PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SDC3	3	FGF2	1	pull down	Chernousov MA (1993)	1
RPL6	0	FGF2	1	two hybrid, pull down	Shen B (1998), Shen B (1998)	2
CSNK2A2	1	CSNK2A1	15	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), So J (2015), Huttlin EL (2015), Wan C (2015), Gao Z (2014), Hein MY (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	9
PRKACA	2	VTN	1	enzymatic study	Gechtman Z (1997)	1
FGFR2	6	FGFR1	2	affinity chromatography technology	Huttlin EL (2017)	1
FGFR2	6	FGF2	1	unspecified method, affinity chromatography technology	Li S (2008), Huttlin EL (2017)	2
FGF2	1	RPS19	1	biochemical, pull down	Soulet F (2001), Soulet F (2001)	2
FGF2	1	THBS1	6	pull down, pull down	Margosio B (2007), Margosio B (2007)	2
FGF2	1	SDC4	0	biochemical	Ma P (2006)	1
PRMT1	3	FGF2	1	enzymatic study	Klein S (2000)	1
FGFR1	2	FGF2	1	pull down, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, pull down	Sher I (2000), Li S (2008), Stachowiak EK (1997), Gonzalez-Martinez D (2004), Hu Y (2009), Lopez ME (2000), Levi E (1996), Riuzzi F (2011), Riuzzi F (2011), Pantoliano MW (1994), Pantoliano MW (1994), Pantoliano MW (1994), Motamed K (2003)	13
CD44	1	FGFR2	6	affinity chromatography technology	Huttlin EL (2017)	1
TUBG1	2	RPL6	0	affinity chromatography technology	Fogeron ML (2013)	1
CSNK2B	5	FGF2	1	pull down	Skjerpen CS (2002)	1
CSNK2A1	15	CSNK2B	5	pull down, affinity chromatography technology, far western blotting, two hybrid, two hybrid, two hybrid, pull down, enzymatic study, affinity chromatography technology, two hybrid, enzymatic study, biochemical, far western blotting, far western blotting, x-ray crystallography, enzymatic study, two hybrid, affinity chromatography technology, two hybrid, biochemical, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology	Kim MS (1998), Kim MS (1998), Marin O (1997), Bosc DG (2000), Ahn BH (2001), Kusk M (1999), Benitez MJ (2001), Uhle S (2003), Olsen BB (2008), Son MY (1999), Son MY (1999), Havugimana PC (2012), Llorens F (2003), Llorens F (2003), Niefind K (2001), Lee NY (2009), Wang J (2011), So J (2015), Wallach T (2013), Wan C (2015), Gao Z (2014), Ren K (2011), Goetz C (1999), Hauri S (2016)	24
COMT	2	FGF2	1	affinity chromatography technology	Hein MY (2015)	1
SDC2	0	FGFR2	6	affinity chromatography technology	Huttlin EL (2017)	1
CSNK2A2	1	FGF2	1	pull down	Skjerpen CS (2002)	1
FGF2	1	PRKACA	2	affinity chromatography technology	Wang F (2015)	1
FGF2	1	SDC2	0	biochemical, affinity chromatography technology	Ma P (2006), Huttlin EL (2017)	2
TUBG1	2	FGF2	1	affinity chromatography technology	Fogeron ML (2013)	1
CSNK2A1	15	FGF2	1	pull down, enzymatic study	Skjerpen CS (2002), Skjerpen CS (2002)	2
CSNK2A2	1	PRMT1	3	affinity chromatography technology	Varjosalo M (2013)	1
GPC3	0	FGF2	1	affinity chromatography technology	Midorikawa Y (2003)	1
FGF2	1	SDC1	0	biochemical, affinity chromatography technology	Ma P (2006), Huttlin EL (2017)	2
CD44	1	FGFR1	2	affinity chromatography technology, affinity chromatography technology	Wakahara K (2005), Huttlin EL (2017)	2
TMEFF1	0	FGF2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CD44	1	FGF2	1	affinity chromatography technology	Huttlin EL (2017)	1
CSNK2A1	15	RPL6	0	enzymatic study	Zhang M (2011)	1
FGFR1	2	AGER	1	affinity chromatography technology, affinity chromatography technology	Riuzzi F (2011), Riuzzi F (2011)	2
CSNK2B	5	CSNK2A2	1	two hybrid, affinity chromatography technology, far western blotting, two hybrid, enzymatic study, biochemical, two hybrid, biochemical, affinity chromatography technology, two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology	Lehner B (2004), Kim MS (1998), Marin O (1997), Bosc DG (2000), Watabe M (2011), Havugimana PC (2012), Wang J (2011), Kristensen AR (2012), Varjosalo M (2013), Wallach T (2013), Hein MY (2015), Goetz C (1999), Hauri S (2016)	13
FGFBP1	2	FGF2	1	pull down	Tassi E (2001)	1
FGF2	1	AGER	1	affinity chromatography technology, affinity chromatography technology	Riuzzi F (2011), Riuzzi F (2011)	2
IFI16	1	CSNK2B	5	affinity chromatography technology	Diner BA (2015)	1
GPC4	0	FGF2	1	pull down	Hagihara K (2000)	1
CSNK2A2	1	GPC4	0	affinity chromatography technology	Varjosalo M (2013)	1
RPL6	0	RPS19	1	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
S100B	0	FGFR1	2	affinity chromatography technology, affinity chromatography technology	Riuzzi F (2011), Riuzzi F (2011)	2
TUBG1	2	PRKACA	2	affinity chromatography technology	Hein MY (2015)	1
S100B	0	FGF2	1	affinity chromatography technology, affinity chromatography technology	Riuzzi F (2011), Riuzzi F (2011)	2
CSNK2A2	1	SDC2	0	affinity chromatography technology	Varjosalo M (2013)	1
IFI16	1	CSNK2A2	1	affinity chromatography technology	Diner BA (2015)	1
VTN	1	FGF2	1	pull down	Schoppet M (2002)	1
IFI16	1	FGF2	1	affinity chromatography technology	Diner BA (2015)	1
CRYAB	0	FGF2	1	unspecified method	Ghosh JG (2007)	1
TES	1	FGF2	1	affinity chromatography technology	Sala S (2017)	1
S100B	0	AGER	1	affinity chromatography technology, affinity chromatography technology	Riuzzi F (2011), Riuzzi F (2011)	2