PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ELL	4	SIRT2	1	affinity chromatography technology	Ewing RM (2007)	1
ACLY	3	SIRT2	1	affinity chromatography technology	Lin R (2013)	1
BTRC	1	SIRT2	1	bioid	Coyaud E (2015)	1
SIRT2	1	VAMP7	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SIRT2	1	HIST1H3A	3	enzymatic study, enzymatic study	Liu B (2009), Das C (2009)	2
RUNX3	1	EP300	36	affinity chromatography technology, affinity chromatography technology	Jin YH (2004), Jin YH (2004)	2
NUDT21	0	SIRT2	1	affinity chromatography technology	Shimazu T (2007)	1
PLA2G4A	1	SIRT2	1	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Movahedi Naini S (2015), Movahedi Naini S (2015), Movahedi Naini S (2015), Movahedi Naini S (2015)	4
MDM2	2	SIRT1	3	affinity chromatography technology, enzymatic study, affinity chromatography technology	Nihira NT (2017), Nihira NT (2017), Nihira NT (2017)	3
RBP1	1	SIRT2	1	affinity chromatography technology	Binda O (2008)	1
SIRT2	1	SCFD2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FBF1	2	SCLT1	1	bioid	Gupta GD (2015)	1
RAB3GAP1	5	RAB3GAP2	7	biochemical, affinity chromatography technology, biochemical	Kristensen AR (2012), Baron Y (2014), Wan C (2015)	3
PPP1CB	9	GYS1	1	affinity chromatography technology	Yadav L (2017)	1
ING1	2	RBP1	1	affinity chromatography technology, affinity chromatography technology	Skowyra D (2001), Nikolaev AY (2004)	2
XPO1	8	DNAJB6	3	affinity chromatography technology	Kirli K (2015)	1
CDK2	0	PPP1CB	9	affinity chromatography technology	Hein MY (2015)	1
XPO1	8	FOXO1	2	affinity chromatography technology	Kirli K (2015)	1
SIRT2	1	CDC20	1	enzymatic study	Kim HS (2011)	1
DNAJB8	0	SIRT2	1	affinity chromatography technology, affinity chromatography technology	Hageman J (2010), Hageman J (2010)	2
GCKR	1	EP300	36	affinity chromatography technology, affinity chromatography technology, enzymatic study	Park JM (2015), Park JM (2015), Park JM (2015)	3
XPO1	8	CDC20	1	affinity chromatography technology	Kirli K (2015)	1
HDAC6	0	SIRT2	1	affinity chromatography technology	Nahhas F (2007)	1
SCLT1	1	SIRT2	1	bioid	Gupta GD (2015)	1
FBF1	2	CBL	7	bioid	Gupta GD (2015)	1
RTN4	4	SPOP	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HDAC6	0	XPO1	8	affinity chromatography technology, affinity chromatography technology	Riolo MT (2012), Kirli K (2015)	2
CDK2	0	CDC20	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), So J (2015), Craney A (2016), Huttlin EL (2017)	4
XPO1	8	SARS	4	affinity chromatography technology	Kirli K (2015)	1
EP300	36	PCK1	1	affinity chromatography technology, affinity chromatography technology	Jiang W (2011), Bian XL (2017)	2
SNAI1	1	HIST1H3A	3	affinity chromatography technology	Lin Y (2010)	1
RPGRIP1L	2	SIRT2	1	bioid	Gupta GD (2015)	1
CDC20	1	TUBA4A	1	affinity chromatography technology	Fogeron ML (2013)	1
SIRT1	3	HIST1H3A	3	enzymatic study	Das C (2009)	1
HDAC6	0	ARHGDIA	3	enzymatic study	Kuhlmann N (2016)	1
SIRT2	1	RUNX3	1	affinity chromatography technology, affinity chromatography technology	Kim WJ (2011), Kim WJ (2011)	2
EP300	36	SKP2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Kitagawa M (2008), Inuzuka H (2012), Inuzuka H (2012), Oh M (2016)	4
CDC20	1	EP300	36	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Turnell AS (2005), Turnell AS (2005), Huttlin EL (2017)	3
BTRC	1	MTDH	1	affinity chromatography technology	Shimizu K (2017)	1
SNAI1	1	MDM2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lim SO (2011), Lim SO (2010), Lim SO (2010)	3
PAPOLA	5	PPP1CB	9	biochemical	Havugimana PC (2012)	1
BTRC	1	MDM2	2	affinity chromatography technology, affinity chromatography technology, pull down	Inuzuka H (2010), Inuzuka H (2010), Inuzuka H (2010)	3
SIRT2	1	RAB3GAP2	7	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SARS	4	PAPOLA	5	biochemical	Wan C (2015)	1
GCKR	1	SIRT2	1	affinity chromatography technology	Park JM (2015)	1
SIRT2	1	EP300	36	enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study	Black JC (2008), Han Y (2008), Han Y (2008), Han Y (2008), Delvecchio M (2013)	5
EP300	36	HDAC6	0	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down	Han Y (2009), Han Y (2009), Liu Y (2012), Kirilyuk A (2012), Girdwood D (2003)	5
SIRT2	1	ORC2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FBF1	2	SIRT2	1	bioid	Gupta GD (2015)	1
EP300	36	FOXO1	2	enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Brent MM (2008), Perrot V (2005), Perrot V (2005), Perrot V (2005), Perrot V (2005), Pramanik KC (2014), Pramanik KC (2014), Mahmud DL (2002), Li X (2015)	9
SNAI1	1	SIRT2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CDK2	0	ARHGDIA	3	affinity chromatography technology	Neganova I (2011)	1
PLA2G4A	1	CDK2	0	affinity chromatography technology	Movahedi Naini S (2015)	1
CDK2	0	SARS	4	affinity chromatography technology	Neganova I (2011)	1
SKP2	2	CDK2	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Marti A (1999), Yam CH (1999), Calvisi DF (2009), Gao D (2009), Bashir T (2010), Yao ZP (2006), Rosner M (2009), Lyapina SA (1998), Zhang H (1995), Zhang H (1995), Inuzuka H (2012), Varjosalo M (2013), Varjosalo M (2013), So J (2015), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	17
CDK2	0	PHB2	1	affinity chromatography technology, affinity chromatography technology	Neganova I (2011), So J (2015)	2
SIRT2	1	FZR1	1	enzymatic study	Kim HS (2011)	1
CBL	7	SIRT2	1	affinity chromatography technology	Choi YH (2014)	1
CDK2	0	ORC2	0	enzymatic study, pull down	Mendez J (2002), Ramachandran N (2004)	2
MANSC1	4	SIRT2	1	affinity chromatography technology	Huttlin EL (2017)	1
SIRT2	1	RAB3GAP1	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DNAJB6	3	HDAC6	0	affinity chromatography technology, affinity chromatography technology	Hageman J (2010), Hageman J (2010)	2
KIAA0930	0	SIRT2	1	affinity chromatography technology	Huttlin EL (2017)	1
SIRT2	1	DEGS1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EP300	36	BTRC	1	affinity chromatography technology, affinity chromatography technology	Kimbrel EA (2009), Kimbrel EA (2009)	2
CBL	7	CBLB	3	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Rorsman C (2016)	2
GSTT2B	0	SIRT2	1	affinity chromatography technology	Huttlin EL (2017)	1
SNAI1	1	EP300	36	affinity chromatography technology	Hsu DS (2014)	1
DNAJB8	0	HDAC6	0	affinity chromatography technology, affinity chromatography technology	Hageman J (2010), Hageman J (2010)	2
PAPOLA	5	SIRT2	1	affinity chromatography technology	Shimazu T (2007)	1
FOXO1	2	SIRT2	1	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology	Daitoku H (2004), Daitoku H (2004), Daitoku H (2004), Zhao Y (2010), Pramanik KC (2014)	5
FOXO1	2	SIRT1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kitamura YI (2005), Bastien-Dionne PO (2011), Yang Y (2005), Yang Y (2005)	4
FZR1	1	CDC20	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down	Stewart S (2005), Stewart S (2005), Wang Y (2007), Wang Y (2007), Tian W (2012), Hyun SY (2013), Hyun SY (2013)	7
HIST1H3A	3	HDAC6	0	pull down	Li X (2014)	1
ODF2	1	SIRT2	1	bioid	Gupta GD (2015)	1
PHB2	1	RUNX3	1	affinity chromatography technology	Ewing RM (2007)	1
EP300	36	HIST1H3A	3	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study	Liu B (2009), Brackertz M (2006), Faiola F (2005), Daujat S (2002), Kalkhoven E (2002), Seo SB (2002), Kim JH (2005), Bordoli L (2001), Kim MY (2001), Kutney SN (2004), Wang F (2010), Loven MA (2004), Kiernan RE (1999), Wong K (2005), Ogryzko VV (1996), Yamaguchi Y (2004), Furumatsu T (2005), An W (2002), Delvecchio M (2013), Delvecchio M (2013), Tropberger P (2013), Das C (2009), Shimura M (2011), Ji A (2003), Fu M (2005), Suganuma T (2002), Tang Z (2013), Kim JH (2006), Lopes da Rosa J (2013), Li X (2014), Wang YL (2008), Du C (2017), Yi P (2017), Wan W (2017)	34
SIRT2	1	GYS1	1	affinity chromatography technology	Ewing RM (2007)	1
SIRT2	1	MDM2	2	enzymatic study	Nihira NT (2017)	1
RUNX3	1	MDM2	2	affinity chromatography technology	Chi XZ (2009)	1
EP300	36	ING1	2	affinity chromatography technology	Vieyra D (2002)	1
TINF2	1	ARHGDIA	3	two hybrid	Lee OH (2011)	1
2952	0	SIRT2	1	affinity chromatography technology	Huttlin EL (2017)	1
SIRT2	1	TRAPPC12	4	affinity chromatography technology	Huttlin EL (2015)	1
NUDT12	0	SIRT2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NUDT21	0	SIRT1	3	affinity chromatography technology	Shimazu T (2007)	1
SIRT2	1	MTDH	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PAPOLA	5	SIRT1	3	affinity chromatography technology	Shimazu T (2007)	1
XPO1	8	GYS1	1	affinity chromatography technology	Kirli K (2015)	1
SIRT2	1	TUBA4A	1	enzymatic study	North BJ (2003)	1
SIRT1	3	RBP1	1	affinity chromatography technology	Binda O (2008)	1
XPO1	8	TUBA4A	1	affinity chromatography technology	Kirli K (2015)	1
RAD51	3	SIRT2	1	two hybrid	Arroyo R (2015)	1
CBLB	3	SIRT2	1	affinity chromatography technology	Choi YH (2014)	1
CEP89	2	SIRT2	1	bioid	Gupta GD (2015)	1
EP300	36	SIRT1	3	affinity chromatography technology, affinity chromatography technology	Bouras T (2005), Bourguignon LY (2009)	2
TINF2	1	SARS	4	two hybrid	Lee OH (2011)	1
XPO1	8	DMD	6	affinity chromatography technology	Kirli K (2015)	1
SIRT2	1	FADS1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
XPO1	8	CBL	7	affinity chromatography technology	Kirli K (2015)	1
SIRT1	3	ING1	2	affinity chromatography technology	Binda O (2008)	1
PPP1CB	9	SIRT2	1	affinity chromatography technology	Hein MY (2015)	1
EP300	36	ARHGDIA	3	enzymatic study	Kuhlmann N (2016)	1
MDM2	2	XPO1	8	affinity chromatography technology	Jacob AG (2014)	1
CDC20	1	HDAC6	0	affinity chromatography technology	Kim AH (2009)	1
SIRT2	1	RTN4	4	affinity chromatography technology	Ewing RM (2007)	1
FOXO1	2	MDM2	2	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	Fu W (2009), Fu W (2009), Fu W (2009), Fu W (2009), Jang H (2016)	5
ING1	2	SIRT2	1	affinity chromatography technology, affinity chromatography technology	Kataoka H (2003), Kataoka H (2003)	2
SKP2	2	BTRC	1	affinity chromatography technology, pull down, affinity chromatography technology	Wei S (2012), Wei S (2012), Wei S (2012)	3
PCK1	1	SIRT2	1	affinity chromatography technology	Jiang W (2011)	1
SKP2	2	FZR1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology	Calvisi DF (2009), Cen B (2010), Bashir T (2004), Bashir T (2004), Hu D (2011), Fukushima H (2013), Gao D (2009), Gao D (2009), Inuzuka H (2012), Inuzuka H (2012), Inuzuka H (2012), Huttlin EL (2017)	12
MOAP1	0	SIRT2	1	affinity chromatography technology	Huttlin EL (2017)	1
SLC22A23	7	SIRT2	1	affinity chromatography technology	Huttlin EL (2017)	1
TINF2	1	SIRT2	1	affinity chromatography technology	Hein MY (2015)	1
SIRT2	1	KRT78	1	affinity chromatography technology	Ewing RM (2007)	1
SPOP	1	CDC20	1	affinity chromatography technology, pull down	Wu F (2017), Wu F (2017)	2
XPO1	8	SIRT2	1	unspecified method, affinity chromatography technology	Xu D (2012), Kirli K (2015)	2
BTRC	1	FZR1	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Fukushima H (2013), Fukushima H (2013), Fukushima H (2013)	3
SPOP	1	SIRT2	1	affinity chromatography technology	Ewing RM (2007)	1
FZR1	1	MOAP1	0	affinity chromatography technology, pull down, enzymatic study	Huang NJ (2012), Huang NJ (2012), Huang NJ (2012)	3
EP300	36	ORC2	0	pull down	Karmakar S (2010)	1
SIRT2	1	SARS	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Huttlin EL (2015), Huttlin EL (2017)	3
PAPOLA	5	NUDT21	0	affinity chromatography technology	Shimazu T (2007)	1
SNAI1	1	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yook JI (2005), Zhou BP (2004), Vinas-Castells R (2010), Wu Y (2009)	4
HIST1H3A	3	PPP1CB	9	affinity chromatography technology, pull down	Zhang H (2013), Zhang H (2013)	2
SIRT2	1	ARHGDIA	3	enzymatic study	Kuhlmann N (2016)	1
SKP2	2	CDC20	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cen B (2010), Bashir T (2004), Kelly A (2014), Craney A (2016), Huttlin EL (2017)	5
MTDH	1	EP300	36	affinity chromatography technology, affinity chromatography technology	Liu L (2017), Liu L (2017)	2
EP300	36	CDK2	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Felzien LK (1999), Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	4
DNAJB6	3	SIRT2	1	affinity chromatography technology, affinity chromatography technology	Hageman J (2010), Hageman J (2010)	2
SIRT2	1	GPAM	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CDK2	0	SIRT2	1	enzymatic study	Movahedi Naini S (2015)	1
SIRT2	1	PHB2	1	affinity chromatography technology	Ewing RM (2007)	1
CDK2	0	FZR1	1	enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology	Sorensen CS (2001), Fukushima H (2013), Lau AW (2013), Chang L (2015), Huttlin EL (2017)	5
DMD	6	SIRT2	1	affinity chromatography technology	Huttlin EL (2017)	1
FOXO1	2	SKP2	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huang H (2005), Huang H (2005), Huang H (2005), Calvisi DF (2009), Park J (2018), Park J (2018)	6
AHI1	4	SIRT2	1	bioid	Gupta GD (2015)	1
SIRT1	3	SIRT2	1	affinity chromatography technology	Binda O (2008)	1
EP300	36	MDM2	2	pull down, affinity chromatography technology, biochemical, pull down, pull down, enzymatic study, affinity chromatography technology, biochemical, enzymatic study	Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Matt T (2004), Wang X (2004), Gillotin S (2010), Kobet E (2000), Nihira NT (2017)	9
CDC20	1	BTRC	1	affinity chromatography technology	Guardavaccaro D (2008)	1
SIRT2	1	SKP2	2	affinity chromatography technology	Li Z (2016)	1