PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
KIAA0368	0	KDM2A	4	affinity chromatography technology	Gorbea C (2010)	1
ATM	9	SMAD7	1	affinity chromatography technology	Zhang S (2006)	1
SMAD7	1	KDM2A	4	two hybrid	Colland F (2004)	1
ATM	9	E2F1	0	enzymatic study	Lin WC (2001)	1
KDM2A	4	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Watanabe N (2004), Busino L (2007), Hauri S (2016)	3
TRIM25	5	RANGAP1	4	affinity chromatography technology	Choudhury NR (2017)	1
HNRNPL	3	REEP5	1	affinity chromatography technology	Fei T (2017)	1
RAB5C	2	KDM2A	4	affinity chromatography technology	Hein MY (2015)	1
KDM2A	4	HIST3H3	0	enzymatic study	Tsukada Y (2006)	1
E2F1	0	UHRF2	1	affinity chromatography technology, affinity chromatography technology	Lu H (2013), Lu H (2013)	2
KDM2A	4	E2F1	0	pull down, affinity chromatography technology	Rizwani W (2014), Rizwani W (2014)	2
TRIM25	5	ELAVL1	0	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
KDM2A	4	UBE2G2	0	two hybrid	Wang J (2011)	1
ELAVL1	0	KDM2A	4	affinity chromatography technology	Abdelmohsen K (2009)	1
FOS	0	KDM2A	4	two hybrid	Bandyopadhyay S (2010)	1
BCL6	6	KDM2A	4	affinity chromatography technology	Miles RR (2005)	1
8339	0	PPP1R2	2	bioid	Lambert JP (2015)	1
SMAD7	1	SMAD3	1	genetic interference, genetic interference, affinity chromatography technology, protein complementation assay	Datta PK (2000), Lebrun JJ (1999), Yan X (2016), Yan X (2016)	4
HNRNPL	3	KDM2A	4	affinity chromatography technology	Fei T (2017)	1
8339	0	KDM2A	4	bioid	Lambert JP (2015)	1
KDM2A	4	STAG2	6	biochemical	Wan C (2015)	1
CBX4	1	RB1	2	genetic interference, affinity chromatography technology	Dahiya A (2001), Dahiya A (2001)	2
UHRF2	1	SKP1	0	far western blotting	Mori T (2011)	1
EED	1	HIST3H3	0	unspecified method, x-ray crystallography	Xu C (2010), Xu C (2010)	2
KRAS	1	UHRF2	1	genetic interference	Luo J (2009)	1
SMAD3	1	FOS	0	two hybrid, pull down, affinity chromatography technology	Zhang Y (1998), Zhang Y (1998), Lee SY (2011)	3
RELA	1	SMAD3	1	two hybrid	Wang J (2011)	1
REEP5	1	KDM2A	4	affinity chromatography technology	Hein MY (2015)	1
KDM2A	4	PPP1R2	2	biochemical	Wan C (2015)	1
CGB2	0	KDM2A	4	affinity chromatography technology	Huttlin EL (2017)	1
ATM	9	KDM2A	4	affinity chromatography technology, affinity chromatography technology	Cao LL (2016), Cao LL (2016)	2
8339	0	ZNF512B	2	bioid	Lambert JP (2015)	1
EED	1	CBX4	1	affinity chromatography technology	Cao Q (2014)	1
HNRNPL	3	STAG2	6	affinity chromatography technology	Fei T (2017)	1
ELAVL1	0	SKP1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
8339	0	MPG	3	bioid	Lambert JP (2015)	1
CBX4	1	HIST3H3	0	enzymatic study, unspecified method	Shi Y (2003), Vermeulen M (2010)	2
TRIM25	5	SMAD3	1	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	HNRNPL	3	affinity chromatography technology	Choudhury NR (2017)	1
ZNF512B	2	KDM2A	4	two hybrid	Colland F (2004)	1
ACTR1B	1	KDM2A	4	biochemical	Wan C (2015)	1
ELAVL1	0	ATM	9	affinity chromatography technology	Abdelmohsen K (2009)	1
KIF20B	3	KDM2A	4	affinity chromatography technology	Hein MY (2015)	1
UHRF2	1	EED	1	affinity chromatography technology	Lai M (2016)	1
KDM2A	4	RB1	2	pull down, affinity chromatography technology	Rizwani W (2014), Rizwani W (2014)	2
PSMB3	0	KDM2A	4	biochemical	Wan C (2015)	1
SKP1	0	PSMB3	0	affinity chromatography technology	Hauri S (2016)	1
TRIM25	5	UBE2G2	0	affinity chromatography technology	Choudhury NR (2017)	1
KRAS	1	KDM2A	4	genetic interference	Luo J (2009)	1
ATM	9	RELA	1	imaging technique	Fang L (2014)	1
UHRF2	1	KDM2A	4	affinity chromatography technology	Lai M (2016)	1
RBPJ	1	RANGAP1	4	affinity chromatography technology	Li X (2015)	1
EED	1	KDM2A	4	affinity chromatography technology	Cao Q (2014)	1
ELAVL1	0	HNRNPL	3	affinity chromatography technology	Abdelmohsen K (2009)	1
MPG	3	KDM2A	4	affinity chromatography technology	Liang C (2013)	1
RANGAP1	4	KDM2A	4	biochemical	Wan C (2015)	1
UHRF2	1	RB1	2	far western blotting, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Mori T (2011), Mori T (2011), Mori T (2011), Mori T (2011), Lai M (2016)	5
ELAVL1	0	KRAS	1	affinity chromatography technology	Abdelmohsen K (2009)	1
UHRF2	1	MPG	3	affinity chromatography technology, affinity chromatography technology	Liang C (2013), Liang C (2013)	2
UBE2G2	0	KIAA0368	0	two hybrid	Gorbea C (2010)	1
TRIM25	5	KDM2A	4	affinity chromatography technology	Choudhury NR (2017)	1
ELAVL1	0	KIF20B	3	affinity chromatography technology	Abdelmohsen K (2009)	1
EED	1	HNRNPL	3	affinity chromatography technology	Cao Q (2014)	1
SKP1	0	ARHGEF7	3	affinity chromatography technology	Hauri S (2016)	1
EED	1	SKP1	0	affinity chromatography technology	Cao Q (2014)	1
HIST3H3	0	HNRNPL	3	unspecified method	Vermeulen M (2010)	1
CBX4	1	KDM2A	4	affinity chromatography technology	Hein MY (2015)	1
HNRNPL	3	KIAA0368	0	affinity chromatography technology	Fei T (2017)	1
RELA	1	KDM2A	4	affinity chromatography technology, enzymatic study	Lu T (2010), Lu T (2010)	2
SMAD3	1	KDM2A	4	two hybrid	Colland F (2004)	1
RBPJ	1	KDM2A	4	affinity chromatography technology	Li X (2015)	1
ELAVL1	0	RBPJ	1	affinity chromatography technology	Abdelmohsen K (2009)	1
KDM2A	4	HIST2H3C	0	enzymatic study	Xu W (2011)	1
ARHGEF7	3	KDM2A	4	biochemical	Wan C (2015)	1
8339	0	CBX4	1	bioid	Lambert JP (2015)	1
CBX4	1	SKP1	0	affinity chromatography technology	Hauri S (2016)	1
ELAVL1	0	PPP1R2	2	affinity chromatography technology	Abdelmohsen K (2009)	1
RELA	1	FOS	0	two hybrid, genetic interference	Yang X (1999), Yang X (1999)	2
RB1	2	E2F1	0	affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology, pull down, affinity chromatography technology, x-ray crystallography, pull down, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Nicolas E (2001), Pardo PS (2002), Choubey D (1996), Fajas L (2000), Dyson N (1993), Dyson N (1993), Wu CL (1995), Taniura H (1998), Dai Y (2003), Fedele M (2006), Fedele M (2006), Brown VD (2002), De Blasio A (2005), Chau CM (2008), Dasgupta P (2004), Yang L (2011), Kruetzfeldt M (2005), Harbour JW (1999), Lee SJ (1998), Gao D (2009), Delston RB (2011), Gupta K (2000), Sdek P (2004), Flemington EK (1993), Chang YH (2012), Inoue Y (2007), Inoue Y (2007), Inoue Y (2007), Liu X (2006), Moberg K (1996), Knudsen ES (1996), Brown VD (1999), Brown VD (1999), Whitaker LL (1998), Whitaker LL (1998), Hagemeier C (1993), Bhat UG (1999), Xiao B (2003), Xiao B (2003), Vidal M (1996), Markham D (2006), Markham D (2006), Ianari A (2009), Ianari A (2009), Dhillon NK (2002), Knudsen ES (1997), Knudsen ES (1997), Gery S (2004), Gery S (2004), Kashuba E (2008), Kashuba E (2008), Pearson A (1997), Ginsberg D (1994), Welch PJ (1995), Wang J (2009), Aoki I (2012), Trimarchi JM (1998), Kumari A (2015), Gamell C (2017), Chen TT (2000), Chen TT (2000), Chen TT (2000), Chen TT (2000)	63
EED	1	ELAVL1	0	affinity chromatography technology	Cao Q (2014)	1
FOS	0	RB1	2	pull down	Nead MA (1998)	1