PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PTEN	24	ARHGAP26	3	affinity chromatography technology	Crockett DK (2005)	1
NRXN1	14	TULP1	1	affinity chromatography technology	Boldt K (2016)	1
OPHN1	4	RHOA	0	enzymatic study	Billuart P (1998)	1
ARHGAP26	3	ARHGAP10	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Boldt K (2016)	2
CDC42	3	CDC42EP2	0	pull down, pull down, two hybrid, two hybrid, two hybrid, two hybrid	Hirsch DS (2001), Joberty G (1999), Joberty G (1999), Bandyopadhyay S (2010), Wang J (2011), Rolland T (2014)	6
ARHGAP26	3	OPHN1	4	affinity chromatography technology	Huttlin EL (2017)	1
ARHGAP26	3	ARHGAP42	2	affinity chromatography technology	Huttlin EL (2017)	1
ELOA	3	ARHGAP26	3	affinity chromatography technology	Boldt K (2016)	1
NYAP2	2	ARHGAP26	3	affinity chromatography technology	Yokoyama K (2011)	1
ARHGAP26	3	ACADS	0	biochemical	Wan C (2015)	1
ARHGAP26	3	RHOA	0	enzymatic study	Shibata H (2001)	1
C2CD2	3	ARHGAP10	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PTEN	24	RHOA	0	affinity chromatography technology, affinity chromatography technology	Chang CC (2012), Chang CC (2012)	2
NRXN1	14	ARHGAP10	1	affinity chromatography technology	Boldt K (2016)	1
ARHGAP26	3	CTR9	10	affinity chromatography technology	Boldt K (2016)	1
NRXN1	14	ARHGAP26	3	affinity chromatography technology	Boldt K (2016)	1
NRXN1	14	MYO16	4	two hybrid	Nakayama M (2002)	1
ARHGAP10	1	CDC42	3	enzymatic study	Shibata H (2001)	1
PKN3	4	ARHGAP10	1	two hybrid, affinity chromatography technology, pull down	Shibata H (2001), Shibata H (2001), Shibata H (2001)	3
SRPK1	2	PTK2	2	enzymatic study	Varjosalo M (2013)	1
ARHGAP26	3	JPH1	0	affinity chromatography technology	Huttlin EL (2017)	1
NRXN1	14	ELOA	3	affinity chromatography technology	Boldt K (2016)	1
ARHGAP26	3	PTK2	2	pull down	Hildebrand JD (1996)	1
RHOA	0	PKN3	4	affinity chromatography technology	Huttlin EL (2017)	1
NYAP1	4	ARHGAP26	3	affinity chromatography technology	Yokoyama K (2011)	1
ARHGAP26	3	RAB11FIP5	1	affinity chromatography technology	Huttlin EL (2017)	1
PKN3	4	ARHGAP26	3	two hybrid, affinity chromatography technology, pull down	Shibata H (2001), Shibata H (2001), Shibata H (2001)	3
C2CD2	3	ARHGAP26	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PTEN	24	PTK2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	Tamura M (1999), Haier J (2002), Crockett DK (2005), Tamura M (1999), Tamura M (1999), Tamura M (1999)	6
SRPK1	2	ARHGAP26	3	enzymatic study	Varjosalo M (2013)	1
ARHGAP26	3	TULP1	1	affinity chromatography technology	Boldt K (2016)	1
ARHGAP26	3	CDC42	3	enzymatic study	Shibata H (2001)	1
OPHN1	4	CDC42	3	enzymatic study	Billuart P (1998)	1
CTR9	10	ELOA	3	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Boldt K (2016)	2
ARHGAP26	3	MICAL1	0	affinity chromatography technology	Huttlin EL (2017)	1
ARHGAP10	1	RHOA	0	enzymatic study	Shibata H (2001)	1
MYO16	4	ARHGAP26	3	affinity chromatography technology	Yokoyama K (2011)	1
CDC42EP2	0	ARHGAP26	3	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2