PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HABP4	1	KAT5	1	two hybrid	Nery FC (2006)	1
SYNCRIP	6	SRSF1	0	biochemical	Havugimana PC (2012)	1
HABP4	1	PPP1R15A	2	two hybrid	Nery FC (2006)	1
TP53	0	PRMT1	3	pull down	An W (2004)	1
DAXX	5	TP53	0	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, unspecified method	Tang J (2006), Kim EJ (2003), Kim EJ (2003), Kim EJ (2003), Ohiro Y (2003), Ohiro Y (2003), Ohiro Y (2003), Ohiro Y (2003), Wethkamp N (2011), Zhao LY (2004), Zhao LY (2004), Zhao LY (2004), Gostissa M (2004), Gostissa M (2004), Gostissa M (2004), Gostissa M (2004), Gostissa M (2004), Zhao LY (2004), Zhao LY (2004), Zhang H (2013), Zhang H (2013), Chen TC (2014), Li Z (2017)	23
PRKCA	7	RACK1	2	affinity chromatography technology	Lee HS (2002)	1
CHD3	19	VIM	0	two hybrid	Goehler H (2004)	1
DAXX	5	PRMT1	3	two hybrid	Weimann M (2013)	1
YBX1	1	C1QBP	0	biochemical	Wan C (2015)	1
UBE2I	0	SRSF1	0	affinity chromatography technology	Pelisch F (2010)	1
PRMT1	3	VIM	0	affinity chromatography technology	Boldt K (2016)	1
HABP4	1	VIM	0	two hybrid	Stelzl U (2005)	1
UBE2I	0	NONO	3	enzymatic study	Matafora V (2009)	1
RACK1	2	SYNCRIP	6	biochemical	Kristensen AR (2012)	1
ENO2	1	HABP4	1	two hybrid	Stelzl U (2005)	1
YBX1	1	SRSF9	1	two hybrid, affinity chromatography technology	Raffetseder U (2003), Raffetseder U (2003)	2
UBE2I	0	PIAS3	2	two hybrid, two hybrid	Bandyopadhyay S (2010), Wang J (2011)	2
TOPORS	6	NONO	3	affinity chromatography technology	Pungaliya P (2007)	1
TOPORS	6	UBE2I	0	two hybrid, pull down	Weger S (2003), Weger S (2005)	2
CHD3	19	HABP4	1	pull down, two hybrid, two hybrid	Lemos TA (2003), Stelzl U (2005), Nery FC (2006)	3
YBX1	1	TP53	0	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kojic S (2004), Okamoto T (2000), Okamoto T (2000), Tian B (2011), Fogeron ML (2013), Horikawa I (2014)	6
HABP4	1	SRSF9	1	affinity chromatography technology, affinity chromatography technology, pull down, two hybrid	Bressan GC (2009), Bressan GC (2009), Bressan GC (2009), Bressan GC (2009)	4
HABP4	1	SYNCRIP	6	affinity chromatography technology, affinity chromatography technology, two hybrid	Bressan GC (2009), Bressan GC (2009), Bressan GC (2009)	3
HABP4	1	RACK1	2	two hybrid, two hybrid, pull down, two hybrid	Nery FC (2004), Nery FC (2004), Nery FC (2004), Nery FC (2006)	4
C1QBP	0	PRKCA	7	pull down, affinity chromatography technology	Storz P (2000), Storz P (2000)	2
TP53	0	KAT5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Legube G (2004), Tyteca S (2006), Tyteca S (2006), Kurash JK (2008), Cheng Z (2008), Cheng Z (2008), Cheng Z (2008), Tang Y (2006), Tang Y (2006), Tang Y (2006), Dai C (2013)	11
NONO	3	HABP4	1	biochemical	Wan C (2015)	1
C1QBP	0	SRSF9	1	far western blotting	Petersen-Mahrt SK (1999)	1
PRKCA	7	HABP4	1	enzymatic study	Nery FC (2004)	1
CRK	0	TP53	0	two hybrid	Grossmann A (2015)	1
CHMP5	0	HABP4	1	biochemical	Wan C (2015)	1
SYNCRIP	6	YBX1	1	biochemical, affinity chromatography technology	Havugimana PC (2012), Hein MY (2015)	2
HABP4	1	C1QBP	0	two hybrid, two hybrid	Nery FC (2006), Bressan GC (2009)	2
PRMT1	3	SYNCRIP	6	enzymatic study, affinity chromatography technology, two hybrid	Wada K (2002), Weimann M (2013), Weimann M (2013)	3
HABP4	1	TOPORS	6	two hybrid	Nery FC (2006)	1
TP53	0	HABP4	1	pull down, affinity chromatography technology, affinity chromatography technology	Nery FC (2006), Nery FC (2006), Nery FC (2006)	3
CHD3	19	TP53	0	two hybrid, two hybrid	Minty A (2000), Goehler H (2004)	2
HABP4	1	YBX1	1	two hybrid, two hybrid	Nery FC (2006), Bressan GC (2009)	2
KAT5	1	UBE2I	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cheng Z (2008), Cheng Z (2008), Cheng Z (2008)	3
UBE2I	0	DAXX	5	two hybrid, enzymatic study, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, two hybrid	Ryu SW (2000), Knipscheer P (2008), Hsieh YL (2013), Hsieh YL (2013), Hsieh YL (2013), Chang CC (2011), Lin DY (2006), Lin DY (2006)	8
HABP4	1	PRMT1	3	two hybrid, pull down	Stelzl U (2005), Stelzl U (2005)	2
TP53	0	VIM	0	affinity chromatography technology	Horikawa I (2014)	1
CRK	0	HABP4	1	two hybrid	Grossmann A (2015)	1
HABP4	1	UBE2I	0	two hybrid	Nery FC (2006)	1
TOPORS	6	TP53	0	two hybrid, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Weger S (2002), Rajendra R (2004), Pungaliya P (2007), Yao Z (2007), Yao Z (2007), Weger S (2005)	6
HABP4	1	PIAS3	2	two hybrid	Nery FC (2006)	1
HABP4	1	SRSF1	0	affinity chromatography technology	Bressan GC (2009)	1
SYNCRIP	6	HMGXB4	0	affinity chromatography technology	Hein MY (2015)	1
UBE2I	0	TP53	0	two hybrid, two hybrid, two hybrid, enzymatic study, two hybrid, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Minty A (2000), Gallagher WM (1999), Shen Z (1996), Bernier-Villamor V (2002), Wang J (2008), Spektor TM (2011), Jakobs A (2007), Mohideen F (2009), Lin JY (2004), Bennett RL (2012), Heo KS (2013), Morimoto M (2003), Rodriguez MS (1999), Muller S (2000), Fernandez-Lloris R (2006), Mohan RD (2007), Brandt M (2013), Weger S (2005)	18
UBE2I	0	CHD3	19	two hybrid	Lee BH (2003)	1
HABP4	1	DAXX	5	two hybrid	Nery FC (2006)	1
SRSF9	1	SRSF1	0	affinity chromatography technology, biochemical	Bressan GC (2009), Wan C (2015)	2
HABP4	1	HMGXB4	0	two hybrid	Nery FC (2006)	1
SRSF1	0	TP53	0	enzymatic study, affinity chromatography technology	Pelisch F (2010), Pelisch F (2010)	2
C1QBP	0	SRSF1	0	pull down	Petersen-Mahrt SK (1999)	1