PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MAPK6	1	RAD23B	1	affinity chromatography technology, affinity chromatography technology	Rodriguez J (2016), Rodriguez J (2016)	2
SMURF1	4	VIM	0	affinity chromatography technology	Xie Y (2013)	1
SPART	0	TUBA1A	13	fluorescent resonance energy transfe	Lu J (2006)	1
HSPA5	0	KPNB1	3	biochemical	Havugimana PC (2012)	1
PLIN3	3	APP	1	pull down	Olah J (2011)	1
SPART	0	ACSL3	1	affinity chromatography technology	Milewska M (2009)	1
WWP2	7	WWP1	3	affinity chromatography technology, affinity chromatography technology	Chaudhary N (2014), Chaudhary N (2014)	2
MAPK6	1	VIM	0	affinity chromatography technology	Rodriguez J (2016)	1
PLIN3	3	RAD23B	1	biochemical	Kristensen AR (2012)	1
HSPA5	0	VIM	0	affinity chromatography technology	Boldt K (2016)	1
KIF5B	1	TUBA1A	13	affinity chromatography technology	Hein MY (2015)	1
CETN2	0	SPART	0	bioid	Gupta GD (2015)	1
SMURF2	3	SMURF1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fukunaga E (2008), Fukunaga E (2008), Lee YS (2011), Huttlin EL (2017)	4
SPART	0	HSPD1	0	affinity chromatography technology	Milewska M (2009)	1
SEC16A	7	SPART	0	affinity chromatography technology	Hein MY (2015)	1
HYPK	2	SPART	0	biochemical	Wan C (2015)	1
SMURF1	4	UBC	7	affinity chromatography technology, enzymatic study, pull down	Xie Y (2013), Kristariyanto YA (2015), Zhang Y (2017)	3
SPART	0	HECW2	13	affinity chromatography technology	Huttlin EL (2017)	1
SPART	0	LMNB1	1	affinity chromatography technology	Milewska M (2009)	1
SMURF2	3	UBC	7	enzymatic study, affinity chromatography technology, enzymatic study, pull down, pull down	Maspero E (2013), Zhang L (2013), Kristariyanto YA (2015), Mari S (2014), Zhang Y (2017)	5
SPART	0	ITCH	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology	Milewska M (2009), Edwards TL (2009), Hooper C (2010), Eastman SW (2009), Ingham RJ (2005), Huttlin EL (2017)	6
SPART	0	APP	1	pull down	Olah J (2011)	1
WWP2	7	UBC	7	enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Sheng Y (2012), Maspero E (2013), Soond SM (2013), Kristariyanto YA (2015)	4
EPS15	1	HSPA9	2	affinity chromatography technology	Brehme M (2009)	1
SPART	0	KPNB1	3	affinity chromatography technology	Milewska M (2009)	1
SPART	0	COPA	6	affinity chromatography technology	Milewska M (2009)	1
COQ9	0	SPART	0	affinity chromatography technology	Floyd BJ (2016)	1
HYPK	2	APP	1	pull down	Olah J (2011)	1
UBC	7	HADHA	3	affinity chromatography technology	Matsumoto M (2005)	1
WWOX	3	HADHA	3	affinity chromatography technology	Abu-Odeh M (2014)	1
MAPK6	1	UBC	7	affinity chromatography technology	Rodriguez J (2016)	1
SPART	0	CLTC	12	affinity chromatography technology	Milewska M (2009)	1
HYPK	2	VIM	0	affinity chromatography technology, affinity chromatography technology	Choudhury KR (2012), Choudhury KR (2012)	2
ZFYVE9	5	SPART	0	two hybrid	Colland F (2004)	1
ITCH	1	WWP1	3	affinity chromatography technology	OConnor HF (2015)	1
SPART	0	VIM	0	affinity chromatography technology	Milewska M (2009)	1
UBC	7	ZFYVE9	5	pull down	Kostaras E (2012)	1
MED20	2	SPART	0	affinity chromatography technology	Lambert JP (2015)	1
MAPK6	1	ACSL3	1	affinity chromatography technology	Rodriguez J (2016)	1
SMURF1	4	CLTC	12	affinity chromatography technology	Xie Y (2013)	1
MAPK6	1	HSPD1	0	two hybrid	Bandyopadhyay S (2010)	1
HSPD1	0	HSPA5	0	biochemical	Havugimana PC (2012)	1
COQ9	0	ACSL4	1	affinity chromatography technology	Floyd BJ (2016)	1
HECW2	13	LMNB1	1	affinity chromatography technology	Lu L (2013)	1
RAD23B	1	CETN2	0	affinity chromatography technology, bioid, affinity chromatography technology	Fong YW (2011), Gupta GD (2015), Lan X (2016)	3
VIM	0	LMNB1	1	affinity chromatography technology	Brown MJ (2001)	1
HSPD1	0	APP	1	affinity chromatography technology, pull down	Kumar P (2007), Olah J (2011)	2
ITCH	1	UBC	7	enzymatic study, unspecified method, enzymatic study, enzymatic study	Sheng Y (2012), Ernst A (2013), Maspero E (2013), Kristariyanto YA (2015)	4
SMURF1	4	HSPA9	2	affinity chromatography technology	Xie Y (2013)	1
DPH5	1	SPART	0	biochemical	Wan C (2015)	1
UBC	7	LMNB1	1	affinity chromatography technology	Matsumoto M (2005)	1
CISD3	1	SPART	0	affinity chromatography technology	Floyd BJ (2016)	1
SPART	0	HSPA9	2	affinity chromatography technology, affinity chromatography technology	Milewska M (2009), Milewska M (2009)	2
ACSL3	1	ACSL4	1	biochemical, affinity chromatography technology	Havugimana PC (2012), Hein MY (2015)	2
WWOX	3	SPART	0	affinity chromatography technology	Abu-Odeh M (2014)	1
SPART	0	HSPA5	0	affinity chromatography technology, affinity chromatography technology	Milewska M (2009), Milewska M (2009)	2
ACSL3	1	APP	1	pull down	Olah J (2011)	1
EPS15	1	HSPA5	0	affinity chromatography technology	Brehme M (2009)	1
SPART	0	NCL	1	affinity chromatography technology, affinity chromatography technology	Milewska M (2009), Milewska M (2009)	2
SMURF1	4	HSPD1	0	affinity chromatography technology	Xie Y (2013)	1
KPNB1	3	NCL	1	biochemical	Wan C (2015)	1
MAPK6	1	TUBA1A	13	two hybrid	Vinayagam A (2011)	1
MED20	2	RAD23B	1	affinity chromatography technology	Lambert JP (2015)	1
RAD23B	1	VIM	0	affinity chromatography technology, affinity chromatography technology	Chen L (2006), Chen L (2006)	2
SPART	0	EPS15	1	two hybrid, pull down	Bakowska JC (2005), Bakowska JC (2005)	2
AIFM1	1	HSPA9	2	affinity chromatography technology	Lenhausen AM (2016)	1
WWP2	7	HSPA5	0	affinity chromatography technology	Chaudhary N (2014)	1
CLTC	12	EPS15	1	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Chi S (2008)	2
SPART	0	SMURF2	3	two hybrid, two hybrid	Eastman SW (2009), Colland F (2004)	2
SPART	0	WWP2	7	two hybrid, affinity chromatography technology	Eastman SW (2009), Chaudhary N (2014)	2
UBC	7	NCL	1	affinity chromatography technology	Matsumoto M (2005)	1
SPART	0	KLC2	2	affinity chromatography technology	Milewska M (2009)	1
SPART	0	WWP1	3	affinity chromatography technology, affinity chromatography technology, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Milewska M (2009), Edwards TL (2009), Eastman SW (2009), Eastman SW (2009), Eastman SW (2009), Eastman SW (2009), Huttlin EL (2017)	7
KLC2	2	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
MAPK6	1	SPART	0	affinity chromatography technology	Rodriguez J (2016)	1
SPART	0	SMURF1	4	two hybrid, enzymatic study, affinity chromatography technology	Eastman SW (2009), Andrews PS (2010), Huttlin EL (2017)	3
CLTC	12	ZFYVE9	5	pull down	Kostaras E (2012)	1
UBC	7	HSPD1	0	affinity chromatography technology, affinity chromatography technology	Matsumoto M (2005), Bish RA (2007)	2
EPS15	1	UBC	7	pull down, pull down, affinity chromatography technology, pull down, pull down, pull down	Woelk T (2006), De Schutter J (2009), Brehme M (2009), Hoeller D (2006), Zhang X (2017), Kristariyanto YA (2017)	6
SMURF1	4	KPNB1	3	affinity chromatography technology	Xie Y (2013)	1
SMURF1	4	APP	1	pull down	Olah J (2011)	1
SPART	0	PLIN3	3	two hybrid, affinity chromatography technology, pull down	Eastman SW (2009), Eastman SW (2009), Tokunaga M (2013)	3
HSPA9	2	APP	1	pull down	Olah J (2011)	1
HECW2	13	ACSL4	1	affinity chromatography technology	Lu L (2013)	1
WWP1	3	UBC	7	enzymatic study	Kristariyanto YA (2015)	1
SPART	0	KIF5B	1	affinity chromatography technology	Milewska M (2009)	1
UBC	7	RAD23B	1	affinity chromatography technology, x-ray crystallography, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, pull down, pull down	Matsumoto M (2005), Ryu KS (2003), Chen L (2006), Nathan JA (2013), Nathan JA (2013), Nakayasu ES (2013), Nakayasu ES (2013), Kristariyanto YA (2015), Zhang X (2017)	9
SMURF1	4	TUBA1A	13	affinity chromatography technology	Xie Y (2013)	1
KLC2	2	KIF5B	1	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Rahman A (1998), Rahman A (1999), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Hein MY (2015)	7
HSPD1	0	HSPA9	2	biochemical	Havugimana PC (2012)	1
SPART	0	AIFM1	1	affinity chromatography technology	Milewska M (2009)	1
WWP2	7	ITCH	1	affinity chromatography technology	Chaudhary N (2014)	1
SPART	0	ACSL4	1	affinity chromatography technology	Milewska M (2009)	1
UBC	7	HSPA5	0	pull down	Nathan JA (2013)	1
SPART	0	HADHA	3	affinity chromatography technology	Milewska M (2009)	1
RAD23B	1	SPART	0	biochemical	Wan C (2015)	1
ITCH	1	KPNB1	3	pull down	Suryaraja R (2013)	1
ACSL4	1	APP	1	pull down	Olah J (2011)	1
MAP3K1	4	SPART	0	enzymatic study	Charlaftis N (2014)	1
UBC	7	SPART	0	affinity chromatography technology	Matsumoto M (2005)	1
SMURF1	4	HSPA5	0	affinity chromatography technology	Xie Y (2013)	1
KPNB1	3	TUBA1A	13	pull down	Ishiguro K (2011)	1
SPART	0	DYNC1H1	41	affinity chromatography technology	Milewska M (2009)	1
SMURF1	4	NCL	1	affinity chromatography technology	Xie Y (2013)	1
SPART	0	POLK	0	affinity chromatography technology	Huttlin EL (2017)	1
WWOX	3	ITCH	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Abu-Odeh M (2014), Abu-Odeh M (2014), Abu-Odeh M (2014)	3
SEC16A	7	CLTC	12	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
VIM	0	APP	1	pull down	Olah J (2011)	1
TUBA1A	13	UBC	7	affinity chromatography technology	Seiberlich V (2012)	1
UBC	7	KPNB1	3	affinity chromatography technology	Matsumoto M (2005)	1