PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SNW1	0	ORC6	0	affinity chromatography technology	Lleres D (2010)	1
CDC5L	2	ORC1	3	pull down	Ramachandran N (2004)	1
FOXE1	2	ORC3	3	affinity chromatography technology	Li X (2015)	1
TUBGCP2	5	MZT2A	0	affinity chromatography technology, affinity chromatography technology	Fogeron ML (2013), Hein MY (2015)	2
ORC3	3	ORC6	0	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Kneissl M (2003), Kneissl M (2003), Vashee S (2001), Sibani S (2005), Sibani S (2005), Ramachandran N (2004)	6
FOXE1	2	ORC2	0	affinity chromatography technology	Li X (2015)	1
ORC6	0	LRWD1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FOXG1	26	LRWD1	1	affinity chromatography technology	Li X (2015)	1
LRWD1	1	PRR3	0	affinity chromatography technology	Hein MY (2015)	1
NTRK1	1	TUBGCP2	5	affinity chromatography technology	Emdal KB (2015)	1
ORC6	0	ORC2	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kneissl M (2003), Vashee S (2001), Vashee S (2001), Sibani S (2005), Sibani S (2005), Keller C (2002), Huttlin EL (2015), Huttlin EL (2017)	8
CUL7	4	DDB1	6	affinity chromatography technology	Hanson D (2014)	1
CDC5L	2	ORC3	3	affinity chromatography technology	Lleres D (2010)	1
ORC3	3	ORC1	3	pull down, affinity chromatography technology	Ramachandran N (2004), Hein MY (2015)	2
SNW1	0	TUBGCP2	5	affinity chromatography technology	Lleres D (2010)	1
FOXQ1	0	FXR1	0	affinity chromatography technology	Li X (2015)	1
FOXQ1	0	LRWD1	1	affinity chromatography technology	Li X (2015)	1
SNW1	0	CDC5L	2	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Zhang C (2003), Wan C (2015), Lleres D (2010), Lleres D (2010)	4
CDC5L	2	TUBG1	2	affinity chromatography technology	Lleres D (2010)	1
TUBGCP2	5	DDB1	6	affinity chromatography technology	Fogeron ML (2013)	1
TUBGCP2	5	TUBGCP6	2	affinity chromatography technology, biochemical, affinity chromatography technology	Fogeron ML (2013), Wan C (2015), Hein MY (2015)	3
SNW1	0	LRWD1	1	affinity chromatography technology	Lleres D (2010)	1
LRWD1	1	TUBGCP6	2	affinity chromatography technology	Hein MY (2015)	1
ORC4	1	ORC5	0	two hybrid, two hybrid, affinity chromatography technology, biochemical, pull down	Kneissl M (2003), Kneissl M (2003), Quintana DG (1998), Dhar SK (2001), Ramachandran N (2004)	5
TEAD2	2	NFATC1	12	affinity chromatography technology	Li X (2015)	1
TUBGCP3	1	MZT2A	0	affinity chromatography technology	Fogeron ML (2013)	1
NFATC1	12	LRWD1	1	affinity chromatography technology	Li X (2015)	1
FOXS1	2	FXR1	0	affinity chromatography technology	Li X (2015)	1
CDC5L	2	ORC4	1	affinity chromatography technology	Lleres D (2010)	1
SNW1	0	ORC5	0	affinity chromatography technology	Lleres D (2010)	1
FOXQ1	0	ORC2	0	affinity chromatography technology	Li X (2015)	1
TUBGCP2	5	TUBG1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fogeron ML (2013), Fogeron ML (2013), Hein MY (2015), Hein MY (2015)	4
LRWD1	1	MZT2A	0	affinity chromatography technology	Hein MY (2015)	1
NTRK1	1	TUBG1	2	affinity chromatography technology	Emdal KB (2015)	1
FOXB1	1	LRWD1	1	affinity chromatography technology	Li X (2015)	1
SNW1	0	ORC4	1	affinity chromatography technology	Lleres D (2010)	1
CC2D1A	1	LRWD1	1	biochemical	Wan C (2015)	1
CUL7	4	SNW1	0	affinity chromatography technology	Hanson D (2014)	1
LRWD1	1	TUBGCP2	5	affinity chromatography technology	Hein MY (2015)	1
RNF126	2	LRWD1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NTRK1	1	CDC5L	2	affinity chromatography technology	Emdal KB (2015)	1
LRWD1	1	ORC5	0	biochemical, affinity chromatography technology	Havugimana PC (2012), Hein MY (2015)	2
NTRK1	1	DNAJC7	2	affinity chromatography technology	Emdal KB (2015)	1
RNF126	2	EGFR	5	affinity chromatography technology, affinity chromatography technology, enzymatic study	Smith CJ (2013), Smith CJ (2013), Smith CJ (2013)	3
NFATC1	12	ORC2	0	affinity chromatography technology	Li X (2015)	1
EGFR	5	LRWD1	1	affinity chromatography technology	Tong J (2014)	1
NFATC1	12	HIST3H3	0	affinity chromatography technology	Li X (2015)	1
TUBGCP3	1	SNW1	0	affinity chromatography technology, affinity chromatography technology	Fogeron ML (2013), Lleres D (2010)	2
RPGR	0	DNAJC7	2	bioid	Gupta GD (2015)	1
ORC1	3	ORC2	0	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Fujita M (2002), Vashee S (2001), Vashee S (2001), Mendez J (2002), Mendez J (2002), Ramachandran N (2004), Vermeulen M (2010), Hein MY (2015), Hein MY (2015)	11
HIST4H4	1	LRWD1	1	unspecified method	Vermeulen M (2010)	1
SNW1	0	ORC3	3	affinity chromatography technology	Lleres D (2010)	1
ORC2	0	ORC4	1	two hybrid, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Kneissl M (2003), Dhar SK (2001), Quintana DG (1997), Vashee S (2001), Vashee S (2001), Sibani S (2005), Keller C (2002), Ramachandran N (2004), Vermeulen M (2010)	11
TEAD2	2	ORC2	0	affinity chromatography technology	Li X (2015)	1
RPGR	0	ORC2	0	affinity chromatography technology	Huttlin EL (2017)	1
EGFR	5	TUBGCP2	5	affinity chromatography technology	Tong J (2014)	1
LRWD1	1	TUBGCP3	1	affinity chromatography technology	Hein MY (2015)	1
TUBG1	2	TUBGCP3	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Choi YK (2010), Choi YK (2010), Fogeron ML (2013), Fogeron ML (2013), Hein MY (2015)	5
TEAD2	2	ORC4	1	affinity chromatography technology	Li X (2015)	1
LYPD4	1	LRWD1	1	affinity chromatography technology	Huttlin EL (2017)	1
NTRK1	1	SNW1	0	affinity chromatography technology	Emdal KB (2015)	1
ORC5	0	ORC6	0	two hybrid	Kneissl M (2003)	1
NTRK1	1	FXR1	0	affinity chromatography technology	Emdal KB (2015)	1
CDC5L	2	DDB1	6	affinity chromatography technology	Lleres D (2010)	1
THBS3	3	LRWD1	1	affinity chromatography technology	Huttlin EL (2015)	1
CDC5L	2	ORC2	0	pull down, affinity chromatography technology	Ramachandran N (2004), Lleres D (2010)	2
CUL4A	2	DDB1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Guerrero-Santoro J (2008), Guerrero-Santoro J (2008), Angers S (2006), Angers S (2006), Jin J (2006), Wang H (2006), Kapetanaki MG (2006), Matsuda N (2005), Hu J (2004), Hu J (2004), Hu J (2004), Ahn J (2010), Maddika S (2009), Fischer ES (2011), Tan L (2007), He YJ (2006), He YJ (2006), He YJ (2006), McCall CM (2008), McCall CM (2008), Shiyanov P (1999), Bennett EJ (2010), Gastaldello S (2012), Kanei-Ishii C (2012), Hodgson AJ (2012), Kulaksiz G (2005), Wu Z (2012), Wu Z (2012), Olma MH (2009), Olma MH (2009), Havugimana PC (2012), Rao F (2014), Wan C (2015), Liu Y (2015), Zha Z (2015), Mouysset J (2015), Gao J (2015), Yang Y (2016), Yang Y (2016), Scherer PC (2016), Eichner R (2016), Mo Y (2017), Mo Y (2017), Peng Z (2016), Higa LA (2006), Ohtake F (2007)	46
FXR1	0	ORC2	0	affinity chromatography technology	Li S (2014)	1
ORC5	0	CDC5L	2	pull down, affinity chromatography technology	Ramachandran N (2004), Lleres D (2010)	2
NTRK1	1	ORC3	3	affinity chromatography technology	Emdal KB (2015)	1
HIST3H3	0	LRWD1	1	unspecified method	Vermeulen M (2010)	1
NTRK1	1	ADD1	8	affinity chromatography technology	Emdal KB (2015)	1
SNW1	0	DDB1	6	affinity chromatography technology	Zhang C (2003)	1
NTRK1	1	GGH	1	affinity chromatography technology	Emdal KB (2015)	1
CDC5L	2	ORC6	0	affinity chromatography technology	Lleres D (2010)	1
FOXM1	3	LRWD1	1	affinity chromatography technology	Li X (2015)	1
TUBG1	2	TUBGCP6	2	affinity chromatography technology, biochemical, affinity chromatography technology	Fogeron ML (2013), Wan C (2015), Hein MY (2015)	3
FOXG1	26	ORC2	0	affinity chromatography technology	Li X (2015)	1
TSC22D4	1	LRWD1	1	affinity chromatography technology	Huttlin EL (2015)	1
TUBGCP2	5	TUBGCP3	1	biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Riehlman TD (2013), Fogeron ML (2013), Fogeron ML (2013), Wan C (2015), Hein MY (2015)	5
RPGR	0	LRWD1	1	affinity chromatography technology	Huttlin EL (2017)	1
STN1	0	LRWD1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LRWD1	1	ADD1	8	affinity chromatography technology	Hein MY (2015)	1
HIST3H3	0	ORC3	3	unspecified method	Vermeulen M (2010)	1
TEAD2	2	ORC3	3	affinity chromatography technology	Li X (2015)	1
CDC5L	2	TUBGCP3	1	affinity chromatography technology	Lleres D (2010)	1
CDC5L	2	LRWD1	1	affinity chromatography technology	Lleres D (2010)	1
NTRK1	1	EGFR	5	affinity chromatography technology	Emdal KB (2015)	1
CUL7	4	HIST4H4	1	affinity chromatography technology	Hanson D (2014)	1
STN1	0	ORC2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CUL7	4	CDC5L	2	affinity chromatography technology	Hanson D (2014)	1
TEAD2	2	LRWD1	1	affinity chromatography technology	Li X (2015)	1
LRWD1	1	DDB1	6	affinity chromatography technology, affinity chromatography technology	Shen Z (2012), Shen Z (2012)	2
CUL7	4	DNAJC7	2	affinity chromatography technology	Hanson D (2014)	1
NFATC1	12	FXR1	0	affinity chromatography technology	Gabriel CH (2016)	1
GGH	1	LRWD1	1	affinity chromatography technology	Huttlin EL (2015)	1
NTRK1	1	TUBGCP3	1	affinity chromatography technology	Emdal KB (2015)	1
HIST3H3	0	ORC2	0	unspecified method	Vermeulen M (2010)	1
EGFR	5	TUBG1	2	affinity chromatography technology	Tong J (2014)	1
HIST3H3	0	ORC5	0	unspecified method	Vermeulen M (2010)	1
ORC4	1	ORC6	0	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Kneissl M (2003), Kneissl M (2003), Kneissl M (2003), Sibani S (2005), Ramachandran N (2004)	5
MPHOSPH8	1	LRWD1	1	affinity chromatography technology	Hein MY (2015)	1
SNW1	0	TUBG1	2	affinity chromatography technology	Lleres D (2010)	1
LRWD1	1	ORC2	0	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Shen Z (2012), Shen Z (2012), Havugimana PC (2012), Vermeulen M (2010), Wan C (2015), Hein MY (2015), Hein MY (2015)	7
NTRK1	1	TUBGCP6	2	affinity chromatography technology	Emdal KB (2015)	1
CUL7	4	FXR1	0	affinity chromatography technology	Hanson D (2014)	1
EGFR	5	ORC5	0	affinity chromatography technology	Tong J (2014)	1
HIST3H3	0	HIST4H4	1	biochemical, affinity chromatography technology	Campos EI (2010), Campos EI (2010)	2
HIST4H4	1	ORC4	1	unspecified method	Vermeulen M (2010)	1
LRWD1	1	TUBG1	2	affinity chromatography technology	Hein MY (2015)	1
FOXM1	3	ORC2	0	affinity chromatography technology	Li X (2015)	1
LRWD1	1	LCOR	4	affinity chromatography technology	Hein MY (2015)	1
RPGR	0	ORC3	3	affinity chromatography technology	Huttlin EL (2017)	1
ORC1	3	ORC4	1	two hybrid, two hybrid, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Hein MY (2015)	3
FOXE1	2	LRWD1	1	affinity chromatography technology	Li X (2015)	1
ORC1	3	ORC5	0	two hybrid, two hybrid, pull down, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Ramachandran N (2004), Hein MY (2015)	4
HIST4H4	1	ORC2	0	unspecified method	Vermeulen M (2010)	1
CDC5L	2	TUBGCP2	5	affinity chromatography technology	Lleres D (2010)	1
ORC3	3	ORC5	0	two hybrid, two hybrid, biochemical, pull down, affinity chromatography technology, pull down, biochemical, pull down	Kneissl M (2003), Kneissl M (2003), Dhar SK (2001), Dhar SK (2001), Pinto S (1999), Vashee S (2001), Havugimana PC (2012), Ramachandran N (2004)	8
FOXS1	2	ORC2	0	affinity chromatography technology	Li X (2015)	1
SNW1	0	ORC2	0	affinity chromatography technology	Lleres D (2010)	1
CUL4A	2	TUBG1	2	affinity chromatography technology, enzymatic study	Thirunavukarasou A (2015), Thirunavukarasou A (2015)	2
ORC2	0	ORC5	0	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Kneissl M (2003), Quintana DG (1998), Dhar SK (2001), Dhar SK (2001), Vashee S (2001), Vashee S (2001), Keller C (2002), Havugimana PC (2012), Ramachandran N (2004), Vermeulen M (2010), Hein MY (2015)	13
FXR1	0	LRWD1	1	affinity chromatography technology	Li S (2014)	1
NTRK1	1	LRWD1	1	affinity chromatography technology	Emdal KB (2015)	1
TUBG1	2	MZT2A	0	affinity chromatography technology	Hein MY (2015)	1
ORC3	3	ORC4	1	biochemical, affinity chromatography technology, pull down, affinity chromatography technology, pull down	Dhar SK (2001), Pinto S (1999), Vashee S (2001), Sibani S (2005), Ramachandran N (2004)	5
NFATC1	12	ORC5	0	affinity chromatography technology	Li X (2015)	1
STN1	0	ORC3	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LRWD1	1	CUL4A	2	affinity chromatography technology, affinity chromatography technology	Shen Z (2012), Shen Z (2012)	2
HIST3H3	0	ORC4	1	unspecified method	Vermeulen M (2010)	1
HIST4H4	1	ORC5	0	unspecified method	Vermeulen M (2010)	1
NTRK1	1	DDB1	6	affinity chromatography technology	Emdal KB (2015)	1
LRWD1	1	ORC3	3	biochemical, affinity chromatography technology	Havugimana PC (2012), Hein MY (2015)	2
ORC2	0	ORC3	3	two hybrid, two hybrid, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Kneissl M (2003), Dhar SK (2001), Dhar SK (2001), Matsuoka S (2007), Pinto S (1999), Pinto S (1999), Vashee S (2001), Vashee S (2001), Sibani S (2005), Sibani S (2005), Keller C (2002), Havugimana PC (2012), Vermeulen M (2010), Wan C (2015), Hein MY (2015)	17
LRWD1	1	ORC4	1	affinity chromatography technology	Hein MY (2015)	1
TUBGCP3	1	TUBGCP6	2	affinity chromatography technology	Fogeron ML (2013)	1
DNAJC7	2	LRWD1	1	affinity chromatography technology	Huttlin EL (2017)	1
FOXS1	2	LRWD1	1	affinity chromatography technology	Li X (2015)	1
CUL7	4	LRWD1	1	affinity chromatography technology	Hanson D (2014)	1
NFATC1	12	DNAJC7	2	affinity chromatography technology	Gabriel CH (2016)	1
HIST4H4	1	ORC3	3	unspecified method	Vermeulen M (2010)	1
LRWD1	1	ORC1	3	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
FOXQ1	0	ORC3	3	affinity chromatography technology	Li X (2015)	1