PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
YWHAE	0	KPNB1	3	affinity chromatography technology	Zuo S (2010)	1
FAN1	2	ANKLE2	5	affinity chromatography technology	Hein MY (2015)	1
PMS1	3	RFC4	1	affinity chromatography technology	Cannavo E (2007)	1
FANCD2	3	FAN1	2	imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, imaging technique, affinity chromatography technology, affinity chromatography technology	Smogorzewska A (2010), Kratz K (2010), Kratz K (2010), MacKay C (2010), MacKay C (2010), MacKay C (2010), MacKay C (2010), Chaudhury I (2014), Unno J (2014)	9
FAN1	2	PCNA	0	affinity chromatography technology	MacKay C (2010)	1
FAN1	2	C1orf52	0	affinity chromatography technology	Hein MY (2015)	1
UBC	7	SSB	0	affinity chromatography technology	Matsumoto M (2005)	1
KPNB1	3	PLEKHA8	3	affinity chromatography technology	Hein MY (2015)	1
UBC	7	RFC3	0	affinity chromatography technology	Matsumoto M (2005)	1
PMS2	4	PCNA	0	affinity chromatography technology, far western blotting, pull down	Cannavo E (2007), Dzantiev L (2004), Genschel J (2017)	3
PMS2	4	KPNB1	3	affinity chromatography technology	Cannavo E (2007)	1
OTUD4	2	UBC	7	enzymatic study, enzymatic study, pull down, pull down	Mevissen TE (2013), Zhao Y (2015), Zhang X (2017), Kwasna D (2018)	4
FAN1	2	CAVIN2	3	affinity chromatography technology	Hein MY (2015)	1
FAN1	2	SSB	0	affinity chromatography technology	Li X (2016)	1
FAN1	2	PRPF4B	3	affinity chromatography technology	Hein MY (2015)	1
FAN1	2	PSMD11	0	affinity chromatography technology	Hein MY (2015)	1
FANCD2	3	BLM	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pichierri P (2004), Pichierri P (2004), Chaudhury I (2014)	3
FAN1	2	YWHAE	0	affinity chromatography technology	MacKay C (2010)	1
FAN1	2	WDR75	3	affinity chromatography technology	Hein MY (2015)	1
PCNA	0	RFC4	1	pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Cai J (1997), Ohta S (2002), Ohta S (2002), Havugimana PC (2012), Han J (2014), Hein MY (2015)	6
FAN1	2	KPNB1	3	affinity chromatography technology	MacKay C (2010)	1
PCNA	0	AKR7A2	1	affinity chromatography technology	Hein MY (2015)	1
MLH1	6	PCNA	0	far western blotting, pull down	Dzantiev L (2004), Genschel J (2017)	2
UBC	7	TRAP1	0	affinity chromatography technology	Matsumoto M (2005)	1
FAN1	2	93144	0	affinity chromatography technology	Li X (2016)	1
SSB	0	RBM34	0	biochemical	Wan C (2015)	1
UBC	7	AP2A2	3	pull down	Zhang X (2017)	1
MLH1	6	PPP2R1A	8	affinity chromatography technology	Cannavo E (2007)	1
FAN1	2	PIK3C2B	5	affinity chromatography technology	Hein MY (2015)	1
MLH1	6	PMS2	4	two hybrid, pull down, two hybrid, two hybrid, affinity chromatography technology, pull down, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, two hybrid, pull down, pull down, pull down, affinity chromatography technology	Mac Partlin M (2003), Mac Partlin M (2003), Kondo E (2001), Kondo E (2001), Kondo E (2001), Kondo E (2001), Guerrette S (1999), Dherin C (2009), Cannavo E (2007), Cannavo E (2007), Cannavo E (2007), Cannavo E (2007), Xie J (2010), Peng M (2007), Nielsen FC (2004), Matton N (2000), Plotz G (2003), Havugimana PC (2012), Brieger A (2010), Dzantiev L (2004), Jaeger AC (2001), Sacho EJ (2008), Hein MY (2015)	23
FANCD2	3	MLH1	6	affinity chromatography technology	Williams SA (2011)	1
FAN1	2	GADD45GIP1	0	affinity chromatography technology	Li X (2016)	1
FAN1	2	SUB1	0	affinity chromatography technology	Li X (2016)	1
HEXA	0	PCNA	0	biochemical	Kristensen AR (2012)	1
FAN1	2	FANCI	1	affinity chromatography technology, affinity chromatography technology, biochemical	MacKay C (2010), MacKay C (2010), MacKay C (2010)	3
FAN1	2	NOP16	2	affinity chromatography technology	Li X (2016)	1
FAN1	2	NUDT16	1	affinity chromatography technology	Li X (2016)	1
HSPBP1	0	ZNF703	0	affinity chromatography technology	Huttlin EL (2017)	1
FAN1	2	HEXA	0	affinity chromatography technology	Hein MY (2015)	1
FAN1	2	FANCG	3	affinity chromatography technology	MacKay C (2010)	1
FAN1	2	PPP2R1A	8	affinity chromatography technology	Hein MY (2015)	1
UBC	7	PSMD11	0	affinity chromatography technology, pull down	Matsumoto M (2005), Zhang X (2017)	2
FANCD2	3	FANCG	3	affinity chromatography technology	Wilson JB (2008)	1
PCNA	0	FANCD2	3	affinity chromatography technology, affinity chromatography technology, pull down, biochemical	Howlett NG (2009), Howlett NG (2009), Howlett NG (2009), Chen X (2016)	4
UBC	7	FANCD2	3	pull down, affinity chromatography technology	Rego MA (2012), Yamamoto KN (2011)	2
FAN1	2	AP2A2	3	affinity chromatography technology	Hein MY (2015)	1
FANCI	1	FANCD2	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, two hybrid, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down, imaging technique, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, pull down, pull down, affinity chromatography technology, two hybrid, two hybrid	Yuan F (2009), Ishiai M (2008), Sims AE (2007), Rego MA (2012), Longerich S (2014), Polito D (2014), Wang D (2016), Oka Y (2015), Oka Y (2015), Oka Y (2015), Oka Y (2015), Unno J (2014), Long DT (2011), Sato K (2014), Sato K (2014), Takahashi D (2014), Gwon GH (2014), Lossaint G (2013), Siddiqui MQ (2017), Inano S (2017)	20
YWHAZ	1	UBC	7	affinity chromatography technology	Jin J (2004)	1
MLH1	6	BLM	2	biochemical, pull down, two hybrid, far western blotting, affinity chromatography technology, far western blotting, two hybrid, affinity chromatography technology, far western blotting, two hybrid, unspecified method, affinity chromatography technology, affinity chromatography technology	Wang Y (2000), Langland G (2001), Langland G (2001), Langland G (2001), Langland G (2001), Freire R (2001), Pedrazzi G (2001), Pedrazzi G (2001), Pedrazzi G (2001), Dherin C (2009), Dherin C (2009), Meetei AR (2003), Meetei AR (2003)	13
FAN1	2	PLEKHA8	3	affinity chromatography technology	Hein MY (2015)	1
PMS2	4	FAN1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cannavo E (2007), Smogorzewska A (2010), Smogorzewska A (2010), Smogorzewska A (2010), MacKay C (2010), Hein MY (2015), Hein MY (2015), St-Denis N (2016)	8
FAN1	2	HSPBP1	0	affinity chromatography technology	Li X (2016)	1
FAN1	2	RPS19BP1	0	affinity chromatography technology	Li X (2016)	1
PMS1	3	MLH1	6	two hybrid, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Kondo E (2001), Cannavo E (2007), Cannavo E (2007), Mastrocola AS (2010), Matton N (2000), Hein MY (2015)	6
FAN1	2	RPL36AL	0	affinity chromatography technology	Li X (2016)	1
FAN1	2	NCOA5	1	affinity chromatography technology	Hein MY (2015)	1
RFC3	0	PCNA	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Merkle CJ (2003), Ohta S (2002), Han J (2014), Wan C (2015)	4
MLH1	6	UBC	7	affinity chromatography technology	Cannavo E (2007)	1
FAN1	2	FBLIM1	2	affinity chromatography technology	Li X (2016)	1
FAN1	2	SUPT5H	2	affinity chromatography technology	Hein MY (2015)	1
PPP2R1A	8	ANKLE2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Glatter T (2009), Fogeron ML (2013), Hein MY (2015), Boldt K (2016), Yadav L (2017), Yadav L (2017)	6
MLH1	6	KPNB1	3	affinity chromatography technology	Cannavo E (2007)	1
RBM34	0	RPL36AL	0	affinity chromatography technology	Huttlin EL (2017)	1
FAN1	2	OTUD4	2	affinity chromatography technology	St-Denis N (2016)	1
UBC	7	PPP2R1A	8	affinity chromatography technology	Matsumoto M (2005)	1
FAN1	2	AKR7A2	1	affinity chromatography technology	Hein MY (2015)	1
FAN1	2	H3F3C	0	affinity chromatography technology	Hein MY (2015)	1
FAN1	2	RBM34	0	affinity chromatography technology	Li X (2016)	1
FAN1	2	ANXA7	0	affinity chromatography technology	Hein MY (2015)	1
FAN1	2	TRAP1	0	affinity chromatography technology	Hein MY (2015)	1
YWHAZ	1	YWHAE	0	two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, two hybrid, biochemical, biochemical, affinity chromatography technology, pull down	Bandyopadhyay S (2010), Zippo A (2009), Zippo A (2009), Havugimana PC (2012), Gloeckner CJ (2007), Wang J (2011), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Gu YM (2006)	10
FAN1	2	MLH3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Smogorzewska A (2010), Smogorzewska A (2010), Smogorzewska A (2010)	3
MLH3	0	MLH1	6	two hybrid, pull down, two hybrid	Kondo E (2001), Ranjha L (2014), Daakour S (2016)	3
BLM	2	FAN1	2	affinity chromatography technology	Chaudhury I (2014)	1
FAN1	2	RFC4	1	affinity chromatography technology	MacKay C (2010)	1
RFC3	0	RFC4	1	affinity chromatography technology, pull down, biochemical, pull down, biochemical, affinity chromatography technology	Ellison V (1998), Uhlmann F (1996), Havugimana PC (2012), Uhlmann F (1997), Wan C (2015), Huttlin EL (2017)	6
FAN1	2	MIER1	2	affinity chromatography technology	Hein MY (2015)	1
UBC	7	PIK3C2B	5	pull down	Zhang X (2017)	1
SUB1	0	SUPT5H	2	biochemical	Wan C (2015)	1
FAN1	2	ZNF703	0	affinity chromatography technology	St-Denis N (2016)	1
PMS2	4	UBC	7	affinity chromatography technology, pull down	Cannavo E (2007), Zhang X (2017)	2
FAN1	2	YWHAZ	1	affinity chromatography technology	MacKay C (2010)	1
FANCG	3	BLM	2	affinity chromatography technology	Meetei AR (2003)	1
FAN1	2	UBC	7	affinity chromatography technology, pull down, pull down	MacKay C (2010), Shereda RD (2010), Shereda RD (2010)	3
MLH1	6	FAN1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Cannavo E (2007), Smogorzewska A (2010), Smogorzewska A (2010), Smogorzewska A (2010), MacKay C (2010), MacKay C (2010), MacKay C (2010), Hein MY (2015), St-Denis N (2016)	9
FAN1	2	FAN1	2	affinity chromatography technology, affinity chromatography technology	MacKay C (2010), Li X (2016)	2
FAN1	2	PMS1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Smogorzewska A (2010), MacKay C (2010), Hein MY (2015), St-Denis N (2016)	4
PMS1	3	PPP2R1A	8	affinity chromatography technology	Cannavo E (2007)	1
FANCI	1	PLEKHA8	3	affinity chromatography technology	Hein MY (2015)	1
FAN1	2	RFC3	0	affinity chromatography technology	MacKay C (2010)	1
FAN1	2	CD99L2	2	affinity chromatography technology	Hein MY (2015)	1
BLM	2	SUPT5H	2	genetic interference	Vizeacoumar FJ (2013)	1
RBM34	0	PRPF4B	3	affinity chromatography technology	Huttlin EL (2017)	1
PMS1	3	UBC	7	affinity chromatography technology	Cannavo E (2007)	1
UBC	7	KPNB1	3	affinity chromatography technology	Matsumoto M (2005)	1