PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TNIK	4	NCOR2	12	two hybrid	Camargo LM (2007)	1
TNIK	4	PAFAH1B1	3	two hybrid	Camargo LM (2007)	1
IKBKB	1	MAP3K7	2	affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hofer-Warbinek R (2000), Wu ZH (2010), Wu ZH (2010), Prickett TD (2008), Fan YH (2011), Neil JR (2008), Wu X (2007), Shambharkar PB (2007), Shambharkar PB (2007), Niu J (2013), Yao F (2015), Yao F (2015), Mei ZZ (2016), Zheng C (2015)	14
DPYSL2	3	DPYSL3	1	two hybrid, affinity chromatography technology	Rolland T (2014), Huttlin EL (2017)	2
DISC1	6	TNIK	4	two hybrid	Camargo LM (2007)	1
SNX6	1	EGFR	5	affinity chromatography technology	Parks WT (2001)	1
TNIK	4	DYNC1H1	41	two hybrid	Camargo LM (2007)	1
DISC1	6	DPYSL2	3	two hybrid	Camargo LM (2007)	1
EGFR	5	DYNC1H1	41	protein complementation assay	Deribe YL (2009)	1
TRAF2	1	SMURF1	4	genetic interference	Li S (2010)	1
MAP3K7	2	TAB2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cheung PC (2004), Cheung PC (2004), Takaesu G (2000), Takaesu G (2001), Ishitani T (2003), Ishitani T (2003), Ea CK (2006), Broglie P (2010), Liu XY (2008), Li S (2011), Li S (2011), Jiang Z (2003), Mendoza H (2008), Ear T (2010), Criollo A (2011), Kim SY (2012), Jiang Z (2002), Jiang Z (2002), Hong S (2007), Shibuya H (1996), Minoda Y (2009), Li M (2010), Scholz R (2010), Kim SI (2009), Yong Kim S (2013), Liu R (2014), Wang J (2015), Moon G (2015), Wade EM (2016), Min Y (2016), Zhang J (2017)	31
EGFR	5	TUBB2A	2	affinity chromatography technology	Foerster S (2013)	1
SMURF1	4	XPO1	8	affinity chromatography technology	Tajima Y (2003)	1
DISC1	6	DYNC1H1	41	two hybrid	Camargo LM (2007)	1
TNIK	4	WWC1	5	two hybrid	Camargo LM (2007)	1
TNIK	4	ANK2	18	two hybrid	Camargo LM (2007)	1
DISC1	6	AGTPBP1	4	two hybrid	Camargo LM (2007)	1
DISC1	6	AKAP9	13	two hybrid	Camargo LM (2007)	1
NCK2	2	EGFR	5	pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Chen M (1998), Braverman LE (1999), Tu Y (1998), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	6
SRGAP3	8	PPP1R13B	9	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NCK2	2	TNIK	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TNIK	4	SRGAP3	8	two hybrid	Camargo LM (2007)	1
DISC1	6	SNX6	1	two hybrid	Camargo LM (2007)	1
DISC1	6	PPM1E	4	two hybrid	Camargo LM (2007)	1
TNIK	4	DPYSL3	1	two hybrid	Camargo LM (2007)	1
XPO1	8	TNIK	4	affinity chromatography technology	Kirli K (2015)	1
CEP63	2	MACF1	12	two hybrid	Camargo LM (2007)	1
TAB2	5	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Takaesu G (2000), Li S (2009), Ishitani T (2003), Hong S (2007)	4
TNIK	4	MAP3K7	2	affinity chromatography technology	Shkoda A (2012)	1
TMEM17	0	DST	13	bioid	Gupta GD (2015)	1
DISC1	6	SPTBN1	6	two hybrid	Camargo LM (2007)	1
DISC1	6	SYNE1	26	affinity chromatography technology, two hybrid, two hybrid	Morris JA (2003), Morris JA (2003), Camargo LM (2007)	3
TNIK	4	TIAM2	1	two hybrid	Camargo LM (2007)	1
SMURF1	4	TNIK	4	enzymatic study	Andrews PS (2010)	1
TNIK	4	SYNE1	26	two hybrid	Camargo LM (2007)	1
DISC1	6	SMARCE1	1	two hybrid	Camargo LM (2007)	1
TMEM17	0	TNIK	4	bioid	Gupta GD (2015)	1
EGFR	5	CLU	1	affinity chromatography technology	Tong J (2014)	1
TNIK	4	IKBKB	1	affinity chromatography technology	Shkoda A (2012)	1
XPO1	8	CLU	1	affinity chromatography technology	Leskov KS (2011)	1
TRAF2	1	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ishitani T (2003), Ishitani T (2003), Hong S (2007), Tan B (2015)	4
TNIK	4	TRIM2	1	two hybrid	Camargo LM (2007)	1
TRAF6	0	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Ishitani T (2003), Takaesu G (2000), Ninomiya-Tsuji J (1999), Takaesu G (2001), Mochida Y (2000), Mochida Y (2000), Walsh MC (2008), Sorrentino A (2008), Frobose H (2006), Ishitani T (2003), Xia ZP (2009), Jiang Z (2003), Jiang Z (2003), Yamazaki K (2009), Yamazaki K (2009), Jiang Z (2002), Jiang Z (2002), Cui W (2012), Jiang Z (2003), Minoda Y (2009), Gao D (2009), Lee HJ (2012), Hirata Y (2006), Hu MM (2014), Fujikawa H (2013), Sun D (2011), Li W (2015), Lin J (2015), Lee Y (2016), Ji YX (2016), Ji YX (2016), Ji YX (2016), Ji YX (2016)	33
TRAF2	1	TRAF6	0	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology	Rual JF (2005), Li S (2011), Davies CC (2005), Relaix F (1998), Rolland T (2014), Yu H (2011), Huttlin EL (2017)	7
XPO1	8	SMARCE1	1	affinity chromatography technology	Kirli K (2015)	1
TNIK	4	TRAF6	0	affinity chromatography technology	Shkoda A (2012)	1
TAB2	5	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ishitani T (2003), Takaesu G (2000), Takaesu G (2000), Takaesu G (2001), Takaesu G (2001), Walsh MC (2008), Ma Q (2008), Windheim M (2008), Xia ZP (2009), Jiang Z (2003), Kanayama A (2004), Kanayama A (2004), Yokota S (2008), Jiang Z (2002), Jiang Z (2002), Jiang Z (2003), Wang J (2011), Yong Kim S (2013), Jeon J (2014), Fujikawa H (2013)	20
TNIK	4	TRAF2	1	affinity chromatography technology	Fu CA (1999)	1
DISC1	6	PAFAH1B1	3	two hybrid	Camargo LM (2007)	1
DISC1	6	MACF1	12	two hybrid	Camargo LM (2007)	1
DISC1	6	DPYSL3	1	two hybrid	Camargo LM (2007)	1
TNIK	4	PPP1R13B	9	two hybrid	Camargo LM (2007)	1
DISC1	6	DST	13	two hybrid	Camargo LM (2007)	1
DISC1	6	TNKS	12	two hybrid	Camargo LM (2007)	1
CEP63	2	PPP1R13B	9	two hybrid	Camargo LM (2007)	1
DISC1	6	SRGAP3	8	two hybrid	Camargo LM (2007)	1
XPO1	8	AGTPBP1	4	affinity chromatography technology	Kirli K (2015)	1
XPO1	8	MAP3K7	2	affinity chromatography technology	Kirli K (2015)	1
CEP63	2	GSE1	14	two hybrid	Camargo LM (2007)	1
CEP63	2	DST	13	two hybrid	Camargo LM (2007)	1
SOS1	5	EGFR	5	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Qian X (2000), Qian X (1998), Buday L (1994), Tong J (2009), Kurada BR (2009), Tong J (2008), Foerster S (2013), Tong J (2014), Kapoor GS (2010)	9
TNIK	4	GSE1	14	two hybrid	Camargo LM (2007)	1
TRAF2	1	IKBKB	1	pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Devin A (2001), Li S (2009), Li S (2009), Li HY (2008), Shen RR (2012), Shen RR (2012), Zhang W (2010), Chen TC (2014), Mei ZZ (2016)	9
NEDD4	2	TNIK	4	pull down, pull down, affinity chromatography technology	Kawabe H (2010), Wang L (2017), Wang L (2017)	3
KBTBD7	3	TNIK	4	affinity chromatography technology	Huttlin EL (2017)	1
UBE2A	0	TNIK	4	affinity chromatography technology	An H (2017)	1
TNIK	4	SMARCE1	1	two hybrid	Camargo LM (2007)	1
SMURF1	4	SPTBN1	6	affinity chromatography technology	Xie Y (2013)	1
TNIK	4	DPYSL2	3	two hybrid	Camargo LM (2007)	1
DISC1	6	TUBB2A	2	two hybrid	Camargo LM (2007)	1
TNIK	4	NEFM	0	two hybrid	Camargo LM (2007)	1
PAFAH1B1	3	DYNC1H1	41	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Tai CY (2002), Tai CY (2002), Tai CY (2002), Ding C (2009), Yamada M (2008), Caspi M (2003), Wan C (2015), Hein MY (2015), Boldt K (2016)	9
TNIK	4	DST	13	two hybrid	Camargo LM (2007)	1
DISC1	6	CLU	1	two hybrid	Camargo LM (2007)	1
IL20RA	2	TNIK	4	affinity chromatography technology	Huttlin EL (2017)	1
TNIK	4	TNKS	12	two hybrid	Camargo LM (2007)	1
TNIK	4	ACTG1	5	two hybrid	Camargo LM (2007)	1
TRAF2	1	ACTG1	5	imaging technique	Chen TC (2014)	1
EGFR	5	TRAF2	1	affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Tong J (2008), Puliyappadamba VT (2013), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	5
TNIK	4	SOS1	5	two hybrid	Camargo LM (2007)	1
TNIK	4	TUBB2A	2	two hybrid	Camargo LM (2007)	1
EGFR	5	XPO1	8	affinity chromatography technology	Foerster S (2013)	1
TNIK	4	MACF1	12	two hybrid	Camargo LM (2007)	1
EGFR	5	AGTPBP1	4	affinity chromatography technology	Yao Z (2017)	1
CEP63	2	SYNE1	26	two hybrid	Camargo LM (2007)	1
DISC1	6	NEFM	0	two hybrid	Camargo LM (2007)	1
PDE4DIP	10	AKAP9	13	affinity chromatography technology	Huttlin EL (2017)	1
EGFR	5	KBTBD7	3	affinity chromatography technology	Yao Z (2017)	1
CEP63	2	SPTBN1	6	two hybrid	Camargo LM (2007)	1
DISC1	6	TIAM2	1	two hybrid	Camargo LM (2007)	1
CEP63	2	NCOR2	12	two hybrid	Camargo LM (2007)	1
TNIK	4	CLU	1	two hybrid	Camargo LM (2007)	1
TNIK	4	HARS	0	two hybrid	Camargo LM (2007)	1
TNIK	4	PDE4DIP	10	two hybrid	Camargo LM (2007)	1
XPO1	8	TAB2	5	affinity chromatography technology	Kirli K (2015)	1
EGFR	5	TNIK	4	affinity chromatography technology	Yao Z (2017)	1
LTBR	0	TRAF2	1	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Marsters SA (1997), Sanjo H (2010), Sanjo H (2010), Li C (2003), Liu HP (2011), Huttlin EL (2015), Huttlin EL (2017)	7
DISC1	6	ACTG1	5	two hybrid	Camargo LM (2007)	1
TNIK	4	SNX6	1	two hybrid	Camargo LM (2007)	1
TRAF6	0	SMURF1	4	genetic interference	Li S (2010)	1
XPO1	8	TNKS	12	affinity chromatography technology	Kirli K (2015)	1
TNIK	4	AKAP9	13	two hybrid	Camargo LM (2007)	1
TNIK	4	AGTPBP1	4	two hybrid	Camargo LM (2007)	1
LTBR	0	TNIK	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MRPS11	1	TNIK	4	affinity chromatography technology	Huttlin EL (2017)	1
SMARCE1	1	CEP63	2	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
CEP63	2	TNIK	4	bioid	Firat-Karalar EN (2014)	1
TNIK	4	TAB2	5	affinity chromatography technology	Shkoda A (2012)	1
TAB2	5	IKBKB	1	enzymatic study	Niu J (2011)	1
TNIK	4	CNKSR2	5	two hybrid	Camargo LM (2007)	1
TRAF6	0	IKBKB	1	affinity chromatography technology	Bidere N (2006)	1
NCK2	2	SOS1	5	affinity chromatography technology	Braverman LE (1999)	1
TNIK	4	SPTBN1	6	two hybrid	Camargo LM (2007)	1
DISC1	6	CEP63	2	two hybrid, affinity chromatography technology, two hybrid	Morris JA (2003), Morris JA (2003), Camargo LM (2007)	3
XPO1	8	WWC1	5	affinity chromatography technology	Kirli K (2015)	1
TNIK	4	GOLGA4	6	two hybrid	Camargo LM (2007)	1
NEDD4	2	EGFR	5	enzymatic study, pull down	Persaud A (2009), Persaud A (2009)	2
TNIK	4	PPM1E	4	two hybrid	Camargo LM (2007)	1