Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
F5 2153 ELTROMBOPAG CHEMBL461101 FDA
F5 2153 THROMBIN CHEMBL2108110 TdgClinicalTrial
F5 2153 THROMBOMODULIN ALFA CHEMBL2108653 DrugBank
F5 2153 DROTRECOGIN ALFA (ACTIVATED) CHEMBL2109065 antagonist, inhibitor, multitarget PharmGKB, TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions, TEND, DrugBank, TTD 11893230, 12030642, 12004250, 11752352, 11714212, 11236773
F5 2153 TAMOXIFEN CHEMBL83 PharmGKB, FDA
F5 2153 ESTRONE SODIUM SULFATE CHEMBL2106240 PharmGKB

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
F5 rs7542281 C warfarin dosage no Samples, genotypes and INRs from a cohort of 551 patients were used to derive an algorithm which was used to predict daily warfarin maintenance dose in a second cohort of 236 patients. Note: the authors state that "SNPs were tested for deviations from HWE using the chi-squared test, and for their association with the warfarin dose by Spearman correlation analysis using a *co-dominant* model." Allele C is not associated with dose of warfarin in people with heart valve replacement as compared to allele T. 25126975 1184757055