PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
FGF12	4	IKZF1	2	two hybrid	Rolland T (2014)	1
YWHAE	0	FGF12	4	pull down	Satoh J (2006)	1
NEDD4L	3	FGF12	4	pull down	Persaud A (2009)	1
FGF12	4	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
DACH1	3	FGF12	4	two hybrid	Rolland T (2014)	1
NEDD4	2	FGF12	4	pull down	Persaud A (2009)	1
FGF12	4	LZTS2	4	two hybrid	Rolland T (2014)	1
MAPK13	1	FGF12	4	enzymatic study	Schoorlemmer J (2002)	1
SRPK2	1	FGF12	4	enzymatic study	Varjosalo M (2013)	1
SMURF1	4	FGF12	4	enzymatic study	Andrews PS (2010)	1
FGF12	4	ZNF460	4	two hybrid	Rolland T (2014)	1
MAPK8IP2	5	MAPK13	1	affinity chromatography technology, affinity chromatography technology	Schoorlemmer J (2002), Schoorlemmer J (2001)	2
SRPK1	2	FGF12	4	enzymatic study	Varjosalo M (2013)	1
PJA1	1	FGF12	4	enzymatic study	Loch CM (2011)	1
DCTD	0	FGF12	4	two hybrid	Rolland T (2014)	1
SMURF1	4	APP	1	pull down	Olah J (2011)	1
MAPK13	1	APP	1	pull down	Olah J (2011)	1
SRPK2	1	APP	1	pull down	Olah J (2011)	1
COIL	1	APP	1	pull down	Olah J (2011)	1
SRPK1	2	SRPK2	1	biochemical	Edmond V (2011)	1
SRPK1	2	APP	1	pull down	Olah J (2011)	1
MAPK8IP2	5	FGF12	4	affinity chromatography technology, two hybrid	Schoorlemmer J (2001), Grossmann A (2015)	2
DPPA2	0	FGF12	4	two hybrid	Yu H (2011)	1
APP	1	MAPK8IP2	5	affinity chromatography technology	Muresan Z (2005)	1
FGF12	4	COIL	1	two hybrid	Rolland T (2014)	1