PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
EGFR	5	BPTF	8	affinity chromatography technology	Yao Z (2017)	1
CUL7	4	RBBP4	3	affinity chromatography technology	Hanson D (2014)	1
RFXANK	0	SMARCA1	2	affinity chromatography technology	Huttlin EL (2017)	1
NSD3	6	HIST3H3	0	pull down, pull down, x-ray crystallography	He C (2013), He C (2013), He C (2013)	3
RBBP7	1	EED	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	5
SIRT7	1	SNRNP200	15	affinity chromatography technology	Tsai YC (2012)	1
CBX6	1	FOXK2	9	affinity chromatography technology	Vandamme J (2011)	1
LLGL2	4	TIMM13	0	affinity chromatography technology	Hauri S (2013)	1
VIRMA	4	BPTF	8	biochemical	Wan C (2015)	1
FOXK2	9	HMGXB4	0	affinity chromatography technology	Li X (2015)	1
EED	1	SMC1A	15	affinity chromatography technology	Cao Q (2014)	1
SMARCA1	2	RBBP7	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Barak O (2003), Huttlin EL (2015), Huttlin EL (2017)	3
BPTF	8	RBBP7	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Barak O (2003), Huttlin EL (2015), Huttlin EL (2017)	3
USF1	0	BPTF	8	affinity chromatography technology, affinity chromatography technology	Huang S (2007), Li X (2011)	2
BRCA1	7	BPTF	8	affinity chromatography technology	Ertych N (2016)	1
DLST	3	SQSTM1	0	affinity chromatography technology	Malty RH (2017)	1
CUL7	4	SQSTM1	0	affinity chromatography technology	Hanson D (2014)	1
CBX6	1	BPTF	8	affinity chromatography technology	Vandamme J (2011)	1
HMGXB4	0	RBBP4	3	biochemical	Havugimana PC (2012)	1
NCAPH2	4	BUB1	3	affinity chromatography technology	Huttlin EL (2017)	1
FOXK2	9	RBBP4	3	pull down	Shan L (2016)	1
BRCA1	7	HNRNPL	3	affinity chromatography technology	Ertych N (2016)	1
BPTF	8	NCOR1	9	biochemical	Havugimana PC (2012)	1
HIST1H3A	3	BPTF	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wysocka J (2006), Wysocka J (2006), Wysocka J (2006)	3
HNRNPL	3	FOXK2	9	affinity chromatography technology	Fei T (2017)	1
NSD3	6	BPTF	8	affinity chromatography technology	Shen C (2015)	1
HIST1H3A	3	EED	1	far western blotting	Tie F (2007)	1
CUL7	4	HNRNPL	3	affinity chromatography technology	Hanson D (2014)	1
C17orf49	1	BPTF	8	affinity chromatography technology, affinity chromatography technology	Vermeulen M (2010), Hein MY (2015)	2
C17orf49	1	RBBP7	1	affinity chromatography technology, affinity chromatography technology	Vermeulen M (2010), Huttlin EL (2015)	2
HIST1H3A	3	NCOR1	9	pull down	Yu J (2003)	1
CUL7	4	DEK	1	affinity chromatography technology	Hanson D (2014)	1
HIST3H3	0	CBX6	1	unspecified method, x-ray crystallography, affinity chromatography technology	Kaustov L (2011), Kaustov L (2011), Vandamme J (2011)	3
HIST1H3A	3	DEK	1	affinity chromatography technology	Ko SI (2006)	1
NCAPH2	4	NCOR1	9	affinity chromatography technology	Huttlin EL (2017)	1
SMC1A	15	BPTF	8	affinity chromatography technology	Hein MY (2015)	1
FOXK2	9	BPTF	8	affinity chromatography technology	Li X (2015)	1
C17orf49	1	HMGXB4	0	affinity chromatography technology	Vermeulen M (2010)	1
SMARCA1	2	BPTF	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Barak O (2003), Barak O (2003), Barak O (2003)	3
BPTF	8	KEAP1	0	two hybrid, pull down, imaging technique, pull down	Strachan GD (2004), Strachan GD (2004), Strachan GD (2004), Strachan GD (2004)	4
CUL7	4	BPTF	8	affinity chromatography technology	Hanson D (2014)	1
BPTF	8	H3F3A	1	pull down, x-ray crystallography	Li H (2006), Li H (2006)	2
EED	1	HIST3H3	0	unspecified method, x-ray crystallography	Xu C (2010), Xu C (2010)	2
LLGL2	4	HMGXB4	0	affinity chromatography technology	Hein MY (2015)	1
HNRNPL	3	EGFR	5	affinity chromatography technology	Fei T (2017)	1
KEAP1	0	BRCA1	7	affinity chromatography technology	Ma J (2012)	1
BPTF	8	NFE2L2	1	pull down	Strachan GD (2004)	1
RFXANK	0	BPTF	8	affinity chromatography technology	Huttlin EL (2017)	1
RBBP7	1	H3F3A	1	affinity chromatography technology	Hauri S (2016)	1
SMAD3	1	BRCA1	7	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dubrovska A (2005), Dubrovska A (2005), Dubrovska A (2005), Li H (2009), Li H (2009)	5
HIST1H3A	3	RBBP7	1	affinity chromatography technology	Foltz DR (2009)	1
SIRT7	1	CUL7	4	affinity chromatography technology	Tsai YC (2012)	1
SIRT7	1	RBBP7	1	affinity chromatography technology, affinity chromatography technology	Tsai YC (2012), Mo Y (2017)	2
FOXK2	9	NCOR1	9	affinity chromatography technology, affinity chromatography technology, biochemical	Li X (2015), Shan L (2016), Shan L (2016)	3
BPTF	8	HMGXB4	0	biochemical	Havugimana PC (2012)	1
RBBP4	3	RBBP7	1	biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	7
KEAP1	0	MAZ	2	affinity chromatography technology	Sowa ME (2009)	1
NCOR1	9	RBBP4	3	biochemical	Havugimana PC (2012)	1
BPTF	8	RBBP4	3	affinity chromatography technology, affinity chromatography technology	Barak O (2003), Hauri S (2016)	2
BPTF	8	TFAP4	3	biochemical	Wan C (2015)	1
BRCA1	7	PGR	1	enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Calvo V (2011), Ma Y (2006), Ma Y (2006), Ma Y (2006), Ma Y (2006)	5
EED	1	RBBP4	3	biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pasini D (2004), Cao R (2004), Hein MY (2015), Hauri S (2016), Hauri S (2016)	5
TFAP4	3	BRCA1	7	affinity chromatography technology	Ku WC (2009)	1
FOXK2	9	SNRNP200	15	affinity chromatography technology	Li X (2015)	1
BUB1	3	BPTF	8	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HIST3H3	0	RBBP7	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method	Campos EI (2010), Campos EI (2010), Campos EI (2010), Yoon HG (2005), Li X (2012)	5
EGFR	5	SMC1A	15	affinity chromatography technology	Tong J (2014)	1
HNRNPL	3	TFAP4	3	affinity chromatography technology	Fei T (2017)	1
SQSTM1	0	BPTF	8	two hybrid	Vinayagam A (2011)	1
SNRNP200	15	VIRMA	4	biochemical	Havugimana PC (2012)	1
KEAP1	0	EGFR	5	affinity chromatography technology, affinity chromatography technology, enzymatic study	Huo L (2015), Huo L (2015), Huo L (2015)	3
BRCA1	7	EED	1	pull down	Wang L (2013)	1
SQSTM1	0	NCOR1	9	pull down	Pridgeon JW (2004)	1
NCAPH2	4	BPTF	8	affinity chromatography technology	Huttlin EL (2017)	1
HIST3H3	0	DEK	1	unspecified method	Vermeulen M (2010)	1
EED	1	DEK	1	affinity chromatography technology	Cao Q (2014)	1
C17orf49	1	SMARCA1	2	affinity chromatography technology	Vermeulen M (2010)	1
BPTF	8	MAZ	2	two hybrid, pull down, pull down, two hybrid	Jordan-Sciutto KL (2000), Jordan-Sciutto KL (2000), Jordan-Sciutto KL (2000), Strachan GD (2004)	4
KEAP1	0	SQSTM1	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Sowa ME (2009), Jain A (2010), Jain A (2010), Lau A (2010), Lau A (2010), Lau A (2010), Lau A (2010), Lau A (2010), Lau A (2010), Inami Y (2011), Fan W (2010), Copple IM (2010), Copple IM (2010), Wright T (2013), Tanji K (2013), Ichimura Y (2013), Ichimura Y (2013), Ichimura Y (2013), Hast BE (2014), Hast BE (2014), Lerner C (2013), Rolland T (2014), Gjyshi O (2015), Bakkar N (2015), Milan E (2015), Park S (2016), Ge W (2017), Mildenberger J (2017), Lu K (2017), Lee Y (2017)	30
HIST3H3	0	RBBP4	3	affinity chromatography technology, unspecified method, unspecified method	Campos EI (2010), Li X (2012), Vermeulen M (2010)	3
HIST1H4I	4	BPTF	8	pull down, affinity chromatography technology, unspecified method, pull down, x-ray crystallography	Ruthenburg AJ (2011), Ruthenburg AJ (2011), Ruthenburg AJ (2011), Ruthenburg AJ (2011), Ruthenburg AJ (2011)	5
BRCA1	7	SMARCD2	1	biochemical	Bochar DA (2000)	1
LLGL2	4	BPTF	8	affinity chromatography technology	Hein MY (2015)	1
TFAP4	3	SNRNP200	15	biochemical	Wan C (2015)	1
RBBP7	1	BRCA1	7	affinity chromatography technology, two hybrid, pull down, far western blotting, pull down	Chen GC (2001), Chen GC (2001), Yarden RI (2001), Yarden RI (2001), Yarden RI (1999)	5
SMAD3	1	SMAD2	5	affinity chromatography technology, genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Nakao A (1997), Lebrun JJ (1999), Dumont E (2003), Brown KA (2008), Brown KA (2008), Wu RY (1997), Wu RY (1997), Tang Y (2003), Tang Y (2003), Wang J (2011), Huttlin EL (2015), Huttlin EL (2017)	12
DEK	1	BPTF	8	biochemical	Wan C (2015)	1
SIRT7	1	BPTF	8	affinity chromatography technology	Tsai YC (2012)	1
SMAD2	5	BPTF	8	pull down	Landry J (2008)	1
EED	1	BPTF	8	affinity chromatography technology	Cao Q (2014)	1
POU5F1	0	DEK	1	affinity chromatography technology	Oliviero G (2015)	1
EGFR	5	NCAPH2	4	affinity chromatography technology	Foerster S (2013)	1
BRCA1	7	NFE2L2	1	affinity chromatography technology, affinity chromatography technology	Gorrini C (2013), Gorrini C (2013)	2
HNRNPL	3	BPTF	8	affinity chromatography technology	Fei T (2017)	1
SMC1A	15	BRCA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yazdi PT (2002), Hill SJ (2014), Ertych N (2016)	3
SMAD3	1	SQSTM1	0	affinity chromatography technology, two hybrid	Wang J (2011), Wang J (2011)	2
HMGXB4	0	NCOR1	9	biochemical	Havugimana PC (2012)	1
SIRT7	1	RBBP4	3	affinity chromatography technology	Tsai YC (2012)	1
H3F3A	1	RBBP4	3	affinity chromatography technology, affinity chromatography technology	Tagami H (2004), Hauri S (2016)	2
HNRNPL	3	RBBP4	3	affinity chromatography technology	Fei T (2017)	1
FOXK2	9	C17orf49	1	affinity chromatography technology	Li X (2015)	1
KEAP1	0	NFE2L2	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, two hybrid, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, unspecified method, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cullinan SB (2003), Shibata T (2008), Wang XJ (2008), Nioi P (2007), Tanigawa S (2007), Tanigawa S (2007), Hong F (2005), Furukawa M (2005), Furukawa M (2005), Zhang DD (2003), McMahon M (2006), Ichikawa T (2009), Niture SK (2009), Niture SK (2009), Wu JH (2010), Wong DP (2010), Wong DP (2010), Yu M (2011), Lau A (2010), Lau A (2010), Kay HY (2010), Sun Z (2011), Sun Z (2011), Li X (2004), Li X (2004), Lo SC (2008), Plafker KS (2010), Plafker KS (2010), Yao JW (2012), Li Y (2012), Lo SC (2006), Lo SC (2006), Lo SC (2006), Eggler AL (2005), Zipper LM (2002), Sekhar KR (2002), Seng S (2009), Hast BE (2013), Hoerer S (2013), Baba K (2013), Wang J (2011), Ichimura Y (2013), Baird L (2013), Baird L (2013), Gorrini C (2013), Schaap M (2013), Jiang ZY (2014), Hast BE (2014), Hast BE (2014), Hast BE (2014), Qin S (2014), Buommino E (2012), Kaspar JW (2012), Kaspar JW (2012), Camp ND (2012), Zhang DD (2004), Furukawa M (2005), Khan H (2015), Huo L (2015), Foygel K (2015), Liu K (2015), Lo SC (2006), Kim WD (2012), Kim WD (2012), Kim WD (2012), Zhang Y (2016), Zhang Y (2016), Wu G (2017), Villeneuve NF (2013), Ma J (2012), Ma J (2012), Ma J (2012), Ge W (2017), Ge W (2017), Yoshizaki Y (2017), Yoshizaki Y (2017), Quinti L (2017), Wang Q (2017), Ha Kim K (2017), Yang C (2016), Mulvaney KM (2016), Lu K (2017)	82
EED	1	SMARCA1	2	affinity chromatography technology	Cao Q (2014)	1
SMARCA1	2	PGR	1	affinity chromatography technology	Lazzaro MA (2006)	1
HIST1H3A	3	SMARCA1	2	affinity chromatography technology	Wysocka J (2006)	1
BPTF	8	SMARCD2	1	biochemical	Havugimana PC (2012)	1
SIRT7	1	VIRMA	4	affinity chromatography technology	Tsai YC (2012)	1
FOXK2	9	SMARCA1	2	affinity chromatography technology	Li X (2015)	1
EED	1	HNRNPL	3	affinity chromatography technology	Cao Q (2014)	1
CUL7	4	HIST1H4I	4	affinity chromatography technology	Hanson D (2014)	1
USF1	0	SMARCA1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huang S (2007), Li X (2011), Li X (2011)	3
USF1	0	RBBP7	1	affinity chromatography technology	Huang S (2007)	1
PGR	1	BPTF	8	affinity chromatography technology	Vicent GP (2011)	1
NCOR1	9	NFE2L2	1	affinity chromatography technology	Ki SH (2005)	1
HIST3H3	0	HNRNPL	3	unspecified method	Vermeulen M (2010)	1
SMARCA1	2	RBBP4	3	affinity chromatography technology, affinity chromatography technology, biochemical	Barak O (2003), Barak O (2003), Havugimana PC (2012)	3
NSD3	6	HIST1H3A	3	enzymatic study, pull down	Morishita M (2014), Sankaran SM (2016)	2
DLST	3	BPTF	8	affinity chromatography technology	Malty RH (2017)	1
RBBP4	3	BRCA1	7	pull down, affinity chromatography technology, affinity chromatography technology	Yarden RI (1999), Yarden RI (1999), Ertych N (2016)	3
SQSTM1	0	NFE2L2	1	imaging technique	Lau A (2010)	1
BRCA1	7	SNRNP200	15	two hybrid, affinity chromatography technology, affinity chromatography technology	Woods NT (2012), Woods NT (2012), Ertych N (2016)	3
HIST3H3	0	HMGXB4	0	unspecified method	Vermeulen M (2010)	1
RBBP7	1	FOXK2	9	affinity chromatography technology, affinity chromatography technology, pull down	Huttlin EL (2015), Huttlin EL (2017), Shan L (2016)	3
SIRT7	1	HIST1H3A	3	pull down	Ford E (2006)	1
TIMM13	0	BPTF	8	affinity chromatography technology	Hein MY (2015)	1
EED	1	SNRNP200	15	affinity chromatography technology	Cao Q (2014)	1
C17orf49	1	RBBP4	3	affinity chromatography technology, affinity chromatography technology	Vermeulen M (2010), Hauri S (2016)	2
LLGL2	4	SQSTM1	0	affinity chromatography technology	Hauri S (2013)	1
FOXK2	9	TFAP4	3	affinity chromatography technology, affinity chromatography technology	Li X (2015), Huttlin EL (2017)	2
NCOR1	9	PGR	1	affinity chromatography technology	De Amicis F (2009)	1
HIST1H3A	3	RBBP4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method	Wysocka J (2006), Nishioka K (2002), Tagami H (2004), Foltz DR (2009), Millard CJ (2016)	5
SMAD3	1	BPTF	8	pull down	Landry J (2008)	1
HIST3H3	0	C17orf49	1	unspecified method	Vermeulen M (2010)	1
USF1	0	RBBP4	3	affinity chromatography technology, affinity chromatography technology	Huang S (2007), Li X (2011)	2
SNRNP200	15	BPTF	8	biochemical	Wan C (2015)	1
CUL7	4	SMC1A	15	affinity chromatography technology	Hanson D (2014)	1
POU5F1	0	BPTF	8	affinity chromatography technology	Oliviero G (2015)	1
CUL7	4	SNRNP200	15	affinity chromatography technology	Hanson D (2014)	1
HIST3H3	0	BPTF	8	pull down, unspecified method	Varier RA (2010), Vermeulen M (2010)	2
HSPB7	1	BPTF	8	affinity chromatography technology	Huttlin EL (2017)	1