PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RUVBL1	2	PABPC1	5	affinity chromatography technology	Izumi N (2010)	1
SMG1	7	EIF4A3	1	affinity chromatography technology, affinity chromatography technology	Kashima I (2006), Izumi N (2010)	2
SMG1	7	SMG8	2	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Yamashita A (2009), Yamashita A (2009), Yamashita A (2009), Izumi N (2010)	4
HSP90AA1	7	EPHA1	5	affinity chromatography technology	Taipale M (2012)	1
RBM8A	2	TTI1	3	affinity chromatography technology	Izumi N (2010)	1
UPF3B	6	UPF2	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, biochemical, affinity chromatography technology	Lehner B (2004), Lejeune F (2003), Lykke-Andersen J (2002), Lykke-Andersen J (2000), Lykke-Andersen J (2000), Kashima I (2006), Lehner B (2004), Wan C (2015), Hein MY (2015)	9
UPF1	8	UPF3B	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lejeune F (2003), Schell T (2003), Lykke-Andersen J (2000), Lykke-Andersen J (2000), Yamashita A (2009), Franks TM (2010), Izumi N (2010), Li S (2014), Hein MY (2015)	9
ELAVL1	0	UPF2	2	affinity chromatography technology	Abdelmohsen K (2009)	1
TTI1	3	SMG1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kaizuka T (2010), Izumi N (2010), Izumi N (2010), Izumi N (2010), Hurov KE (2010)	5
TTI1	3	HSPA4	3	affinity chromatography technology, affinity chromatography technology	Takai H (2010), Izumi N (2010)	2
ELAVL1	0	PRKCI	1	affinity chromatography technology	Abdelmohsen K (2009)	1
EGFR	5	HSP90B1	3	protein complementation assay, affinity chromatography technology, affinity chromatography technology	Deribe YL (2009), Lavictoire SJ (2003), Yao Z (2017)	3
UPF1	8	SMG9	2	affinity chromatography technology	Yamashita A (2009)	1
TTI1	3	TUBA1A	13	affinity chromatography technology	Izumi N (2010)	1
RUVBL1	2	TUBA1A	13	affinity chromatography technology	Izumi N (2010)	1
HSP90AA1	7	EEF2	11	affinity chromatography technology	Falsone SF (2005)	1
SMG1	7	HSPA4	3	affinity chromatography technology	Izumi N (2010)	1
RBM8A	2	SMG8	2	affinity chromatography technology, affinity chromatography technology	Yamashita A (2009), Izumi N (2010)	2
EGFR	5	HSPA4	3	protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay	Deribe YL (2009), Deribe YL (2009), Citri A (2002), Tong J (2008), Kotlyar M (2015), Petschnigg J (2014)	6
EPHA1	5	SMG9	2	affinity chromatography technology	Huttlin EL (2017)	1
SMG1	7	UPF3B	6	affinity chromatography technology, affinity chromatography technology	Ivanov PV (2008), Kashima I (2006)	2
RUVBL1	2	TTI1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Takai H (2010), Izumi N (2010), Izumi N (2010), Izumi N (2010), Izumi N (2010), Cloutier P (2017)	7
UPF1	8	GSPT2	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Kashima I (2006), Singh G (2008), Singh G (2008), Huttlin EL (2017)	4
PRKCI	1	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Brajenovic M (2004), Taipale M (2012)	2
RBM8A	2	EIF4A3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Chan CC (2004), Chan CC (2004), Singh G (2012), Singh G (2012), Izumi N (2010), Barbosa I (2012)	6
EPHA1	5	SMG1	7	affinity chromatography technology	Huttlin EL (2017)	1
SMG1	7	GSPT1	3	affinity chromatography technology	Kashima I (2006)	1
UPF3A	2	UPF2	2	affinity chromatography technology, affinity chromatography technology	Lejeune F (2003), Lykke-Andersen J (2000)	2
RUVBL2	4	POLR2E	0	affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Izumi N (2010)	2
TTI1	3	TELO2	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Kaizuka T (2010), Kaizuka T (2010), Takai H (2010), Takai H (2010), Izumi N (2010), Kristensen AR (2012), Hurov KE (2010)	7
HSP90AA1	7	HSPA4	3	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical	Kim TS (2006), Hidalgo-de-Quintana J (2008), Skarra DV (2011), Wan C (2015)	4
UPF1	8	RUVBL1	2	affinity chromatography technology, affinity chromatography technology	Izumi N (2010), Cloutier P (2017)	2
UPF1	8	UPF3A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Schell T (2003), Yamashita A (2001), Lykke-Andersen J (2000)	3
UPF3B	6	EIF4A3	1	biochemical, affinity chromatography technology, biochemical, pull down	Sato H (2009), Sato H (2009), Singh G (2012), Barbosa I (2012)	4
GSPT1	3	RUVBL1	2	biochemical	Wan C (2015)	1
EEF2	11	PABPC1	5	biochemical	Havugimana PC (2012)	1
TUBG1	2	HSPA4	3	biochemical	Wigley WC (1999)	1
EGFR	5	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay	Citri A (2002), Yang S (2006), Shimamura T (2005), Lavictoire SJ (2003), Lavictoire SJ (2003), Foerster S (2013), Kotlyar M (2015), Petschnigg J (2014)	8
PABPC1	5	GSPT1	3	pull down, affinity chromatography technology, unspecified method, affinity chromatography technology, biochemical	Hoshino S (1999), Kozlov G (2004), Kozlov G (2004), Ivanov PV (2008), Wan C (2015)	5
HSP90AA1	7	TUBA1A	13	affinity chromatography technology, affinity chromatography technology	Hu Y (2003), Skarra DV (2011)	2
SMG1	7	TUBA1A	13	affinity chromatography technology	Izumi N (2010)	1
ELAVL1	0	GSPT1	3	affinity chromatography technology	Abdelmohsen K (2009)	1
RBM8A	2	NCBP2	0	affinity chromatography technology	Kashima I (2006)	1
RBM8A	2	SMG7	3	affinity chromatography technology, affinity chromatography technology	Kashima I (2006), Izumi N (2010)	2
TELO2	6	SMG1	7	affinity chromatography technology, affinity chromatography technology	Kaizuka T (2010), Takai H (2007)	2
ELAVL1	0	SMG1	7	affinity chromatography technology	Abdelmohsen K (2009)	1
EGFR	5	RUVBL2	4	affinity chromatography technology	Yao Z (2017)	1
RBM8A	2	UPF3A	2	pull down, affinity chromatography technology	Kim VN (2001), Kim VN (2001)	2
PRKCI	1	SMG1	7	two hybrid, pull down, affinity chromatography technology	Diaz-Meco MT (1996), Diaz-Meco MT (1996), Diaz-Meco MT (1996)	3
HSP90B1	3	SMG1	7	affinity chromatography technology	Hein MY (2015)	1
GSPT1	3	GSPT2	2	biochemical, affinity chromatography technology	Kristensen AR (2012), Huttlin EL (2017)	2
HTR6	3	TTI1	3	affinity chromatography technology	Meffre J (2012)	1
UPF3A	2	SMG1	7	affinity chromatography technology, affinity chromatography technology	Yamashita A (2001), Kashima I (2006)	2
HAUS2	2	TUBG1	2	affinity chromatography technology	Fogeron ML (2013)	1
SMG1	7	SMG9	2	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yamashita A (2009), Yamashita A (2009), Yamashita A (2009), Yamashita A (2009), Izumi N (2010), Hein MY (2015)	6
SMG1	7	PABPC1	5	affinity chromatography technology	Kashima I (2006)	1
ELAVL1	0	PABPC1	5	affinity chromatography technology	Abdelmohsen K (2009)	1
HSP90AA1	7	POLR2E	0	affinity chromatography technology, affinity chromatography technology	Gano JJ (2010), Skarra DV (2011)	2
SMG1	7	SMG7	3	affinity chromatography technology, affinity chromatography technology	Kashima I (2006), Kashima I (2006)	2
RUVBL2	4	TELO2	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Takai H (2010), Takai H (2010)	3
RBM8A	2	PABPC1	5	affinity chromatography technology, affinity chromatography technology	Kashima I (2006), Izumi N (2010)	2
RUVBL1	2	RUVBL2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, biochemical, two hybrid, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Ewing RM (2007), Jeronimo C (2007), Jeronimo C (2007), Puri T (2007), Rashid S (2009), Kim JH (2007), Kim JH (2007), McKeegan KS (2007), Lee JS (2010), Lee JS (2010), Cai Y (2007), Cai Y (2007), Ikura T (2000), Havugimana PC (2012), Venteicher AS (2008), Venteicher AS (2008), Bauer A (2000), Bauer A (2000), Bauer A (2000), Salzer U (1999), Izumi N (2010), Kristensen AR (2012), Rolland T (2014), Wan C (2015), Jeganathan A (2015), Huttlin EL (2017), Cloutier P (2017), Cloutier P (2017)	29
HTR6	3	TELO2	6	affinity chromatography technology	Meffre J (2012)	1
UPF3A	2	UPF3B	6	affinity chromatography technology	Lejeune F (2003)	1
TELO2	6	HSPA4	3	affinity chromatography technology	Takai H (2010)	1
SMG9	2	SMG8	2	affinity chromatography technology, affinity chromatography technology	Yamashita A (2009), Hein MY (2015)	2
TELO2	6	RUVBL1	2	affinity chromatography technology, affinity chromatography technology	Takai H (2010), Izumi N (2010)	2
UPF1	8	RBM8A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yamashita A (2009), Yamashita A (2009), Kashima I (2006), Izumi N (2010), Izumi N (2010)	5
ELAVL1	0	SMG7	3	affinity chromatography technology	Abdelmohsen K (2009)	1
EGFR	5	TELO2	6	affinity chromatography technology	Foerster S (2013)	1
SMG1	7	SMG1	7	enzymatic study	Yamashita A (2001)	1
RUVBL1	2	SMG8	2	affinity chromatography technology	Izumi N (2010)	1
EGFR	5	TUBG1	2	affinity chromatography technology	Tong J (2014)	1
SMG1	7	UPF1	8	enzymatic study, unspecified method, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Yamashita A (2001), Yamashita A (2001), Yamashita A (2001), Yamashita A (2009), Yamashita A (2009), Ivanov PV (2008), Isken O (2008), Kashima I (2006), Kashima I (2006), Kashima I (2006), Izumi N (2010)	11
UPF1	8	UPF2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lejeune F (2003), Schell T (2003), Schell T (2003), Mendell JT (2000), Yamashita A (2001), Lykke-Andersen J (2000), Lykke-Andersen J (2000), Azzalin CM (2006), Azzalin CM (2006), Kaygun H (2005), Yamashita A (2009), Franks TM (2010), Ivanov PV (2008), Kashima I (2006), Izumi N (2010), Li S (2014)	16
UPF1	8	MAGOH	0	affinity chromatography technology	Yamashita A (2009)	1
MAGOH	0	RBM8A	2	two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Zhao XF (2000), Kataoka N (2001), Kataoka N (2001), Zhao XF (2000), Singh G (2012), Hegele A (2012), Hegele A (2012), Rolland T (2014), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	12
SMG1	7	HSP90AA1	7	affinity chromatography technology	Izumi N (2010)	1
SMG1	7	MAGOH	0	affinity chromatography technology, affinity chromatography technology	Kashima I (2006), Izumi N (2010)	2
PABPC1	5	GSPT2	2	pull down, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology	Hoshino S (1999), Hoshino S (1999), Singh G (2008), Singh G (2008), Huttlin EL (2017)	5
SMG1	7	POLR2E	0	affinity chromatography technology, affinity chromatography technology	Izumi N (2010), Izumi N (2010)	2
EGFR	5	SMG1	7	affinity chromatography technology	Yao Z (2017)	1
UPF1	8	EIF4A3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yamashita A (2009), Franks TM (2010), Izumi N (2010)	3
RBM8A	2	UPF3B	6	affinity chromatography technology, affinity chromatography technology, pull down	Kashima I (2006), Izumi N (2010), Barbosa I (2012)	3
SMG1	7	NCBP2	0	affinity chromatography technology	Kashima I (2006)	1
UPF1	8	RUVBL2	4	affinity chromatography technology, affinity chromatography technology	Izumi N (2010), Cloutier P (2017)	2
EGFR	5	TUBA1A	13	affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Wu SL (2006), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	4
RBM8A	2	SMG1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yamashita A (2009), Kashima I (2006), Kashima I (2006), Izumi N (2010), Izumi N (2010)	5
RBM8A	2	RUVBL2	4	affinity chromatography technology	Izumi N (2010)	1
RBM8A	2	GSPT1	3	affinity chromatography technology	Yamashita A (2009)	1
SMG1	7	RUVBL2	4	affinity chromatography technology, affinity chromatography technology	Izumi N (2010), Izumi N (2010)	2
RUVBL1	2	ELAVL1	0	affinity chromatography technology	Jeronimo C (2007)	1
UPF1	8	EEF2	11	affinity chromatography technology, affinity chromatography technology	Yamashita A (2009), Yamashita A (2009)	2
RBM8A	2	SMG9	2	affinity chromatography technology, affinity chromatography technology	Yamashita A (2009), Izumi N (2010)	2
TUBG1	2	TUBA1A	13	affinity chromatography technology	Fogeron ML (2013)	1
GSPT1	3	EEF2	11	biochemical	Wan C (2015)	1
POLR2E	0	HSP90B1	3	two hybrid	Vinayagam A (2011)	1
RUVBL2	4	TTI1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Takai H (2010), Izumi N (2010), Izumi N (2010), Cloutier P (2017)	5
RBM8A	2	RUVBL1	2	affinity chromatography technology	Izumi N (2010)	1
SMG1	7	RUVBL1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Izumi N (2010), Izumi N (2010), Izumi N (2010)	3
UPF2	2	SMG1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Yamashita A (2001), Ivanov PV (2008), Kashima I (2006), Kashima I (2006), Kashima I (2006), Izumi N (2010)	6
TTI1	3	POLR2E	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Izumi N (2010), Izumi N (2010), Izumi N (2010), Kristensen AR (2012)	4
HAUS2	2	SMG1	7	affinity chromatography technology	Fogeron ML (2013)	1
UPF1	8	SMG8	2	affinity chromatography technology	Yamashita A (2009)	1
RUVBL1	2	HSPA4	3	affinity chromatography technology	Izumi N (2010)	1
RBM8A	2	UPF2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yamashita A (2009), Kashima I (2006), Kashima I (2006), Izumi N (2010), Hein MY (2015)	5
SMG1	7	TUBG1	2	affinity chromatography technology	Izumi N (2010)	1
UPF1	8	PABPC1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Schell T (2003), Yamashita A (2009), Franks TM (2010)	3
UPF1	8	NCBP2	0	affinity chromatography technology	Yamashita A (2009)	1
EPHA1	5	SMG8	2	affinity chromatography technology	Huttlin EL (2017)	1
SMG1	7	GSPT2	2	affinity chromatography technology	Kashima I (2006)	1
SMG1	7	EEF2	11	affinity chromatography technology	Izumi N (2010)	1
MAGOH	0	EIF4A3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Chan CC (2004), Chan CC (2004), Singh G (2012), Singh G (2012), Singh G (2012), Singh G (2012), Barbosa I (2012)	7
UPF3B	6	MAGOH	0	pull down	Barbosa I (2012)	1
UPF1	8	SMG7	3	affinity chromatography technology, affinity chromatography technology	Franks TM (2010), Izumi N (2010)	2
TUBG1	2	HSP90AA1	7	biochemical, affinity chromatography technology, affinity chromatography technology	Wigley WC (1999), Fogeron ML (2013), Hein MY (2015)	3
RUVBL1	2	SMG9	2	affinity chromatography technology	Izumi N (2010)	1
EGFR	5	TTI1	3	affinity chromatography technology	Foerster S (2013)	1
HTR6	3	SMG1	7	affinity chromatography technology	Meffre J (2012)	1
UPF1	8	GSPT1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yamashita A (2009), Ivanov PV (2008), Ivanov PV (2008), Isken O (2008), Kashima I (2006)	5
RUVBL1	2	POLR2E	0	affinity chromatography technology, affinity chromatography technology	Izumi N (2010), Izumi N (2010)	2