PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
NLGN1	5	DLG2	4	two hybrid	Irie M (1997)	1
NLGN3	3	DLG2	4	two hybrid	Irie M (1997)	1
NLGN3	3	DLG3	1	two hybrid	Irie M (1997)	1
NRXN3	7	NLGN1	5	pull down	Ichtchenko K (1996)	1
NRXN1	14	NLGN1	5	pull down, pull down	Comoletti D (2003), Ichtchenko K (1996)	2
NLGN3	3	DLG4	11	two hybrid	Irie M (1997)	1
NLGN3	3	NLGN1	5	affinity chromatography technology	Huttlin EL (2017)	1
NLGN1	5	DLG4	11	two hybrid, pull down	Irie M (1997), Irie M (1997)	2
NLGN1	5	DLG3	1	two hybrid	Irie M (1997)	1
NRXN3	7	NLGN3	3	pull down	Ichtchenko K (1996)	1
DLG3	1	DLG4	11	two hybrid, pull down	Masuko N (1999), Masuko N (1999)	2
B3GAT3	1	NLGN1	5	affinity chromatography technology	Huttlin EL (2017)	1
DLG2	4	DLG4	11	affinity chromatography technology	Hsueh YP (1997)	1
NRXN2	7	NLGN1	5	pull down	Ichtchenko K (1996)	1
NRXN1	14	NLGN3	3	pull down	Ichtchenko K (1996)	1