PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CTTN	1	DNM2	2	affinity chromatography technology	Hashimoto S (2006)	1
CDH1	4	TRIM25	5	bioid	Guo Z (2014)	1
TRIM25	5	SHANK2	8	affinity chromatography technology	Choudhury NR (2017)	1
DLG4	11	DLGAP4	4	two hybrid	Takeuchi M (1997)	1
DYNLL1	0	MYO5A	17	pull down, pull down, affinity chromatography technology, two hybrid	Naisbitt S (2000), Naisbitt S (2000), Naisbitt S (2000), Lo KW (2001)	4
DLGAP1	6	DYNLL2	0	two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Naisbitt S (2000), Naisbitt S (2000), Naisbitt S (2000), Naisbitt S (2000), Naisbitt S (2000), Naisbitt S (2000)	6
TRIM25	5	DLGAP4	4	affinity chromatography technology	Choudhury NR (2017)	1
DLG4	11	DLGAP3	2	two hybrid	Takeuchi M (1997)	1
SHANK2	8	DYNLL1	0	affinity chromatography technology	Naisbitt S (2000)	1
EGFR	5	ARHGEF7	3	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
HNRNPL	3	EGFR	5	affinity chromatography technology	Fei T (2017)	1
EGFR	5	DNM2	2	affinity chromatography technology	Tong J (2014)	1
CDH1	4	CTTN	1	bioid	Guo Z (2014)	1
SHANK2	8	DLGAP3	2	two hybrid	Boeckers TM (1999)	1
TRIM25	5	MYO5A	17	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	HNRNPL	3	affinity chromatography technology	Choudhury NR (2017)	1
HNRNPL	3	NLK	1	affinity chromatography technology	Fei T (2017)	1
SHANK2	8	DYNLL2	0	affinity chromatography technology	Naisbitt S (2000)	1
DYNLL2	0	DLG4	11	pull down, affinity chromatography technology	Naisbitt S (2000), Naisbitt S (2000)	2
DLGAP1	6	MYO5A	17	pull down	Naisbitt S (2000)	1
HNRNPL	3	SHANK2	8	affinity chromatography technology	Fei T (2017)	1
TRIM25	5	XPO1	8	affinity chromatography technology	Choudhury NR (2017)	1
CDH1	4	EGFR	5	affinity chromatography technology, two hybrid, imaging technique, protein complementation assay, affinity chromatography technology, bioid	Pece S (2000), Kotlyar M (2015), Chen TC (2014), Petschnigg J (2014), Li J (2013), Guo Z (2014)	6
DLGAP1	6	DLG4	11	affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, far western blotting, affinity chromatography technology, affinity chromatography technology	Naisbitt S (2000), Takeuchi M (1997), Takeuchi M (1997), Satoh K (1997), Satoh K (1997), Boeckers TM (1999), Wu H (2000), Kim E (1997), Kim E (1997), Kim E (1997), Kim E (1997)	11
SHANK2	8	SHARPIN	1	unspecified method	Mameza MG (2013)	1
SHANK2	8	DLGAP4	4	two hybrid	Boeckers TM (1999)	1
EGFR	5	CTTN	1	affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Tong J (2014), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	4
DLGAP1	6	DYNLL1	0	two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid	Naisbitt S (2000), Naisbitt S (2000), Naisbitt S (2000), Naisbitt S (2000), Naisbitt S (2000), Lo KW (2001)	6
EGFR	5	XPO1	8	affinity chromatography technology	Foerster S (2013)	1
NLK	1	SHANK2	8	affinity chromatography technology	Varjosalo M (2013)	1
DNM2	2	SHANK2	8	two hybrid, affinity chromatography technology, pull down	Okamoto PM (2001), Okamoto PM (2001), Okamoto PM (2001)	3
SHANK2	8	DLGAP2	4	two hybrid	Boeckers TM (1999)	1
SHANK2	8	DLG4	11	affinity chromatography technology, affinity chromatography technology	Naisbitt S (2000), Boeckers TM (1999)	2
HNRNPL	3	MYO5A	17	affinity chromatography technology	Fei T (2017)	1
CDH1	4	SHANK2	8	bioid	Guo Z (2014)	1
DYNLL1	0	DYNLL2	0	biochemical, affinity chromatography technology	Wan C (2015), Boldt K (2016)	2
DLGAP1	6	SHANK2	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Naisbitt S (2000), Naisbitt S (2000), Boeckers TM (1999), Boeckers TM (1999), Boeckers TM (1999)	5
SHANK2	8	MYO5A	17	affinity chromatography technology	Naisbitt S (2000)	1
EGFR	5	SHANK2	8	affinity chromatography technology	Yao Z (2017)	1
DYNLL1	0	DLG4	11	pull down, affinity chromatography technology	Naisbitt S (2000), Naisbitt S (2000)	2
SHANK2	8	CTTN	1	two hybrid, affinity chromatography technology	Du Y (1998), Du Y (1998)	2
DYNLL2	0	MYO5A	17	two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Naisbitt S (2000), Naisbitt S (2000), Naisbitt S (2000), Naisbitt S (2000), Puthalakath H (2001)	5
TRIM25	5	DNM2	2	affinity chromatography technology	Choudhury NR (2017)	1
ARHGEF7	3	SHANK2	8	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Park E (2003), Park E (2003), Park E (2003), Park E (2003)	4
DLG4	11	DLGAP2	4	two hybrid, pull down	Takeuchi M (1997), Takeuchi M (1997)	2
XPO1	8	SHANK2	8	affinity chromatography technology	Kirli K (2015)	1