PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
GGA2	2	APP	1	pull down	Olah J (2011)	1
GGA3	6	RABEP1	4	two hybrid, unspecified method, affinity chromatography technology, x-ray crystallography, pull down, x-ray crystallography, two hybrid	Mattera R (2003), Miller GJ (2003), Miller GJ (2003), Miller GJ (2003), Zhu G (2006), Zhu G (2006), Mattera R (2004)	7
APP	1	BACE1	2	affinity chromatography technology	Lakshmana MK (2009)	1
GGA1	0	APP	1	affinity chromatography technology, pull down	Wahle T (2006), Wahle T (2006)	2
GGA1	0	BACE2	1	unspecified method, pull down	He X (2002), He X (2002)	2
GGA2	2	SYNRG	5	affinity chromatography technology	Hirst J (2000)	1
VCP	6	GGA2	2	affinity chromatography technology	Yu CC (2013)	1
SORT1	1	BACE1	2	affinity chromatography technology, affinity chromatography technology	Finan GM (2011), Finan GM (2011)	2
XPO1	8	FBXO7	1	pull down	Nelson DE (2011)	1
HGS	5	GGA2	2	pull down	Pridgeon JW (2009)	1
ARF1	1	GGA3	6	two hybrid, two hybrid, two hybrid, pull down, pull down	DellAngelica EC (2000), Puertollano R (2001), Puertollano R (2001), DellAngelica EC (2000), Takatsu H (2002)	5
GGA2	2	SPG21	0	two hybrid	Rual JF (2005)	1
SORT1	1	GGA1	0	two hybrid, pull down, two hybrid, unspecified method, pull down, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology	Jacobsen L (2002), Jacobsen L (2002), Shiba T (2002), Cramer JF (2010), Cramer JF (2010), Cramer JF (2010), Takatsu H (2001), Takatsu H (2001), Takatsu H (2001)	9
HGS	5	APP	1	pull down, pull down, pull down	Pridgeon JW (2009), Olah J (2011), Virok DP (2011)	3
SORL1	9	GGA1	0	two hybrid, pull down, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology	Jacobsen L (2002), Jacobsen L (2002), Cramer JF (2010), Cramer JF (2010), Schmidt V (2007), von Einem B (2015)	6
CLTC	12	HGS	5	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Raiborg C (2001), Raiborg C (2001), Nakamura M (2006), Zlatic SA (2011)	4
GGA2	2	CCDC91	3	affinity chromatography technology	Lui WW (2003)	1
SORL1	9	GGA2	2	two hybrid, pull down	Jacobsen L (2002), Jacobsen L (2002)	2
ATXN1	2	TOLLIP	3	two hybrid	Lim J (2006)	1
GGA3	6	CLINT1	1	unspecified method	Miller GJ (2003)	1
XPO1	8	CLINT1	1	affinity chromatography technology	Kirli K (2015)	1
GGA1	0	VPS18	4	pull down, affinity chromatography technology	Yogosawa S (2006), Yogosawa S (2006)	2
GGA1	0	ARF1	1	pull down, two hybrid, pull down, affinity chromatography technology	Collins BM (2003), Mattera R (2004), Takatsu H (2002), Fukaya M (2011)	4
STAB1	9	GGA3	6	pull down	Kzhyshkowska J (2004)	1
PI4KB	0	GGA2	2	pull down, imaging technique	Daboussi L (2017), Daboussi L (2017)	2
GGA1	0	CLTC	12	pull down, pull down, two hybrid, affinity chromatography technology, x-ray crystallography, pull down	Puertollano R (2001), Zhang F (2007), Knuehl C (2006), Knuehl C (2006), Knuehl C (2006), Inoue M (2007)	6
GGA2	2	VPS18	4	pull down, affinity chromatography technology	Yogosawa S (2006), Yogosawa S (2006)	2
GGA2	2	MAP1A	1	affinity chromatography technology	Hirst J (2000)	1
GGA2	2	BACE2	1	unspecified method, pull down	He X (2002), He X (2002)	2
TRIM23	3	GGA2	2	two hybrid	Rual JF (2005)	1
HTT	14	GGA2	2	two hybrid	Suter B (2013)	1
GGA2	2	RABEP1	4	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, two hybrid, affinity chromatography technology	Mattera R (2003), Mattera R (2003), Zhai P (2003), Zhu Y (2001), Zhu G (2006), Zhu G (2006), Hirst J (2000), Mattera R (2004), Huttlin EL (2017)	9
VCP	6	APP	1	affinity chromatography technology	Jang JK (2017)	1
GGA1	0	GGA3	6	imaging technique, pull down, pull down	Ghosh P (2003), Ghosh P (2003), Ghosh P (2003)	3
STAB1	9	GGA2	2	pull down	Kzhyshkowska J (2004)	1
VPS18	4	VCP	6	affinity chromatography technology	Hein MY (2015)	1
GGA3	6	CLTC	12	pull down	Puertollano R (2001)	1
ATXN1	2	IGF2R	11	two hybrid	Suter B (2013)	1
MAP3K1	4	GGA2	2	enzymatic study	Charlaftis N (2014)	1
RNF11	0	APP	1	pull down	Olah J (2011)	1
FBXO7	1	GGA2	2	enzymatic study	Teixeira FR (2016)	1
GGA2	2	IGF2R	11	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Zhu Y (2001), He X (2003), Takatsu H (2001), Misra S (2002)	4
ARF3	0	GGA2	2	two hybrid	Boman AL (2000)	1
HTT	14	VCP	6	pull down, affinity chromatography technology, affinity chromatography technology, pull down	Yang H (2010), Yu CC (2013), Fujita K (2013), Fujita K (2013)	4
VCP	6	ATXN1	2	affinity chromatography technology, pull down	Fujita K (2013), Fujita K (2013)	2
GGA2	2	RNF11	0	unspecified method, pull down	Santonico E (2014), Santonico E (2014)	2
STAB1	9	GGA1	0	pull down	Kzhyshkowska J (2004)	1
FBXO7	1	CLTC	12	affinity chromatography technology	Teixeira FR (2016)	1
BACE1	2	GGA3	6	affinity chromatography technology, pull down, affinity chromatography technology	He X (2003), He X (2003), von Einem B (2015)	3
XPO1	8	TOLLIP	3	affinity chromatography technology	Kirli K (2015)	1
GGA3	6	VPS18	4	pull down, affinity chromatography technology, enzymatic study	Yogosawa S (2006), Yogosawa S (2006), Yogosawa S (2006)	3
CPLX1	0	GGA2	2	biochemical	Havugimana PC (2012)	1
XPO1	8	PI4KB	0	affinity chromatography technology	Kirli K (2015)	1
SORT1	1	GGA2	2	two hybrid, pull down, two hybrid, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology	Nielsen MS (2001), Nielsen MS (2001), Jacobsen L (2002), Jacobsen L (2002), Takatsu H (2001), Takatsu H (2001), Takatsu H (2001)	7
GGA1	0	IGF2R	11	two hybrid, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid	Shiba T (2002), Shiba T (2002), Shiba T (2004), He X (2003), Doray B (2002), Takatsu H (2001), Takatsu H (2001), Takatsu H (2001), Misra S (2002)	9
NECAP2	0	APP	1	pull down	Olah J (2011)	1
CA8	0	GGA2	2	two hybrid	Rolland T (2014)	1
RNF11	0	GGA1	0	pull down, two hybrid, affinity chromatography technology, pull down, unspecified method	Santonico E (2010), Colland F (2004), Santonico E (2014), Santonico E (2014), Santonico E (2014)	5
ATXN1	2	GGA2	2	two hybrid	Suter B (2013)	1
CLINT1	1	CLTC	12	pull down, pull down, affinity chromatography technology	Kalthoff C (2002), Mills IG (2003), Hein MY (2015)	3
ARF1	1	ARF3	0	biochemical	Havugimana PC (2012)	1
VCP	6	GGA1	0	affinity chromatography technology	Yu CC (2013)	1
GGA2	2	GGA3	6	pull down, pull down	Ghosh P (2003), Ghosh P (2003)	2
GGA2	2	NECAP2	0	affinity chromatography technology	Mattera R (2004)	1
ARF3	0	GGA1	0	two hybrid, two hybrid, pull down, pull down, pull down	Boman AL (2002), Boman AL (2000), Boman AL (2000), McKay MM (2004), Takatsu H (2002)	5
RNF11	0	GGA3	6	two hybrid, unspecified method, imaging technique	Colland F (2004), Santonico E (2014), Santonico E (2014)	3
SORL1	9	APP	1	affinity chromatography technology	Schmidt V (2007)	1
4074	0	GGA1	0	two hybrid, pull down, affinity chromatography technology, unspecified method	Puertollano R (2001), Puertollano R (2001), Stoeckli J (2004), Stoeckli J (2004)	4
GGA1	0	CLINT1	1	unspecified method	Inoue M (2007)	1
GGA1	0	NECAP2	0	affinity chromatography technology	Mattera R (2004)	1
ARF3	0	GGA3	6	two hybrid, two hybrid	Boman AL (2002), Boman AL (2000)	2
GGA2	2	ARF1	1	pull down	Takatsu H (2002)	1
GGA1	0	MAP1A	1	affinity chromatography technology	Hirst J (2000)	1
GGA2	2	CLTC	12	pull down, affinity chromatography technology, pull down	Puertollano R (2001), Zhu Y (2001), Zhang F (2007)	3
SORT1	1	GGA3	6	affinity chromatography technology	Takatsu H (2001)	1
PIN1	0	GGA2	2	two hybrid	Rual JF (2005)	1
XPO1	8	GGA2	2	affinity chromatography technology	Kirli K (2015)	1
XPO1	8	MAP3K1	4	affinity chromatography technology	Kirli K (2015)	1
GGA1	0	SYNRG	5	two hybrid, unspecified method, unspecified method, affinity chromatography technology	Takatsu H (2000), Collins BM (2003), Inoue M (2007), Hirst J (2000)	4
MAP3K1	4	HGS	5	enzymatic study	Charlaftis N (2014)	1
TRIM23	3	SPG21	0	two hybrid	Rolland T (2014)	1
GGA1	0	CCDC91	3	affinity chromatography technology, x-ray crystallography, unspecified method, fluorescent resonance energy transfe, affinity chromatography technology	Lui WW (2003), Collins BM (2003), Collins BM (2003), Mardones GA (2007), Huttlin EL (2017)	5
GGA1	0	GGA2	2	imaging technique, pull down, pull down, affinity chromatography technology	Ghosh P (2003), Ghosh P (2003), Ghosh P (2003), Huttlin EL (2017)	4
GGA3	6	SYNRG	5	unspecified method	Miller GJ (2003)	1
BACE1	2	GGA2	2	affinity chromatography technology, pull down, affinity chromatography technology	He X (2003), He X (2003), von Einem B (2015)	3
GGA1	0	RABEP1	4	pull down, affinity chromatography technology, two hybrid, x-ray crystallography, affinity chromatography technology, pull down, x-ray crystallography, unspecified method, affinity chromatography technology, pull down, two hybrid	Mattera R (2003), Mattera R (2003), Mattera R (2003), Zhu G (2004), Zhai P (2003), Zhu G (2006), Zhu G (2006), Inoue M (2007), Hirst J (2000), Zhu G (2004), Mattera R (2004)	11
GGA1	0	TOLLIP	3	pull down	Katoh Y (2004)	1
XPO1	8	SYNRG	5	affinity chromatography technology	Kirli K (2015)	1
RNF11	0	HGS	5	affinity chromatography technology	Kostaras E (2012)	1
BACE1	2	GGA1	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe, pull down, x-ray crystallography, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down	von Arnim CA (2004), von Arnim CA (2004), Shiba T (2004), Shiba T (2004), He X (2003), He X (2003), He X (2003), Wahle T (2005), Wahle T (2005), Wahle T (2005), von Einem B (2015), von Einem B (2015)	12
IGF2R	11	GGA3	6	two hybrid, two hybrid, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, two hybrid	Kametaka S (2005), Kato Y (2002), Kato Y (2002), Kato Y (2002), He X (2003), Doray B (2002), Takatsu H (2001), Misra S (2002), Misra S (2002)	9
4074	0	GGA2	2	two hybrid	Puertollano R (2001)	1
4074	0	GGA3	6	two hybrid, x-ray crystallography	Puertollano R (2001), Misra S (2002)	2
GGA2	2	CLINT1	1	pull down, pull down, affinity chromatography technology	Wasiak S (2002), Kalthoff C (2002), Huttlin EL (2017)	3
GGA2	2	TOLLIP	3	pull down	Katoh Y (2004)	1
GGA3	6	TOLLIP	3	pull down	Katoh Y (2004)	1