miller GJ (2003), Miller GJ (2003), Zhu G (2006), Zhu G (2006), Mattera R (2004)	7
PACS1	17	GGA3	6	affinity chromatography technology, pull down, pull down	Scott GK (2006), Scott GK (2006), Scott GK (2006)	3
NXF1	0	SNX17	0	affinity chromatography technology	Castello A (2012)	1
CDH1	4	CLINT1	1	bioid	Guo Z (2014)	1
NXF1	0	BACE1	2	affinity chromatography technology	Castello A (2012)	1
TSG101	1	CRK	0	affinity chromatography technology, imaging technique	Kumar B (2016), Kumar B (2016)	2
CDH1	4	ITGB1	4	bioid	Guo Z (2014)	1
GGA2	2	SYNRG	5	affinity chromatography technology	Hirst J (2000)	1
CDH1	4	CRK	0	bioid	Guo Z (2014)	1
TMEM17	0	CLINT1	1	bioid	Gupta GD (2015)	1
UBC	7	TOLLIP	3	pull down, pull down, pull down, biochemical, pull down, pull down, pull down, pull down	Fenner BJ (2009), Nathan JA (2013), Mitra S (2013), Mitra S (2013), Shih SC (2003), Lu K (2014), Lu K (2014), Zhang X (2017)	8
GGA3	6	UBC	7	pull down, pull down, pull down, two hybrid, x-ray crystallography, affinity chromatography technology, pull down, x-ray crystallography, pull down, pull down, pull down	Shiba Y (2004), Shiba Y (2004), Kang EL (2010), Kametaka S (2005), Kawasaki M (2005), Kawasaki M (2005), Kawasaki M (2005), Prag G (2005), Prag G (2005), Bilodeau PS (2004), Zhang X (2017)	11
TMEM17	0	ITGB1	4	bioid	Gupta GD (2015)	1
GGA1	0	MON2	3	affinity chromatography technology	Singer-Krueger B (2008)	1
SORT1	1	BACE1	2	affinity chromatography technology, affinity chromatography technology	Finan GM (2011), Finan GM (2011)	2
ITCH	1	LAPTM5	3	affinity chromatography technology, enzymatic study	Ishihara T (2011), Ishihara T (2011)	2
CRK	0	GGA3	6	affinity chromatography technology	Parachoniak CA (2011)	1
ARF1	1	GGA3	6	two hybrid, two hybrid, two hybrid, pull down, pull down	DellAngelica EC (2000), Puertollano R (2001), Puertollano R (2001), DellAngelica EC (2000), Takatsu H (2002)	5
TOLLIP	3	ITCH	1	affinity chromatography technology	Li S (2011)	1
NXF1	0	GGA3	6	affinity chromatography technology	Castello A (2012)	1
SORT1	1	GGA1	0	two hybrid, pull down, two hybrid, unspecified method, pull down, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology	Jacobsen L (2002), Jacobsen L (2002), Shiba T (2002), Cramer JF (2010), Cramer JF (2010), Cramer JF (2010), Takatsu H (2001), Takatsu H (2001), Takatsu H (2001)	9
CDH1	4	GGA3	6	bioid	Guo Z (2014)	1
NXF1	0	CLTC	12	affinity chromatography technology	Castello A (2012)	1
GGA3	6	ARF6	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology	Cho HJ (2010), Frittoli E (2008), Jing J (2009), Li CC (2007)	4
NEDD4	2	UBC	7	x-ray crystallography, pull down, unspecified method, enzymatic study, x-ray crystallography, enzymatic study, pull down, pull down	Maspero E (2011), Maspero E (2011), Ernst A (2013), Maspero E (2013), Mari S (2014), Mari S (2014), Mari S (2014), Kathman SG (2015)	8
GGA1	0	UBC	7	pull down, affinity chromatography technology, two hybrid, pull down, pull down	Shiba Y (2004), Mattera R (2004), Mattera R (2004), Fenner BJ (2009), Wang J (2007)	5
CYTH2	2	ARF6	0	enzymatic study, affinity chromatography technology, pull down	Frank S (1998), Yano H (2008), Laroche G (2007)	3
MOV10	6	GGA3	6	affinity chromatography technology	Castello A (2012)	1
GGA3	6	CLINT1	1	unspecified method	Miller GJ (2003)	1
GGA1	0	VPS18	4	pull down, affinity chromatography technology	Yogosawa S (2006), Yogosawa S (2006)	2
GGA1	0	ARF1	1	pull down, two hybrid, pull down, affinity chromatography technology	Collins BM (2003), Mattera R (2004), Takatsu H (2002), Fukaya M (2011)	4
STAB1	9	GGA3	6	pull down	Kzhyshkowska J (2004)	1
GGA3	6	ITCH	1	affinity chromatography technology	Santonico E (2014)	1
NXF1	0	4074	0	affinity chromatography technology	Castello A (2012)	1
CDH1	4	MET	7	affinity chromatography technology, affinity chromatography technology	Davies G (2001), Davies G (2001)	2
GGA1	0	CLTC	12	pull down, pull down, two hybrid, affinity chromatography technology, x-ray crystallography, pull down	Puertollano R (2001), Zhang F (2007), Knuehl C (2006), Knuehl C (2006), Knuehl C (2006), Inoue M (2007)	6
NEDD4	2	LAPTM5	3	affinity chromatography technology, enzymatic study, two hybrid	Pak Y (2006), Persaud A (2009), Colland F (2004)	3
GGA2	2	VPS18	4	pull down, affinity chromatography technology	Yogosawa S (2006), Yogosawa S (2006)	2
GGA3	6	TSG101	1	two hybrid	Puertollano R (2004)	1
MOV10	6	HAUS4	0	affinity chromatography technology	Castello A (2012)	1
GGA2	2	RABEP1	4	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, two hybrid, affinity chromatography technology	Mattera R (2003), Mattera R (2003), Zhai P (2003), Zhu Y (2001), Zhu G (2006), Zhu G (2006), Hirst J (2000), Mattera R (2004), Huttlin EL (2017)	9
GGA1	0	GGA3	6	imaging technique, pull down, pull down	Ghosh P (2003), Ghosh P (2003), Ghosh P (2003)	3
TMEM17	0	GGA3	6	bioid	Gupta GD (2015)	1
STAB1	9	GGA2	2	pull down	Kzhyshkowska J (2004)	1
TSG101	1	NEDD4	2	affinity chromatography technology	Medina G (2005)	1
ITCH	1	UBC	7	enzymatic study, unspecified method, enzymatic study, enzymatic study	Sheng Y (2012), Ernst A (2013), Maspero E (2013), Kristariyanto YA (2015)	4
GGA3	6	CLTC	12	pull down	Puertollano R (2001)	1
CDH1	4	IGF2R	11	bioid	Guo Z (2014)	1
ARF6	0	CLTC	12	affinity chromatography technology	Krauss M (2006)	1
GGA2	2	IGF2R	11	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Zhu Y (2001), He X (2003), Takatsu H (2001), Misra S (2002)	4
ARF3	0	GGA2	2	two hybrid	Boman AL (2000)	1
MOV10	6	4074	0	affinity chromatography technology	Castello A (2012)	1
GGA2	2	RNF11	0	unspecified method, pull down	Santonico E (2014), Santonico E (2014)	2
STAB1	9	GGA1	0	pull down	Kzhyshkowska J (2004)	1
RNF11	0	NEDD4	2	affinity chromatography technology, enzymatic study, two hybrid	Santonico E (2010), Persaud A (2009), Colland F (2004)	3
BACE1	2	GGA3	6	affinity chromatography technology, pull down, affinity chromatography technology	He X (2003), He X (2003), von Einem B (2015)	3
SNX17	0	GGA3	6	affinity chromatography technology	Ratcliffe CD (2016)	1
GGA1	0	TSG101	1	two hybrid	Mattera R (2004)	1
GGA1	0	ARF6	0	pull down, affinity chromatography technology	Takatsu H (2002), Fukaya M (2011)	2
GGA3	6	VPS18	4	pull down, affinity chromatography technology, enzymatic study	Yogosawa S (2006), Yogosawa S (2006), Yogosawa S (2006)	3
LAPTM5	3	GGA3	6	affinity chromatography technology	Pak Y (2006)	1
CRK	0	UBC	7	affinity chromatography technology	Brehme M (2009)	1
MET	7	GGA3	6	affinity chromatography technology, imaging technique	Parachoniak CA (2011), Parachoniak CA (2011)	2
MOV10	6	SNX17	0	affinity chromatography technology	Castello A (2012)	1
SORT1	1	GGA2	2	two hybrid, pull down, two hybrid, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology	Nielsen MS (2001), Nielsen MS (2001), Jacobsen L (2002), Jacobsen L (2002), Takatsu H (2001), Takatsu H (2001), Takatsu H (2001)	7
GGA1	0	IGF2R	11	two hybrid, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid	Shiba T (2002), Shiba T (2002), Shiba T (2004), He X (2003), Doray B (2002), Takatsu H (2001), Takatsu H (2001), Takatsu H (2001), Misra S (2002)	9
HAUS4	0	GGA3	6	biochemical	Wan C (2015)	1
NXF1	0	UBC	7	affinity chromatography technology	Castello A (2012)	1
NXF1	0	TSG101	1	affinity chromatography technology	Castello A (2012)	1
NXF1	0	VPS11	3	affinity chromatography technology	Castello A (2012)	1
RNF11	0	GGA1	0	pull down, two hybrid, affinity chromatography technology, pull down, unspecified method	Santonico E (2010), Colland F (2004), Santonico E (2014), Santonico E (2014), Santonico E (2014)	5
UBC	7	ARF1	1	affinity chromatography technology	Matsumoto M (2005)	1
CLINT1	1	CLTC	12	pull down, pull down, affinity chromatography technology	Kalthoff C (2002), Mills IG (2003), Hein MY (2015)	3
MOV10	6	VPS11	3	affinity chromatography technology	Castello A (2012)	1
TSG101	1	VPS11	3	two hybrid	Markson G (2009)	1
UBC	7	CDKN2A	1	pull down, imaging technique	Zhang X (2017), Zhang X (2017)	2
ARF1	1	ARF3	0	biochemical	Havugimana PC (2012)	1
CDKN2A	1	GGA3	6	fluorescent resonance energy transfe	Bill A (2011)	1
MOV10	6	UBC	7	affinity chromatography technology	Castello A (2012)	1
GGA2	2	GGA3	6	pull down, pull down	Ghosh P (2003), Ghosh P (2003)	2
VPS11	3	GGA3	6	enzymatic study	Yogosawa S (2006)	1
SNX17	0	ITGB1	4	affinity chromatography technology	Ratcliffe CD (2016)	1
ARF3	0	GGA1	0	two hybrid, two hybrid, pull down, pull down, pull down	Boman AL (2002), Boman AL (2000), Boman AL (2000), McKay MM (2004), Takatsu H (2002)	5
MET	7	CRK	0	affinity chromatography technology	Oh YM (2014)	1
RNF11	0	GGA3	6	two hybrid, unspecified method, imaging technique	Colland F (2004), Santonico E (2014), Santonico E (2014)	3
CDKN2A	1	GGA1	0	two hybrid	Lu L (2001)	1
CDH1	4	UBC	7	bioid	Guo Z (2014)	1
GGA3	6	MON2	3	affinity chromatography technology	Singer-Krueger B (2008)	1
4074	0	GGA1	0	two hybrid, pull down, affinity chromatography technology, unspecified method	Puertollano R (2001), Puertollano R (2001), Stoeckli J (2004), Stoeckli J (2004)	4
TSG101	1	UBC	7	affinity chromatography technology, x-ray crystallography, affinity chromatography technology, pull down, x-ray crystallography, pull down, pull down	Schlundt A (2009), Sundquist WI (2004), Bishop N (2002), Bishop N (2002), Pornillos O (2002), Kharitidi D (2015), Zhang X (2017)	7
GGA1	0	CLINT1	1	unspecified method	Inoue M (2007)	1
NEDD4	2	GGA3	6	affinity chromatography technology	Pak Y (2006)	1
ARF3	0	GGA3	6	two hybrid, two hybrid	Boman AL (2002), Boman AL (2000)	2
GGA2	2	ARF1	1	pull down	Takatsu H (2002)	1
GGA2	2	CLTC	12	pull down, affinity chromatography technology, pull down	Puertollano R (2001), Zhu Y (2001), Zhang F (2007)	3
CYTH2	2	ARF1	1	enzymatic study	Frank S (1998)	1
SORT1	1	GGA3	6	affinity chromatography technology	Takatsu H (2001)	1
GGA3	6	CYTH2	2	pull down	Li CC (2007)	1
ADRA2A	0	GGA3	6	pull down	Zhang M (2016)	1
VPS11	3	VPS18	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim BY (2001), Kim BY (2001), Huttlin EL (2015), Wartosch L (2015), Hein MY (2015), Hein MY (2015), Huttlin EL (2017), Hunter MR (2017)	8
MOV10	6	BACE1	2	affinity chromatography technology	Castello A (2012)	1
ITCH	1	RNF11	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shembade N (2009), Santonico E (2010), Pranski EL (2012), Kitching R (2003)	4
GGA1	0	SYNRG	5	two hybrid, unspecified method, unspecified method, affinity chromatography technology	Takatsu H (2000), Collins BM (2003), Inoue M (2007), Hirst J (2000)	4
TMEM17	0	IGF2R	11	bioid	Gupta GD (2015)	1
ITGB1	4	GGA3	6	imaging technique, affinity chromatography technology	Ratcliffe CD (2016), Ratcliffe CD (2016)	2
NXF1	0	HAUS4	0	affinity chromatography technology	Castello A (2012)	1
GGA1	0	GGA2	2	imaging technique, pull down, pull down, affinity chromatography technology	Ghosh P (2003), Ghosh P (2003), Ghosh P (2003), Huttlin EL (2017)	4
GGA3	6	SYNRG	5	unspecified method	Miller GJ (2003)	1
NXF1	0	CDKN2A	1	affinity chromatography technology	Castello A (2012)	1
BACE1	2	GGA2	2	affinity chromatography technology, pull down, affinity chromatography technology	He X (2003), He X (2003), von Einem B (2015)	3
GGA1	0	RABEP1	4	pull down, affinity chromatography technology, two hybrid, x-ray crystallography, affinity chromatography technology, pull down, x-ray crystallography, unspecified method, affinity chromatography technology, pull down, two hybrid	Mattera R (2003), Mattera R (2003), Mattera R (2003), Zhu G (2004), Zhai P (2003), Zhu G (2006), Zhu G (2006), Inoue M (2007), Hirst J (2000), Zhu G (2004), Mattera R (2004)	11
GGA1	0	TOLLIP	3	pull down	Katoh Y (2004)	1
MOV10	6	TSG101	1	affinity chromatography technology	Castello A (2012)	1
GGA3	6	729873	0	pull down, affinity chromatography technology	Frittoli E (2008), Frittoli E (2008)	2
RNF11	0	UBC	7	two hybrid, two hybrid	Li H (2004), Colland F (2004)	2
BACE1	2	GGA1	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe, pull down, x-ray crystallography, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down	von Arnim CA (2004), von Arnim CA (2004), Shiba T (2004), Shiba T (2004), He X (2003), He X (2003), He X (2003), Wahle T (2005), Wahle T (2005), Wahle T (2005), von Einem B (2015), von Einem B (2015)	12
IGF2R	11	GGA3	6	two hybrid, two hybrid, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, two hybrid	Kametaka S (2005), Kato Y (2002), Kato Y (2002), Kato Y (2002), He X (2003), Doray B (2002), Takatsu H (2001), Misra S (2002), Misra S (2002)	9
UBC	7	LAPTM5	3	pull down	Pak Y (2006)	1
4074	0	GGA2	2	two hybrid	Puertollano R (2001)	1
4074	0	GGA3	6	two hybrid, x-ray crystallography	Puertollano R (2001), Misra S (2002)	2
GGA2	2	CLINT1	1	pull down, pull down, affinity chromatography technology	Wasiak S (2002), Kalthoff C (2002), Huttlin EL (2017)	3
UBC	7	RABEP1	4	pull down, pull down	Nathan JA (2013), Zhang X (2017)	2
GGA2	2	TOLLIP	3	pull down	Katoh Y (2004)	1
TMEM17	0	TOLLIP	3	bioid	Gupta GD (2015)	1
MOV10	6	CDKN2A	1	affinity chromatography technology	Castello A (2012)	1
TMEM17	0	GGA1	0	bioid	Gupta GD (2015)	1
GGA3	6	TOLLIP	3	pull down	Katoh Y (2004)	1