PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SDCBP	0	MAPRE3	0	two hybrid	Rolland T (2014)	1
AURKB	2	MAPRE3	0	affinity chromatography technology, enzymatic study	Ban R (2009), Ban R (2009)	2
NUFIP1	0	MAPRE3	0	affinity chromatography technology	Huttlin EL (2017)	1
CKAP5	2	MAPRE1	0	biochemical	Wan C (2015)	1
MAPRE2	0	MAPRE1	0	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017), Boldt K (2016)	4
AURKA	1	MAPRE2	0	affinity chromatography technology, enzymatic study	Ban R (2009), Ban R (2009)	2
JUN	0	MAPRE3	0	pull down	Miyamoto-Sato E (2010)	1
PDE4DIP	10	MAPRE3	0	affinity chromatography technology	Huttlin EL (2017)	1
AURKB	2	MAPRE1	0	affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology	Ban R (2009), Sun L (2008), Sun L (2008), Sun L (2008), Sun L (2008)	5
GAS2L1	2	MAPRE1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	3
CALR	1	MAPRE3	0	biochemical	Wan C (2015)	1
DCTN1	6	MAPRE3	0	bioid	Gupta GD (2015)	1
MAPRE1	0	MAPRE3	0	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rolland T (2014), Xia P (2012), Huttlin EL (2015), Huttlin EL (2017), Boldt K (2016)	5
MAPRE2	0	MAPRE3	0	two hybrid	Rual JF (2005)	1
SDCBP	0	SIAH1	2	two hybrid	Rolland T (2014)	1
DCTN1	6	MAPRE1	0	bioid, affinity chromatography technology, affinity chromatography technology	Gupta GD (2015), Hein MY (2015), Boldt K (2016)	3
AURKB	2	AURKA	1	affinity chromatography technology	Fogeron ML (2013)	1
GAS2L1	2	MAPRE3	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
APPL2	4	MAPRE3	0	two hybrid, affinity chromatography technology	Grossmann A (2015), Grossmann A (2015)	2
MAPRE1	0	KIF2C	1	pull down, affinity chromatography technology, affinity chromatography technology	Xia P (2012), Hein MY (2015), Boldt K (2016)	3
DCTN1	6	KIF2C	1	bioid	Gupta GD (2015)	1
LMO2	2	MAPRE3	0	two hybrid, two hybrid, two hybrid	Rual JF (2005), Rolland T (2014), Yu H (2011)	3
AURKA	1	MAPRE3	0	affinity chromatography technology, enzymatic study	Ban R (2009), Ban R (2009)	2
DCTN1	6	MAPRE2	0	bioid	Gupta GD (2015)	1
MAPRE3	0	PTGES3	0	biochemical	Wan C (2015)	1
MAPRE3	0	TXN2	0	two hybrid	Rolland T (2014)	1
SDCBP	0	PDE4DIP	10	two hybrid	Rolland T (2014)	1
KIF2C	1	MAPRE3	0	affinity chromatography technology	Boldt K (2016)	1
MAPRE3	0	SIAH1	2	pull down, enzymatic study	Ban R (2009), Ban R (2009)	2
PDE4DIP	10	MAPRE1	0	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rolland T (2014), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	4
LMO2	2	MAPRE1	0	two hybrid	Rolland T (2014)	1
PTGES3	0	CALR	1	biochemical	Wan C (2015)	1
PSMB1	1	MAPRE3	0	two hybrid	Rolland T (2014)	1
DCTN1	6	AURKB	2	bioid	Gupta GD (2015)	1
CKAP5	2	MAPRE3	0	biochemical	Wan C (2015)	1
EIF4E2	2	MAPRE3	0	two hybrid	Rolland T (2014)	1
MAPRE1	0	KIF18B	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017), Boldt K (2016)	4
AURKB	2	MAPRE2	0	affinity chromatography technology, enzymatic study	Ban R (2009), Ban R (2009)	2
MAPRE2	0	TXN2	0	two hybrid	Rolland T (2014)	1
PSMA1	1	MAPRE1	0	two hybrid	Rolland T (2014)	1
PSMB1	1	MAPRE1	0	affinity chromatography technology	Boldt K (2016)	1
DOK4	3	MAPRE3	0	two hybrid	Grossmann A (2015)	1
TROAP	4	MAPRE3	0	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
PSMA1	1	MAPRE3	0	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
AURKA	1	KIF2C	1	enzymatic study	Zhang X (2008)	1
LMO2	2	MAPRE2	0	two hybrid, two hybrid, affinity chromatography technology	Rual JF (2005), Rolland T (2014), Huttlin EL (2017)	3
DGUOK	1	MAPRE3	0	affinity chromatography technology	Huttlin EL (2017)	1
PSMB1	1	MAPRE2	0	affinity chromatography technology	Boldt K (2016)	1
KIF18B	3	KIF2C	1	affinity chromatography technology	Boldt K (2016)	1
AURKA	1	MAPRE1	0	affinity chromatography technology	Ban R (2009)	1
HAX1	1	MAPRE3	0	affinity chromatography technology	Huttlin EL (2017)	1
PSMA1	1	PSMB1	1	biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	5
TROAP	4	MAPRE1	0	two hybrid, affinity chromatography technology	Rolland T (2014), Huttlin EL (2017)	2
AURKA	1	PSMA1	1	affinity chromatography technology	Fogeron ML (2013)	1
KIF18B	3	MAPRE3	0	affinity chromatography technology	Boldt K (2016)	1