PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PRMT5	3	HIST1H3A	3	enzymatic study, enzymatic study, enzymatic study, enzymatic study	Pal S (2003), Amente S (2005), Pal S (2004), Migliori V (2012)	4
KDM6B	16	SMAD2	5	affinity chromatography technology	Dahle O (2010)	1
TK1	0	KDM6B	16	two hybrid	Vinayagam A (2011)	1
PRMT7	0	HIST1H3A	3	enzymatic study	Migliori V (2012)	1
SMAD4	9	SMAD2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Moren A (2003), Wotton D (1999), Mori N (2001), Wu JW (2002), Wu JW (2002), Nakao A (1997), Wicks SJ (2000), Wu JW (2001), Chen X (1997), Hanai J (1999), Lebrun JJ (1999), Poncelet AC (2001), Razani B (2001), Razani B (2001), Wang B (2008), Moren A (2005), Kurisaki K (2003), Prunier C (2003), Kato Y (2002), Xu J (2000), Wang L (2011), He W (2006), He W (2006), Dupont S (2009), Brown JD (1999), Pardali K (2000), Fu G (2011), Chen W (2007), Gao S (2009), Lin X (2003), Seo SR (2006), Brown KA (2008), Brown KA (2008), Halder SK (2005), Barrios-Rodiles M (2005), Barrios-Rodiles M (2005), Dai F (2007), Chacko BM (2004), Chacko BM (2004), Chacko BM (2004), Wu RY (1997), Wu RY (1997), Tomita M (2004), Colland F (2004), Tang Y (2003), Ding L (2009), Fattet L (2013), Wang J (2011), Ali A (2013), Yamakawa N (2002), Yamakawa N (2002), Li X (2015), Zhou F (2014), Yang Y (2015), Yan X (2016), Zhou F (2017)	56
KDM6B	16	PRMT5	3	genetic interference	Wong AS (2016)	1
BRD4	8	PRMT5	3	genetic interference	Wong AS (2016)	1
HIST1H3A	3	BRD4	8	affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology	Zippo A (2009), Zippo A (2009), Zippo A (2009)	3
KMT2A	58	ASH2L	2	affinity chromatography technology, biochemical, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, biochemical, pull down	Yokoyama A (2004), Yokoyama A (2004), Yokoyama A (2004), Blobel GA (2009), Butler JS (2011), Mak AB (2010), Dharmarajan V (2012), Patel A (2014), Tang Z (2013), Li Y (2016), Alicea-Velazquez NL (2016), Weirich S (2017), Weirich S (2017)	13
KDM3A	11	PRMT5	3	genetic interference	Wong AS (2016)	1
KDM6B	16	KMT2A	58	genetic interference	Wong AS (2016)	1
ASH2L	2	HIST1H3A	3	enzymatic study	Pavri R (2006)	1
BRD4	8	KDM3A	11	genetic interference	Wong AS (2016)	1
TDG	0	KDM6B	16	affinity chromatography technology	Sun J (2015)	1
KDM6B	16	SMAD1	0	affinity chromatography technology	Akizu N (2010)	1
CSNK2B	5	KDM6B	16	two hybrid	Vinayagam A (2011)	1
KDM6B	16	WDR5	2	affinity chromatography technology	De Santa F (2007)	1
SMAD1	0	SMAD4	9	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Harada J (2003), Hanai J (1999), Lopez-Rovira T (2002), Kato Y (2002), Wang L (2011), Li L (2004), Hata A (1998), Barrios-Rodiles M (2005), Wu RY (1997), Wu RY (1997), Colland F (2004), Qiu T (2007), Yan X (2016), Zhou F (2017)	14
HIST1H3A	3	WDR5	2	affinity chromatography technology, pull down, x-ray crystallography, x-ray crystallography, x-ray crystallography, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Higa LA (2006), Higa LA (2006), Schuetz A (2006), Couture JF (2006), Ruthenburg AJ (2006), Han Z (2006), Wysocka J (2005), Wysocka J (2005), Wysocka J (2005), Wysocka J (2005), Bailey JK (2015)	11
SMAD3	1	SMAD1	0	affinity chromatography technology, two hybrid, two hybrid	Brown KA (2008), Wu RY (1997), Wu RY (1997)	3
KDM6B	16	SMAD4	9	affinity chromatography technology	Akizu N (2010)	1
PRMT5	3	WDR5	2	affinity chromatography technology, pull down, biochemical	Xu Z (2012), Xu Z (2012), Xu Z (2012)	3
RBBP5	3	KMT2A	58	affinity chromatography technology, biochemical, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, pull down	Yokoyama A (2004), Yokoyama A (2004), Yokoyama A (2004), Blobel GA (2009), Dou Y (2005), Dharmarajan V (2012), Hu D (2013), Tang Z (2013), Alicea-Velazquez NL (2016), Weirich S (2017), Weirich S (2017)	11
BRD4	8	KDM6B	16	genetic interference, genetic interference	Wong AS (2016), Wong AS (2016)	2
KDM6B	16	RBBP5	3	affinity chromatography technology	De Santa F (2007)	1
WAS	0	RBBP5	3	affinity chromatography technology	Taylor MD (2010)	1
KDM6B	16	KDM3A	11	genetic interference	Wong AS (2016)	1
RBBP5	3	WDR5	2	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yokoyama A (2004), Lee JH (2005), Higa LA (2006), Wysocka J (2005), Wysocka J (2005), Patel SR (2007), Cho YW (2007), Avdic V (2011), Avdic V (2011), Avdic V (2011), Mo R (2006), Gan Q (2011), Mak AB (2010), Mak AB (2010), Wu MZ (2011), Huttlin EL (2015), Bailey JK (2015), Huttlin EL (2017), Carugo A (2016), Hauri S (2016)	20
ASH2L	2	RBBP5	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, pull down	Yokoyama A (2004), Lee JH (2005), Lee JH (2005), Garapaty S (2009), Wysocka J (2005), Patel SR (2007), Patel SR (2007), Cho YW (2007), Cho YW (2007), Butler JS (2011), Avdic V (2011), Mo R (2006), Mo R (2006), Cao F (2010), Cao F (2010), Mak AB (2010), Mak AB (2010), Rolland T (2014), Tang Z (2013), Yu H (2011), Li Y (2016)	21
WAS	0	KDM6B	16	affinity chromatography technology	Taylor MD (2010)	1
SMAD3	1	SMAD2	5	affinity chromatography technology, genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Nakao A (1997), Lebrun JJ (1999), Dumont E (2003), Brown KA (2008), Brown KA (2008), Wu RY (1997), Wu RY (1997), Tang Y (2003), Tang Y (2003), Wang J (2011), Huttlin EL (2015), Huttlin EL (2017)	12
SMAD4	9	TDG	0	two hybrid	Colland F (2004)	1
KDM6B	16	HIST1H3A	3	enzymatic study	Agger K (2007)	1
ASH2L	2	WDR5	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yokoyama A (2004), Lee JH (2005), Wysocka J (2005), McKinnell IW (2008), McKinnell IW (2008), Patel SR (2007), Butler JS (2011), Mo R (2006), Gan Q (2011), Gan Q (2011), Mak AB (2010), Mak AB (2010), Wu MZ (2011), Havugimana PC (2012), Tang Z (2013), Huttlin EL (2015), Bailey JK (2015), Huttlin EL (2017), Hauri S (2016)	19
WDR5	2	KMT2A	58	affinity chromatography technology, biochemical, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, unspecified method, unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, pull down, affinity chromatography technology	Yokoyama A (2004), Yokoyama A (2004), Yokoyama A (2004), Song JJ (2008), Avdic V (2011), Paggetti J (2010), Mak AB (2010), Dharmarajan V (2012), Dharmarajan V (2012), Zhang P (2012), Senisterra G (2013), Tang Z (2013), Shinsky SA (2014), Huttlin EL (2015), Huttlin EL (2017), Alicea-Velazquez NL (2016), Weirich S (2017), Weirich S (2017), Hauri S (2016)	19
HIST1H3A	3	KMT2A	58	pull down, pull down, x-ray crystallography, enzymatic study, unspecified method, enzymatic study, enzymatic study	Chang PY (2010), Chang PY (2010), Wang Z (2010), Shinsky SA (2014), Shinsky SA (2014), Nakamura T (2002), Patel A (2014)	7
SMAD3	1	SMAD4	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, pull down, pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, affinity chromatography technology	Seoane J (2004), Moren A (2003), Wu JW (2002), Nakao A (1997), Hanai J (1999), Lebrun JJ (1999), Poncelet AC (2001), Jablonska E (2010), Prunier C (2003), Kato Y (2002), Kaimori A (2010), Tang LY (2011), Tang LY (2011), Dupont S (2009), Dupont S (2009), Pardali K (2000), Kardassis D (2000), Xu L (2003), Fu G (2011), Chen W (2007), Kang JM (2012), Gao S (2009), Li H (2009), Li H (2009), Brown KA (2008), Brown KA (2008), Halder SK (2005), Barrios-Rodiles M (2005), Dai F (2007), Dai F (2007), Chacko BM (2004), Chacko BM (2004), Chacko BM (2004), Stroschein SL (1999), Stroschein SL (1999), Stroschein SL (1999), Wu RY (1997), Wu RY (1997), Wu RY (1997), Wu RY (1997), Tomita M (2004), Colland F (2004), Colland F (2004), Tang Y (2003), Ding L (2009), Fattet L (2013), Wang J (2011), Xue J (2014), Ali A (2013), Gao S (2009), Yamakawa N (2002), Yamakawa N (2002), Wang G (2005), Li X (2015), Zhou F (2014), Yang Y (2015), Yan X (2016), Yan X (2016), Wu Y (2017), Wu Y (2017)	60
BRD4	8	KMT2A	58	genetic interference	Wong AS (2016)	1
KDM6B	16	ASH2L	2	affinity chromatography technology	De Santa F (2007)	1
KDM6B	16	PRMT7	0	genetic interference	Wong AS (2016)	1
KDM6B	16	SMAD3	1	affinity chromatography technology	Dahle O (2010)	1
SMAD2	5	SMAD1	0	affinity chromatography technology, two hybrid, two hybrid, fluorescent resonance energy transfe	Brown KA (2008), Wu RY (1997), Wu RY (1997), Ivanov AA (2017)	4