Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
F3 2152 CHEMBL204997 CHEMBL204997 DrugBank 10592235
F3 2152 CHEMBL209022 CHEMBL209022 DrugBank 10592235
F3 2152 CHEMBL377956 CHEMBL377956 DrugBank 10592235

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
F3 rs3917643 CT simvastatin efficacy yes With simvastatin treatment (40 mg/day), the rate of reduction in maximum rates of formation of thrombin-antithrombin complexes and of prothrombin 1.2 fragments was greater following vascular injury in CT patients as compared to TT patients. There were no CC patients in this study. Baseline levels and at-site levels after injury were higher in CT patients than in TT patients. Genotype CT is associated with increased response to simvastatin in people with Myocardial Ischemia as compared to genotype TT. 19027114 981865016