PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PINK1	2	TRAF6	0	affinity chromatography technology, enzymatic study	Lee HJ (2012), Murata H (2013)	2
SARM1	3	IRAK1	1	affinity chromatography technology	Li S (2011)	1
SARM1	3	NLRX1	7	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
ZG16B	0	SARM1	3	affinity chromatography technology	Huttlin EL (2017)	1
TRAF6	0	IRAK2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Wesche H (1999), Muzio M (1997), Keating SE (2007), Li S (2011), Li S (2011), Wang J (2011), Wang H (2015), Huttlin EL (2017)	8
SARM1	3	CDIPT	0	affinity chromatography technology	Li S (2011)	1
PINK1	2	IRAK1	1	affinity chromatography technology, affinity chromatography technology	Lee HJ (2012), Lee HJ (2012)	2
MYD88	1	IRAK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chen BC (2002), Wesche H (1999), Li S (2002), Fitzgerald KA (2001), Fitzgerald KA (2001), Li S (2011), Neumann D (2007), Zhou J (2011), Burns K (2003), Mizobe T (2007), Loiarro M (2007), Choi KC (2006), Rao N (2005), Rao N (2005), Li CH (2006)	15
POC1B	2	SARM1	3	affinity chromatography technology	Huttlin EL (2017)	1
NLRX1	7	CDIPT	0	affinity chromatography technology	Li S (2011)	1
IRAK2	3	STT3A	1	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
SARM1	3	STT3A	1	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
RHOT2	1	SARM1	3	affinity chromatography technology	Huttlin EL (2017)	1
SARM1	3	IRAK2	3	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
MYD88	1	IRAK2	3	affinity chromatography technology, genetic interference, affinity chromatography technology, affinity chromatography technology	Wesche H (1999), Fitzgerald KA (2001), Muzio M (1997), Zhou J (2011)	4
TRAF6	0	NLRX1	7	affinity chromatography technology	Xia X (2011)	1
TRAF6	0	IRAK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Wesche H (1999), Qian Y (2001), Cao Z (1996), Takatsuna H (2003), Li S (2002), Ling L (2000), Ling L (2000), Takaesu G (2001), Muzio M (1997), Chen F (2008), Li X (2001), Li X (2001), Xiong Y (2011), Xiong Y (2011), Tang H (2010), Muroi M (2011), Liu A (2012), Lee JY (2009), Lee JY (2009), Kollewe C (2004), Jiang Z (2002), Jensen LE (2001), Liu G (2007), Liu G (2007), Jiang Z (2003), Nguyen T (2009), Choi KC (2006), Rao N (2005), Rao N (2005), Lakshmanan U (2007), Lee HJ (2012), Lee HJ (2012), Zhang X (2013), Yao J (2007), Hu MM (2014), Jeon J (2014), Conze DB (2008), Tanishima M (2017)	38
MYD88	1	TRAF6	0	genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fitzgerald KA (2001), Zhou J (2011), Zhou J (2011), Zhang X (2013), Zhang X (2013), Hirata Y (2006)	6
TRAF6	0	TICAM2	0	pull down, pull down, affinity chromatography technology, pull down	Bin LH (2003), Bin LH (2003), Verstak B (2014), Verstak B (2014)	4
TOMM20	0	TRAF6	0	affinity chromatography technology	Murata H (2013)	1
TRAF2	1	TRAF6	0	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology	Rual JF (2005), Li S (2011), Davies CC (2005), Relaix F (1998), Rolland T (2014), Yu H (2011), Huttlin EL (2017)	7
SARM1	3	TICAM2	0	protein complementation assay	Ulrichts P (2007)	1
IRAK1	1	IRAK2	3	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, fluorescent resonance energy transfe	Li S (2011), Li S (2011), Ross K (2002), Ross K (2002)	4
RNF2	1	HYOU1	2	affinity chromatography technology	Cao Q (2014)	1
PINK1	2	RHOT2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Weihofen A (2009), Weihofen A (2009), Weihofen A (2009)	3
RNF2	1	SARM1	3	affinity chromatography technology	Cao Q (2014)	1
TOMM20	0	SARM1	3	affinity chromatography technology	Murata H (2013)	1
SARM1	3	NFXL1	2	affinity chromatography technology	Li S (2011)	1
PINK1	2	SARM1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Murata H (2013), Murata H (2013), Murata H (2013)	3
NTRK1	1	RHOT2	1	affinity chromatography technology	Emdal KB (2015)	1
CARNMT1	2	SARM1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SARM1	3	TRAF2	1	affinity chromatography technology	Murata H (2013)	1
SARM1	3	HYOU1	2	affinity chromatography technology	Li S (2011)	1
NTRK1	1	TRAF6	0	affinity chromatography technology, enzymatic study, affinity chromatography technology	Jadhav T (2008), Geetha T (2005), Zheng C (2015)	3
IRAK1	1	CCDC47	2	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
SARM1	3	GHITM	1	affinity chromatography technology, pull down, affinity chromatography technology	Li S (2011), Li S (2011), Huttlin EL (2017)	3
NTRK1	1	SARM1	3	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	CCDC47	2	affinity chromatography technology	Emdal KB (2015)	1
SARM1	3	CLGN	1	affinity chromatography technology	Li S (2011)	1
NTRK1	1	HYOU1	2	affinity chromatography technology	Emdal KB (2015)	1
SARM1	3	TRAF6	0	affinity chromatography technology	Murata H (2013)	1
CHRM4	5	SARM1	3	affinity chromatography technology	Huttlin EL (2017)	1
NTRK1	1	STT3A	1	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	CLGN	1	affinity chromatography technology	Emdal KB (2015)	1
RNF2	1	TRAF2	1	affinity chromatography technology	Cao Q (2014)	1
SARM1	3	MYD88	1	protein complementation assay	Ulrichts P (2007)	1
SARM1	3	CCDC47	2	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
CAV3	0	SARM1	3	affinity chromatography technology	Huttlin EL (2017)	1
C1orf87	0	SARM1	3	affinity chromatography technology	Huttlin EL (2017)	1
TOMM20	0	PINK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lazarou M (2012), Lazarou M (2012), Murata H (2013)	3
RNF2	1	NFXL1	2	affinity chromatography technology	Cao Q (2014)	1
RNF2	1	RHOT2	1	affinity chromatography technology	Cao Q (2014)	1