PPI network (data source: BioGrid)

Symbol A GeneA coding DNM count Symbol B GeneB coding DNM count Interaction detection method Publication Evidence
FHL2 0 SRF 1 pull down, affinity chromatography technology, affinity chromatography technology Philippar U (2004), Philippar U (2004), Philippar U (2004) 3
ESR1 0 DBN1 1 affinity chromatography technology, pull down Tarallo R (2011), Nalvarte I (2010) 2
CSNK1D 3 SMAD4 9 affinity chromatography technology Ding L (2009) 1
EP300 36 SMAD3 1 affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Qiu P (2006), Furumatsu T (2005), Itoh S (2000), Akiyoshi S (1999), Abecassis L (2004), Kaimori A (2010), Janknecht R (1998), Janknecht R (1998), Nishihara A (1999), Nishihara A (1999), Furumatsu T (2005), Ghosh AK (2004), Shen X (1998), Shen X (1998), Ghosh AK (2001), Postigo AA (2003), Postigo AA (2003), Yang WS (2005), Lim JY (2012), Lim JY (2012), Jinnin M (2007), Wang G (2005) 22
KCNA5 2 FHL1 1 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Poparic I (2011), Yang Z (2008), Yang Z (2008) 3
SRPK1 2 EWSR1 2 affinity chromatography technology So J (2015) 1
FHL2 0 SMAD3 1 pull down, affinity chromatography technology Ding L (2009), Ding L (2009) 2
SP1 0 EP300 36 affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, affinity chromatography technology, two hybrid, imaging technique, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology Gao J (2009), Goto T (2006), Hung JJ (2006), Hung JJ (2006), Hung JJ (2006), Choi HS (2002), Walker GE (2001), Kundu TK (2000), Suzuki T (2000), Suzuki T (2000), Wang X (2008), Wang X (2008), Wang X (2008), Chen YJ (2007), Chen YJ (2007), Azahri NS (2012), Azahri NS (2012), Li J (2013), Li J (2013), Wang SA (2014) 20
EP300 36 SMAD4 9 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology Kim RH (2000), Luciakova K (2008), Janknecht R (1998), Chung CL (2011), Shen X (1998), Dornan D (2003), Yang Y (2015) 7
FHL1 1 SMAD3 1 pull down, affinity chromatography technology, affinity chromatography technology Ding L (2009), Ding L (2009), Ding L (2009) 3
DEAF1 12 SP1 0 affinity chromatography technology, affinity chromatography technology Syddall CM (2013), Syddall CM (2013) 2
FHL2 0 SMAD4 9 pull down, affinity chromatography technology Ding L (2009), Ding L (2009) 2
CFTR 5 DBN1 1 affinity chromatography technology Pankow S (2015) 1
SRF 1 CREBBP 29 affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology Matsuzaki K (2003), Matsuzaki K (2003), Ramirez S (1997), Ramirez S (1997) 4
SMURF1 4 UBC 7 affinity chromatography technology, enzymatic study, pull down Xie Y (2013), Kristariyanto YA (2015), Zhang Y (2017) 3
LMNA 2 FHL1 1 bioid Roux KJ (2012) 1
FHL1 1 RING1 2 two hybrid, pull down, affinity chromatography technology Qin H (2004), Qin H (2004), Qin H (2004) 3
AKT1 1 CREBBP 29 pull down, enzymatic study Drendall CI (2010), Drendall CI (2010) 2
CFTR 5 FHL2 0 affinity chromatography technology Pankow S (2015) 1
EP300 36 ESR1 0 pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, two hybrid, enzymatic study, affinity chromatography technology, enzymatic study, pull down, pull down Fajas L (2002), Fan S (2002), Fan S (2002), Fan S (2002), Kang YK (2002), Kang YK (2002), Hao L (2010), Jin W (2008), Cui Y (2006), Dutertre M (2003), Dutertre M (2003), Shiozawa T (2003), Kim SH (2010), Ma Y (2010), Ma Y (2010), Fujita T (2003), Likhite VS (2004), Band AM (2011), Loven MA (2004), Nalvarte I (2010), Yi P (2015) 21
CFTR 5 FHL1 1 affinity chromatography technology Pankow S (2015) 1
SMAD4 9 SMAD2 5 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Moren A (2003), Wotton D (1999), Mori N (2001), Wu JW (2002), Wu JW (2002), Nakao A (1997), Wicks SJ (2000), Wu JW (2001), Chen X (1997), Hanai J (1999), Lebrun JJ (1999), Poncelet AC (2001), Razani B (2001), Razani B (2001), Wang B (2008), Moren A (2005), Kurisaki K (2003), Prunier C (2003), Kato Y (2002), Xu J (2000), Wang L (2011), He W (2006), He W (2006), Dupont S (2009), Brown JD (1999), Pardali K (2000), Fu G (2011), Chen W (2007), Gao S (2009), Lin X (2003), Seo SR (2006), Brown KA (2008), Brown KA (2008), Halder SK (2005), Barrios-Rodiles M (2005), Barrios-Rodiles M (2005), Dai F (2007), Chacko BM (2004), Chacko BM (2004), Chacko BM (2004), Wu RY (1997), Wu RY (1997), Tomita M (2004), Colland F (2004), Tang Y (2003), Ding L (2009), Fattet L (2013), Wang J (2011), Ali A (2013), Yamakawa N (2002), Yamakawa N (2002), Li X (2015), Zhou F (2014), Yang Y (2015), Yan X (2016), Zhou F (2017) 56
SMURF1 4 FHL1 1 affinity chromatography technology Xie Y (2013) 1
SMAD2 5 CSNK1D 3 affinity chromatography technology, affinity chromatography technology, enzymatic study Brown KA (2008), Ding L (2009), Ding L (2009) 3
EP300 36 UBC 7 enzymatic study, affinity chromatography technology Delvecchio M (2013), Kirilyuk A (2012) 2
SMURF1 4 LMNA 2 enzymatic study Andrews PS (2010) 1
AKT1 1 ESR1 0 enzymatic study Campbell RA (2001) 1
SMAD3 1 USP15 4 affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology Inui M (2011), Inui M (2011), Inui M (2011), Eichhorn PJ (2012), Wijnhoven P (2015) 5
FHL2 0 EP300 36 pull down, affinity chromatography technology Labalette C (2004), Labalette C (2004) 2
SP1 0 ESR1 0 imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down Koslowski M (2009), Jin W (2008), Dong J (2006), Dong J (2006), Castet A (2006), He S (2005), He S (2005), Varshochi R (2005), Varshochi R (2005), Petz LN (2004), Li D (2007), Itoh Y (2007), Saville B (2000), Gibson LL (2005) 14
UBC 7 FHL2 0 affinity chromatography technology Matsumoto M (2005) 1
G3BP1 4 FHL1 1 affinity chromatography technology Jain S (2016) 1
LMNA 2 USP15 4 bioid Roux KJ (2012) 1
SMAD4 9 AKT1 1 affinity chromatography technology Song K (2006) 1
SP1 0 TTN 102 affinity chromatography technology Chuang JY (2012) 1
ESR1 0 CREBBP 29 pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology Sheppard HM (2001), Fan S (2002), Fan S (2002), Fan S (2002), Jin W (2008), Jaber BM (2004), Jaber BM (2004), Heery DM (1997), Ku TK (2007), Crowe DL (2006) 10
G3BP1 4 LMNA 2 affinity chromatography technology Jain S (2016) 1
FHL1 1 AKAP12 4 two hybrid Vinayagam A (2011) 1
FHL1 1 DEAF1 12 two hybrid Vinayagam A (2011) 1
FHL1 1 NRIP1 4 two hybrid, pull down, affinity chromatography technology, affinity chromatography technology Lin J (2009), Lin J (2009), Lin J (2009), Lin J (2009) 4
CSNK1D 3 FHL1 1 affinity chromatography technology, pull down, affinity chromatography technology Ding L (2009), Ding L (2009), Ding L (2009) 3
EWSR1 2 FHL1 1 affinity chromatography technology Elzi DJ (2014) 1
LMNA 2 PRNP 4 two hybrid Dittmer TA (2014) 1
CSNK1D 3 PDE4DIP 10 affinity chromatography technology Huttlin EL (2017) 1
UBC 7 G3BP1 4 affinity chromatography technology Matsumoto M (2005) 1
FHL1 1 HIVEP3 12 affinity chromatography technology, two hybrid, pull down Qin H (2004), Qin H (2004), Qin H (2004) 3
SMAD2 5 SP1 0 affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology Poncelet AC (2001), Pardali K (2000), Pardali K (2000), Pardali K (2000), Barrasa JI (2011) 5
ESR1 0 SRPK1 2 affinity chromatography technology Tarallo R (2011) 1
LMNA 2 TTN 102 affinity chromatography technology Depreux FF (2015) 1
SP1 0 SRF 1 pull down Biesiada E (1999) 1
SP1 0 SMAD3 1 affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Botella LM (2001), Poncelet AC (2001), Pardali K (2000), Pardali K (2000), Pardali K (2000), Pardali K (2000), Barrasa JI (2011), Jungert K (2006), Sanchez-Elsner T (2002) 9
SMAD2 5 SMURF1 4 affinity chromatography technology, affinity chromatography technology, two hybrid Komuro A (2004), Ito I (2010), Colland F (2004) 3
PRNP 4 PDE4DIP 10 pull down Satoh J (2009) 1
FHL1 1 ESR1 0 affinity chromatography technology, affinity chromatography technology Lin J (2009), Zhang F (2012) 2
SMURF1 4 ESR1 0 affinity chromatography technology, affinity chromatography technology, pull down Ito I (2010), Ito I (2010), Ito I (2010) 3
EWSR1 2 SMAD4 9 two hybrid Rual JF (2005) 1
FHL1 1 MYBPC1 4 two hybrid, affinity chromatography technology, pull down McGrath MJ (2006), McGrath MJ (2006), McGrath MJ (2006) 3
AKT1 1 EP300 36 affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down Lin WN (2008), Lee IT (2010), Sundaresan NR (2011), Howie HL (2011), Chen J (2004), Chen J (2004) 6
ESR1 0 G3BP1 4 affinity chromatography technology Tarallo R (2011) 1
SMURF1 4 CSNK1D 3 enzymatic study Andrews PS (2010) 1
SMURF1 4 USP15 4 affinity chromatography technology Xie Y (2013) 1
EED 1 LMNA 2 affinity chromatography technology Cao Q (2014) 1
FHL1 1 SMAD4 9 pull down, affinity chromatography technology, affinity chromatography technology Ding L (2009), Ding L (2009), Ding L (2009) 3
EP300 36 EWSR1 2 two hybrid, bioid Wang J (2011), Elzi DJ (2014) 2
EWSR1 2 CREBBP 29 pull down, bioid Araya N (2003), Elzi DJ (2014) 2
CREBBP 29 SP1 0 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Goto T (2006), Leclerc GJ (2010), Chuang JY (2012), Guo W (2014) 4
SMAD4 9 USP15 4 affinity chromatography technology, affinity chromatography technology Inui M (2011), Eichhorn PJ (2012) 2
SMAD3 1 SMURF1 4 affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology Komuro A (2004), Colland F (2004), Li Y (2017), Li Y (2017) 4
ESR1 0 NRIP1 4 pull down, pull down, far western blotting, pull down, pull down, two hybrid, affinity chromatography technology Cavailles V (1995), Thenot S (1997), LHorset F (1996), LHorset F (1996), Castet A (2006), Heery DM (1997), Li W (2015) 7
CFTR 5 LMNA 2 affinity chromatography technology Pankow S (2015) 1
SP1 0 SMAD4 9 affinity chromatography technology, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology Luciakova K (2008), Pardali K (2000), Pardali K (2000), Pardali K (2000), Chung CL (2011), Jungert K (2006) 6
FHL1 1 EED 1 two hybrid Vinayagam A (2011) 1
SP1 0 FHL1 1 affinity chromatography technology Chuang JY (2012) 1
SMAD2 5 AKT1 1 affinity chromatography technology Song K (2006) 1
SMAD2 5 CREBBP 29 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology Xi Q (2008), Chan EC (2010), He W (2006), Chen W (2007), Colland F (2004), Cui Q (2005) 6
CREBBP 29 SMAD3 1 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Kang JS (2005), Alliston T (2005), Xi Q (2008), Cui Q (2005), Cui Q (2005), Chen W (2007), Nishihara A (1999), Tomita M (2004), Oussaief L (2009), Oussaief L (2009), Cui Q (2005) 11
EP300 36 SMAD2 5 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology Wotton D (1999), Pessah M (2001), Furumatsu T (2005), Wang J (2011), Suganuma T (2002) 5
FHL1 1 CREBBP 29 affinity chromatography technology Hubbi ME (2012) 1
SMAD3 1 SMAD2 5 affinity chromatography technology, genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology Nakao A (1997), Lebrun JJ (1999), Dumont E (2003), Brown KA (2008), Brown KA (2008), Wu RY (1997), Wu RY (1997), Tang Y (2003), Tang Y (2003), Wang J (2011), Huttlin EL (2015), Huttlin EL (2017) 12
SRPK1 2 FHL1 1 enzymatic study Varjosalo M (2013) 1
CFTR 5 AKAP12 4 affinity chromatography technology Pankow S (2015) 1
CREBBP 29 EP300 36 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Crusselle-Davis VJ (2007), Dohda T (2004), Dohda T (2004) 3
UBC 7 FHL1 1 affinity chromatography technology Matsumoto M (2005) 1
USP15 4 UBC 7 pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, pull down Hetfeld BK (2005), Bremm A (2010), Komander D (2009), Loch CM (2012), Herhaus L (2014), Wauer T (2015), Das T (2017), Zhang X (2017), Kwasna D (2018) 9
FHL2 0 FHL1 1 pull down Lange S (2002) 1
FHL1 1 AKT1 1 affinity chromatography technology Zhang F (2012) 1
FHL1 1 TTN 102 two hybrid, two hybrid Raskin A (2012), Raskin A (2012) 2
SMAD4 9 CREBBP 29 affinity chromatography technology Yang Y (2015) 1
CREBBP 29 FHL2 0 affinity chromatography technology Labalette C (2004) 1
SMAD2 5 USP15 4 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Inui M (2011), Eichhorn PJ (2012), Wijnhoven P (2015) 3
FHL2 0 SMAD2 5 pull down, affinity chromatography technology Ding L (2009), Ding L (2009) 2
SMAD3 1 SMAD4 9 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, pull down, pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, affinity chromatography technology Seoane J (2004), Moren A (2003), Wu JW (2002), Nakao A (1997), Hanai J (1999), Lebrun JJ (1999), Poncelet AC (2001), Jablonska E (2010), Prunier C (2003), Kato Y (2002), Kaimori A (2010), Tang LY (2011), Tang LY (2011), Dupont S (2009), Dupont S (2009), Pardali K (2000), Kardassis D (2000), Xu L (2003), Fu G (2011), Chen W (2007), Kang JM (2012), Gao S (2009), Li H (2009), Li H (2009), Brown KA (2008), Brown KA (2008), Halder SK (2005), Barrios-Rodiles M (2005), Dai F (2007), Dai F (2007), Chacko BM (2004), Chacko BM (2004), Chacko BM (2004), Stroschein SL (1999), Stroschein SL (1999), Stroschein SL (1999), Wu RY (1997), Wu RY (1997), Wu RY (1997), Wu RY (1997), Tomita M (2004), Colland F (2004), Colland F (2004), Tang Y (2003), Ding L (2009), Fattet L (2013), Wang J (2011), Xue J (2014), Ali A (2013), Gao S (2009), Yamakawa N (2002), Yamakawa N (2002), Wang G (2005), Li X (2015), Zhou F (2014), Yang Y (2015), Yan X (2016), Yan X (2016), Wu Y (2017), Wu Y (2017) 60
UBC 7 HIVEP3 12 affinity chromatography technology Matsumoto M (2005) 1
SP1 0 DBN1 1 affinity chromatography technology Chuang JY (2012) 1
ESR1 0 EWSR1 2 affinity chromatography technology Tarallo R (2011) 1
FHL1 1 SRF 1 pull down Philippar U (2004) 1
FHL2 0 MYBPC1 4 two hybrid, affinity chromatography technology McGrath MJ (2006), McGrath MJ (2006) 2
FHL1 1 RBPJ 1 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Qin H (2004), Li X (2015), Fu W (2014) 3
FHL1 1 EP300 36 affinity chromatography technology Hubbi ME (2012) 1
PRNP 4 FHL1 1 pull down Satoh J (2009) 1
FHL1 1 SMAD2 5 pull down, affinity chromatography technology, affinity chromatography technology Ding L (2009), Ding L (2009), Ding L (2009) 3
FHL1 1 DBN1 1 two hybrid Vinayagam A (2011) 1
EED 1 RING1 2 affinity chromatography technology, imaging technique, affinity chromatography technology Cao Q (2014), Cao Q (2014), Cao Q (2014) 3
ESR1 0 FHL2 0 two hybrid Kobayashi S (2004) 1
USP15 4 FHL1 1 affinity chromatography technology, pull down Isumi Y (2011), Isumi Y (2011) 2
EWSR1 2 TTN 102 bioid Elzi DJ (2014) 1
SMAD4 9 SMURF1 4 affinity chromatography technology, affinity chromatography technology Moren A (2005), Zhang L (2013) 2
FHL1 1 HES1 0 two hybrid Vinayagam A (2011) 1
SMAD3 1 CSNK1D 3 affinity chromatography technology, affinity chromatography technology, enzymatic study Brown KA (2008), Ding L (2009), Ding L (2009) 3
FHL2 0 TTN 102 two hybrid, pull down Lange S (2002), Lange S (2002) 2
FHL1 1 PDE4DIP 10 two hybrid Vinayagam A (2011) 1
SMAD3 1 AKT1 1 affinity chromatography technology, imaging technique Song K (2006), Chen TC (2014) 2
ESR1 0 SMAD2 5 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down Matsuda T (2001), Ito I (2010), Ito I (2010), Ito I (2010) 4
SMAD3 1 ESR1 0 affinity chromatography technology Ito I (2010) 1
FHL1 1 TXNIP 2 two hybrid Vinayagam A (2011) 1