Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
FDPS 2224 ALENDRONIC ACID CHEMBL870 inhibitor TdgClinicalTrial, GuideToPharmacologyInteractions, TEND
FDPS 2224 CHEMBL437758 CHEMBL437758 inhibitor GuideToPharmacologyInteractions
FDPS 2224 DROPERIDOL CHEMBL1108 inhibitor GuideToPharmacologyInteractions
FDPS 2224 ISOPENTENYLPYROPHOSPHATE CHEMBL356362 DrugBank 10592235
FDPS 2224 FARNESYL DIPHOSPHATE CHEMBL69330 DrugBank 10592235
FDPS 2224 CHEMBL1229266 CHEMBL1229266 DrugBank 10592235
FDPS 2224 (CYCLOHEXYLAMINO)METHYLENEDIPHOSPHONIC ACID CHEMBL56253 inhibitor GuideToPharmacologyInteractions
FDPS 2224 IBANDRONIC ACID CHEMBL997 inhibitor TdgClinicalTrial, GuideToPharmacologyInteractions, TEND
FDPS 2224 MINODRONIC ACID CHEMBL319144 inhibitor TdgClinicalTrial, GuideToPharmacologyInteractions
FDPS 2224 PAMIDRONIC ACID CHEMBL834 inhibitor TdgClinicalTrial, GuideToPharmacologyInteractions, TEND
FDPS 2224 PIRIDRONIC ACID CHEMBL99369 inhibitor GuideToPharmacologyInteractions
FDPS 2224 RISEDRONIC ACID CHEMBL923 inhibitor TdgClinicalTrial, GuideToPharmacologyInteractions, TEND
FDPS 2224 GERANYL DIPHOSPHATE CHEMBL41342 DrugBank 10592235
FDPS 2224 RISEDRONATE SODIUM CHEMBL1654 inhibitor ChemblInteractions
FDPS 2224 ZOLEDRONIC ACID CHEMBL924 inhibitor TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions, TEND, DrugBank 11752352, 17477829, 17535895, 11160603
FDPS 2224 DOXAPRAM CHEMBL1754 inhibitor GuideToPharmacologyInteractions
FDPS 2224 CHEMBL99553 CHEMBL99553 inhibitor GuideToPharmacologyInteractions
FDPS 2224 CHEMBL294192 CHEMBL294192 inhibitor GuideToPharmacologyInteractions
FDPS 2224 DORZOLAMIDE CHEMBL218490 inhibitor GuideToPharmacologyInteractions
FDPS 2224 DIMETHYLALLYL DIPHOSPHATE CHEMBL343480 DrugBank 10592235
FDPS 2224 IBANDRONATE SODIUM CHEMBL1201008 inhibitor ChemblInteractions
FDPS 2224 DROMOSTANOLONE PROPIONATE CHEMBL1201048 inhibitor GuideToPharmacologyInteractions
FDPS 2224 MEDRONIC ACID CHEMBL180570 PharmGKB
FDPS 2224 ALENDRONATE SODIUM CHEMBL675 inhibitor ChemblInteractions
FDPS 2224 PAMIDRONATE DISODIUM CHEMBL676 inhibitor ChemblInteractions

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
FDPS rs2297480 T Bisphosphonates efficacy yes Increased hip bone mineral density change. BMD measured at baseline and after treatment with antiresortive drugs (alendronate, risedronate or raloxifene) for at least 12 months. Most of them (>90%) were also given vitamin D and calcium supplements. Allele T is associated with increased response to Bisphosphonates in people with Osteoporosis as compared to allele G. 21151198 1448106156
FDPS rs11264359 A Bisphosphonates efficacy yes Increased hip bone mineral density change. BMD measured at baseline and after treatment with antiresortive drugs (alendronate, risedronate or raloxifene) for at least 12 months. Most of them (>90%) were also given vitamin D and calcium supplements. Allele A is associated with increased response to Bisphosphonates in people with Osteoporosis as compared to allele G. 21151198 1448106204