PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
YWHAZ	1	APP	1	pull down	Olah J (2011)	1
HNRNPL	3	APP	1	affinity chromatography technology	Fei T (2017)	1
FAM206A	0	ZHX2	3	affinity chromatography technology	Huttlin EL (2017)	1
ZHX1	1	ZHX3	1	two hybrid, two hybrid, pull down	Yamada K (2003), Yamada K (2003), Yamada K (2003)	3
YWHAZ	1	HNRNPL	3	affinity chromatography technology	Ewing RM (2007)	1
ATXN1	2	ZHX3	1	two hybrid	Lim J (2006)	1
HRAS	2	ZHX2	3	two hybrid, pull down, affinity chromatography technology	Depaux A (2007), Edsjoe A (2001), Wang JB (2005)	3
YWHAZ	1	ZHX2	3	affinity chromatography technology	Goeransson O (2006)	1
DOCK5	6	ZHX2	3	affinity chromatography technology	Huttlin EL (2017)	1
ZHX1	1	ZHX2	3	affinity chromatography technology	Hein MY (2015)	1
ZHX2	3	APP	1	pull down	Olah J (2011)	1
HNRNPL	3	ZHX2	3	affinity chromatography technology	Fei T (2017)	1
NAGPA	2	ZHX2	3	two hybrid	Wang J (2011)	1
ATXN1	2	DOCK5	6	two hybrid	Suter B (2013)	1
HNRNPL	3	DOCK5	6	affinity chromatography technology	Fei T (2017)	1
ATXN1	2	ZHX2	3	two hybrid	Lim J (2006)	1
HNRNPL	3	ATXN1	2	affinity chromatography technology	Fei T (2017)	1
YWHAQ	0	YWHAZ	1	affinity chromatography technology, biochemical, affinity chromatography technology	Pozuelo-Rubio M (2010), Kristensen AR (2012), Hein MY (2015)	3
LAT	0	ZHX2	3	two hybrid	Wang J (2011)	1
DHRS2	2	ZHX2	3	two hybrid	Wang J (2011)	1
YWHAQ	0	ZHX2	3	pull down	Liu YC (1997)	1
ZHX2	3	RRAS	2	affinity chromatography technology	Swiercz JM (2009)	1
ZHX2	3	ZHX3	1	pull down, pull down, two hybrid	Kawata H (2003), Kawata H (2003), Kawata H (2003)	3
ZHX1	1	ATXN1	2	two hybrid, two hybrid, affinity chromatography technology	Yamada K (2003), Lim J (2006), Lim J (2006)	3