PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CCNE1	1	RB1	2	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Harbour JW (1999), Manenti S (1999), Horton LE (1997), Higashi H (1996), Jiang W (1998), Connell-Crowley L (1997), Gaiddon C (2003), Zarkowska T (1997), Nakanishi M (1999)	9
HSP90AA1	7	TERF1	1	affinity chromatography technology	Hein MY (2015)	1
RB1	2	LIN54	1	pull down	Korenjak M (2004)	1
FOXM1	3	SUMO1	0	fluorescent resonance energy transfe	Myatt SS (2013)	1
ZBTB33	1	CTNNB1	30	pull down, affinity chromatography technology, affinity chromatography technology	Del Valle-Perez B (2011), Del Valle-Perez B (2011), Del Valle-Perez B (2011)	3
FOXM1	3	GSK3B	1	affinity chromatography technology	Chen Y (2016)	1
ZBTB33	1	FOXM1	3	affinity chromatography technology	Hein MY (2015)	1
FOXM1	3	DARS	0	affinity chromatography technology	Li X (2015)	1
FOXM1	3	PRC1	4	affinity chromatography technology	Li X (2015)	1
CHEK2	2	FOXM1	3	enzymatic study	Tan Y (2007)	1
CDK2	0	LIN37	0	affinity chromatography technology	So J (2015)	1
CDK1	0	UBE2I	0	enzymatic study, affinity chromatography technology	Tomasi ML (2012), Tomasi ML (2012)	2
FOXM1	3	LIN37	0	affinity chromatography technology	Li X (2015)	1
CDK1	0	HSP90AA1	7	affinity chromatography technology	Garcia-Morales P (2007)	1
CCNB1	3	CDK2	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shanahan F (1999), Di Fiore B (2010), Nishiyama A (2000), Wolthuis R (2008), Desai D (1995), Varjosalo M (2013), Varjosalo M (2013), So J (2015), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	11
CDK4	2	CDK6	0	affinity chromatography technology, fluorescent resonance energy transfe	Varjosalo M (2013), Ivanov AA (2017)	2
HSP90AA1	7	PRPF8	14	affinity chromatography technology	Gano JJ (2010)	1
LIN9	3	RB1	2	affinity chromatography technology, pull down, pull down	Gagrica S (2004), Gagrica S (2004), Korenjak M (2004)	3
CREBBP	29	BCL6	6	enzymatic study	Pasqualucci L (2011)	1
CDK4	2	CHEK2	2	genetic interference	Shen JP (2017)	1
LIN54	1	MYBL2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Litovchick L (2007), Litovchick L (2007), Schmit F (2007), Schmit F (2007), Schmit F (2009), Rashid NN (2014)	6
CDK2	0	LARS	1	affinity chromatography technology	Neganova I (2011)	1
TRIM25	5	HSP90AA1	7	affinity chromatography technology	Choudhury NR (2017)	1
CTNNB1	30	SP1	0	affinity chromatography technology	Ponce E (2014)	1
FOXM1	3	FBXW7	2	affinity chromatography technology	Chen Y (2016)	1
FOXM1	3	KIF22	1	affinity chromatography technology	Li X (2015)	1
TRIM25	5	AXIN1	1	affinity chromatography technology	Choudhury NR (2017)	1
HSP90AA1	7	CDK4	2	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tsutsumi S (2012), Wang H (2002), Taipale M (2012), Varjosalo M (2013), Huttlin EL (2015), Woodford MR (2016), Huttlin EL (2017)	7
CTNNB1	30	CREBBP	29	genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ma H (2005), Sustmann C (2008), Taurin S (2006), Zhao Y (2016), Benoit YD (2017)	5
RNASEH2B	0	FOXM1	3	affinity chromatography technology	Hein MY (2015)	1
KIF22	1	CCNB1	3	affinity chromatography technology	Hein MY (2015)	1
IARS	5	QARS	1	biochemical, biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	4
FOXM1	3	LARS	1	affinity chromatography technology	Li X (2015)	1
FOXM1	3	OS9	4	two hybrid	Wang J (2011)	1
UBE2I	0	PRPF8	14	enzymatic study	Matafora V (2009)	1
RNF168	0	SUMO1	0	affinity chromatography technology	Guturi KK (2016)	1
HSP90AA1	7	GSK3A	1	affinity chromatography technology, affinity chromatography technology	Taipale M (2012), Taipale M (2012)	2
SNRNP200	15	PRPF8	14	two hybrid, two hybrid, biochemical, x-ray crystallography, two hybrid, biochemical, affinity chromatography technology	Liu S (2006), Liu S (2006), Havugimana PC (2012), Mozaffari-Jovin S (2013), Pena V (2007), Wan C (2015), Boldt K (2016)	7
TRIM25	5	CTNNB1	30	affinity chromatography technology	Choudhury NR (2017)	1
HSP90AA1	7	FZR1	1	genetic interference	Srivas R (2016)	1
CDC25B	4	CDK1	0	affinity chromatography technology, affinity chromatography technology	Vincent I (2001), Zhong Y (2017)	2
CTNNB1	30	FOXM1	3	affinity chromatography technology	Chen Y (2016)	1
OTUB1	0	SMAD3	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Herhaus L (2013), Herhaus L (2013), Herhaus L (2013)	3
SP1	0	CDK1	0	imaging technique, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study	Chuang JY (2012), Chuang JY (2012), Chuang JY (2012), Chuang JY (2012), Yang HC (2014), Yang HC (2014)	6
GSK3B	1	AXIN1	1	two hybrid, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Mak BC (2003), Hino S (2005), Oosterveen T (2007), Kim MJ (2008), Kitagawa M (1999), Cha B (2011), Cha B (2011), Arnold HK (2009), Kashikar ND (2011), Kashikar ND (2011), Zhou F (2012), Yan D (2012), Zhang YG (2012), Sue Ng S (2010), Kim JW (2003), Tang Y (2008), Luo W (2007), Li VS (2012), Rosano L (2009), Yamamoto H (2006), Fei C (2013), Wang J (2011), Varjosalo M (2013), Gao C (2014), Varjosalo M (2013), Castellone MD (2005), Hein MY (2015), Chen TC (2014), Chen Y (2016), Novellasdemunt L (2017)	36
FOXM1	3	PRPF8	14	affinity chromatography technology	Li X (2015)	1
HSP90AA1	7	FOXM1	3	affinity chromatography technology	Taipale M (2012)	1
FOXM1	3	RNF8	2	affinity chromatography technology, affinity chromatography technology	Kongsema M (2016), Kongsema M (2016)	2
CDC25B	4	FOXM1	3	affinity chromatography technology	Major ML (2004)	1
FOXM1	3	GTF3C4	0	affinity chromatography technology	Li X (2015)	1
CDK6	0	FOXM1	3	enzymatic study	Anders L (2011)	1
BCL6	6	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Cerchietti LC (2009), Cerchietti LC (2009)	2
UBE2I	0	RB1	2	enzymatic study, pull down	Ledl A (2005), Ledl A (2005)	2
FBXW7	2	GSK3B	1	affinity chromatography technology	Kwon YW (2012)	1
FOXM1	3	MYBL2	2	affinity chromatography technology	Li X (2015)	1
TRIM25	5	PRPF8	14	affinity chromatography technology	Choudhury NR (2017)	1
CDK2	0	RB1	2	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Shintani S (2000), Nair JS (2009), Takaki T (2004), Shen WH (2004), He W (2003), Peiretti A (2003), Harbour JW (1999), Horton LE (1997), Higashi H (1996), Delston RB (2011), Kim KS (2002), Chen W (2004), Liberal V (2012), Boyer Arnold N (2005), Dynlacht BD (1997), Knudsen ES (1996), Jiang W (1998), De Luca A (1997), Chen Z (2002), Hara E (1997), Connell-Crowley L (1997), Matsuura I (2004), Chen J (1996), Gaiddon C (2003), Seo DW (2006), Zarkowska T (1997), Grimmler M (2007), Nakanishi M (1999), Pevarello P (2005), Iyer NG (2007), Chan HM (2001), Pan W (2001)	32
FOXM1	3	TRMT1L	2	affinity chromatography technology	Li X (2015)	1
FBXL2	2	FOXM1	3	affinity chromatography technology, affinity chromatography technology	Li LQ (2016), Li LQ (2016)	2
CDC25B	4	CCNB1	3	affinity chromatography technology	Li X (2016)	1
CDC27	2	CTNNB1	30	pull down	Gomes NP (2006)	1
RB1	2	CDC27	2	affinity chromatography technology, biochemical, two hybrid, pull down	Binne UK (2007), Binne UK (2007), Chen PL (1995), Chen PL (1995)	4
DARS	0	IARS	5	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
GSK3A	1	CTNNB1	30	enzymatic study, affinity chromatography technology	Koo J (2015), Hein MY (2015)	2
CCNE1	1	CDK4	2	affinity chromatography technology, fluorescent resonance energy transfe	Datta NS (1998), Ivanov AA (2017)	2
CREBBP	29	CDC27	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nath S (2011), Nath S (2011), Townsend K (2009)	3
UBE2I	0	CREBBP	29	affinity chromatography technology, pull down, enzymatic study, two hybrid	Hsieh YL (2013), Hsieh YL (2013), Hsieh YL (2013), Liu ST (2012)	4
CDK2	0	QARS	1	affinity chromatography technology	Neganova I (2011)	1
TRIM25	5	RBMX	2	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
FOXM1	3	BMS1	1	affinity chromatography technology	Li X (2015)	1
CDK2	0	CREBBP	29	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	4
FOXM1	3	SNRNP200	15	affinity chromatography technology	Li X (2015)	1
MYBL2	2	CREBBP	29	genetic interference, affinity chromatography technology, affinity chromatography technology	Bessa M (2001), Bessa M (2001), Kurahashi T (2005)	3
CCNE1	1	MYBL2	2	enzymatic study	Johnson TK (1999)	1
GSK3B	1	CCNE1	1	enzymatic study, imaging technique	Welcker M (2003), Chen TC (2014)	2
CCNE1	1	HERC5	2	affinity chromatography technology, pull down	Mitsui K (1999), Mitsui K (1999)	2
UBE2I	0	SART1	3	enzymatic study	Vertegaal AC (2004)	1
LARS	1	QARS	1	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	3
FBXW7	2	CCNE1	1	enzymatic study, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, pull down, unspecified method, enzymatic study, affinity chromatography technology	Welcker M (2003), Thompson BJ (2007), Hao B (2007), Hao B (2007), van Drogen F (2006), Minella AC (2005), Busino L (2012), Ye X (2004), Ye X (2004), Grim JE (2008), Jin J (2005), Welcker M (2007), Strohmaier H (2001), Strohmaier H (2001), Strohmaier H (2001), Welcker M (2013), Welcker M (2013), Pashkova N (2010), Pashkova N (2010), Nateri AS (2004), Pierce NW (2009), Wang Y (2017)	22
TRIM25	5	USP5	2	affinity chromatography technology	Choudhury NR (2017)	1
FOXM1	3	DNAJC9	0	affinity chromatography technology	Li X (2015)	1
SP1	0	CCNB1	3	imaging technique, affinity chromatography technology, affinity chromatography technology	Chuang JY (2012), Chuang JY (2012), Yang HC (2014)	3
DARS	0	LARS	1	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	3
CTNNB1	30	GSK3B	1	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Davies G (2001), Kishida S (1999), Fischer L (2002), Kitagawa M (1999), Hart M (1999), Su Y (2008), Huang X (2009), Ding Q (2005), Piao S (2008), Varjosalo M (2013), Gao C (2014), Koo J (2015), Chen TC (2014), Lu D (2012), Kuslansky Y (2016), Novellasdemunt L (2017), Lu WJ (2015)	17
TRIM25	5	FOXM1	3	affinity chromatography technology	Choudhury NR (2017)	1
UBE2I	0	FOXM1	3	enzymatic study	Myatt SS (2013)	1
CDC27	2	FOXM1	3	affinity chromatography technology	Park HJ (2008)	1
RB1	2	FZR1	1	affinity chromatography technology, biochemical	Binne UK (2007), Binne UK (2007)	2
LIN54	1	LIN37	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Litovchick L (2007), Litovchick L (2007), Litovchick L (2007), Litovchick L (2007), Schmit F (2007), Schmit F (2007), Schmit F (2007), Huttlin EL (2015), Huttlin EL (2017)	9
CDK1	0	EZH2	4	enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology	Chen S (2010), Avdic V (2011), Avdic V (2011), Avdic V (2011), Wei Y (2011), Wei Y (2011), Kaneko S (2010), Wan J (2015), Li Z (2017)	9
CDK2	0	CDK1	0	affinity chromatography technology, affinity chromatography technology	Neganova I (2011), Huttlin EL (2017)	2
TRIM25	5	BANP	1	affinity chromatography technology	Choudhury NR (2017)	1
CDK2	0	ORC2	0	enzymatic study, pull down	Mendez J (2002), Ramachandran N (2004)	2
CDK2	0	CDK6	0	biochemical, imaging technique	Cheng A (2000), Chen TC (2014)	2
CDK2	0	IARS	5	affinity chromatography technology	Neganova I (2011)	1
FBXW7	2	CTNNB1	30	affinity chromatography technology, affinity chromatography technology	Jiang JX (2016), Jiang JX (2016)	2
CDK1	0	PRC1	4	enzymatic study	Jiang W (1998)	1
SMAD3	1	CDC27	2	affinity chromatography technology	Stroschein SL (2001)	1
EZH2	4	SNRNP200	15	affinity chromatography technology	Cao Q (2014)	1
FOXM1	3	USP5	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chen Y (2016), Chen Y (2016), Li XY (2017), Li XY (2017)	4
SMAD3	1	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tian YC (2002), Dahle O (2010), Charbonney E (2011), Zhou B (2012)	4
FBXW7	2	TRIM25	5	two hybrid	Arroyo R (2015)	1
SP1	0	SMAD3	1	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Botella LM (2001), Poncelet AC (2001), Pardali K (2000), Pardali K (2000), Pardali K (2000), Pardali K (2000), Barrasa JI (2011), Jungert K (2006), Sanchez-Elsner T (2002)	9
EZH2	4	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Li X (2009), Li X (2009), Shi B (2007), Shi B (2007), Shi B (2007)	5
FBXO31	4	FOXM1	3	affinity chromatography technology	Jeffery JM (2017)	1
CHEK2	2	FZR1	1	genetic interference	Srivas R (2016)	1
GSK3B	1	HSP90AA1	7	enzymatic study	Muller P (2012)	1
SP1	0	RB1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Singh J (2002), Chang YC (2001), Opitz OG (2000)	3
RNF8	2	CHEK2	2	affinity chromatography technology, enzymatic study	Feng L (2012), Feng L (2012)	2
CTNNB1	30	BCL6	6	pull down	Kotlyar M (2015)	1
CDK1	0	FOXM1	3	affinity chromatography technology, enzymatic study	Major ML (2004), Major ML (2004)	2
LIN54	1	LIN9	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Litovchick L (2007), Litovchick L (2007), Litovchick L (2007), Litovchick L (2007), Schmit F (2007), Schmit F (2007), Huttlin EL (2017)	7
FZR1	1	CDC27	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhou Y (2003), Kramer ER (1998), Farhana L (2002), Cen B (2010), Sorensen CS (2001), Binne UK (2007), Wang X (2008), Tran K (2008), Wang LY (2012), Wang LY (2012), Ban KH (2007), Lv XB (2010), Huang KT (2012), Song MS (2011), Fukushima H (2013), Lau AW (2013), Cotto-Rios XM (2011), Vodermaier HC (2003), Vodermaier HC (2003), Vodermaier HC (2003), Choi BH (2014), Jeganathan KB (2006), Fang G (1998), Sedgwick GG (2012), Kelly A (2014), Listovsky T (2013), Pavlides SC (2016), Huttlin EL (2017)	28
CDK2	0	SMARCA5	4	affinity chromatography technology	Neganova I (2011)	1
DHX29	2	FOXM1	3	biochemical	Havugimana PC (2012)	1
CDK1	0	FZR1	1	enzymatic study, affinity chromatography technology	Gutierrez GJ (2010), Huttlin EL (2017)	2
TRIM25	5	SMAD3	1	affinity chromatography technology	Choudhury NR (2017)	1
CTNNB1	30	CCNE1	1	pull down, affinity chromatography technology, affinity chromatography technology	Park CS (2004), Park CS (2004), Park CS (2004)	3
CTNNB1	30	CDK2	0	pull down, affinity chromatography technology	Park CS (2004), Park CS (2004)	2
FBXW7	2	RBMX	2	genetic interference	Bailey ML (2015)	1
CDK2	0	EZH2	4	enzymatic study	Chen S (2010)	1
8339	0	FOXM1	3	bioid	Lambert JP (2015)	1
TERF1	1	FOXM1	3	affinity chromatography technology	Hein MY (2015)	1
GSK3B	1	QARS	1	two hybrid	Vinayagam A (2011)	1
CDK4	2	FOXM1	3	enzymatic study	Anders L (2011)	1
FOXM1	3	QARS	1	affinity chromatography technology	Li X (2015)	1
FBXW7	2	EZH2	4	affinity chromatography technology, affinity chromatography technology, pull down	Jin X (2017), Jin X (2017), Jin X (2017)	3
CDK4	2	SMAD3	1	enzymatic study, imaging technique	Matsuura I (2004), Chen TC (2014)	2
HSP90AA1	7	CDK6	0	affinity chromatography technology	Taipale M (2012)	1
HSP90AA1	7	FBXL2	2	affinity chromatography technology	Taipale M (2012)	1
FZR1	1	CCNE1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
FOXM1	3	LRWD1	1	affinity chromatography technology	Li X (2015)	1
TRIM25	5	FZR1	1	affinity chromatography technology	Choudhury NR (2017)	1
CCNB1	3	PRC1	4	enzymatic study	Jiang W (1998)	1
FOXM1	3	ACAT1	1	biochemical	Havugimana PC (2012)	1
CDK4	2	RB1	2	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Nair JS (2009), Takaki T (2004), Deep G (2006), Kehn K (2004), Scholz A (2003), Gladden AB (2003), Mori S (1999), Higashi H (1996), Musgrove EA (1996), Sarmento LM (2005), Kim KS (2002), Li J (2002), Garcia-Morales P (2006), Tsai CH (2009), Miralem T (2003), Toji S (2004), Halder SK (2005), Dynlacht BD (1997), Mandal M (1998), Voit R (1999), Annicotte JS (2006), Connell-Crowley L (1997), Matsuura I (2004), Chen J (1996), Kitagawa M (1996), Anders L (2011), Gaiddon C (2003), Seo DW (2006), Kabuta T (2013), Lee B (2006), Kossatz U (2006), Zarkowska T (1997), Nakanishi M (1999), Iyer NG (2007), Guidoboni M (2005), Barbash O (2009), Wang C (2001), Denicourt C (2008), Pan W (2001)	39
CCNE1	1	FOXM1	3	affinity chromatography technology, enzymatic study	Major ML (2004), Luescher-Firzlaff JM (2006)	2
FBXW7	2	CDK2	0	affinity chromatography technology, affinity chromatography technology	Zhang W (2012), Zhang W (2012)	2
CREBBP	29	SP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Goto T (2006), Leclerc GJ (2010), Chuang JY (2012), Guo W (2014)	4
PARD6B	0	FOXM1	3	affinity chromatography technology	Hein MY (2015)	1
CDK2	0	UBE2I	0	affinity chromatography technology	Neganova I (2011)	1
AXIN1	1	GSK3A	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Arnold HK (2009), Fei C (2013), Varjosalo M (2013), Hein MY (2015), Chen Y (2016)	5
SART1	3	SNRNP200	15	two hybrid, pull down, biochemical	Liu S (2006), Liu S (2006), Wan C (2015)	3
FOXM1	3	EZH2	4	imaging technique, affinity chromatography technology, affinity chromatography technology	Mahara S (2016), Mahara S (2016), Mahara S (2016)	3
HSP90AA1	7	FBXW7	2	affinity chromatography technology	Taipale M (2012)	1
IARS	5	LARS	1	biochemical, biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	4
FOXM1	3	LIN54	1	affinity chromatography technology	Li X (2015)	1
CDK6	0	RB1	2	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Garcia-Morales P (2006), Aprelikova O (1995), Yarbrough WG (1999), Dynlacht BD (1997), Jiang W (1998), Anders L (2011), Nakanishi M (1999), Iyer NG (2007)	8
EZH2	4	TRIM25	5	affinity chromatography technology	Cao Q (2014)	1
CDK2	0	FOXM1	3	affinity chromatography technology, enzymatic study	Major ML (2004), Luescher-Firzlaff JM (2006)	2
FOXM1	3	PARS2	1	affinity chromatography technology	Li X (2015)	1
CREBBP	29	SUMO1	0	x-ray crystallography, pull down	Diehl C (2016), Diehl C (2016)	2
FOXM1	3	RBMX	2	affinity chromatography technology	Li X (2015)	1
CCNE1	1	CDK1	0	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Shanahan F (1999), Koff A (1992), Koff A (1992), Horton LE (1997)	4
HERC5	2	CCNB1	3	pull down	Mitsui K (1999)	1
AXIN1	1	FOXM1	3	affinity chromatography technology, affinity chromatography technology	Chen Y (2016), Chen Y (2016)	2
SMAD3	1	ZBTB3	3	two hybrid	Ravasi T (2010)	1
TRIM25	5	PRC1	4	affinity chromatography technology	Choudhury NR (2017)	1
CTNNB1	30	SMARCA5	4	affinity chromatography technology, pull down, affinity chromatography technology	Sierra J (2006), Sierra J (2006), Gomes NP (2006)	3
TRIM25	5	SART1	3	affinity chromatography technology	Choudhury NR (2017)	1
CREBBP	29	SMAD3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kang JS (2005), Alliston T (2005), Xi Q (2008), Cui Q (2005), Cui Q (2005), Chen W (2007), Nishihara A (1999), Tomita M (2004), Oussaief L (2009), Oussaief L (2009), Cui Q (2005)	11
DARS	0	QARS	1	biochemical, biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	4
SMAD3	1	FOXM1	3	pull down, affinity chromatography technology	Xue J (2014), Xue J (2014)	2
KIF18A	3	FOXM1	3	affinity chromatography technology	Hein MY (2015)	1
CDK2	0	SP1	0	enzymatic study	Fojas de Borja P (2001)	1
TRIM25	5	CDK1	0	affinity chromatography technology	Choudhury NR (2017)	1
BANP	1	FOXM1	3	two hybrid	Wang J (2011)	1
FZR1	1	FOXM1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Park HJ (2008), Myatt SS (2013), Laoukili J (2008), Laoukili J (2008)	4
CDK6	0	CTNNB1	30	imaging technique	Chen TC (2014)	1
FOXM1	3	SART1	3	affinity chromatography technology	Li X (2015)	1
CDK4	2	DNAJC9	0	affinity chromatography technology	Boldt K (2016)	1
8339	0	KIF18A	3	bioid	Lambert JP (2015)	1
FOXM1	3	DDX52	0	affinity chromatography technology	Li X (2015)	1
TRIM25	5	RNF8	2	affinity chromatography technology	Choudhury NR (2017)	1
RB1	2	FOXM1	3	affinity chromatography technology	Major ML (2004)	1
8339	0	RNASEH2B	0	bioid	Lambert JP (2015)	1
FOXM1	3	ECT2	2	affinity chromatography technology	Li X (2015)	1
ORC2	0	PES1	3	biochemical	Wan C (2015)	1
LRWD1	1	ORC2	0	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Shen Z (2012), Shen Z (2012), Havugimana PC (2012), Vermeulen M (2010), Wan C (2015), Hein MY (2015), Hein MY (2015)	7
ECT2	2	SNRNP200	15	two hybrid, affinity chromatography technology	Woods NT (2012), Woods NT (2012)	2
SART1	3	PRPF8	14	affinity chromatography technology, biochemical, biochemical	Makarova OV (2001), Havugimana PC (2012), Wan C (2015)	3
FOXM1	3	IARS	5	affinity chromatography technology	Li X (2015)	1
OTUB1	0	FOXM1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Karunarathna U (2016), Karunarathna U (2016), Wang Y (2016), Wang Y (2016), Wang Y (2016), Wang Y (2016), Wang Y (2016)	7
DCAF1	5	FOXM1	3	affinity chromatography technology, affinity chromatography technology, pull down	Wang X (2017), Wang X (2017), Wang X (2017)	3
CCNE1	1	CDK6	0	affinity chromatography technology, fluorescent resonance energy transfe	Datta NS (1998), Ivanov AA (2017)	2
FOXM1	3	HERC5	2	affinity chromatography technology	Li X (2015)	1
TRIM25	5	CREBBP	29	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
OTUB1	0	CCNB1	3	affinity chromatography technology	Scholz CC (2016)	1
FOXM1	3	ORC2	0	affinity chromatography technology	Li X (2015)	1
LIN37	0	MYBL2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Litovchick L (2007), Litovchick L (2007), Schmit F (2007), Schmit F (2007), Schmit F (2007), Huttlin EL (2015), Huttlin EL (2017)	7
RNF168	0	FOXM1	3	affinity chromatography technology, affinity chromatography technology	Kongsema M (2016), Kongsema M (2016)	2
FOXM1	3	DEPDC1	1	affinity chromatography technology	Li X (2015)	1
ECT2	2	OTUB1	0	two hybrid	Woods NT (2012)	1
FOXM1	3	SMARCA5	4	affinity chromatography technology	Li X (2015)	1
CCNB1	3	RB1	2	enzymatic study, enzymatic study	Jiang W (1998), Knudsen ES (1997)	2
CCNB1	3	FZR1	1	pull down, enzymatic study, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, imaging technique, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology	Ke PY (2004), Huang NJ (2012), Pfleger CM (2001), Miller JJ (2006), Song MS (2011), Frye JJ (2013), Lau AW (2013), Brown NG (2014), Summers MK (2009), ODonovan KJ (2010), Wu T (2010), Shoji S (2014), Vodermaier HC (2003), Kim HS (2011), Lu L (2013), Yamaguchi M (2015), Brown NG (2015), Chen TC (2014), Williamson A (2011), Qiao R (2016), Brown NG (2016), Huttlin EL (2017)	22
FOXM1	3	LIN9	3	affinity chromatography technology	Li X (2015)	1
FZR1	1	CDK6	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CDK2	0	SMAD3	1	enzymatic study, imaging technique	Matsuura I (2004), Chen TC (2014)	2
UBE2I	0	SNRNP200	15	enzymatic study	Matafora V (2009)	1
CREBBP	29	FOXM1	3	affinity chromatography technology	Major ML (2004)	1
CCNE1	1	PRC1	4	enzymatic study	Jiang W (1998)	1
8339	0	PRC1	4	bioid	Lambert JP (2015)	1
CTNNB1	30	AXIN1	1	pull down, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Hocevar BA (2003), Hino S (2005), Stoothoff WH (2002), Kim MJ (2008), Kitagawa M (1999), Kitagawa M (1999), Arnold HK (2009), Zhang YG (2012), Godin JD (2010), Godin JD (2010), Sue Ng S (2010), Sue Ng S (2010), Tang Y (2008), Li VS (2012), Yamamoto H (2006), Fei C (2013), Hein MY (2015), Kuslansky Y (2016), Novellasdemunt L (2017)	25
SP1	0	HSP90AA1	7	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Hung JJ (2005), Hung JJ (2005), Wang SA (2009), Wang SA (2009)	4
CCNB1	3	CDK1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shanahan F (1999), Yang Q (2000), Pines J (1989), Kong M (2000), Amador V (2007), Paulsen MT (2006), Niida H (2005), Pereg Y (2010), Tamura D (2010), Kiviharju-af Haellstroem TM (2007), Pan ZQ (1993), Pan ZQ (1993), Pan ZQ (1993), van Zon W (2010), Desai D (1995), Vazquez-Novelle MD (2010), Smith EM (2008), Poon RY (1996), OConnor PM (1993), Fosbrink M (2009), Linares JF (2011), Varjosalo M (2013), Felzien LK (1998), Toby GG (2003), So J (2015), Huttlin EL (2015), Wan C (2015), Jenkins RH (2014), Hein MY (2015), Hein MY (2015), Voets E (2015), Lin Z (2015), Lin Z (2015), Huttlin EL (2017)	34
BCL6	6	FOXM1	3	affinity chromatography technology	Phan RT (2007)	1
8339	0	KIF22	1	bioid	Lambert JP (2015)	1
CCNB1	3	FOXM1	3	affinity chromatography technology	Major ML (2004)	1
SP1	0	CDK4	2	affinity chromatography technology	Tapias A (2008)	1
CDK1	0	RB1	2	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Horton LE (1997), Lees JA (1991), Knudsen ES (1996), Jiang W (1998), De Luca A (1997), Chen Z (2002), Knudsen ES (1997), Pan W (2001)	8
CDK2	0	CDC25B	4	two hybrid, enzymatic study	Conklin DS (1995), Cheng A (2005)	2
FOXM1	3	GSK3A	1	affinity chromatography technology	Chen Y (2016)	1
TRIM25	5	CDK6	0	affinity chromatography technology	Choudhury NR (2017)	1
LIN9	3	LIN37	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Litovchick L (2007), Litovchick L (2007), Litovchick L (2007), Litovchick L (2007), Schmit F (2007), Schmit F (2007), Schmit F (2007), Huttlin EL (2015), Huttlin EL (2017)	9
HSP90AA1	7	SNRNP200	15	affinity chromatography technology	Gano JJ (2010)	1
CTNNB1	30	HERC5	2	affinity chromatography technology, affinity chromatography technology	Lee JH (2010), Park YS (2017)	2
CDK4	2	QARS	1	two hybrid	Vinayagam A (2011)	1
TRIM25	5	IARS	5	affinity chromatography technology	Choudhury NR (2017)	1
HSP90AA1	7	RB1	2	genetic interference	Srivas R (2016)	1
CHEK2	2	RB1	2	enzymatic study, pull down, affinity chromatography technology	Inoue Y (2007), Inoue Y (2007), Inoue Y (2007)	3
RNF168	0	SMARCA5	4	affinity chromatography technology, affinity chromatography technology	Smeenk G (2012), Smeenk G (2012)	2
CDK2	0	MYBL2	2	enzymatic study, enzymatic study, enzymatic study	Mueller-Tidow C (2001), Bartsch O (1999), Johnson TK (1999)	3
CREBBP	29	CCNE1	1	affinity chromatography technology	Wang A (2004)	1
GSK3B	1	SMAD3	1	affinity chromatography technology, pull down, affinity chromatography technology	Guo X (2008), Guo X (2008), Choi SI (2011)	3
FZR1	1	CDK4	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TRIM25	5	GSK3A	1	affinity chromatography technology	Choudhury NR (2017)	1
CDK2	0	FZR1	1	enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology	Sorensen CS (2001), Fukushima H (2013), Lau AW (2013), Chang L (2015), Huttlin EL (2017)	5
CDK6	0	EZH2	4	enzymatic study	Anders L (2011)	1
CDK2	0	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Neganova I (2011), Varjosalo M (2013)	2
LIN9	3	MYBL2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Litovchick L (2007), Litovchick L (2007), Schmit F (2007), Schmit F (2007), Osterloh L (2007), Osterloh L (2007), Yamauchi T (2008), Rashid NN (2014), Huttlin EL (2017)	9
PES1	3	SART1	3	affinity chromatography technology	Kellner M (2015)	1
CCNB1	3	CDC27	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Jeganathan KB (2006), Farhana L (2002), van Zon W (2010), Miller JJ (2006), Voets E (2015)	5
FOXM1	3	PES1	3	affinity chromatography technology	Li X (2015)	1
CDK2	0	PRC1	4	enzymatic study	Jiang W (1998)	1
FOXM1	3	SP1	0	imaging technique, pull down, affinity chromatography technology	Xu K (2013), Xu K (2013), Xu K (2013)	3
FOXM1	3	ZC3H11A	4	affinity chromatography technology	Li X (2015)	1
FOXM1	3	ZBTB3	3	two hybrid	Ravasi T (2010)	1
UBE2I	0	SUMO1	0	affinity chromatography technology, pull down, two hybrid, two hybrid, fluorescent resonance energy transfe, pull down, two hybrid, two hybrid, pull down, pull down, two hybrid, pull down, fluorescent resonance energy transfe, pull down, two hybrid, pull down, pull down, enzymatic study, enzymatic study, biochemical, affinity chromatography technology	Ewing RM (2007), Tatham MH (2003), Minty A (2000), Shen Z (1996), Song Y (2011), Knipscheer P (2007), Boutell C (2011), Gong L (1997), Gong L (1997), Hemelaar J (2004), Hecker CM (2006), Hecker CM (2006), Martin SF (2008), Everett RD (2014), Rolland T (2014), Zilio N (2013), Carbia-Nagashima A (2007), Knipscheer P (2007), Matic I (2008), Wan C (2015), Hein MY (2015)	21
FOXM1	3	SMC2	3	affinity chromatography technology	Li X (2015)	1
CCNE1	1	CDK2	0	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	McKenzie PP (2003), Shanahan F (1999), Koff A (1992), Koff A (1992), Mayer C (2004), Connor MK (2003), Boudrez A (2000), Varshochi R (2005), Jeong JH (2010), Bustany S (2011), Yeh ES (2006), Hui S (2011), Kim J (2007), Kiviharju-af Haellstroem TM (2007), Abbas T (2007), Nishimura T (2005), Matsumoto Y (2004), Harwell RM (2004), Harwell RM (2004), Peiretti A (2003), Peiretti A (2003), Kim YB (2000), Manenti S (1999), Datta NS (1998), Sheaff RJ (1997), Higashi H (1996), Higashi H (1996), Musgrove EA (1996), Vlach J (1996), Grim JE (2008), Liu S (2009), Ciarallo S (2002), Desai D (1995), Baydoun HH (2010), Baydoun HH (2010), Chu I (2007), Chu I (2007), Levkau B (1998), Poon RY (1996), Zhao J (1998), Zhao J (1998), Larrea MD (2009), Varjosalo M (2013), Varjosalo M (2013), Chan HM (2001), So J (2015), Ungermannova D (2005), Song MS (2011), Huttlin EL (2015), Hein MY (2015), Lin CH (2015), Lin CH (2015), Davis RJ (2017), Huttlin EL (2017)	54
CTNNB1	30	RBMX	2	affinity chromatography technology	Sato S (2005)	1
8339	0	LIN9	3	bioid	Lambert JP (2015)	1