PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RHOBTB2	6	RHOBTB3	1	affinity chromatography technology, two hybrid, affinity chromatography technology	Berthold J (2008), Berthold J (2008), Berthold J (2008)	3
RHOBTB3	1	VHL	0	affinity chromatography technology, pull down, two hybrid	Zhang CS (2015), Zhang CS (2015), Zhang CS (2015)	3
RHOBTB3	1	UBXN11	1	two hybrid	Rolland T (2014)	1
HAVCR2	0	RHOBTB3	1	affinity chromatography technology	Huttlin EL (2017)	1
TRIM25	5	HSP90AA1	7	affinity chromatography technology	Choudhury NR (2017)	1
100132285	0	RHOBTB3	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
VHL	0	EGLN1	3	affinity chromatography technology, affinity chromatography technology, pull down	Foxler DE (2012), Zhang CS (2015), Zhang CS (2015)	3
RABGGTB	1	RHOBTB3	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HIF1A	1	RBX1	2	affinity chromatography technology	Heir P (2013)	1
HSP90AA1	7	HIF1A	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hogenesch JB (1997), Qian DZ (2006), Kong X (2006), Kubo T (2004), Zhou J (2004), Fu B (2007), Choi YK (2010), Choi YK (2010), Lee JM (2011), Liu YV (2007), Liu YV (2007), Katschinski DM (2004), Katschinski DM (2004), Katschinski DM (2004), Trisciuoglio D (2010), Trisciuoglio D (2010), Ueda K (2008), Sun H (2013), Kawanami D (2009), Prince TL (2015), Prince TL (2015), Isaacs JS (2004), Lee SH (2015)	23
FAS	2	RHOBTB3	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RHOBTB3	1	NUP210	9	affinity chromatography technology	Huttlin EL (2017)	1
TRIM25	5	RHOBTB3	1	affinity chromatography technology	Choudhury NR (2017)	1
NTRK1	1	NUP210	9	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	RHOBTB3	1	affinity chromatography technology	Emdal KB (2015)	1
RHOBTB3	1	PLIN3	3	biochemical	Espinosa EJ (2009)	1
RHOBTB3	1	PCYOX1	3	affinity chromatography technology	Huttlin EL (2017)	1
NTRK1	1	HGS	5	affinity chromatography technology	Emdal KB (2015)	1
HTR7	2	CUL3	17	affinity chromatography technology	Matthys A (2012)	1
ISLR	0	RHOBTB3	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RBX1	2	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dias DC (2002), Furukawa M (2005), Hu J (2004), Furukawa M (2002), Ichikawa T (2009), Ichikawa T (2009), Lee DF (2009), Tron AE (2012), Oshikawa K (2003), Plafker KS (2009), Lu A (2013), Meyer-Schaller N (2009), Theurillat JP (2014), Huang DT (2009), Ibeawuchi SR (2015), Schumacher FR (2015), Kasahara K (2014), Kasahara K (2014)	18
NTRK1	1	CUL3	17	affinity chromatography technology	Emdal KB (2015)	1
BHLHE40	5	RBPMS	0	two hybrid	Rolland T (2014)	1
ISLR	0	PCYOX1	3	affinity chromatography technology	Huttlin EL (2015)	1
VHL	0	HSP90AA1	7	affinity chromatography technology, genetic interference	Yang C (2013), Shen JP (2017)	2
RHOBTB2	6	CUL3	17	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Wilkins A (2004), Wilkins A (2004), Wilkins A (2004), Bennett EJ (2010), Berthold J (2008), Berthold J (2008), Berthold J (2008)	7
RHOBTB3	1	RHOBTB3	1	affinity chromatography technology, two hybrid, affinity chromatography technology	Berthold J (2008), Berthold J (2008), Zhang CS (2015)	3
LIMD1	4	EGLN1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Foxler DE (2012), Foxler DE (2012), Zhang CS (2015)	3
BHLHE40	5	RHOBTB3	1	two hybrid	Rolland T (2014)	1
VHL	0	RBX1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Kohroki J (2005), Kamura T (2002), Kuznetsova AV (2003), Norman JA (2006), Knauth K (2006), Kamura T (2004), Heir P (2013), Essers PB (2014), Lee SB (2016)	10
RBPMS	0	RHOBTB3	1	two hybrid	Rolland T (2014)	1
VHL	0	HIF1A	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, far western blotting, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, pull down, protein complementation assay, pull down, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Corn PG (2003), Li Z (2003), Mahon PC (2001), Tanimoto K (2000), Min JH (2002), Yu F (2001), Yu F (2001), Jung JE (2008), Jung JE (2008), Andre H (2008), Park YK (2008), Kim BY (2008), Park SS (2008), Baek JH (2007), Baek JH (2007), Baek JH (2007), Kondo S (2006), Ietta F (2006), Kwon SJ (2005), Bae MK (2005), Baek JH (2005), Hon WC (2002), Hon WC (2002), Lewis MD (2004), Kasuno K (2004), Metzen E (2003), Metzen E (2003), Zhou J (2003), Yuan Y (2003), Maynard MA (2003), Jeong JW (2002), Yoo YG (2008), Hansen WJ (2002), Masson N (2001), Masson N (2001), Clifford SC (2001), Jaakkola P (2001), Jaakkola P (2001), Kamura T (2000), Kamura T (2000), Kamura T (2000), Ohh M (2000), Ohh M (2000), Cockman ME (2000), Cockman ME (2000), Sufan RI (2006), Chang CC (2011), Sufan RI (2009), Stickle NH (2004), Luo W (2010), Lee HY (2011), Roe JS (2011), Ivan M (2001), Ivan M (2001), Huang LE (2002), Callapina M (2005), Callapina M (2005), Maranchie JK (2002), DAngelo G (2003), DAngelo G (2003), Miller F (2005), Grosfeld A (2007), Grosfeld A (2007), Rajakumar A (2008), Bonicalzi ME (2001), Bemis L (2004), Berra E (2001), Yu F (2001), Bex C (2007), Zhou J (2012), Wiesener MS (2002), Maxwell PH (1999), Maxwell PH (1999), Lee SH (2012), Lee SH (2012), Ivan M (2002), Aprelikova O (2009), Choi CY (2009), Choi CY (2009), Heir P (2013), Russell RC (2008), Russell RC (2008), Park JH (2011), Park JH (2011), Liu Q (2013), Yeh IJ (2013), Choi YK (2010), Yang F (2014), Yang F (2014), Yang F (2014), Parsanejad M (2014), Yang C (2013), Yang C (2013), Chen K (2013), Park MH (2014), Gerez J (2015), Hein MY (2015), Park MH (2015), Fu R (2016), Alahari S (2015), Zhang CS (2015), Song D (2013), Chen K (2016), Hicks KC (2016), Groulx I (2002), Groulx I (2002), Groulx I (2002), Huttlin EL (2017), Guo J (2016), Sun W (2017), Sun W (2017), Guo J (2016), Li YM (2005), Yoo YG (2004), Kimura M (2008), Ferrer CM (2014)	116
CD83	0	RHOBTB3	1	affinity chromatography technology	Huttlin EL (2017)	1
RHOBTB3	1	ARF5	0	affinity chromatography technology	Huttlin EL (2017)	1
RHOBTB3	1	HTR7	2	affinity chromatography technology, affinity chromatography technology	Matthys A (2012), Matthys A (2012)	2
IL4R	1	HGS	5	affinity chromatography technology, pull down	Amano Y (2011), Amano Y (2011)	2
VHL	0	LIMD1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Foxler DE (2012), Foxler DE (2012), Zhang CS (2015), Zhang CS (2015)	4
FAS	2	ARF5	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
VHL	0	RBPMS	0	pull down	Lai Y (2012)	1
EGLN1	3	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Song D (2013), Song D (2013), Song D (2013), Song D (2014), Song D (2014)	5
RHOBTB3	1	EGLN1	3	affinity chromatography technology, affinity chromatography technology	Zhang CS (2015), Zhang CS (2015)	2
CUL3	17	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Taipale M (2012)	2
IL1R2	2	RHOBTB3	1	affinity chromatography technology	Huttlin EL (2017)	1
NTRK1	1	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rao R (2010), Taipale M (2012), Emdal KB (2015)	3
RHOBTB3	1	RBX1	2	affinity chromatography technology, pull down	Lu A (2013), Lu A (2013)	2
PLIN3	3	RAB9A	0	pull down	Hanna J (2002)	1
RHOBTB2	6	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, two hybrid	Manjarrez JR (2014), Prince TL (2015), Prince TL (2015)	3
CCNE1	1	CUL3	17	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Singer JD (1999), Singer JD (1999), Singer JD (1999), Wimuttisuk W (2007), Jin X (2016), Jin X (2016), Jin X (2016)	7
RAB9A	0	RABGGTB	1	affinity chromatography technology	Huttlin EL (2017)	1
CUL3	17	RHOBTB3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Berthold J (2008), Berthold J (2008), Lu A (2013), Lu A (2013), Lu A (2013), Huttlin EL (2017)	7
RHOBTB3	1	HSP90AA1	7	affinity chromatography technology	Zhang CS (2015)	1
IL17RB	0	RHOBTB3	1	affinity chromatography technology	Huttlin EL (2017)	1
HIF1A	1	EGLN1	3	pull down, pull down, pull down, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Percy MJ (2006), Baek JH (2005), Yoo YG (2008), Chowdhury R (2009), Choi YK (2010), Park MH (2014), Park MH (2015), Park MH (2015), Barth S (2007), Song D (2013), Guo J (2016), Kumar P (2015)	12
RHOBTB3	1	LIMD1	4	affinity chromatography technology, affinity chromatography technology	Zhang CS (2015), Zhang CS (2015)	2
CCNB1	3	RHOBTB3	1	affinity chromatography technology	Lu A (2013)	1
IL4R	1	RHOBTB3	1	affinity chromatography technology	Huttlin EL (2017)	1
CCNE1	1	RHOBTB3	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Lu A (2013), Lu A (2013), Lu A (2013)	3
TRIM25	5	RHOBTB2	6	affinity chromatography technology	Choudhury NR (2017)	1
NRG1	1	RHOBTB3	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RHOBTB3	1	PBK	0	affinity chromatography technology	Huttlin EL (2017)	1
RAB9A	0	RHOBTB3	1	two hybrid, pull down	Espinosa EJ (2009), Espinosa EJ (2009)	2
HGS	5	RHOBTB3	1	pull down	Pridgeon JW (2009)	1
RHOBTB3	1	HIF1A	1	affinity chromatography technology	Zhang CS (2015)	1