PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TRIM23	3	TRAIP	0	two hybrid	Woodsmith J (2012)	1
UBE2E1	1	UBOX5	4	two hybrid	Markson G (2009)	1
MLH1	6	UBOX5	4	two hybrid, two hybrid	Rual JF (2005), Daakour S (2016)	2
UBE2D4	0	TRAF6	0	two hybrid	Markson G (2009)	1
USP2	0	TRAIP	0	two hybrid	Hayes SD (2012)	1
TRIM23	3	UBE2D1	0	pull down, pull down	Vichi A (2005), Vichi A (2006)	2
UBE2D2	0	UBE2V1	0	biochemical	Havugimana PC (2012)	1
TRAIP	0	UBE2D2	0	pull down	Besse A (2007)	1
TRAF6	0	UBOX5	4	two hybrid	Woodsmith J (2012)	1
MLH1	6	TRIM23	3	two hybrid	Brieger A (2010)	1
UBE2K	0	TRAIP	0	two hybrid	Markson G (2009)	1
TRIM23	3	UBE2W	0	pull down	Dawidziak DM (2017)	1
VCP	6	UBOX5	4	two hybrid	Rolland T (2014)	1
UBE2D1	0	TRAF6	0	two hybrid, pull down	Markson G (2009), Markson G (2009)	2
UBE2E2	1	UBOX5	4	two hybrid	Markson G (2009)	1
UBE2E1	1	NEDD4	2	enzymatic study, pull down, affinity chromatography technology, pull down, pull down, enzymatic study, pull down, pull down	Anan T (1998), Malakhova OA (2008), Malakhova OA (2008), Woelk T (2006), Sarkari F (2013), Sarkari F (2013), Sugeno N (2014), Zhang X (2017)	8
TRIM23	3	UBE2E1	1	pull down, pull down, pull down, enzymatic study, pull down	Ko JA (2006), Vichi A (2005), Vichi A (2006), Vichi A (2005), Dawidziak DM (2017)	5
TRIM23	3	UBE2D2	0	pull down, pull down, pull down	Vichi A (2005), Vichi A (2006), Dawidziak DM (2017)	3
UBE2D2	0	UBE2L3	1	biochemical	Havugimana PC (2012)	1
UBE2E2	1	TRIM23	3	two hybrid	Markson G (2009)	1
UBE2H	3	TRAIP	0	two hybrid	Markson G (2009)	1
UBE2D4	0	UBOX5	4	two hybrid	Markson G (2009)	1
USP2	0	TRAF6	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, two hybrid, enzymatic study	Bremm A (2010), Li Y (2013), Li Y (2013), Rolland T (2014), Li Y (2013)	5
NEDD4	2	UBE2D1	0	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Vina-Vilaseca A (2010), Sehat B (2008), Platta HW (2012), Tofaris GK (2011), Uchiki T (2009), Liu PY (2012), Sugeno N (2014), Kim HT (2007), Chen Z (2016)	9
TRIM23	3	UBOX5	4	two hybrid	Woodsmith J (2012)	1
UBE2D3	1	UBOX5	4	two hybrid, pull down	Markson G (2009), Hatakeyama S (2001)	2
USP2	0	UBOX5	4	two hybrid	Hayes SD (2012)	1
UBE2H	3	TRIM23	3	two hybrid	Markson G (2009)	1
TRAIP	0	UBE2D1	0	pull down	Besse A (2007)	1
UBE2V1	0	UBOX5	4	two hybrid	Markson G (2009)	1
TRAF6	0	UBE2E1	1	pull down	Markson G (2009)	1
NEDD4	2	UBE2D2	0	two hybrid, enzymatic study, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Hatakeyama S (1997), Anan T (1998), Sehat B (2008), Arevalo JC (2006), Woelk T (2006), Persaud A (2009), Zeng F (2009), Sarkari F (2013), Liu PY (2012), Sugeno N (2014), Bustos F (2015), Chesarino NM (2015), Sun M (2016)	13
UBE2L3	1	NEDD4	2	enzymatic study, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Anan T (1998), Bruce MC (2008), Wiesner S (2007), Vina-Vilaseca A (2010), Anindya R (2007), Lin Q (2010), Chung S (2011), Tofaris GK (2011), Han L (2013), Persaud A (2014), Uchiki T (2009), Miyazaki K (2003), Zhang W (2016), Zhang X (2017)	14
TRAIP	0	TRAF6	0	affinity chromatography technology	Besse A (2007)	1
UBE2W	0	UBOX5	4	two hybrid	Markson G (2009)	1
TRAF6	0	UBE2V1	0	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Deng L (2000), Lamothe B (2007), Kanayama A (2004), Shi CS (2010), Xia ZP (2009), Yang WL (2009), Murata H (2013), Ning S (2008), Sun L (2004), Lin Y (2014)	10
TRAF6	0	UBE2L3	1	pull down, pull down	Geetha T (2005), Babu JR (2005)	2
UBE2D3	1	NEDD4	2	enzymatic study, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down, pull down, pull down	Anan T (1998), Wang X (2008), Maspero E (2011), Katz M (2002), Wu K (2011), Maspero E (2013), Hong SW (2013), Zhou W (2014), Sugeno N (2014), Maspero E (2013), Miyazaki K (2003), Mari S (2014), Song F (2013), Fan CD (2013)	14
UBOX5	4	UBE2L3	1	two hybrid, pull down, two hybrid	Pringa E (2001), Pringa E (2001), Markson G (2009)	3
UBE2V1	0	UBE2K	0	biochemical	Wan C (2015)	1
USP2	0	TRIM23	3	two hybrid	Hayes SD (2012)	1
UBE2D1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
TRAF6	0	VCP	6	affinity chromatography technology	Ewing RM (2007)	1
TRAIP	0	UBE2D3	1	pull down	Besse A (2007)	1
TRAIP	0	UBOX5	4	two hybrid	Woodsmith J (2012)	1
UBE2D1	0	UBOX5	4	two hybrid	Markson G (2009)	1
UBE2K	0	UBE2D2	0	biochemical	Wan C (2015)	1
TRIM23	3	UBE2D3	1	pull down, pull down, pull down	Vichi A (2005), Vichi A (2006), Dawidziak DM (2017)	3
NEDD4	2	UBOX5	4	enzymatic study, pull down	Persaud A (2009), Persaud A (2009)	2
UBE2H	3	UBOX5	4	two hybrid	Markson G (2009)	1
UBOX5	4	UBOX5	4	enzymatic study	Hatakeyama S (2001)	1
UBE2D2	0	UBOX5	4	two hybrid	Markson G (2009)	1
UBE2K	0	UBOX5	4	two hybrid	Markson G (2009)	1
UBE2D3	1	TRAF6	0	two hybrid, enzymatic study, pull down, pull down, pull down	Markson G (2009), Petroski MD (2007), Xia ZP (2009), Markson G (2009), Wauer T (2015)	5
UBE2D2	0	TRAF6	0	two hybrid, pull down	Markson G (2009), Markson G (2009)	2
TRIM23	3	UBE2D4	0	pull down	Dawidziak DM (2017)	1